ATE333510T1 - Enzymatische messung von mycophenolsäure - Google Patents
Enzymatische messung von mycophenolsäureInfo
- Publication number
- ATE333510T1 ATE333510T1 AT00935908T AT00935908T ATE333510T1 AT E333510 T1 ATE333510 T1 AT E333510T1 AT 00935908 T AT00935908 T AT 00935908T AT 00935908 T AT00935908 T AT 00935908T AT E333510 T1 ATE333510 T1 AT E333510T1
- Authority
- AT
- Austria
- Prior art keywords
- mycophenolic acid
- enzymatic measurement
- measurement
- present
- biological samples
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title abstract 3
- 238000005259 measurement Methods 0.000 title abstract 3
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title abstract 3
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title abstract 3
- 229960000951 mycophenolic acid Drugs 0.000 title abstract 3
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/328,741 US6107052A (en) | 1999-06-09 | 1999-06-09 | Enzymatic measurement of mycophenolic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE333510T1 true ATE333510T1 (de) | 2006-08-15 |
Family
ID=23282234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00935908T ATE333510T1 (de) | 1999-06-09 | 2000-05-11 | Enzymatische messung von mycophenolsäure |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6107052A (de) |
| EP (1) | EP1112373B1 (de) |
| JP (1) | JP3854864B2 (de) |
| AT (1) | ATE333510T1 (de) |
| CA (1) | CA2339821C (de) |
| DE (1) | DE60029413T2 (de) |
| ES (1) | ES2267541T3 (de) |
| WO (1) | WO2000075363A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6811998B2 (en) * | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
| US6524808B1 (en) * | 1999-06-25 | 2003-02-25 | Roche Diagnostics Corporation | Enzyme inhibition immunoassay |
| DE60140929D1 (de) * | 2000-11-14 | 2010-02-11 | Roche Diagnostics Gmbh | Immunoassay für HIV-Protease-Hemstoffe |
| US7083642B2 (en) * | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| US20050203612A1 (en) * | 2000-12-22 | 2005-09-15 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
| US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
| US7077859B2 (en) | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
| US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| US20050125054A1 (en) * | 2000-12-22 | 2005-06-09 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
| JP4347044B2 (ja) * | 2001-07-26 | 2009-10-21 | アバンテク バスキュラー コーポレーション | 可変放出プロフィールを有する治療用薬剤を送達するための装置 |
| US7276362B2 (en) * | 2004-01-30 | 2007-10-02 | Roche Diagnostics Operations, Inc. | Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides |
| MXPA06005659A (es) * | 2004-04-26 | 2007-04-10 | Teva Gyogyszergyar Zartkoruen | Proceso para preparacion de acido micofenolico y derivados de ester del mismo. |
| SI2032712T1 (sl) * | 2006-06-29 | 2010-06-30 | Ivax Pharmaceuticals Sro | Regulacija proizvodnje kislinskega metabolita |
| EP2024506A1 (de) * | 2007-04-11 | 2009-02-18 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Verfahren zur reduzierung des verunreinigungslevels bei der myophenolsäure-fermentierung |
| EP3918087A1 (de) * | 2019-01-31 | 2021-12-08 | Roche Diagnostics GmbH | Stabilisierung von nadph oder nadh in ammoniaknachweis-assays |
| CN112481354A (zh) * | 2019-09-11 | 2021-03-12 | 上海云泽生物科技有限公司 | 一种霉酚酸检测试剂及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US5665583A (en) * | 1988-08-12 | 1997-09-09 | Arch Dev Corp | Methods and materials relating to IMPDH and GMP production |
| US5283257A (en) * | 1992-07-10 | 1994-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treating hyperproliferative vascular disease |
| WO1994012184A1 (en) * | 1992-11-24 | 1994-06-09 | Syntex (U.S.A.) Inc. | Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis |
| US5380879A (en) * | 1994-02-18 | 1995-01-10 | Syntex (U.S.A.) Inc. | Derivatives of mycophenolic acid |
| US5444072A (en) * | 1994-02-18 | 1995-08-22 | Syntex (U.S.A.) Inc. | 6-substituted mycophenolic acid and derivatives |
| US6225073B1 (en) * | 1994-07-07 | 2001-05-01 | Dade Behring Marburg Gmbh | Immunoassay for mycophenolic acid |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| HUP0004421A3 (en) * | 1996-04-23 | 2002-10-28 | Vertex Pharmaceuticals Inc Cam | Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme |
| US6153398A (en) * | 1997-12-24 | 2000-11-28 | The University Of Chicago | Method to identify specific inhibitors of IMP dehydrogenase |
-
1999
- 1999-06-09 US US09/328,741 patent/US6107052A/en not_active Expired - Lifetime
-
2000
- 2000-05-11 CA CA002339821A patent/CA2339821C/en not_active Expired - Lifetime
- 2000-05-11 JP JP2001501643A patent/JP3854864B2/ja not_active Expired - Lifetime
- 2000-05-11 DE DE60029413T patent/DE60029413T2/de not_active Expired - Lifetime
- 2000-05-11 AT AT00935908T patent/ATE333510T1/de active
- 2000-05-11 WO PCT/US2000/012872 patent/WO2000075363A2/en not_active Ceased
- 2000-05-11 ES ES00935908T patent/ES2267541T3/es not_active Expired - Lifetime
- 2000-05-11 EP EP00935908A patent/EP1112373B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000075363A2 (en) | 2000-12-14 |
| CA2339821A1 (en) | 2000-12-14 |
| DE60029413T2 (de) | 2007-02-22 |
| US6107052A (en) | 2000-08-22 |
| DE60029413D1 (de) | 2006-08-31 |
| ES2267541T3 (es) | 2007-03-16 |
| WO2000075363A3 (en) | 2001-04-12 |
| EP1112373A2 (de) | 2001-07-04 |
| CA2339821C (en) | 2009-01-27 |
| EP1112373B1 (de) | 2006-07-19 |
| JP3854864B2 (ja) | 2006-12-06 |
| JP2003523730A (ja) | 2003-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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