ATE332924T1 - Peptidfragment der ligandenbindungstasche des östrogenrezeptors 3 (err3), kristallstrukturen davon, und deren verwendung - Google Patents

Peptidfragment der ligandenbindungstasche des östrogenrezeptors 3 (err3), kristallstrukturen davon, und deren verwendung

Info

Publication number
ATE332924T1
ATE332924T1 AT03734717T AT03734717T ATE332924T1 AT E332924 T1 ATE332924 T1 AT E332924T1 AT 03734717 T AT03734717 T AT 03734717T AT 03734717 T AT03734717 T AT 03734717T AT E332924 T1 ATE332924 T1 AT E332924T1
Authority
AT
Austria
Prior art keywords
err3
ligand binding
estrogen receptor
peptide fragment
crystal structures
Prior art date
Application number
AT03734717T
Other languages
English (en)
Inventor
Dino Moras
Jean-Paul Renaud
Holger Greschik
Jean-Marie Wurtz
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE332924T1 publication Critical patent/ATE332924T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03734717T 2002-01-31 2003-01-30 Peptidfragment der ligandenbindungstasche des östrogenrezeptors 3 (err3), kristallstrukturen davon, und deren verwendung ATE332924T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35255102P 2002-01-31 2002-01-31

Publications (1)

Publication Number Publication Date
ATE332924T1 true ATE332924T1 (de) 2006-08-15

Family

ID=27663106

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03734717T ATE332924T1 (de) 2002-01-31 2003-01-30 Peptidfragment der ligandenbindungstasche des östrogenrezeptors 3 (err3), kristallstrukturen davon, und deren verwendung

Country Status (8)

Country Link
US (2) US20050208490A1 (de)
EP (1) EP1470158B1 (de)
JP (1) JP2005537780A (de)
AT (1) ATE332924T1 (de)
AU (1) AU2003239333A1 (de)
CA (1) CA2474855A1 (de)
DE (1) DE60306750T2 (de)
WO (1) WO2003064468A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005025359D1 (de) * 2004-07-16 2011-01-27 Lynxrail Corp Gerät zur bestimmung von schwankbewegung und anstellwinkel eines schienenfahrzeugradsatzes
US7655756B2 (en) 2005-05-27 2010-02-02 Johnson & Johnson Pharmaceutical Research & Development, Llc Crystallized structure of estrogen related receptor gamma in complex with bisphenol A
WO2007130431A2 (en) * 2006-05-03 2007-11-15 Novartis Ag FUNCTION OF ESTROGEN RELATED RECEPTOR GAMMA (ERRγ) IN INCREASING MITOCHONDRIAL BIOGENESIS
US20090134325A1 (en) * 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US8187871B2 (en) * 2009-08-11 2012-05-29 Janssen Pharmaceutica N.V. Co-crystallization of ERR-α with a ligand that forms a reversible covalent bond

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
DE69329920T2 (de) * 1992-03-27 2001-09-27 Akiko Itai Verfahren zur analyse der struktur von stabilen zusammengesetzten biopolymerligandmolekuelen
CA2292611A1 (en) * 1997-06-10 1998-12-17 Karo Bio Ab Estrogen receptor ligands
WO2000026365A1 (en) * 1998-11-04 2000-05-11 Kazusa Dna Research Institute Foundation NOVEL GENE AND PROTEIN ERRη ENCODED THEREBY

Also Published As

Publication number Publication date
JP2005537780A (ja) 2005-12-15
WO2003064468A3 (en) 2004-04-08
AU2003239333A1 (en) 2003-09-02
WO2003064468A2 (en) 2003-08-07
US7279325B2 (en) 2007-10-09
EP1470158A2 (de) 2004-10-27
US20040009558A1 (en) 2004-01-15
CA2474855A1 (en) 2003-08-07
EP1470158B1 (de) 2006-07-12
US20050208490A1 (en) 2005-09-22
DE60306750T2 (de) 2007-09-20
DE60306750D1 (de) 2006-08-24

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties