ATE347105T1 - Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer - Google Patents

Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer

Info

Publication number
ATE347105T1
ATE347105T1 AT03024289T AT03024289T ATE347105T1 AT E347105 T1 ATE347105 T1 AT E347105T1 AT 03024289 T AT03024289 T AT 03024289T AT 03024289 T AT03024289 T AT 03024289T AT E347105 T1 ATE347105 T1 AT E347105T1
Authority
AT
Austria
Prior art keywords
hiv protease
assay
kit
protease inhibitors
protease inhibitor
Prior art date
Application number
AT03024289T
Other languages
English (en)
Inventor
Lili Arabshahi
Haijuan Li
Der Eltz Herbert Von
Erasmus Huber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE347105T1 publication Critical patent/ATE347105T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT03024289T 2002-10-29 2003-10-23 Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer ATE347105T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/284,040 US6821744B2 (en) 2002-10-29 2002-10-29 Method, assay, and kit for quantifying HIV protease inhibitors

Publications (1)

Publication Number Publication Date
ATE347105T1 true ATE347105T1 (de) 2006-12-15

Family

ID=32107581

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03024289T ATE347105T1 (de) 2002-10-29 2003-10-23 Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer

Country Status (7)

Country Link
US (1) US6821744B2 (de)
EP (1) EP1418432B1 (de)
JP (1) JP2004147655A (de)
AT (1) ATE347105T1 (de)
CA (1) CA2447172A1 (de)
DE (1) DE60310012T2 (de)
ES (1) ES2277018T3 (de)

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US20060270058A1 (en) * 2005-05-31 2006-11-30 United Drug Testing Lab Inc. Method for collecting, extracting and quantifying drugs from saliva samples and surfaces
KR100709555B1 (ko) 2005-09-29 2007-04-20 한국과학기술연구원 고성능 액체크로마토그래피-질량분석기를 이용한 혈장 중의에이즈 치료제 검출 방법
KR101457716B1 (ko) 2006-11-01 2014-11-03 베크만 컬터, 인코포레이티드 친화도 분석을 위한 결합 표면
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
SMT201800284T1 (it) 2011-06-10 2018-07-17 Univ Oregon Health & Science Glicoproteine cmv e vettori ricombinanti
EP2568289A3 (de) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper
EP2586461A1 (de) 2011-10-27 2013-05-01 Christopher L. Parks Von einem eingehüllten Virus abgeleitete Virenpartikel
HU230404B1 (hu) 2012-05-18 2016-04-28 Debreceni Egyetem Hígításon alapuló gátlóhatást mérő módszer
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
EP2848937A1 (de) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Verfahren zur Identifizierung neuartiger HIV-1-Immunogene
EP2873423B1 (de) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9925258B2 (en) 2015-10-02 2018-03-27 International Aids Vaccine Initiative Replication-competent VSV-HIV Env vaccines
JP7109374B2 (ja) * 2016-04-14 2022-07-29 エフ．ホフマン－ラ ロシュ アーゲー 体液の試料中の標的分析物の濃度を決定するための方法

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US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4868132A (en) 1987-02-03 1989-09-19 Abbott Laboratories Fluorescence polarization immunoassay for amphetamine/methamphetamine
DE3806430A1 (de) 1988-02-29 1989-09-07 Boehringer Mannheim Gmbh Verfahren zur bestimmung eines proteins nach dem prinzip des fluoreszenz-polarisations-immunoassays
DE3819846A1 (de) 1988-06-10 1989-12-14 Hans Prof Dr Dr Wolf Testsystem fuer die entwicklung von inhibitoren der protease von hiv
DK93990D0 (da) 1990-04-17 1990-04-17 Carlsberg As Fluorogene peptider og deres anvendelse ved bestemmelse af enzymatisk aktivitet
KR930701619A (ko) 1990-06-01 1993-06-12 레나토 스가르비 인체 면역 결핍 바이러스의 gag 단백질 전구체 p55에 대한 단일클론 항체
US5171662A (en) 1990-09-13 1992-12-15 The Upjohn Company Method of detecting HIV protease activity
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
CA2159639A1 (en) 1993-04-02 1994-10-13 Vincent J. Miles Method for selective inactivation of viral replication
US5436131A (en) 1993-04-02 1995-07-25 Merck & Co., Inc. Color screening assay for identifying inhibitor resistant HIV protease mutants
US5741715A (en) 1995-05-30 1998-04-21 Roche Diagnostic Systems, Inc. Quinidine immunoassay and reagents
IT1298693B1 (it) 1996-04-24 2000-01-12 Hoffmann La Roche Derivati della fluoresceina 4'-metil sostituiti
CN1225134A (zh) 1996-05-14 1999-08-04 曼尼托巴大学 用固相法检测生物活性物质
WO1998053093A1 (en) 1997-05-23 1998-11-26 Bioarray Solutions Llc Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
PL341661A1 (en) 1997-10-10 2001-04-23 Cytovia Novel fluorescent reporter particles and their application in combination with testing capsizes
FR2773994B1 (fr) 1998-01-23 2002-10-11 Univ Nice Sophia Antipolis Prodrogues issues d'anti-proteases inhibitrices du virus de l'immunodeficience humaine (vih) pour l'amelioration de leur biodisponibilite, de leur tropisme vers et/ou de leur delivrance dans le systeme nerveux central
JP4776775B2 (ja) 1998-06-23 2011-09-21 アメリカ合衆国 Ｈｉｖ感染哺乳動物を治療するための医薬組成物
DE69920473T2 (de) 1998-07-21 2006-02-23 Cytovia, Inc., San Diego Neue fluoreszenzfarbstoffe und ihre anwendung in fluoreszenznachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung
JP4860085B2 (ja) * 2000-03-16 2012-01-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 表面結合リガンドから溶出された分析物を捕捉するための方法
EP1207394B1 (de) 2000-11-14 2009-12-30 Roche Diagnostics GmbH Immunoassay für HIV-Protease-Hemstoffe
WO2002059154A2 (en) * 2001-01-26 2002-08-01 Abgenix, Inc. Neutralizing human monoclonal antibodies against hiv-1, their production and uses

Also Published As

Publication number Publication date
DE60310012T2 (de) 2007-06-06
US20040081957A1 (en) 2004-04-29
US6821744B2 (en) 2004-11-23
EP1418432A1 (de) 2004-05-12
EP1418432B1 (de) 2006-11-29
CA2447172A1 (en) 2004-04-29
JP2004147655A (ja) 2004-05-27
ES2277018T3 (es) 2007-07-01
DE60310012D1 (de) 2007-01-11

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