ATE332903T1 - Kondensierte pyridoindolderivate - Google Patents

Kondensierte pyridoindolderivate

Info

Publication number: ATE332903T1
Authority: AT; Austria
Prior art keywords: condensed; pyridoindole derivatives; pyridoindole; derivatives; compounds
Prior art date: 2000-10-03

Application number

AT01981804T

Other languages

English (en)

Inventor

Mark W Orme

Jason Scott Sawyer

Alain Claude-Marie Daugan

Romain Luc Marie Gosimini

Lisa M Schultze

Original Assignee

Lilly Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-03

Filing date

2001-09-17

Publication date

2006-08-15

2001-09-17 Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE332903T1 publication Critical patent/ATE332903T1/de

Links

IVCGJOSPVGENCT-UHFFFAOYSA-N 1h-pyrrolo[2,3-f]quinoline Chemical class N1=CC=CC2=C(NC=C3)C3=CC=C21 IVCGJOSPVGENCT-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Pregnancy & Childbirth (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT01981804T 2000-10-03 2001-09-17 Kondensierte pyridoindolderivate ATE332903T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23773400P	2000-10-03	2000-10-03

Publications (1)

Publication Number	Publication Date
ATE332903T1 true ATE332903T1 (de)	2006-08-15

Family

ID=22894936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01981804T ATE332903T1 (de)	2000-10-03	2001-09-17	Kondensierte pyridoindolderivate

Country Status (10)

Country	Link
US (1)	US6858620B2 (de)
EP (1)	EP1335923B1 (de)
JP (1)	JP4246488B2 (de)
AT (1)	ATE332903T1 (de)
AU (1)	AU2002213421A1 (de)
CA (1)	CA2423312A1 (de)
DE (1)	DE60121461T2 (de)
ES (1)	ES2267831T3 (de)
MX (1)	MXPA03002911A (de)
WO (1)	WO2002028865A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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ES2278956T3 (es) *	2001-04-25	2007-08-16	Lilly Icos Llc	Derivados de carbolina como inhibidores de fosfodiesterasa 5 (pde5) para el tratamiento de enfermedades cardiovasculares y de la disfuncion erectil.
DE60332387D1 (de)	2002-12-13	2010-06-10	Warner Lambert Co	Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege
JP2007518788A (ja)	2004-01-22	2007-07-12	ファイザー・インク	バソプレッシンのアンタゴニスト活性を阻害するトリアゾール誘導体
MXPA06010542A (es) *	2004-03-15	2007-03-28	Ptc Therapeutics Inc	Derivados de carbolina tetra-ciclica para la inhibicion de angiogenesis.
CA2577442A1 (en)	2004-08-17	2006-03-02	The Johns Hopkins University	Pde5 inhibitor compositions and methods for treating cardiac indications
JP2008509971A (ja)	2004-08-18	2008-04-03	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	Ｅｇ５キネシンのインヒビターとして使用するためのベンゾチエノピリジン
WO2006079645A1 (en) *	2005-01-27	2006-08-03	Nycomed Gmbh	Novel indolopyridines , benzofuranopyridines and benzothienopyridines
AU2006208710A1 (en) *	2005-01-28	2006-08-03	4Sc Ag	Indolopyridines, benzofuranopyridines and benzothienopyridines
NZ571357A (en)	2006-02-22	2010-11-26	4Sc Ag	Indolopyridines as EG5 kinesin modulators
FR2914924A1 (fr) *	2007-04-13	2008-10-17	Fourtillan Snc	Derives de 4,5,11,11a-tetrahydro-1h,6h-oxazolo[3',4': 1,6] pyrido[3,4-b]indol-3-one et leur utilisation en therapeutique.
BRPI0907122B8 (pt)	2008-01-11	2021-05-25	Albany Molecular Res Inc	compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
US20120283282A1 (en) *	2009-06-18	2012-11-08	Arleen Rifkind	Photoproducts of Tryptophan, Their Synthesis and Uses Thereof
US8637501B2 (en)	2009-07-01	2014-01-28	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US9073925B2 (en)	2009-07-01	2015-07-07	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
ES2882258T3 (es)	2012-12-21	2021-12-01	Mayo Found Medical Education & Res	Métodos y materiales para tratar estenosis de la válvula aórtica calcificada
KR102367876B1 (ko)	2013-11-22	2022-02-24	사브레 테라퓨틱스 엘엘씨	오토탁신 억제제 화합물
CA2930735A1 (en)	2013-11-22	2015-05-28	Sabre Therapeutics Llc	Tetracyclic autotaxin inhibitors
EP3098279B1 (de) *	2014-01-23	2018-06-27	Asahi Kasei Kabushiki Kaisha	Haftzusammensetzung und haftband
EA036337B1 (ru)	2015-05-27	2020-10-28	Сабре Терапьютикс Ллс	Ингибиторы аутотаксина и их применения
MX2021012409A (es)	2019-04-10	2021-11-12	Mayo Found Medical Education & Res	Metodos y materiales para el tratamiento dependiente del genero de la disfuncion cardiovascular.
FI130627B (en)	2021-03-31	2023-12-18	Equinorm Ltd	Novel heterocyclic compounds and their use

