ATE332919T1 - Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen - Google Patents

Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen

Info

Publication number: ATE332919T1
Authority: AT; Austria
Prior art keywords: phosphoserine; inhibitors; phosphothreonen; specific; specific isomerases
Prior art date: 1997-09-08

Application number

AT98946921T

Other languages

English (en)

Inventor

Kun Ping Lu

Lewis C Cantley

Michael Yaffee

Gunter Fischer

Original Assignee

Beth Israel Hospital

Max Planck Gesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-08

Filing date

1998-09-04

Publication date

2006-08-15

1998-09-04 Application filed by Beth Israel Hospital, Max Planck Gesellschaft filed Critical Beth Israel Hospital

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE332919T1 publication Critical patent/ATE332919T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
102000004195 Isomerases Human genes 0.000 title 1
108090000769 Isomerases Proteins 0.000 title 1
BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 title 1
229950006137 dexfosfoserine Drugs 0.000 title 1
BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 title 1
102000009658 Peptidylprolyl Isomerase Human genes 0.000 abstract 1
108010020062 Peptidylprolyl Isomerase Proteins 0.000 abstract 1
USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98946921T 1997-09-08 1998-09-04 Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen ATE332919T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5816497P	1997-09-08	1997-09-08
US08/988,842 US6462173B1 (en)	1997-09-08	1997-12-11	Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases

Publications (1)

Publication Number	Publication Date
ATE332919T1 true ATE332919T1 (de)	2006-08-15

Family

ID=26737312

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98946921T ATE332919T1 (de)	1997-09-08	1998-09-04	Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen

Country Status (8)

Country	Link
US (2)	US6462173B1 (de)
EP (1)	EP1012178B1 (de)
JP (1)	JP2001515917A (de)
AT (1)	ATE332919T1 (de)
AU (1)	AU751271B2 (de)
CA (1)	CA2303462A1 (de)
DE (1)	DE69835215T2 (de)
WO (1)	WO1999012962A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7125677B2 (en)	1995-11-13	2006-10-24	The Salk Institute For Biological Studies	NIMA interacting proteins
US5972697A (en)	1995-11-13	1999-10-26	The Salk Institute For Biological Studies	NIMA interacting proteins
US20010016346A1 (en) *	1998-06-09	2001-08-23	Joseph P. Noel	Pedtidyl-prolyl cis-trans isomerase inhibitors and uses therefore
US6495376B1 (en) *	1999-02-18	2002-12-17	Beth Israel Deaconess Medical Center	Methods and compositions for regulating protein-protein interactions
US20020025521A1 (en)	1999-11-29	2002-02-28	Lu Kun Ping	Pin1 as a marker for abnormal cell growth
AU2002255525B2 (en) *	2001-02-09	2007-01-04	Pintex Pharmaceuticals, Inc.	Pin1 as a marker for prostate cancer
ATE421525T1 (de) *	2001-08-20	2009-02-15	Max Planck Gesellschaft	Katalyse der cis-trans isomerisierung von sekundären-amid peptidverbindungen
CA2472580A1 (en) *	2002-01-07	2003-07-17	Sequoia Pharmaceuticals	Broad spectrum inhibitors
WO2003074001A2 (en) *	2002-03-01	2003-09-12	Pintex Pharmaceuticals, Inc.	Methods for designing specific inhibitors for pin1 proline isomerase and pin1-related molecules
AU2003258982A1 (en) *	2002-06-28	2004-01-19	Pintex Pharmaceuticals, Inc.	Methods of inhibiting pin1-associated states using a fredericamycin a compound
WO2004016751A2 (en) *	2002-08-15	2004-02-26	Beth Israel Deaconess Medical Center	Methods of treating neurodegenerative diseases
US20040176277A1 (en) *	2003-03-03	2004-09-09	Pintex Pharmaceuticals, Inc.	Methods of treating Pin1 associated disorders
US20080058276A1 (en) *	2006-01-13	2008-03-06	Cornell Research Foundation, Inc.	Alzheimer's disease therapeutics based on pin-1 catalyzed conformational changes in phosphorylated amyloid precursor protein
US8771693B2 (en) *	2009-10-27	2014-07-08	Beth Israel Deaconess Medical Center, Inc.	Methods and compositions for the generation and use of conformation-specific antibodies
WO2012125724A1 (en)	2011-03-14	2012-09-20	Beth Israel Deaconess Medical Center	Methods and compositions for the treatment of proliferative disorders
WO2012149334A2 (en)	2011-04-27	2012-11-01	Beth Israel Deaconess Medical Center, Inc.	Methods and compositions for the generation and use of conformation-specific antibodies
WO2012162698A1 (en)	2011-05-26	2012-11-29	Beth Israel Deaconess Medical Center, Inc.	Methods and compositions for the treatment of immune disorders
AU2013271378A1 (en)	2012-06-07	2014-12-18	Beth Israel Deaconess Medical Center, Inc.	Methods and compositions for the inhibition of Pin1
CN105283196B (zh)	2013-03-15	2018-10-12	贝丝以色列女执事医疗中心	用于产生和使用构象-特异性抗体的方法和组合物
US9968579B2 (en)	2014-07-17	2018-05-15	Beth Isreal Deaconess Medical Center, Inc.	ATRA for modulating Pin1 activity and stability
WO2016011265A2 (en)	2014-07-17	2016-01-21	Beth Israel Deaconess Medical Center, Inc.	Biomarkers for pin1-associated disorders
US10548864B2 (en)	2015-03-12	2020-02-04	Beth Israel Deaconess Medical Center, Inc.	Enhanced ATRA-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444682A (en) *	1982-11-04	1984-04-24	The Salk Institute For Biological Studies	Method of sulfation
US4490364A (en) *	1983-05-20	1984-12-25	The Salk Institute For Biological Studies	CCK Agonists II
GB2145084B (en)	1983-08-18	1987-01-28	Ss Pharmaceutical Co	Fredericamycin derivatives
US4612132A (en)	1984-07-20	1986-09-16	Chevron Research Company	Modified succinimides
US5013722A (en) *	1986-06-06	1991-05-07	Hoffmann-Laroche Inc.	Cholecystokinin analogs for controlling appetite
US4673678A (en)	1986-07-25	1987-06-16	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble derivatives of fredericamycin A
JPH03146477A (ja) *	1989-10-31	1991-06-21	Asahi Glass Co Ltd	セラミックス接着用組成物およびセラミックスの接着方法
US5733734A (en) *	1991-08-14	1998-03-31	The Trustees Of The University Of Pennsylvania	Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
US5166208A (en)	1991-10-09	1992-11-24	Boston College	Fredericamycin A derivatives
US5643873A (en)	1992-05-06	1997-07-01	Affymax Technologies N.V.	Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5532167A (en)	1994-01-07	1996-07-02	Beth Israel Hospital	Substrate specificity of protein kinases
US5654276A (en)	1995-06-07	1997-08-05	Affymax Technologies N.V.	Peptides and compounds that bind to the IL-5 receptor
US5972697A (en)	1995-11-13	1999-10-26	The Salk Institute For Biological Studies	NIMA interacting proteins

1997
- 1997-12-11 US US08/988,842 patent/US6462173B1/en not_active Expired - Lifetime
1998
- 1998-09-04 AU AU27032/99A patent/AU751271B2/en not_active Revoked
- 1998-09-04 EP EP98946921A patent/EP1012178B1/de not_active Expired - Lifetime
- 1998-09-04 AT AT98946921T patent/ATE332919T1/de not_active IP Right Cessation
- 1998-09-04 WO PCT/US1998/018862 patent/WO1999012962A1/en not_active Ceased
- 1998-09-04 CA CA002303462A patent/CA2303462A1/en not_active Abandoned
- 1998-09-04 DE DE69835215T patent/DE69835215T2/de not_active Expired - Fee Related
- 1998-09-04 JP JP2000510767A patent/JP2001515917A/ja active Pending
2002
- 2002-07-10 US US10/193,768 patent/US20030109423A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1012178A1 (de)	2000-06-28
AU751271B2 (en)	2002-08-08
DE69835215D1 (de)	2006-08-24
WO1999012962A8 (en)	1999-07-01
EP1012178B1 (de)	2006-07-12
AU2703299A (en)	1999-05-24
JP2001515917A (ja)	2001-09-25
US6462173B1 (en)	2002-10-08
US20030109423A1 (en)	2003-06-12
WO1999012962A1 (en)	1999-03-18
DE69835215T2 (de)	2007-05-31
CA2303462A1 (en)	1999-03-18

Legal Events

Date	Code	Title	Description
2007-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE332919T1 (de)	2006-08-15	Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen
DE60041505D1 (de)	2009-03-19	Inzektizide proteinen von bacillus thuringiensis
FI965019A7 (fi)	1996-12-13	Entsyymi-inhibiittoreita
NO962269D0 (no)	1996-05-31	Enzyminhibitorer
DE69620161D1 (de)	2002-05-02	Thrombininhibitoren
NO973657D0 (no)	1997-08-08	Trombin-inhibitorer
EA199900162A1 (ru)	1999-10-28	Ингибиторы клеточной адгезии
DE60010098D1 (de)	2004-05-27	28-epirapaloge
ATE214693T1 (de)	2002-04-15	Aminoguanidine und alkoxyguanidine als protease- hemmer
EP1009415A4 (de)	2000-10-25	g(B)-LAKTAMASE HEMMER UND VERWENDUNGEN DAVON
DE19680255T1 (de)	1997-06-05	Inhibitoren der Enzymaktivität von Rotamase
ATE225772T1 (de)	2002-10-15	Thrombin-inhibitoren
ATE239755T1 (de)	2003-05-15	Thrombin inhibitoren
DE69828682D1 (de)	2005-02-24	Nanomolare, non-peptidische inhibitoren von cathepsin d
TR199802240T2 (de)	1999-02-22
FI942625A7 (fi)	1994-12-05	Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina
ES2191830T3 (es)	2003-09-16	Inhibidores de trombina.
DK0956294T3 (da)	2004-10-11	Thrombininhibitorer
BR9610075A (pt)	1999-03-02	Inibidores prolil endopeptidase
MXPA02011558A (es)	2003-04-25	Inhibidores de mmp-2/mp-9 novedosos.
EP0679051A3 (de)	1997-01-02	Kontaktierung von Betätigungs- und Anzeigemitteln.
NO20011901L (no)	2001-04-18	Antikonvulsive derivater nyttige ved behandling av alkoholavhengighet og -misbruk
ATE282629T1 (de)	2004-12-15	Thrombininhibitoren
DE69431454D1 (de)	2002-11-07	Amylase Inhibitoren
ATE531690T1 (de)	2011-11-15	Inhibitoren von peptiddeformylase