ATE332919T1 - Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen - Google Patents

Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen

Info

Publication number: ATE332919T1
Authority: AT; Austria
Prior art keywords: phosphoserine; inhibitors; phosphothreonen; specific; specific isomerases
Prior art date: 1997-09-08

Application number

AT98946921T

Other languages

English (en)

Inventor

Kun Ping Lu

Lewis C Cantley

Michael Yaffee

Gunter Fischer

Original Assignee

Beth Israel Hospital

Max Planck Gesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-08

Filing date

1998-09-04

Publication date

2006-08-15

1998-09-04 Application filed by Beth Israel Hospital, Max Planck Gesellschaft filed Critical Beth Israel Hospital

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE332919T1 publication Critical patent/ATE332919T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
102000004195 Isomerases Human genes 0.000 title 1
108090000769 Isomerases Proteins 0.000 title 1
BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 title 1
229950006137 dexfosfoserine Drugs 0.000 title 1
BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 title 1
102000009658 Peptidylprolyl Isomerase Human genes 0.000 abstract 1
108010020062 Peptidylprolyl Isomerase Proteins 0.000 abstract 1
USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98946921T 1997-09-08 1998-09-04 Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen ATE332919T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5816497P	1997-09-08	1997-09-08
US08/988,842 US6462173B1 (en)	1997-09-08	1997-12-11	Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases

Publications (1)

Publication Number	Publication Date
ATE332919T1 true ATE332919T1 (de)	2006-08-15

Family

ID=26737312

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98946921T ATE332919T1 (de)	1997-09-08	1998-09-04	Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen

Country Status (8)

Country	Link
US (2)	US6462173B1 (de)
EP (1)	EP1012178B1 (de)
JP (1)	JP2001515917A (de)
AT (1)	ATE332919T1 (de)
AU (1)	AU751271B2 (de)
CA (1)	CA2303462A1 (de)
DE (1)	DE69835215T2 (de)
WO (1)	WO1999012962A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7125677B2 (en)	1995-11-13	2006-10-24	The Salk Institute For Biological Studies	NIMA interacting proteins
US5972697A (en)	1995-11-13	1999-10-26	The Salk Institute For Biological Studies	NIMA interacting proteins
US20010016346A1 (en) *	1998-06-09	2001-08-23	Joseph P. Noel	Pedtidyl-prolyl cis-trans isomerase inhibitors and uses therefore
US6495376B1 (en) *	1999-02-18	2002-12-17	Beth Israel Deaconess Medical Center	Methods and compositions for regulating protein-protein interactions
US20020025521A1 (en)	1999-11-29	2002-02-28	Lu Kun Ping	Pin1 as a marker for abnormal cell growth
EP1446044A4 (de) *	2001-02-09	2007-08-08	Pintex Pharmaceuticals Inc	Pin1 als marker für prostatakrebs
DE50213241D1 (de) *	2001-08-20	2009-03-12	Max Planck Gesellschaft	Katalyse der cis-trans isomerisierung von sekundären-amid peptidverbindungen
US7109230B2 (en) *	2002-01-07	2006-09-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
AU2003213698A1 (en) *	2002-03-01	2003-09-16	Pintex Pharmaceuticals, Inc.	Methods for designing specific inhibitors for pin1 proline isomerase and pin1-related molecules
AU2003258982A1 (en) *	2002-06-28	2004-01-19	Pintex Pharmaceuticals, Inc.	Methods of inhibiting pin1-associated states using a fredericamycin a compound
WO2004016751A2 (en) *	2002-08-15	2004-02-26	Beth Israel Deaconess Medical Center	Methods of treating neurodegenerative diseases
US20040176277A1 (en) *	2003-03-03	2004-09-09	Pintex Pharmaceuticals, Inc.	Methods of treating Pin1 associated disorders
US20080058276A1 (en) *	2006-01-13	2008-03-06	Cornell Research Foundation, Inc.	Alzheimer's disease therapeutics based on pin-1 catalyzed conformational changes in phosphorylated amyloid precursor protein
WO2011056561A1 (en) *	2009-10-27	2011-05-12	Beth Israel Deaconess Medical Center	Methods and compositions for the generation and use of conformation-specific antibodies
WO2012125724A1 (en)	2011-03-14	2012-09-20	Beth Israel Deaconess Medical Center	Methods and compositions for the treatment of proliferative disorders
US10487114B2 (en)	2011-04-27	2019-11-26	Beth Israel Deaconess Medical Center, Inc.	Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof
US9439884B2 (en)	2011-05-26	2016-09-13	Beth Israel Deaconess Medical Center, Inc.	Methods for the treatment of immune disorders
EP2858648B1 (de)	2012-06-07	2018-08-22	Beth Israel Deaconess Medical Center, Inc.	Verfahren und zusammensetzungen zur pin1-hemmung
ES2835716T3 (es)	2013-03-15	2021-06-23	Beth Israel Deaconess Medical Ct Inc	Procedimientos y composiciones para la generación y el uso de anticuerpos específicos de conformación
WO2016011265A2 (en)	2014-07-17	2016-01-21	Beth Israel Deaconess Medical Center, Inc.	Biomarkers for pin1-associated disorders
WO2016011268A1 (en)	2014-07-17	2016-01-21	Beth Israel Deaconess Medical Center, Inc.	Atra for modulating pin1 activity and stability
US10548864B2 (en)	2015-03-12	2020-02-04	Beth Israel Deaconess Medical Center, Inc.	Enhanced ATRA-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444682A (en) *	1982-11-04	1984-04-24	The Salk Institute For Biological Studies	Method of sulfation
US4490364A (en) *	1983-05-20	1984-12-25	The Salk Institute For Biological Studies	CCK Agonists II
US4584377A (en)	1983-08-18	1986-04-22	Ss Pharmaceutical Co., Ltd.	Novel Fredericamycin A derivatives
US4612132A (en)	1984-07-20	1986-09-16	Chevron Research Company	Modified succinimides
US5013722A (en) *	1986-06-06	1991-05-07	Hoffmann-Laroche Inc.	Cholecystokinin analogs for controlling appetite
US4673678A (en)	1986-07-25	1987-06-16	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble derivatives of fredericamycin A
JPH03146477A (ja) *	1989-10-31	1991-06-21	Asahi Glass Co Ltd	セラミックス接着用組成物およびセラミックスの接着方法
US5733734A (en) *	1991-08-14	1998-03-31	The Trustees Of The University Of Pennsylvania	Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
US5166208A (en)	1991-10-09	1992-11-24	Boston College	Fredericamycin A derivatives
US5643873A (en)	1992-05-06	1997-07-01	Affymax Technologies N.V.	Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5532167A (en)	1994-01-07	1996-07-02	Beth Israel Hospital	Substrate specificity of protein kinases
US5654276A (en)	1995-06-07	1997-08-05	Affymax Technologies N.V.	Peptides and compounds that bind to the IL-5 receptor
US5972697A (en)	1995-11-13	1999-10-26	The Salk Institute For Biological Studies	NIMA interacting proteins

1997
- 1997-12-11 US US08/988,842 patent/US6462173B1/en not_active Expired - Lifetime
1998
- 1998-09-04 AU AU27032/99A patent/AU751271B2/en not_active Revoked
- 1998-09-04 JP JP2000510767A patent/JP2001515917A/ja active Pending
- 1998-09-04 WO PCT/US1998/018862 patent/WO1999012962A1/en not_active Ceased
- 1998-09-04 DE DE69835215T patent/DE69835215T2/de not_active Expired - Fee Related
- 1998-09-04 CA CA002303462A patent/CA2303462A1/en not_active Abandoned
- 1998-09-04 AT AT98946921T patent/ATE332919T1/de not_active IP Right Cessation
- 1998-09-04 EP EP98946921A patent/EP1012178B1/de not_active Expired - Lifetime
2002
- 2002-07-10 US US10/193,768 patent/US20030109423A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1012178B1 (de)	2006-07-12
EP1012178A1 (de)	2000-06-28
CA2303462A1 (en)	1999-03-18
WO1999012962A8 (en)	1999-07-01
DE69835215T2 (de)	2007-05-31
WO1999012962A1 (en)	1999-03-18
AU2703299A (en)	1999-05-24
JP2001515917A (ja)	2001-09-25
US20030109423A1 (en)	2003-06-12
US6462173B1 (en)	2002-10-08
AU751271B2 (en)	2002-08-08
DE69835215D1 (de)	2006-08-24

Legal Events

Date	Code	Title	Description
2007-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69835215D1 (de)	2006-08-24	Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen
DE60041505D1 (de)	2009-03-19	Inzektizide proteinen von bacillus thuringiensis
FI965019A7 (fi)	1996-12-13	Entsyymi-inhibiittoreita
FI962315L (fi)	1996-08-05	Entsyymi-inhibiittorit
DE69620161D1 (de)	2002-05-02	Thrombininhibitoren
FI973282A0 (fi)	1997-08-08	Trombiinin inhibiittoreita
EA199900162A1 (ru)	1999-10-28	Ингибиторы клеточной адгезии
DE60010098D1 (de)	2004-05-27	28-epirapaloge
ATE214693T1 (de)	2002-04-15	Aminoguanidine und alkoxyguanidine als protease- hemmer
EP1009415A4 (de)	2000-10-25	g(B)-LAKTAMASE HEMMER UND VERWENDUNGEN DAVON
DE19680255T1 (de)	1997-06-05	Inhibitoren der Enzymaktivität von Rotamase
DE69528528D1 (de)	2002-11-14	Thrombin-inhibitoren
DK0858464T3 (da)	2003-08-25	Thrombin-inhibitorer
DE69804857D1 (de)	2002-05-16	Integritätsprüfung von elektroden
DE69828682D1 (de)	2005-02-24	Nanomolare, non-peptidische inhibitoren von cathepsin d
NO996578D0 (no)	1999-12-30	Urokinase-inhibitorer
TR199802240T2 (de)	1999-02-22
FI942625L (fi)	1994-12-05	Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina
ES2191830T3 (es)	2003-09-16	Inhibidores de trombina.
PT927183E (pt)	2004-12-31	Inibidores espirociclicos de metaloproteases
DK0956294T3 (da)	2004-10-11	Thrombininhibitorer
BR9610075A (pt)	1999-03-02	Inibidores prolil endopeptidase
FI973929A0 (fi)	1997-10-10	WOF inhibitor
ATE322898T1 (de)	2006-04-15	Inhibitoren von mycobakterien
EP0679051A3 (de)	1997-01-02	Kontaktierung von Betätigungs- und Anzeigemitteln.