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GB8420969D0 (en) *	1984-08-17	1984-09-19	Tanabe Seiyaku Co	Tetrahydro-beta-carboline derivative
EP0357122A3 (de)	1988-08-29	1991-10-23	Duphar International Research B.V	Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung
US5622960A (en)	1992-04-14	1997-04-22	The United States Of America As Represented By The Department Of Health And Human Services	Topoisomerase II inhibitors and therapeutic uses therefor
GB9514473D0 (en)	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds

2001
- 2001-09-17 DE DE60121461T patent/DE60121461T2/de not_active Expired - Lifetime
- 2001-09-17 US US10/363,528 patent/US6858620B2/en not_active Expired - Fee Related
- 2001-09-17 AT AT01981804T patent/ATE332903T1/de not_active IP Right Cessation
- 2001-09-17 CA CA002423312A patent/CA2423312A1/en not_active Abandoned
- 2001-09-17 ES ES01981804T patent/ES2267831T3/es not_active Expired - Lifetime
- 2001-09-17 WO PCT/US2001/042175 patent/WO2002028865A2/en not_active Ceased
- 2001-09-17 AU AU2002213421A patent/AU2002213421A1/en not_active Abandoned
- 2001-09-17 EP EP01981804A patent/EP1335923B1/de not_active Expired - Lifetime
- 2001-09-17 JP JP2002532448A patent/JP4246488B2/ja not_active Expired - Fee Related
- 2001-09-17 MX MXPA03002911A patent/MXPA03002911A/es active IP Right Grant

Also Published As

Publication number	Publication date
ES2267831T3 (es)	2007-03-16
DE60121461T2 (de)	2007-02-08
EP1335923B1 (de)	2006-07-12
WO2002028865A2 (en)	2002-04-11
JP4246488B2 (ja)	2009-04-02
WO2002028865A3 (en)	2003-02-27
US6858620B2 (en)	2005-02-22
CA2423312A1 (en)	2002-04-11
US20040082787A1 (en)	2004-04-29
EP1335923A2 (de)	2003-08-20
AU2002213421A1 (en)	2002-04-15
JP2004511448A (ja)	2004-04-15
DE60121461D1 (de)	2006-08-24
MXPA03002911A (es)	2003-09-10

Legal Events

Date	Code	Title	Description
2007-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
ATE302775T1 (de)	2005-09-15	Carbolinderivate
DE60112306D1 (de)	2005-09-01	Kondensierte pyrazindionderivate als pde5 inhibitore
ATE346067T1 (de)	2006-12-15	Carbolinderivate
ES2170252T3 (es)	2002-08-01	Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
DE60230127D1 (de)	2009-01-15	Inhibitoren von integrin alpha-v-beta-6
MXPA03009750A (es)	2004-06-30	Compuestos quimicos.
ATE302776T1 (de)	2005-09-15	Kondensierte pyridoindolderivate
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
DE60110124D1 (de)	2005-05-19	Kondensierte pyrazindionderivate als pde inhibitoren
DE60122559D1 (de)	2006-10-05	Indolderivate als pde5-inhibitoren
DE60213798D1 (de)	2006-09-21	Carbolinderivate als pdev inhibitoren
MXPA03000887A (es)	2004-04-05	Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
ATE360422T1 (de)	2007-05-15	Tetrazyklische verbindungen als pde5-inhibitoren
CY1105981T1 (el)	2011-04-06	Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων