ATE333874T1 - Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzen - Google Patents
Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzenInfo
- Publication number
- ATE333874T1 ATE333874T1 AT00916646T AT00916646T ATE333874T1 AT E333874 T1 ATE333874 T1 AT E333874T1 AT 00916646 T AT00916646 T AT 00916646T AT 00916646 T AT00916646 T AT 00916646T AT E333874 T1 ATE333874 T1 AT E333874T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclooxygenase
- pain
- treatment
- linolenic acid
- mediated inflammation
- Prior art date
Links
- 102000010907 Cyclooxygenase 2 Human genes 0.000 title abstract 4
- 108010037462 Cyclooxygenase 2 Proteins 0.000 title abstract 4
- 206010061218 Inflammation Diseases 0.000 title 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 title 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 229960004488 linolenic acid Drugs 0.000 title 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 abstract 1
- 229940108924 conjugated linoleic acid Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/357,268 US6077868A (en) | 1999-07-20 | 1999-07-20 | Selective inhibition of cyclooxygenase-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE333874T1 true ATE333874T1 (de) | 2006-08-15 |
Family
ID=23404937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00916646T ATE333874T1 (de) | 1999-07-20 | 2000-03-24 | Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6077868A (de) |
| EP (1) | EP1196161B1 (de) |
| AT (1) | ATE333874T1 (de) |
| AU (1) | AU3772000A (de) |
| CA (1) | CA2379649C (de) |
| DE (1) | DE60029591T2 (de) |
| ES (1) | ES2269122T3 (de) |
| WO (1) | WO2001005395A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| EP1231913A2 (de) * | 1999-07-09 | 2002-08-21 | Pharmacia Corporation | Behandlung von cyclooxygenase-2 bedingten erkrankungen unter verwendung von conjugierten fettsäureverbindungen |
| EP1097708B1 (de) * | 1999-11-02 | 2003-09-17 | Loders Croklaan B.V. | Verwendung von trans-trans-Isomeren von konjugierter Linolsäure |
| WO2001041760A2 (en) * | 1999-12-08 | 2001-06-14 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| PE20021017A1 (es) | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
| US7365099B2 (en) | 2001-05-31 | 2008-04-29 | Wisconsin Alumni Research Foundation | Animal body fat control |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| US20030212138A1 (en) * | 2002-01-14 | 2003-11-13 | Pharmacia Corporation | Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor |
| US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
| US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
| JP2006511606A (ja) | 2002-12-13 | 2006-04-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 下部尿路症状を治療するα−２−δリガンド |
| US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| US20050014832A1 (en) * | 2003-07-16 | 2005-01-20 | Lc Usa Llc | Treatment |
| US20050014729A1 (en) * | 2003-07-16 | 2005-01-20 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
| DE10332712A1 (de) * | 2003-07-18 | 2005-02-10 | Cognis Deutschland Gmbh & Co. Kg | Verwendung von c9,t11-Isomeren der konjugierten Linolsäure |
| US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
| US20050113409A1 (en) * | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
| US20050154059A1 (en) * | 2004-01-13 | 2005-07-14 | Cook Mark E. | Method of treating type III hypersensitive reaction-related diseases and conditions by using conjugated linoleic acid |
| WO2005079808A1 (en) | 2004-01-22 | 2005-09-01 | Pfizer Limited | Triazole derivatives which inhibit vasopressin antagonistic activity |
| US20070225333A1 (en) * | 2004-04-28 | 2007-09-27 | Bryans Justin S | 3-Heterocyclyl-4-Phenyl-Triazole Derivatives as Inhibitors of the Vasopressin Via Receptor |
| US20070281044A1 (en) * | 2006-06-02 | 2007-12-06 | Mueller Mark J | Use of cold-pressed edible seed oils, flours, and/or blends thereof as anti-inflammatory and cox-2 inhibitory agents |
| JP5308350B2 (ja) | 2006-12-22 | 2013-10-09 | レコルダーティ アイルランド リミテッド | α２δリガンドおよびＮＳＡＩＤを用いた下部尿路機能障害の併用療法 |
| EP3509604B1 (de) | 2016-09-07 | 2026-02-18 | Trustees of Tufts College | Kombinationstherapien mit immuno-dash-inhibitoren und pge2-antagonisten |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4434101A (en) * | 1981-09-14 | 1984-02-28 | Hoffmann-La Roche Inc. | Inhibitors of SRS-synthesis |
| US5070104A (en) * | 1989-02-17 | 1991-12-03 | Wisconsin Alumni Research Foundation | Methods of chelating metal and novel compositions therefor |
| US5017614A (en) * | 1989-02-17 | 1991-05-21 | Wisconsin Alumni Research Foundation | Methods of preventing oxidation, quenching singlet oxygen and inhibiting mold growth and novel compositions therefor |
| US5430066A (en) * | 1992-04-29 | 1995-07-04 | Wisconsin Alumni Research Foundation | Methods for preventing weight loss, reduction in weight gain, and anorexia due to immune stimulation |
| US5428072A (en) * | 1992-04-29 | 1995-06-27 | Wisconsin Alumni Research Foundation | Method of increasing the efficiency of feed conversion in animals |
| US5554646A (en) * | 1992-04-29 | 1996-09-10 | Wisconsin Alumni Research Foundation | Method for reducing body fat in animals |
| US5760082C1 (en) * | 1994-08-29 | 2001-03-06 | Wisconsin Alumni Res Found | Dietetic foods containing conjugated linoleic acids |
| US5747537A (en) * | 1995-09-05 | 1998-05-05 | Washington University | Method of inhibiting parasitic activity |
| US5585400A (en) * | 1996-02-27 | 1996-12-17 | Wisconsin Alumni Research Foundation | Methods of attenuating the allergic response in animals |
| CA2267109C (en) * | 1996-11-05 | 2006-08-22 | Wisconsin Alumni Research Foundation | Use of conjugated linoleic acid to enhance natural killer lymphocyte function |
| US5851572A (en) * | 1997-04-25 | 1998-12-22 | Wisconsin Alumni Research Foundation | Method of increasing fat firmness and improving meat quality in animals with conjugated linolenic acid |
| US6136985A (en) * | 1997-12-23 | 2000-10-24 | Dcv, Inc. | CLA esters and uses thereof |
| US6077525A (en) * | 1998-04-10 | 2000-06-20 | The George Washington University | Use of conjugated linoleic acids |
-
1999
- 1999-07-20 US US09/357,268 patent/US6077868A/en not_active Expired - Lifetime
-
2000
- 2000-03-24 CA CA002379649A patent/CA2379649C/en not_active Expired - Lifetime
- 2000-03-24 AT AT00916646T patent/ATE333874T1/de not_active IP Right Cessation
- 2000-03-24 WO PCT/US2000/007824 patent/WO2001005395A1/en not_active Ceased
- 2000-03-24 ES ES00916646T patent/ES2269122T3/es not_active Expired - Lifetime
- 2000-03-24 DE DE60029591T patent/DE60029591T2/de not_active Expired - Lifetime
- 2000-03-24 AU AU37720/00A patent/AU3772000A/en not_active Abandoned
- 2000-03-24 EP EP00916646A patent/EP1196161B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1196161B1 (de) | 2006-07-26 |
| CA2379649A1 (en) | 2001-01-25 |
| EP1196161A1 (de) | 2002-04-17 |
| US6077868A (en) | 2000-06-20 |
| DE60029591T2 (de) | 2007-08-09 |
| ES2269122T3 (es) | 2007-04-01 |
| WO2001005395A1 (en) | 2001-01-25 |
| CA2379649C (en) | 2009-03-10 |
| AU3772000A (en) | 2001-02-05 |
| DE60029591D1 (de) | 2006-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |