ATE347105T1 - Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer - Google Patents

Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer

Info

Publication number
ATE347105T1
ATE347105T1 AT03024289T AT03024289T ATE347105T1 AT E347105 T1 ATE347105 T1 AT E347105T1 AT 03024289 T AT03024289 T AT 03024289T AT 03024289 T AT03024289 T AT 03024289T AT E347105 T1 ATE347105 T1 AT E347105T1
Authority
AT
Austria
Prior art keywords
hiv protease
assay
kit
protease inhibitors
protease inhibitor
Prior art date
Application number
AT03024289T
Other languages
English (en)
Inventor
Lili Arabshahi
Haijuan Li
Der Eltz Herbert Von
Erasmus Huber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE347105T1 publication Critical patent/ATE347105T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT03024289T 2002-10-29 2003-10-23 Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer ATE347105T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/284,040 US6821744B2 (en) 2002-10-29 2002-10-29 Method, assay, and kit for quantifying HIV protease inhibitors

Publications (1)

Publication Number Publication Date
ATE347105T1 true ATE347105T1 (de) 2006-12-15

Family

ID=32107581

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03024289T ATE347105T1 (de) 2002-10-29 2003-10-23 Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer

Country Status (7)

Country Link
US (1) US6821744B2 (de)
EP (1) EP1418432B1 (de)
JP (1) JP2004147655A (de)
AT (1) ATE347105T1 (de)
CA (1) CA2447172A1 (de)
DE (1) DE60310012T2 (de)
ES (1) ES2277018T3 (de)

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US20060270058A1 (en) * 2005-05-31 2006-11-30 United Drug Testing Lab Inc. Method for collecting, extracting and quantifying drugs from saliva samples and surfaces
KR100709555B1 (ko) 2005-09-29 2007-04-20 한국과학기술연구원 고성능 액체크로마토그래피-질량분석기를 이용한 혈장 중의에이즈 치료제 검출 방법
EP2069790B1 (de) * 2006-11-01 2015-04-29 Beckman Coulter, Inc. Bindungsoberflächen für affinitätstests
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
DK2691530T3 (en) 2011-06-10 2018-05-22 Univ Oregon Health & Science CMV GLYCOPROTEIN AND RECOMBINANT VECTORS
EP2568289A3 (de) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
HU230404B1 (hu) 2012-05-18 2016-04-28 Debreceni Egyetem Hígításon alapuló gátlóhatást mérő módszer
EP2679596B1 (de) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 Env-proteinvariante
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3069730A3 (de) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
EP3072901A1 (de) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
US9925258B2 (en) 2015-10-02 2018-03-27 International Aids Vaccine Initiative Replication-competent VSV-HIV Env vaccines
JP7109374B2 (ja) * 2016-04-14 2022-07-29 エフ．ホフマン－ラ ロシュ アーゲー 体液の試料中の標的分析物の濃度を決定するための方法

Family Cites Families (22)

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US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4868132A (en) 1987-02-03 1989-09-19 Abbott Laboratories Fluorescence polarization immunoassay for amphetamine/methamphetamine
DE3806430A1 (de) 1988-02-29 1989-09-07 Boehringer Mannheim Gmbh Verfahren zur bestimmung eines proteins nach dem prinzip des fluoreszenz-polarisations-immunoassays
DE3819846A1 (de) 1988-06-10 1989-12-14 Hans Prof Dr Dr Wolf Testsystem fuer die entwicklung von inhibitoren der protease von hiv
DK93990D0 (da) 1990-04-17 1990-04-17 Carlsberg As Fluorogene peptider og deres anvendelse ved bestemmelse af enzymatisk aktivitet
WO1991019000A1 (en) 1990-06-01 1991-12-12 Gruppo Lepetit S.P.A. A MONOCLONAL ANTIBODY AGAINST THE GAG PROTEIN PRECURSOR p55 OF HUMAN IMMUNODEFICIENCY VIRUS
US5171662A (en) 1990-09-13 1992-12-15 The Upjohn Company Method of detecting HIV protease activity
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5436131A (en) 1993-04-02 1995-07-25 Merck & Co., Inc. Color screening assay for identifying inhibitor resistant HIV protease mutants
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US5741715A (en) 1995-05-30 1998-04-21 Roche Diagnostic Systems, Inc. Quinidine immunoassay and reagents
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EP0912757A4 (de) 1996-05-14 2003-03-05 Univ Manitoba Bestimmung biologisch aktiver substanzen mit hilfe von festphasen
WO1998053093A1 (en) 1997-05-23 1998-11-26 Bioarray Solutions Llc Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
KR20010031056A (ko) 1997-10-10 2001-04-16 시토비아 인크. 신규 형광 리포터 분자 및 카스파제에 대한 분석을 비롯한이의 용도
US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
FR2773994B1 (fr) 1998-01-23 2002-10-11 Univ Nice Sophia Antipolis Prodrogues issues d'anti-proteases inhibitrices du virus de l'immunodeficience humaine (vih) pour l'amelioration de leur biodisponibilite, de leur tropisme vers et/ou de leur delivrance dans le systeme nerveux central
ES2604662T3 (es) 1998-06-23 2017-03-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Ensayo de acondicionamiento físico y métodos para reducir la resistencia del VIH a la terapia
AU5116099A (en) 1998-07-21 2000-02-14 Sui Xiong Cai Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
ATE335202T1 (de) * 2000-03-16 2006-08-15 Biacore Ab Verfahren zur erfassung von analyten, die aus oberflächengebundenen liganden eluiert werden
EP1207394B1 (de) 2000-11-14 2009-12-30 Roche Diagnostics GmbH Immunoassay für HIV-Protease-Hemstoffe
JP2005510201A (ja) * 2001-01-26 2005-04-21 アブジェニックス インコーポレイテッド Ｈｉｖ−１に対する中和ヒトモノクローナル抗体、それらの産生および使用

Also Published As

Publication number Publication date
EP1418432A1 (de) 2004-05-12
US6821744B2 (en) 2004-11-23
CA2447172A1 (en) 2004-04-29
EP1418432B1 (de) 2006-11-29
DE60310012D1 (de) 2007-01-11
JP2004147655A (ja) 2004-05-27
ES2277018T3 (es) 2007-07-01
US20040081957A1 (en) 2004-04-29
DE60310012T2 (de) 2007-06-06

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