ATE332903T1 - Kondensierte pyridoindolderivate - Google Patents

Kondensierte pyridoindolderivate

Info

Publication number: ATE332903T1
Authority: AT; Austria
Prior art keywords: condensed; pyridoindole derivatives; pyridoindole; derivatives; compounds
Prior art date: 2000-10-03

Application number

AT01981804T

Other languages

English (en)

Inventor

Mark W Orme

Jason Scott Sawyer

Alain Claude-Marie Daugan

Romain Luc Marie Gosimini

Lisa M Schultze

Original Assignee

Lilly Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-03

Filing date

2001-09-17

Publication date

2006-08-15

2001-09-17 Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE332903T1 publication Critical patent/ATE332903T1/de

Links

IVCGJOSPVGENCT-UHFFFAOYSA-N 1h-pyrrolo[2,3-f]quinoline Chemical class N1=CC=CC2=C(NC=C3)C3=CC=C21 IVCGJOSPVGENCT-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pregnancy & Childbirth (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Diabetes (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT01981804T 2000-10-03 2001-09-17 Kondensierte pyridoindolderivate ATE332903T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23773400P	2000-10-03	2000-10-03

Publications (1)

Publication Number	Publication Date
ATE332903T1 true ATE332903T1 (de)	2006-08-15

Family

ID=22894936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01981804T ATE332903T1 (de)	2000-10-03	2001-09-17	Kondensierte pyridoindolderivate

Country Status (10)

Country	Link
US (1)	US6858620B2 (de)
EP (1)	EP1335923B1 (de)
JP (1)	JP4246488B2 (de)
AT (1)	ATE332903T1 (de)
AU (1)	AU2002213421A1 (de)
CA (1)	CA2423312A1 (de)
DE (1)	DE60121461T2 (de)
ES (1)	ES2267831T3 (de)
MX (1)	MXPA03002911A (de)
WO (1)	WO2002028865A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03009750A (es)	2001-04-25	2004-06-30	Lilly Icos Llc	Compuestos quimicos.
PT1572173E (pt)	2002-12-13	2010-05-10	Warner Lambert Co	Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
EP1708718A1 (de)	2004-01-22	2006-10-11	Pfizer Limited	Triazol-derivate zur hemmung der vasopressing-antagonistischen aktivität
CN1960725A (zh) *	2004-03-15	2007-05-09	Ptc医疗公司	用于抑制血管发生的四环咔啉衍生物
JP5070052B2 (ja)	2004-08-17	2012-11-07	ザ・ジョンズ・ホプキンス・ユニバーシティ	Ｐｄｅ５阻害剤組成物及び心臓疾患を治療する方法
DE602005024572D1 (de)	2004-08-18	2010-12-16	4Sc Ag	Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
AU2006208709A1 (en) *	2005-01-27	2006-08-03	4Sc Ag	Novel indolopyridines , benzofuranopyridines and benzothienopyridines
WO2006079644A1 (en) *	2005-01-28	2006-08-03	Nycomed Gmbh	Indolopyridines, benzofuranopyridines and benzothienopyridines
US8530493B2 (en)	2006-02-22	2013-09-10	4Sc Ag	Indolopyridines as Eg5 kinesin modulators
FR2914924A1 (fr) *	2007-04-13	2008-10-17	Fourtillan Snc	Derives de 4,5,11,11a-tetrahydro-1h,6h-oxazolo[3',4': 1,6] pyrido[3,4-b]indol-3-one et leur utilisation en therapeutique.
CA2727055C (en)	2008-01-11	2016-12-20	Albany Molecular Research, Inc.	(1-azinone) -substituted pyridoindoles as mch antagonists
WO2010148350A1 (en) *	2009-06-18	2010-12-23	Cornell University	Photoproducts of tryptophan, their synthesis and uses thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en)	2009-07-01	2014-01-14	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
US8697700B2 (en)	2010-12-21	2014-04-15	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
US9789126B2 (en)	2012-12-21	2017-10-17	Mayo Foundation For Medical Education And Research	Methods and materials for treating calcific aortic valve stenosis
PE20160654A1 (es)	2013-11-22	2016-07-15	Pharmakea Inc	Compuestos de inhibidor de autotaxina
CA2930735A1 (en)	2013-11-22	2015-05-28	Sabre Therapeutics Llc	Tetracyclic autotaxin inhibitors
EA031755B1 (ru) *	2014-01-23	2019-02-28	Асахи Касеи Кабусики Кайся	Клейкая композиция и чувствительная к давлению клейкая лента
CN116059203A (zh)	2015-05-27	2023-05-05	赛博治疗有限责任公司	自分泌运动因子抑制剂及其用途
MX2021012409A (es)	2019-04-10	2021-11-12	Mayo Found Medical Education & Res	Metodos y materiales para el tratamiento dependiente del genero de la disfuncion cardiovascular.
FI130627B (en)	2021-03-31	2023-12-18	Equinorm Ltd	Novel heterocyclic compounds and their use
CN117903136A (zh) *	2024-01-12	2024-04-19	山东大学	一种no供体型pde5抑制剂及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8420969D0 (en) *	1984-08-17	1984-09-19	Tanabe Seiyaku Co	Tetrahydro-beta-carboline derivative
EP0357122A3 (de) *	1988-08-29	1991-10-23	Duphar International Research B.V	Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung
US5622960A (en)	1992-04-14	1997-04-22	The United States Of America As Represented By The Department Of Health And Human Services	Topoisomerase II inhibitors and therapeutic uses therefor
GB9514473D0 (en)	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds

2001
- 2001-09-17 AU AU2002213421A patent/AU2002213421A1/en not_active Abandoned
- 2001-09-17 WO PCT/US2001/042175 patent/WO2002028865A2/en not_active Ceased
- 2001-09-17 US US10/363,528 patent/US6858620B2/en not_active Expired - Fee Related
- 2001-09-17 CA CA002423312A patent/CA2423312A1/en not_active Abandoned
- 2001-09-17 DE DE60121461T patent/DE60121461T2/de not_active Expired - Lifetime
- 2001-09-17 EP EP01981804A patent/EP1335923B1/de not_active Expired - Lifetime
- 2001-09-17 AT AT01981804T patent/ATE332903T1/de not_active IP Right Cessation
- 2001-09-17 JP JP2002532448A patent/JP4246488B2/ja not_active Expired - Fee Related
- 2001-09-17 ES ES01981804T patent/ES2267831T3/es not_active Expired - Lifetime
- 2001-09-17 MX MXPA03002911A patent/MXPA03002911A/es active IP Right Grant

Also Published As

Publication number	Publication date
DE60121461D1 (de)	2006-08-24
US20040082787A1 (en)	2004-04-29
AU2002213421A1 (en)	2002-04-15
DE60121461T2 (de)	2007-02-08
EP1335923A2 (de)	2003-08-20
JP2004511448A (ja)	2004-04-15
ES2267831T3 (es)	2007-03-16
US6858620B2 (en)	2005-02-22
MXPA03002911A (es)	2003-09-10
EP1335923B1 (de)	2006-07-12
WO2002028865A3 (en)	2003-02-27
WO2002028865A2 (en)	2002-04-11
JP4246488B2 (ja)	2009-04-02
CA2423312A1 (en)	2002-04-11

Legal Events

Date	Code	Title	Description
2007-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
ATE302775T1 (de)	2005-09-15	Carbolinderivate
DE60112306D1 (de)	2005-09-01	Kondensierte pyrazindionderivate als pde5 inhibitore
ATE346067T1 (de)	2006-12-15	Carbolinderivate
ES2170252T3 (es)	2002-08-01	Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
DE60230127D1 (de)	2009-01-15	Inhibitoren von integrin alpha-v-beta-6
MXPA03009750A (es)	2004-06-30	Compuestos quimicos.
ATE302776T1 (de)	2005-09-15	Kondensierte pyridoindolderivate
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
DE60110124D1 (de)	2005-05-19	Kondensierte pyrazindionderivate als pde inhibitoren
DE60122559D1 (de)	2006-10-05	Indolderivate als pde5-inhibitoren
DE60213798D1 (de)	2006-09-21	Carbolinderivate als pdev inhibitoren
MXPA03000887A (es)	2004-04-05	Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
ATE360422T1 (de)	2007-05-15	Tetrazyklische verbindungen als pde5-inhibitoren
CY1105981T1 (el)	2011-04-06	Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων