ATE333518T1 - Verfahren zur identifizierug oder testung von agonisten für bzw. antagonisten gegen ppar - Google Patents

Verfahren zur identifizierug oder testung von agonisten für bzw. antagonisten gegen ppar

Info

Publication number
ATE333518T1
ATE333518T1 AT98938950T AT98938950T ATE333518T1 AT E333518 T1 ATE333518 T1 AT E333518T1 AT 98938950 T AT98938950 T AT 98938950T AT 98938950 T AT98938950 T AT 98938950T AT E333518 T1 ATE333518 T1 AT E333518T1
Authority
AT
Austria
Prior art keywords
identifying
ppar
antagonists against
tested
substance
Prior art date
Application number
AT98938950T
Other languages
English (en)
Inventor
Tomoyasu Taniguchi
Junko Mizukami
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of ATE333518T1 publication Critical patent/ATE333518T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT98938950T 1997-08-27 1998-08-24 Verfahren zur identifizierug oder testung von agonisten für bzw. antagonisten gegen ppar ATE333518T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23108497A JP4296608B2 (ja) 1997-08-27 1997-08-27 Ｐｐａｒのアゴニスト及びアンタゴニストのスクリーニング方法

Publications (1)

Publication Number Publication Date
ATE333518T1 true ATE333518T1 (de) 2006-08-15

Family

ID=16918043

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98938950T ATE333518T1 (de) 1997-08-27 1998-08-24 Verfahren zur identifizierug oder testung von agonisten für bzw. antagonisten gegen ppar

Country Status (7)

Country Link
US (2) US6365361B1 (de)
EP (1) EP1057896B1 (de)
JP (1) JP4296608B2 (de)
AT (1) ATE333518T1 (de)
AU (1) AU8749498A (de)
DE (1) DE69835301T2 (de)
WO (1) WO1999010532A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586189B2 (en) * 1999-06-18 2003-07-01 City Of Hope Screening method for PPAR-γ ligands
EP1629082A4 (de) * 2000-10-20 2009-07-22 Univ Massachusetts Mit glucosetransport in zusammenhang stehende gene und deren verwendungen
CA2390686A1 (en) * 2001-06-14 2002-12-14 Pierre Chambon Cofactor-based screening method for nuclear receptor modulators and related modulators
AT500023B1 (de) * 2001-09-27 2007-09-15 Bmt Medizinische Forschung Und Funktioneller screen für transskriptionsfaktoren
WO2003061583A2 (en) * 2002-01-18 2003-07-31 Incyte Genomics Inc. Digenic mutations associated with severe insulin resistance and type 2 diabetes and their use in the diagnosis and treatment of diabetes
CA2474353A1 (en) * 2002-01-23 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Method for screening a drug ameliorating insulin resistance
JPWO2004005497A1 (ja) * 2002-07-02 2005-11-04 アステラス製薬株式会社 インスリン抵抗性改善薬スクリーニング方法
KR20050026508A (ko) * 2002-07-24 2005-03-15 3-디멘져널 파마슈티칼즈 인코오포레이티드 리간드 확인 방법
US7335481B2 (en) * 2002-07-24 2008-02-26 Christer Owman Methods of identifying compounds that affect a fatty acid cell-surface receptor
GB0302446D0 (en) * 2003-02-03 2003-03-05 Imp College Innovations Ltd Screening for modulators of fat storage
KR100576575B1 (ko) * 2003-09-16 2006-05-04 한국생명공학연구원 피피에이알감마에 대한 단일클론 항체, 특이 항체분비 융합세포주 및 항체를 이용한 염증, 암, 대사성 질환과 같은 질병 관련 조절인자를 검색하는 방법
CN1303218C (zh) * 2003-12-19 2007-03-07 中国科学院上海药物研究所 过氧化物酶体增长因子活化受体拮抗剂和激动剂的筛选方法
US7307169B2 (en) * 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
EP1709188A1 (de) * 2004-01-16 2006-10-11 Ceres, Inc. Pflanzenzellen enthaltend rezepture polypeptide
US7691823B2 (en) * 2004-03-05 2010-04-06 University Of Massachusetts RIP140 regulation of glucose transport
EP1865954A4 (de) 2005-03-21 2010-12-15 Metabolex Inc Verfahren zur vermeidung von ödem bei der behandlung oder prävention von auf ppar gamma ansprechenden erkrankungen einschliesslich krebs
US9173875B2 (en) 2006-04-11 2015-11-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Treatment for nicotine-induced lung disease using peroxisome proliferator-activated receptor gamma agonists
JP2014014293A (ja) * 2012-07-06 2014-01-30 Kri Inc Ｐｐａｒ活性物質検出形質転換酵母及びｐｐａｒ活性物質検出方法。
US12031161B2 (en) 2020-10-09 2024-07-09 University Of Massachusetts Targeting Nrip1 to alleviate metabolic disease
CN113308490B (zh) * 2021-05-18 2023-02-28 华中农业大学 利用双荧光素酶报告基因系统及分子对接技术筛选PGC-1α小分子调控剂的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5989808A (en) * 1994-06-14 1999-11-23 American Cyanamid Company Identification of compounds affecting specific interaction of peptide binding pairs
US6689574B1 (en) * 1997-10-07 2004-02-10 Merck & Co., Inc. Assays for nuclear receptor agonists and antagonists using fluorescence resonance energy transfer

Also Published As

Publication number Publication date
EP1057896A4 (de) 2003-08-06
US7045298B2 (en) 2006-05-16
JP4296608B2 (ja) 2009-07-15
EP1057896B1 (de) 2006-07-19
JPH1156369A (ja) 1999-03-02
EP1057896A1 (de) 2000-12-06
AU8749498A (en) 1999-03-16
US20020119499A1 (en) 2002-08-29
DE69835301D1 (de) 2006-08-31
DE69835301T2 (de) 2007-07-19
US6365361B1 (en) 2002-04-02
WO1999010532A1 (en) 1999-03-04

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