ATE334109T1 - Materialien und verfahren zur herstellung von stilbenen - Google Patents

Materialien und verfahren zur herstellung von stilbenen

Info

Publication number: ATE334109T1
Authority: AT; Austria
Prior art keywords: substituted; stilbenes; methods; materials; cis
Prior art date: 2000-12-21

Application number

AT01271340T

Other languages

English (en)

Inventor

John A Hadfield

Alan T Mcgown

Keira Gaukroger

Lucy Annette Hepworth

Nicholas James Lawrence

Original Assignee

Cancer Res Ventures Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-21

Filing date

2001-12-14

Publication date

2006-08-15

2001-12-14 Application filed by Cancer Res Ventures Ltd filed Critical Cancer Res Ventures Ltd

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE334109T1 publication Critical patent/ATE334109T1/de

Links

235000021286 stilbenes Nutrition 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 4
239000000463 material Substances 0.000 title abstract 2
PJANXHGTPQOBST-VAWYXSNFSA-N trans-stilbene Chemical compound C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 title abstract 2
150000001629 stilbenes Chemical class 0.000 abstract 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 abstract 1
HVXBOLULGPECHP-WAYWQWQTSA-N Combretastatin A4 Chemical compound C1=C(O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 HVXBOLULGPECHP-WAYWQWQTSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000003935 benzaldehydes Chemical class 0.000 abstract 1
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzenecarboxaldehyde Natural products O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001642 boronic acid derivatives Chemical class 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
229960005537 combretastatin A-4 Drugs 0.000 abstract 1
HVXBOLULGPECHP-UHFFFAOYSA-N combretastatin A4 Natural products C1=C(O)C(OC)=CC=C1C=CC1=CC(OC)=C(OC)C(OC)=C1 HVXBOLULGPECHP-UHFFFAOYSA-N 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000006114 decarboxylation reaction Methods 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT01271340T 2000-12-21 2001-12-14 Materialien und verfahren zur herstellung von stilbenen ATE334109T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0031263.7A GB0031263D0 (en)	2000-12-21	2000-12-21	Materials and methods for synthesizing stilbenes

Publications (1)

Publication Number	Publication Date
ATE334109T1 true ATE334109T1 (de)	2006-08-15

Family

ID=9905600

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01271340T ATE334109T1 (de)	2000-12-21	2001-12-14	Materialien und verfahren zur herstellung von stilbenen

Country Status (8)

Country	Link
US (1)	US20040143023A1 (de)
EP (1)	EP1351911B1 (de)
AT (1)	ATE334109T1 (de)
AU (1)	AU2002217267A1 (de)
CA (1)	CA2432592A1 (de)
DE (1)	DE60121809T2 (de)
GB (1)	GB0031263D0 (de)
WO (1)	WO2002049994A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005507912A (ja)	2001-10-26	2005-03-24	オキシジーン，インコーポレイテッド	改良型血管標的化剤としての官能化スチルベン誘導体
CA2516078C (en)	2003-02-28	2014-04-29	Oxigene, Inc.	Catechol compositions and use thereof
EP2236131A3 (de)	2003-07-01	2011-03-02	President and Fellows of Harvard College	SIRT1 Modulatoren zur Veränderung der Lebensdauer/Stressreaktion von Zellen/Organismen
US8017634B2 (en)	2003-12-29	2011-09-13	President And Fellows Of Harvard College	Compositions for treating obesity and insulin resistance disorders
JP2007527418A (ja)	2003-12-29	2007-09-27	プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ	肥満及びインシュリン耐性障害を治療又は防止するための組成物
CN1723884A (zh) *	2004-07-21	2006-01-25	中国人民解放军军事医学科学院放射医学研究所	顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途
WO2006138418A2 (en)	2005-06-14	2006-12-28	President And Fellows Of Harvard College	Improvement of cognitive performance with sirtuin activators
WO2007113845A1 (en) *	2006-04-03	2007-10-11	Alembic Limited	A process for the preparation of (e)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-n, n-diethyl-2-propenamide (entacapone)
CN101085743B (zh) *	2006-06-06	2012-02-15	浙江大德药业集团有限公司	含氟烷氧基康普立停衍生物及制法和用途
CN102557998A (zh) *	2010-12-17	2012-07-11	东北林业大学	一种合成反式芪类化合物的方法及其在制备抗肿瘤药物中的应用
EP2724156B1 (de)	2011-06-27	2017-08-16	The Jackson Laboratory	Verfahren und zusammensetzungen zur behandlung von krebs und autoimmunerkrankungen
TW201702218A (zh)	2014-12-12	2017-01-16	美國杰克森實驗室	關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2496803A (en) *	1947-01-15	1950-02-07	Du Pont	Production of veratraldehyde from vanillin
US2817681A (en) *	1954-12-20	1957-12-24	Monsanto Chemicals	Arylacetic acids
US4996237A (en) *	1987-01-06	1991-02-26	Arizona Board Of Regents	Combretastatin A-4
CA1338645C (en) *	1987-01-06	1996-10-15	George R. Pettit	Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins"
US5430062A (en) *	1992-05-21	1995-07-04	Research Corporation Technologies, Inc.	Stilbene derivatives as anticancer agents
US5561122A (en) *	1994-12-22	1996-10-01	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Combretastatin A-4 prodrug
WO2001021165A1 (en) *	1999-09-21	2001-03-29	Rutgers, The State University	Resveratrol analogs for prevention of disease

2000
- 2000-12-21 GB GBGB0031263.7A patent/GB0031263D0/en not_active Ceased
2001
- 2001-12-14 WO PCT/GB2001/005534 patent/WO2002049994A2/en not_active Ceased
- 2001-12-14 AU AU2002217267A patent/AU2002217267A1/en not_active Abandoned
- 2001-12-14 DE DE60121809T patent/DE60121809T2/de not_active Expired - Fee Related
- 2001-12-14 CA CA002432592A patent/CA2432592A1/en not_active Abandoned
- 2001-12-14 US US10/451,516 patent/US20040143023A1/en not_active Abandoned
- 2001-12-14 EP EP01271340A patent/EP1351911B1/de not_active Expired - Lifetime
- 2001-12-14 AT AT01271340T patent/ATE334109T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1351911A2 (de)	2003-10-15
WO2002049994A2 (en)	2002-06-27
EP1351911B1 (de)	2006-07-26
US20040143023A1 (en)	2004-07-22
GB0031263D0 (en)	2001-01-31
WO2002049994A3 (en)	2002-10-17
CA2432592A1 (en)	2002-06-27
DE60121809D1 (de)	2006-09-07
DE60121809T2 (de)	2007-02-01
AU2002217267A1 (en)	2002-07-01

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Legal Events

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2007-05-15

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Publication of translation of european patent specification

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Country of ref document: EP

2008-03-15

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Ceased due to non-payment of the annual fee