ATE330958T1 - Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate - Google Patents

Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate

Info

Publication number: ATE330958T1
Authority: AT; Austria
Prior art keywords: böindol; 6öpyrido; pyrazino; derivatives; compounds
Prior art date: 2000-06-23

Application number

AT01935629T

Other languages

English (en)

Inventor

Mark W Orme

Jason Scott Sawyer

Lisa M Schultze

Alain Claude-Marie Daugan

Francoise Gellibert

Original Assignee

Lilly Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-05-15

Publication date

2006-07-15

2001-05-15 Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc

2006-07-15 Application granted granted Critical

2006-07-15 Publication of ATE330958T1 publication Critical patent/ATE330958T1/de

Links

150000001875 compounds Chemical class 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01935629T 2000-06-23 2001-05-15 Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate ATE330958T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US21364700P	2000-06-23	2000-06-23

Publications (1)

Publication Number	Publication Date
ATE330958T1 true ATE330958T1 (de)	2006-07-15

Family

ID=22795930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01935629T ATE330958T1 (de)	2000-06-23	2001-05-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate

Country Status (10)

Country	Link
US (1)	US6911542B2 (de)
EP (1)	EP1366049B1 (de)
JP (1)	JP4169149B2 (de)
AT (1)	ATE330958T1 (de)
AU (1)	AU2001261707A1 (de)
CA (1)	CA2412594C (de)
DE (1)	DE60121048T2 (de)
ES (1)	ES2269401T3 (de)
MX (1)	MXPA02012472A (de)
WO (1)	WO2002000656A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004011429A1 (ja) *	2002-07-26	2004-02-05	Nihon Nohyaku Co., Ltd.	新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
JP2004107323A (ja) *	2002-07-26	2004-04-08	Nippon Nohyaku Co Ltd	新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
EP1708718A1 (de)	2004-01-22	2006-10-11	Pfizer Limited	Triazol-derivate zur hemmung der vasopressing-antagonistischen aktivität
JP5070052B2 (ja)	2004-08-17	2012-11-07	ザ・ジョンズ・ホプキンス・ユニバーシティ	Ｐｄｅ５阻害剤組成物及び心臓疾患を治療する方法
ES2278552T1 (es) *	2005-04-12	2007-08-16	Teva Pharmaceutical Industries Ltd	Preparacion de intermediarios de tadalafil.
US9789126B2 (en)	2012-12-21	2017-10-17	Mayo Foundation For Medical Education And Research	Methods and materials for treating calcific aortic valve stenosis
US9695174B2 (en) *	2013-10-07	2017-07-04	Millennium Pharmaceuticals, Inc.	Inhibitor of breast cancer resistance protein (BCRP)
CA2987109C (en) *	2015-06-26	2020-07-07	Chongqing University of Arts and Sciences	6-(benzo[d][1,3]dioxol-5-yl)-2-substituted-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6h,7h)-dione derivatives as phosphodiesterase type-5 inhibitors
CN106279164B (zh) *	2015-06-26	2019-11-01	重庆迪康尔乐制药有限公司	5型磷酸二酯酶抑制剂及其应用
CN105384740A (zh) *	2015-12-18	2016-03-09	海南通用康力制药有限公司	一种制备他达拉非的中间体高纯度晶体及制备方法
MX2021012409A (es)	2019-04-10	2021-11-12	Mayo Found Medical Education & Res	Metodos y materiales para el tratamiento dependiente del genero de la disfuncion cardiovascular.
CN117903136A (zh) *	2024-01-12	2024-04-19	山东大学	一种no供体型pde5抑制剂及其应用
CN119390695A (zh) *	2024-12-31	2025-02-07	威胜生物医药(苏州)股份有限公司	一种水溶性氨基他达那非衍生物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9401090D0 (en)	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514464D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Medicaments

2001
- 2001-05-15 AU AU2001261707A patent/AU2001261707A1/en not_active Abandoned
- 2001-05-15 AT AT01935629T patent/ATE330958T1/de not_active IP Right Cessation
- 2001-05-15 WO PCT/US2001/015935 patent/WO2002000656A2/en not_active Ceased
- 2001-05-15 ES ES01935629T patent/ES2269401T3/es not_active Expired - Lifetime
- 2001-05-15 DE DE60121048T patent/DE60121048T2/de not_active Expired - Lifetime
- 2001-05-15 MX MXPA02012472A patent/MXPA02012472A/es active IP Right Grant
- 2001-05-15 CA CA002412594A patent/CA2412594C/en not_active Expired - Fee Related
- 2001-05-15 JP JP2002505780A patent/JP4169149B2/ja not_active Expired - Fee Related
- 2001-05-15 EP EP01935629A patent/EP1366049B1/de not_active Expired - Lifetime
- 2001-05-15 US US10/297,682 patent/US6911542B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2004513072A (ja)	2004-04-30
US20030225094A1 (en)	2003-12-04
CA2412594A1 (en)	2002-01-03
EP1366049A2 (de)	2003-12-03
ES2269401T3 (es)	2007-04-01
DE60121048T2 (de)	2007-01-25
US6911542B2 (en)	2005-06-28
EP1366049B1 (de)	2006-06-21
CA2412594C (en)	2009-03-17
WO2002000656A2 (en)	2002-01-03
DE60121048D1 (de)	2006-08-03
MXPA02012472A (es)	2004-01-26
JP4169149B2 (ja)	2008-10-22
WO2002000656A3 (en)	2003-10-02
AU2001261707A1 (en)	2002-01-08

Legal Events

Date	Code	Title	Description
2006-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60112974D1 (en)	2005-09-29	Carbolinderivate
ATE211139T1 (de)	2002-01-15	Tetrahydroimidazopyridoindoldione als cgmp spezifische pde hemmer
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
DE60216233D1 (en)	2007-01-04	Carbolinderivate
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
MXPA02012659A (es)	2003-09-22	Derivados de pirazindiona condensados.
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
ATE259813T1 (de)	2004-03-15	Triazolopyrimidinderivate
MXPA03003971A (es)	2004-02-12	Derivados de indol como inhibidores de pde5.
ATE293111T1 (de)	2005-04-15	Kondensierte pyrazindionderivate als pde inhibitoren
MXPA03000887A (es)	2004-04-05	Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
CA2445620A1 (en)	2002-12-12	Tetracyclic compounds as pde5-inhibitors
CY1105981T1 (el)	2011-04-06	Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων