ATE334391T1 - Isolierung und analyse von proteinen - Google Patents

Isolierung und analyse von proteinen

Info

Publication number
ATE334391T1
ATE334391T1 AT00911077T AT00911077T ATE334391T1 AT E334391 T1 ATE334391 T1 AT E334391T1 AT 00911077 T AT00911077 T AT 00911077T AT 00911077 T AT00911077 T AT 00911077T AT E334391 T1 ATE334391 T1 AT E334391T1
Authority
AT
Austria
Prior art keywords
proteins
isolation
analysis
sequencing
methods
Prior art date
Application number
AT00911077T
Other languages
English (en)
Inventor
Francis J Carr
Original Assignee
Biovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9906551.8A external-priority patent/GB9906551D0/en
Priority claimed from GBGB9907057.5A external-priority patent/GB9907057D0/en
Priority claimed from GBGB9907641.6A external-priority patent/GB9907641D0/en
Priority claimed from GBGB9914874.4A external-priority patent/GB9914874D0/en
Priority claimed from GBGB9915363.7A external-priority patent/GB9915363D0/en
Priority claimed from GBGB9915677.0A external-priority patent/GB9915677D0/en
Priority claimed from GBGB9916511.0A external-priority patent/GB9916511D0/en
Priority claimed from GBGB9920503.1A external-priority patent/GB9920503D0/en
Priority claimed from GBGB9922285.3A external-priority patent/GB9922285D0/en
Application filed by Biovation Ltd filed Critical Biovation Ltd
Application granted granted Critical
Publication of ATE334391T1 publication Critical patent/ATE334391T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1214—Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00911077T 1999-03-23 2000-03-17 Isolierung und analyse von proteinen ATE334391T1 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB9906551.8A GB9906551D0 (en) 1999-03-23 1999-03-23 Display of proteins
GBGB9907057.5A GB9907057D0 (en) 1999-03-29 1999-03-29 Protein analysis
GBGB9907641.6A GB9907641D0 (en) 1999-04-06 1999-04-06 Protein analysis
GBGB9914874.4A GB9914874D0 (en) 1999-06-28 1999-06-28 Protein analysis
GBGB9915363.7A GB9915363D0 (en) 1999-07-02 1999-07-02 Protein analysis
GBGB9915677.0A GB9915677D0 (en) 1999-07-06 1999-07-06 Protein analysis
GBGB9916511.0A GB9916511D0 (en) 1999-07-14 1999-07-14 Protein analysis
GBGB9920503.1A GB9920503D0 (en) 1999-08-31 1999-08-31 Protein analysis
GBGB9922285.3A GB9922285D0 (en) 1999-09-21 1999-09-21 Protein analysis

Publications (1)

Publication Number Publication Date
ATE334391T1 true ATE334391T1 (de) 2006-08-15

Family

ID=27576378

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00911077T ATE334391T1 (de) 1999-03-23 2000-03-17 Isolierung und analyse von proteinen

Country Status (18)

Country Link
EP (1) EP1163519B1 (de)
JP (1) JP2003536048A (de)
KR (1) KR20020021779A (de)
CN (1) CN1344370A (de)
AT (1) ATE334391T1 (de)
AU (1) AU772069B2 (de)
BR (1) BR0009206A (de)
CA (1) CA2366559C (de)
CZ (1) CZ20013399A3 (de)
DE (1) DE60029572T2 (de)
ES (1) ES2265917T3 (de)
HK (1) HK1045561A1 (de)
HU (1) HUP0200400A3 (de)
MX (1) MXPA01009567A (de)
NO (1) NO20014584L (de)
PL (1) PL350318A1 (de)
SK (1) SK13242001A3 (de)
WO (1) WO2000057183A1 (de)

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US20070072179A1 (en) * 2002-05-10 2007-03-29 Frank Essmann Solid-phase assisted spectroscopic and spectrometric analysis of complex biopolymer mixtures
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
CN1314968C (zh) * 2004-03-11 2007-05-09 复旦大学 痕量多肽或蛋白质富集及其直接分析方法
WO2007012982A2 (en) * 2005-07-28 2007-02-01 Biosystems International Sas Normalization of complex analyte mixtures
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US8148085B2 (en) 2006-05-15 2012-04-03 Sea Lane Biotechnologies, Llc Donor specific antibody libraries
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EP3421592B1 (de) * 2011-04-28 2023-09-13 The Board of Trustees of the Leland Stanford Junior University Identifizierung von mit einer probe assoziierten polynukleotiden
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
CN102703442A (zh) * 2012-05-08 2012-10-03 中国农业科学院北京畜牧兽医研究所 一种检测犬细小病毒的生物条形码及其应用
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CN105277638A (zh) * 2014-07-22 2016-01-27 沈鹤霄 一种单克隆抗体IgG质谱测序方法
KR102594707B1 (ko) 2015-07-13 2023-10-26 피벗 바이오, 인크. 식물 형질 개선을 위한 방법 및 조성물
JP2018537119A (ja) 2015-10-05 2018-12-20 マサチューセッツ インスティテュート オブ テクノロジー リファクターされたｎｉｆクラスターを使用する窒素固定
CN106855477A (zh) * 2015-12-09 2017-06-16 中国科学院大连化学物理研究所 基于埃德曼降解的蛋白质c-末端肽富集方法
CN105651852A (zh) * 2016-01-11 2016-06-08 南昌大学 一种利用质谱数据分析蛋白交联位点的方法
CN119574873A (zh) 2016-05-02 2025-03-07 Encodia公司 采用核酸编码的大分子分析
KR102264642B1 (ko) * 2016-10-31 2021-06-15 유니베르시태트 취리히 단백질 스크리닝 및 검출 방법
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EP3861009A4 (de) 2018-10-05 2023-01-11 Board of Regents, The University of Texas System Erfassung und freisetzung von n-terminalem festphasenpeptid
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JP7725466B2 (ja) * 2019-11-13 2025-08-19 アムニクス ファーマシューティカルズ， インコーポレイテッド バーコード化されたｘｔｅｎポリペプチドおよびその組成物、ならびにその作製および使用方法
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Also Published As

Publication number Publication date
WO2000057183A1 (en) 2000-09-28
HUP0200400A2 (hu) 2002-05-29
DE60029572D1 (de) 2006-09-07
ES2265917T3 (es) 2007-03-01
CA2366559A1 (en) 2000-09-28
KR20020021779A (ko) 2002-03-22
CA2366559C (en) 2011-03-08
AU772069B2 (en) 2004-04-08
EP1163519A1 (de) 2001-12-19
DE60029572T2 (de) 2007-07-26
HUP0200400A3 (en) 2006-06-28
PL350318A1 (en) 2002-12-02
MXPA01009567A (es) 2003-08-19
CZ20013399A3 (cs) 2002-01-16
JP2003536048A (ja) 2003-12-02
BR0009206A (pt) 2001-12-26
HK1045561A1 (zh) 2002-11-29
SK13242001A3 (sk) 2002-09-10
NO20014584D0 (no) 2001-09-21
NO20014584L (no) 2001-11-19
AU3307300A (en) 2000-10-09
CN1344370A (zh) 2002-04-10
EP1163519B1 (de) 2006-07-26

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