ATE332924T1 - Peptidfragment der ligandenbindungstasche des östrogenrezeptors 3 (err3), kristallstrukturen davon, und deren verwendung - Google Patents
Peptidfragment der ligandenbindungstasche des östrogenrezeptors 3 (err3), kristallstrukturen davon, und deren verwendungInfo
- Publication number
- ATE332924T1 ATE332924T1 AT03734717T AT03734717T ATE332924T1 AT E332924 T1 ATE332924 T1 AT E332924T1 AT 03734717 T AT03734717 T AT 03734717T AT 03734717 T AT03734717 T AT 03734717T AT E332924 T1 ATE332924 T1 AT E332924T1
- Authority
- AT
- Austria
- Prior art keywords
- err3
- ligand binding
- estrogen receptor
- peptide fragment
- crystal structures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- High Energy & Nuclear Physics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35255102P | 2002-01-31 | 2002-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE332924T1 true ATE332924T1 (de) | 2006-08-15 |
Family
ID=27663106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03734717T ATE332924T1 (de) | 2002-01-31 | 2003-01-30 | Peptidfragment der ligandenbindungstasche des östrogenrezeptors 3 (err3), kristallstrukturen davon, und deren verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20050208490A1 (de) |
| EP (1) | EP1470158B1 (de) |
| JP (1) | JP2005537780A (de) |
| AT (1) | ATE332924T1 (de) |
| AU (1) | AU2003239333A1 (de) |
| CA (1) | CA2474855A1 (de) |
| DE (1) | DE60306750T2 (de) |
| WO (1) | WO2003064468A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2305533A3 (de) * | 2004-07-16 | 2012-04-18 | Lynxrail Corporation | Vorrichtung zum Erkennen des Gierens und des Angriffwinkels des Radsatzes eines Schienenfahrzeuges |
| WO2006130503A2 (en) * | 2005-05-27 | 2006-12-07 | Janssen Pharmaceutica N.V. | Errϝ peptide fragment complexes and uses thereof in drug discovery |
| WO2007130431A2 (en) * | 2006-05-03 | 2007-11-15 | Novartis Ag | FUNCTION OF ESTROGEN RELATED RECEPTOR GAMMA (ERRγ) IN INCREASING MITOCHONDRIAL BIOGENESIS |
| US20090134325A1 (en) * | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| WO2011019556A1 (en) * | 2009-08-11 | 2011-02-17 | Janssen Pharmaceutica Nv | CO-CRYSTALLIZATION OF ERR-A α WITH A LIGAND THAT FORMS A REVERSIBLE CONVALENT BOND |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5331573A (en) * | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
| US5642292A (en) * | 1992-03-27 | 1997-06-24 | Akiko Itai | Methods for searching stable docking models of biopolymer-ligand molecule complex |
| JP2002506433A (ja) * | 1997-06-10 | 2002-02-26 | カロ バイオ アクチェブラーグ | エストロゲン・レセプター・リガンド |
| AU3788500A (en) * | 1998-11-04 | 2000-05-22 | Kazusa Dna Research Institute Foundation | Novel gene and protein err encoded thereby |
-
2003
- 2003-01-30 AT AT03734717T patent/ATE332924T1/de not_active IP Right Cessation
- 2003-01-30 EP EP03734717A patent/EP1470158B1/de not_active Expired - Lifetime
- 2003-01-30 DE DE60306750T patent/DE60306750T2/de not_active Expired - Lifetime
- 2003-01-30 CA CA002474855A patent/CA2474855A1/en not_active Abandoned
- 2003-01-30 US US10/503,050 patent/US20050208490A1/en not_active Abandoned
- 2003-01-30 AU AU2003239333A patent/AU2003239333A1/en not_active Abandoned
- 2003-01-30 WO PCT/EP2003/000959 patent/WO2003064468A2/en not_active Ceased
- 2003-01-30 JP JP2003564088A patent/JP2005537780A/ja active Pending
- 2003-01-31 US US10/355,218 patent/US7279325B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60306750D1 (de) | 2006-08-24 |
| CA2474855A1 (en) | 2003-08-07 |
| US20050208490A1 (en) | 2005-09-22 |
| WO2003064468A3 (en) | 2004-04-08 |
| EP1470158A2 (de) | 2004-10-27 |
| DE60306750T2 (de) | 2007-09-20 |
| EP1470158B1 (de) | 2006-07-12 |
| JP2005537780A (ja) | 2005-12-15 |
| AU2003239333A1 (en) | 2003-09-02 |
| US7279325B2 (en) | 2007-10-09 |
| US20040009558A1 (en) | 2004-01-15 |
| WO2003064468A2 (en) | 2003-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |