ATE333888T1 - Verwendung eines polypeptids, welches die extrazelluläre domäne von il-20ra und il-20rb enthält, zur behandlung von entzündungen - Google Patents
Verwendung eines polypeptids, welches die extrazelluläre domäne von il-20ra und il-20rb enthält, zur behandlung von entzündungenInfo
- Publication number
- ATE333888T1 ATE333888T1 AT01970886T AT01970886T ATE333888T1 AT E333888 T1 ATE333888 T1 AT E333888T1 AT 01970886 T AT01970886 T AT 01970886T AT 01970886 T AT01970886 T AT 01970886T AT E333888 T1 ATE333888 T1 AT E333888T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammation
- treatment
- extracellular domain
- polypeptide containing
- seq
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 101001044895 Homo sapiens Interleukin-20 receptor subunit beta Proteins 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 title 1
- 102100022706 Interleukin-20 receptor subunit alpha Human genes 0.000 title 1
- 101710174006 Interleukin-20 receptor subunit alpha Proteins 0.000 title 1
- 102100022705 Interleukin-20 receptor subunit beta Human genes 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23330500P | 2000-09-15 | 2000-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE333888T1 true ATE333888T1 (de) | 2006-08-15 |
Family
ID=22876714
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01970886T ATE333888T1 (de) | 2000-09-15 | 2001-09-13 | Verwendung eines polypeptids, welches die extrazelluläre domäne von il-20ra und il-20rb enthält, zur behandlung von entzündungen |
| AT05028379T ATE460429T1 (de) | 2000-09-15 | 2001-09-13 | Polypeptide enthaltend extrazellulären domäne von il-20ra und/oderr il-20rb |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05028379T ATE460429T1 (de) | 2000-09-15 | 2001-09-13 | Polypeptide enthaltend extrazellulären domäne von il-20ra und/oderr il-20rb |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7855269B2 (de) |
| EP (2) | EP1803733B1 (de) |
| JP (1) | JP4908723B2 (de) |
| AT (2) | ATE333888T1 (de) |
| AU (1) | AU2001290837A1 (de) |
| CA (1) | CA2422033A1 (de) |
| DE (2) | DE60141546D1 (de) |
| DK (1) | DK1351703T3 (de) |
| ES (1) | ES2267814T3 (de) |
| WO (1) | WO2002022153A2 (de) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965704A (en) * | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
| EP2177616B1 (de) * | 2000-08-08 | 2012-02-29 | ZymoGenetics, Inc. | Lösliche Zcyctor 11 Cytokinrezeptoren |
| EP1803733B1 (de) * | 2000-09-15 | 2010-03-10 | ZymoGenetics, Inc. | Polypeptide enthaltend extrazellulären Domäne von IL-20RA und/oderr IL-20RB |
| EP1606317B1 (de) * | 2003-03-24 | 2010-07-28 | ZymoGenetics, Inc. | Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung |
| US20040248097A1 (en) * | 2003-05-23 | 2004-12-09 | Ming-Shi Chang | Interleukin-20 variants and promoters |
| JP2007501813A (ja) * | 2003-08-08 | 2007-02-01 | ノボ ノルディスク アクティーゼルスカブ | 新生血管形成と関連した症状を治療および診断するためのインターロイキン−20 |
| EP3434275A1 (de) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Auf die verwendung von auristatin-konjugaten mit antikörpern basierter nachweis für krebszellen |
| EP2143733A1 (de) * | 2003-11-21 | 2010-01-13 | ZymoGenetics, Inc. | Anti-il-20-Rezeptor-Antikörper und Bindungspartner und Verfahren zur Anwendung bei Entzündungen |
| MXPA06014065A (es) | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| EA015706B1 (ru) * | 2004-10-22 | 2011-10-31 | Займоджинетикс, Инк. | Моноклональное антитело или его фрагмент, связывающиеся с полипептидом il-22ra, гуманизированное антитело, полученное из указанного антитела, гибридомы, продуцирующие антитело, и применение указанного антитела |
| EP2192132A3 (de) * | 2005-02-08 | 2010-08-18 | ZymoGenetics, Inc. | Anti-il-20-, Anti-il-22- und Anti-il-22ra-Antikörper und Bindungspartner sowie Verwendungsverfahren bei Entzündungen |
| ATE555383T1 (de) | 2006-06-22 | 2012-05-15 | Novo Nordisk As | Lösliche heterodimere rezeptoren und ihre verwendung |
| JP2013504585A (ja) | 2009-09-09 | 2013-02-07 | セントローズ, エルエルシー | 細胞外標的化薬物複合体 |
| WO2011130598A1 (en) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| SG185428A1 (en) | 2010-06-08 | 2012-12-28 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| WO2012074757A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| US8679767B2 (en) | 2011-05-12 | 2014-03-25 | Genentech, Inc. | Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides |
| PT2750713E (pt) | 2011-10-14 | 2016-01-20 | Genentech Inc | Pirrolobenzodiazepinas e conjugados das mesmas |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| NZ707486A (en) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
| US9931414B2 (en) | 2012-10-12 | 2018-04-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| ES2649990T3 (es) | 2012-10-12 | 2018-01-16 | Medimmune Limited | Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| ES2738310T3 (es) | 2012-10-12 | 2020-01-21 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas |
| EP2906296B1 (de) | 2012-10-12 | 2018-03-21 | ADC Therapeutics SA | Pyrrolobenzodiazepin-antikörper-konjugate |
| HK1216176A1 (zh) | 2012-12-21 | 2016-10-21 | Medlmmune Limited | 用於治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
| BR112015014669B1 (pt) | 2012-12-21 | 2023-09-26 | Medimmune Limited | Compostos pirrolobenzodiazepinas, conjugados compreendendo os mesmos e uso destes para tratar uma doença proliferativa |
| CA2905181C (en) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy |
| AU2014244245C1 (en) | 2013-03-13 | 2018-04-19 | Genentech, Inc. | Pyrrolobenzodiazepines and conjugates thereof |
| CN105142674B (zh) | 2013-03-13 | 2018-11-13 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓和其结合物 |
| JP6993084B2 (ja) | 2013-08-12 | 2022-02-03 | ジェネンテック, インコーポレイテッド | 1-(クロロメチル)-2,3-ジヒドロ-1h-ベンゾ[e]インドール二量体抗体 - 薬物コンジュゲート化合物、並びに使用及び処置の方法 |
| EP3054985B1 (de) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP3054983B1 (de) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
| EP3054986B1 (de) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
| CA2928952A1 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| EP3082876B1 (de) | 2013-12-16 | 2018-01-17 | Genentech, Inc. | 1-(chlormethyl)-2,3-dihydro-1h-benzo[e]indoldimer-antikörper-wirkstoff-konjugatverbindungen und verfahren zur verwendung und behandlung |
| UA118113C2 (uk) | 2013-12-16 | 2018-11-26 | Дженентек, Інк. | Пептидоміметичні сполуки та їх кон'югати антитіла з лікарським засобом |
| EP3149049B1 (de) | 2014-05-27 | 2022-10-26 | The University Of Queensland | Il-22 zur verwendung in der behandlung von stoffwechselkrankheiten |
| AU2015271709B2 (en) | 2014-06-06 | 2020-11-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| TW201625688A (zh) | 2014-09-12 | 2016-07-16 | 建南德克公司 | 經半胱胺酸改造之抗體及接合物 |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| US10149913B2 (en) | 2014-09-12 | 2018-12-11 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| JP2017533887A (ja) | 2014-09-17 | 2017-11-16 | ジェネンテック, インコーポレイテッド | ピロロベンゾジアゼピン類及びその抗体ジスルフィドコンジュゲート |
| EP3223854A1 (de) | 2014-11-25 | 2017-10-04 | ADC Therapeutics SA | Pyrrolobenzodiazepin-antikörper-konjugate |
| MX2017007169A (es) | 2014-12-03 | 2018-05-02 | Genentech Inc | Compuestos de amina cuaternaria y conjugados de anticuerpofármaco de los mismos. |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| JP6812364B2 (ja) | 2015-06-03 | 2021-01-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 癌診断用抗gitr抗体 |
| KR102111338B1 (ko) | 2015-10-02 | 2020-05-15 | 제넨테크, 인크. | 피롤로벤조디아제핀 항체 약물 콘쥬게이트 및 이의 사용 방법 |
| WO2017064675A1 (en) | 2015-10-16 | 2017-04-20 | Genentech, Inc. | Hindered disulfide drug conjugates |
| EP3365025B1 (de) | 2015-10-20 | 2020-07-15 | Genentech, Inc. | Calicheamicin-antikörper-arzneimittelkonjugate und verfahren zur verwendung |
| CA3005855A1 (en) | 2015-11-19 | 2017-05-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| US20170315132A1 (en) | 2016-03-25 | 2017-11-02 | Genentech, Inc. | Multiplexed total antibody and antibody-conjugated drug quantification assay |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| JP7022080B2 (ja) | 2016-05-27 | 2022-02-17 | ジェネンテック, インコーポレイテッド | 部位特異的抗体-薬物複合体の特徴付けのための生化学分析的方法 |
| US10639378B2 (en) | 2016-06-06 | 2020-05-05 | Genentech, Inc. | Silvestrol antibody-drug conjugates and methods of use |
| EP3496763B1 (de) | 2016-08-11 | 2026-04-01 | Genentech, Inc. | Pyrrolobenzodiazepineprodroge und deren antikörperkonjugate |
| EP3522933B1 (de) | 2016-10-05 | 2021-12-15 | F. Hoffmann-La Roche AG | Verfahren zur herstellung von antikörperarzneimittelkonjugaten |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| US11160872B2 (en) | 2017-02-08 | 2021-11-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| EP3612537B1 (de) | 2017-04-18 | 2022-07-13 | Medimmune Limited | Pyrrolobenzodiazepinkonjugate |
| CN110536703B (zh) | 2017-04-20 | 2024-07-12 | Adc治疗有限公司 | 使用抗axl抗体-药物缀合物的组合疗法 |
| CN110869392A (zh) | 2017-05-16 | 2020-03-06 | 百时美施贵宝公司 | 用抗gitr激动性抗体治疗癌症 |
| UA127900C2 (uk) | 2017-06-14 | 2024-02-07 | Ейдісі Терапьютікс Са | Схема дозування для введення adc до cd19 |
| RS62928B1 (sr) | 2017-08-18 | 2022-03-31 | Medimmune Ltd | Konjugati pirolobenzodiazepina |
| US10301319B2 (en) | 2017-09-20 | 2019-05-28 | Ph Pharma Co., Ltd. | Thailanstatin analogs |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| TW202037381A (zh) | 2018-10-24 | 2020-10-16 | 瑞士商赫孚孟拉羅股份公司 | 綴合化學降解誘導劑及使用方法 |
| EP3894427A1 (de) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photovernetzende peptide zur stellenspezifischen konjugation an fc-haltige proteine |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| ES2967878T3 (es) | 2019-03-15 | 2024-05-06 | Medimmune Ltd | Dímeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento del cáncer |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
| EP4637833A2 (de) | 2022-12-23 | 2025-10-29 | Genentech, Inc. | Cereblon-abbaukonjugate und verwendungen davon |
| AU2024257248A1 (en) | 2023-04-17 | 2025-11-06 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
| WO2026006689A2 (en) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Bcl-xl degrader antibody conjugates and uses thereof |
| WO2026006688A2 (en) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Degrader antibody conjugates and uses thereof |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| US5436155A (en) | 1991-12-31 | 1995-07-25 | Arch Development Corporation | Isolated DNA encoding a somatostatin receptor |
| US5789192A (en) | 1992-12-10 | 1998-08-04 | Schering Corporation | Mammalian receptors for interleukin-10 (IL-10) |
| US5985614A (en) * | 1996-08-30 | 1999-11-16 | Human Genome Sciences, Inc. | Polynucleotides encoding interleukin-19 |
| WO1999046281A2 (en) | 1998-03-10 | 1999-09-16 | Genentech, Inc. | Novel polypeptides and nucleic acids encoding the same |
| US5945511A (en) * | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
| WO2000012708A2 (en) | 1998-09-01 | 2000-03-09 | Genentech, Inc. | Further pro polypeptides and sequences thereof |
| WO2000078961A1 (en) | 1999-06-23 | 2000-12-28 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6486301B1 (en) | 1997-07-16 | 2002-11-26 | Human Genome Sciences, Inc. | Interleukin-20 |
| WO1999003982A1 (en) | 1997-07-16 | 1999-01-28 | Human Genome Sciences, Inc. | Interleukin-20 |
| US5965704A (en) | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
| US6020163A (en) | 1997-08-06 | 2000-02-01 | Zymogenetics, Inc. | Lipocalin homolog |
| US6576743B1 (en) | 1997-11-26 | 2003-06-10 | Zymogenetics, Inc. | Mammalian cytokine-like polypeptide-10 |
| CN1618969A (zh) | 1997-11-26 | 2005-05-25 | 津莫吉尼蒂克斯公司 | 哺乳动物细胞因子样多肽-10 |
| ATE272114T1 (de) | 1998-01-23 | 2004-08-15 | Immunex Corp | Rezeptoren für il-18 |
| JP2002505879A (ja) | 1998-03-09 | 2002-02-26 | シェーリング コーポレイション | ヒトレセプタータンパク質;関連する試薬および方法 |
| US6982320B2 (en) | 1998-03-19 | 2006-01-03 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| WO1999061630A2 (en) | 1998-05-26 | 1999-12-02 | Regeneron Pharmaceuticals, Inc. | Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system |
| AU2222700A (en) | 1998-12-31 | 2000-07-31 | Millennium Pharmaceuticals, Inc. | Class ii cytokine receptor-like proteins and nucleic acids encoding them |
| WO2000073457A1 (en) | 1999-05-27 | 2000-12-07 | Schering-Corporation | Mammalian interleukin-10 homologs: il-d110 and il-d210 |
| DE60045139D1 (de) * | 1999-12-23 | 2010-12-02 | Zymogenetics Inc | Löslicher Interleukin-20-Rezeptor |
| US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
| US7122632B2 (en) * | 1999-12-23 | 2006-10-17 | Zymogenetics, Inc. | Soluble Interleukin-20 receptor |
| EP2295079A3 (de) | 1999-12-23 | 2011-03-23 | ZymoGenetics, L.L.C. | Verfahren zur Behandlung von Entzündungen |
| EP2177616B1 (de) | 2000-08-08 | 2012-02-29 | ZymoGenetics, Inc. | Lösliche Zcyctor 11 Cytokinrezeptoren |
| EP1803733B1 (de) * | 2000-09-15 | 2010-03-10 | ZymoGenetics, Inc. | Polypeptide enthaltend extrazellulären Domäne von IL-20RA und/oderr IL-20RB |
| EP1390060A2 (de) | 2001-01-26 | 2004-02-25 | Eli Lilly And Company | Verwendung von lp82 zur behandlung von störungen des körpergewichtes |
| CA2433933A1 (en) | 2001-02-28 | 2002-09-12 | Eli Lilly And Company | Use of lp82 to treat hematopoietic disorders |
| DK1399472T3 (da) | 2001-03-09 | 2009-10-05 | Zymogenetics Inc | Oplöselig heterodimer cytokinreceptor |
| DE10154579A1 (de) | 2001-11-07 | 2003-05-28 | Medigene Ag | Topikale Verwendung von Cytokinen und Chemokinen zur Behandlung von viralen oder mykotischen Hauterkrankungen oder Tumorerkrankungen |
| IL161978A0 (en) | 2001-12-17 | 2005-11-20 | Zymogenetics Inc | Method for treating cervical cancer |
| EP1606317B1 (de) | 2003-03-24 | 2010-07-28 | ZymoGenetics, Inc. | Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung |
-
2001
- 2001-09-13 EP EP05028379A patent/EP1803733B1/de not_active Expired - Lifetime
- 2001-09-13 AU AU2001290837A patent/AU2001290837A1/en not_active Abandoned
- 2001-09-13 ES ES01970886T patent/ES2267814T3/es not_active Expired - Lifetime
- 2001-09-13 WO PCT/US2001/028557 patent/WO2002022153A2/en not_active Ceased
- 2001-09-13 AT AT01970886T patent/ATE333888T1/de active
- 2001-09-13 DE DE60141546T patent/DE60141546D1/de not_active Expired - Lifetime
- 2001-09-13 EP EP01970886A patent/EP1351703B1/de not_active Expired - Lifetime
- 2001-09-13 US US09/951,268 patent/US7855269B2/en not_active Expired - Fee Related
- 2001-09-13 JP JP2002526403A patent/JP4908723B2/ja not_active Expired - Fee Related
- 2001-09-13 AT AT05028379T patent/ATE460429T1/de not_active IP Right Cessation
- 2001-09-13 CA CA002422033A patent/CA2422033A1/en not_active Abandoned
- 2001-09-13 DK DK01970886T patent/DK1351703T3/da active
- 2001-09-13 DE DE60121808T patent/DE60121808T2/de not_active Expired - Lifetime
-
2010
- 2010-11-09 US US12/942,302 patent/US20110077207A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1803733A2 (de) | 2007-07-04 |
| DE60141546D1 (de) | 2010-04-22 |
| EP1803733B1 (de) | 2010-03-10 |
| DE60121808D1 (de) | 2006-09-07 |
| US7855269B2 (en) | 2010-12-21 |
| EP1351703B1 (de) | 2006-07-26 |
| WO2002022153A2 (en) | 2002-03-21 |
| CA2422033A1 (en) | 2002-03-21 |
| AU2001290837A1 (en) | 2002-03-26 |
| JP2004525074A (ja) | 2004-08-19 |
| WO2002022153A3 (en) | 2003-06-19 |
| ATE460429T1 (de) | 2010-03-15 |
| DK1351703T3 (da) | 2006-11-27 |
| DE60121808T2 (de) | 2007-03-29 |
| EP1351703A2 (de) | 2003-10-15 |
| US20020085992A1 (en) | 2002-07-04 |
| JP4908723B2 (ja) | 2012-04-04 |
| EP1803733A3 (de) | 2007-10-31 |
| ES2267814T3 (es) | 2007-03-16 |
| US20110077207A1 (en) | 2011-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60121808D1 (de) | Verwendung eines polypeptids, welches die extrazelluläre domäne von il-20ra und il-20rb enthält, zur behandlung von entzündungen | |
| IL189629A0 (en) | Compositions containing human ctla-4 antibodies | |
| ATE272650T1 (de) | Analoge des magensaft inhibierenden peptides und ihre verwendung für die behandlung von diabetes | |
| DE60023870T2 (de) | Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte | |
| ATE262895T1 (de) | Verwendung von hemmern des maillard-reaktion zur behandlung von krankheiten zufolge amyloidosis | |
| ATE224713T1 (de) | Verwendung von pyridyl-alkan-,pyridiyl alkan- und/oder pyridyl-säuren amiden zur behandlung von tumoren oder für immunsuppression | |
| MX9706969A (es) | 3-(1,2,3,6-tetrahidropiridin-4-il)-1h-indoles y 3-(piperidin-4-il)-1h-indoles sustituidos en la posicion 5: agonistas del 5-ht1f novedosos. | |
| ATE478944T1 (de) | Zytokin ligand zur behandlung von asthma und atemwegsüberreaktivität | |
| ATE462006T1 (de) | Isoform des vegfs | |
| ATE494884T1 (de) | Oxidative zusammensetzung zur behandlung von keratinfasern, die spezielle aminosilikone enthält | |
| ATE428413T1 (de) | Neue verwendung von peptidverbindungen zur behandlung ovn zentralen neuropathischen schmerzen | |
| DE60331546D1 (de) | Verwendung von aspartic proteasen in den bereichen kosmetik und behandlung | |
| DE60023860D1 (de) | Verfahren zur herstellung von rekombinanten peptiden | |
| PL322001A1 (en) | 1-aryl-2-acetylamino ethane compounds, their application as antagonists of neurokinin, in particular of neurokinin 1 | |
| ATE190352T1 (de) | Dorsalgewebe beeinflussender faktor und zusammensetzungen | |
| MXPA04005079A (es) | Variantes del dominio c2 del factor viii. | |
| DE69328549D1 (de) | Für einen humanen serotoninrezeptor (5-ht4b) kodierende dns und ihre verwendung | |
| DE69808475D1 (de) | Aminosäurederivate zur behandlung von schlaganfall | |
| DK0840792T3 (da) | (S)-hydroxynitrillyase fra Hevea brasiliensis | |
| DE60024997D1 (de) | Vgf polypeptide und verfahren zur behandlung von vgf-erkrankungen | |
| ATE405577T1 (de) | Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung | |
| ATE452903T1 (de) | Modifizierte peptide und deren verwendung zur behandlung von autoimmunkrankheiten | |
| ATE244760T1 (de) | Wachtumsfaktor aus der harp-reihe, verfahren zu ihrer herstellung und verwendungen davon | |
| ATE397753T1 (de) | Screening-verfahren für eine prophylaktische und therapeutische substanz für eine nierenerkrankung | |
| ATE292970T1 (de) | Topische zusammensetzung enthaltend brucin und ihre verwendung zur behandlung von hautschäden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1351703 Country of ref document: EP |