ATE330968T1 - Cyclosporin-derivate und verfahren zu deren herstellung - Google Patents
Cyclosporin-derivate und verfahren zu deren herstellungInfo
- Publication number
- ATE330968T1 ATE330968T1 AT00901297T AT00901297T ATE330968T1 AT E330968 T1 ATE330968 T1 AT E330968T1 AT 00901297 T AT00901297 T AT 00901297T AT 00901297 T AT00901297 T AT 00901297T AT E330968 T1 ATE330968 T1 AT E330968T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- derivatives
- cyclosporine derivatives
- relates
- cyclosporine
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH22099 | 1999-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330968T1 true ATE330968T1 (de) | 2006-07-15 |
Family
ID=4182021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00901297T ATE330968T1 (de) | 1999-02-05 | 2000-02-07 | Cyclosporin-derivate und verfahren zu deren herstellung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6790935B1 (de) |
| EP (1) | EP1150999B1 (de) |
| AT (1) | ATE330968T1 (de) |
| AU (1) | AU2125300A (de) |
| CY (1) | CY1105452T1 (de) |
| DE (1) | DE60028936T2 (de) |
| DK (1) | DK1150999T3 (de) |
| ES (1) | ES2267492T3 (de) |
| PT (1) | PT1150999E (de) |
| WO (1) | WO2000046239A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6995139B2 (en) * | 2001-04-20 | 2006-02-07 | Debiopharm S.A. | Cyclic undecapeptide pro-drugs and uses thereof |
| JP2008526816A (ja) * | 2005-01-10 | 2008-07-24 | デビオファーム ソシエテ アノニム | 心筋虚血状態の間の投与のための薬剤の製造のための環状ウンデカペプチドの使用 |
| BRPI0605658B8 (pt) * | 2006-12-29 | 2021-05-25 | Embrapa Pesquisa Agropecuaria | peptídeo antibiótico rico em glicina derivado de planta |
| US8153815B2 (en) * | 2008-10-07 | 2012-04-10 | Hoffman-La Roche Inc. | Pseudoproline dipeptides |
| ES2921576T3 (es) | 2008-12-19 | 2022-08-29 | Vertex Pharma | Compuestos útiles como inhibidores de la quinasa ATR |
| US8349312B2 (en) * | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8367053B2 (en) * | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8685917B2 (en) * | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| NZ603477A (en) | 2010-05-12 | 2014-09-26 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
| BR112013014890B1 (pt) | 2010-12-15 | 2023-10-24 | Contravir Pharmaceuticals, Inc | Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos |
| CN106496173A (zh) | 2011-09-30 | 2017-03-15 | 沃泰克斯药物股份有限公司 | 用于制备可用作atr激酶抑制剂的化合物的方法 |
| CN108685922A (zh) | 2011-09-30 | 2018-10-23 | 沃泰克斯药物股份有限公司 | 用atr抑制剂治疗胰腺癌和非小细胞肺癌 |
| CN108478577A (zh) | 2012-04-05 | 2018-09-04 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物及其组合疗法 |
| AR090964A1 (es) * | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
| JP2015519368A (ja) | 2012-06-01 | 2015-07-09 | アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンａ類似体 |
| DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
| US9914755B2 (en) | 2015-01-08 | 2018-03-13 | Allergan, Inc. | Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized |
| AU2016331955B2 (en) | 2015-09-30 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
| CN107176970B (zh) * | 2017-07-06 | 2019-11-19 | 中国医药集团总公司四川抗菌素工业研究所 | 一种树脂催化法合成伪脯氨酸杂环肽的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE54936B1 (en) | 1980-02-14 | 1990-03-28 | Sandoz Ltd | A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| US4798823A (en) | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| GB8717300D0 (en) | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| AU759480B2 (en) | 1998-07-01 | 2003-04-17 | Debiopharm S.A. | Novel cyclosporin with improved activity profile |
-
2000
- 2000-02-07 WO PCT/IB2000/000133 patent/WO2000046239A1/fr not_active Ceased
- 2000-02-07 DK DK00901297T patent/DK1150999T3/da active
- 2000-02-07 PT PT00901297T patent/PT1150999E/pt unknown
- 2000-02-07 ES ES00901297T patent/ES2267492T3/es not_active Expired - Lifetime
- 2000-02-07 US US09/890,636 patent/US6790935B1/en not_active Expired - Fee Related
- 2000-02-07 DE DE60028936T patent/DE60028936T2/de not_active Expired - Fee Related
- 2000-02-07 EP EP00901297A patent/EP1150999B1/de not_active Expired - Lifetime
- 2000-02-07 AU AU21253/00A patent/AU2125300A/en not_active Abandoned
- 2000-02-07 AT AT00901297T patent/ATE330968T1/de not_active IP Right Cessation
-
2006
- 2006-09-14 CY CY20061101311T patent/CY1105452T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2267492T3 (es) | 2007-03-16 |
| DK1150999T3 (da) | 2006-10-30 |
| WO2000046239A1 (fr) | 2000-08-10 |
| US6790935B1 (en) | 2004-09-14 |
| EP1150999A1 (de) | 2001-11-07 |
| CY1105452T1 (el) | 2010-04-28 |
| AU2125300A (en) | 2000-08-25 |
| DE60028936D1 (de) | 2006-08-03 |
| DE60028936T2 (de) | 2007-01-11 |
| EP1150999B1 (de) | 2006-06-21 |
| PT1150999E (pt) | 2006-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1150999 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |