ATE344456T1 - Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen - Google Patents
Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinenInfo
- Publication number
- ATE344456T1 ATE344456T1 AT01932999T AT01932999T ATE344456T1 AT E344456 T1 ATE344456 T1 AT E344456T1 AT 01932999 T AT01932999 T AT 01932999T AT 01932999 T AT01932999 T AT 01932999T AT E344456 T1 ATE344456 T1 AT E344456T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- epptides
- affinity
- identifying
- selected signature
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 238000003314 affinity selection Methods 0.000 abstract 1
- 239000012491 analyte Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20322700P | 2000-05-05 | 2000-05-05 | |
| US20818400P | 2000-05-31 | 2000-05-31 | |
| US20837200P | 2000-05-31 | 2000-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE344456T1 true ATE344456T1 (de) | 2006-11-15 |
Family
ID=27394529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01932999T ATE344456T1 (de) | 2000-05-05 | 2001-05-04 | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6864099B2 (de) |
| EP (1) | EP1311858B1 (de) |
| JP (1) | JP2003532900A (de) |
| AT (1) | ATE344456T1 (de) |
| AU (3) | AU2001259470A1 (de) |
| CA (1) | CA2402871C (de) |
| DE (1) | DE60124265D1 (de) |
| IL (2) | IL152620A (de) |
| WO (1) | WO2001086306A2 (de) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| JP2003532900A (ja) * | 2000-05-05 | 2003-11-05 | パーデュー・リサーチ・ファウンデーション | タンパク質を同定及び定量化するための親和性により選択されるサインペプチド |
| WO2002039119A2 (en) * | 2000-10-27 | 2002-05-16 | The Johns Hopkins University | Method for assaying protein nitrosylation |
| US20020090652A1 (en) * | 2000-12-22 | 2002-07-11 | Fu Emil Wei-Ming | Inverse labeling method for the rapid identification of marker/target proteins |
| US20030077616A1 (en) * | 2001-04-19 | 2003-04-24 | Ciphergen Biosystems, Inc. | Biomolecule characterization using mass spectrometry and affinity tags |
| WO2003027682A2 (en) * | 2001-09-27 | 2003-04-03 | Purdue Research Foundation | Controlling isotope effects during fractionation of analytes |
| US20030077572A1 (en) * | 2001-10-11 | 2003-04-24 | Abramson Fred P. | Quantitative differential display using isotope ratio monitoring |
| IL161498A0 (en) * | 2001-10-24 | 2004-09-27 | Univ California | Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water |
| WO2003068919A2 (en) * | 2002-02-12 | 2003-08-21 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
| AU2003234688A1 (en) * | 2002-04-05 | 2003-10-27 | The Regents Of The University Of California | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
| DE60328392D1 (de) * | 2002-04-30 | 2009-08-27 | Gyros Patent Ab | Mittels einer integrierten mikrofluidischen vorrichtung |
| US20070072179A1 (en) * | 2002-05-10 | 2007-03-29 | Frank Essmann | Solid-phase assisted spectroscopic and spectrometric analysis of complex biopolymer mixtures |
| CA2487314A1 (en) * | 2002-06-03 | 2003-12-11 | The Institute For Systems Biology | Methods for quantitative proteome analysis of glycoproteins |
| US20070269895A1 (en) * | 2002-06-03 | 2007-11-22 | The Institute For Systems Biology | Methods for quantitative proteome analysis of glycoproteins |
| DE10227599B4 (de) * | 2002-06-20 | 2005-04-28 | Proteome Factory Ag | Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe |
| FR2842826B1 (fr) * | 2002-07-25 | 2006-01-20 | Centre Nat Rech Scient | Procede de fabrication de puces biologiques |
| WO2004011426A2 (en) | 2002-07-30 | 2004-02-05 | The Regents Of The University Of California | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
| WO2004015391A2 (en) * | 2002-08-12 | 2004-02-19 | Cornell Research Foundation, Inc. | Mass spectrometry-based identification of proteins |
| AU2003268416A1 (en) * | 2002-09-04 | 2004-03-29 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
| ATE415486T1 (de) * | 2002-09-13 | 2008-12-15 | Univ California | Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese |
| US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| TW200502394A (en) * | 2002-09-16 | 2005-01-16 | Univ California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| US7632686B2 (en) | 2002-10-03 | 2009-12-15 | Anderson Forschung Group | High sensitivity quantitation of peptides by mass spectrometry |
| CN100558879C (zh) * | 2002-10-03 | 2009-11-11 | 诺曼·利·安德森 | 用质谱法高灵敏度定量肽 |
| DE10247896B4 (de) * | 2002-10-14 | 2007-01-18 | Bruker Daltonik Gmbh | Mehrdimensionale Trennung von Biosubstanzgemischen für massenspektrometrische Analysen |
| CN1852765A (zh) * | 2002-10-18 | 2006-10-25 | 普罗梅加公司 | 用于分离分子的组合物 |
| WO2004038752A2 (en) * | 2002-10-21 | 2004-05-06 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Contiguous capillary electrospray sources and analytical device |
| AU2003291731B2 (en) | 2002-11-04 | 2009-09-10 | The Regents Of The University Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| US7425451B2 (en) | 2002-12-13 | 2008-09-16 | Agilent Technologies, Inc. | Triazine derivatives as universal peptide isotope tag reagents (U-PIT) |
| US7109040B2 (en) * | 2002-12-13 | 2006-09-19 | Agilent Technologies, Inc. | Modular isotope coding approach to proteomic analysis |
| US7422865B2 (en) * | 2003-01-13 | 2008-09-09 | Agilent Technologies, Inc. | Method of identifying peptides in a proteomic sample |
| JP2004301715A (ja) * | 2003-03-31 | 2004-10-28 | Institute Of Physical & Chemical Research | タンパク質の一次構造情報収集方法、それに用いる疎水性微細粒子担体及びタンパク質一次構造情報自動取得システム |
| US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| AU2004267802B2 (en) * | 2003-08-18 | 2011-03-17 | Tethys Bioscience, Inc. | Methods for reducing complexity of a sample using small epitope antibodies |
| US20050202406A1 (en) | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| JP2005189104A (ja) | 2003-12-25 | 2005-07-14 | Shimadzu Corp | タンパク質又はペプチドの濃縮分離法 |
| WO2005078440A2 (en) * | 2004-02-06 | 2005-08-25 | Applera Corporation | Preparation of biologically derived fluids for biomarker determination by mass spectrometry |
| WO2005075993A1 (en) * | 2004-02-10 | 2005-08-18 | Korea Basic Science Institute | Selective labeling agent for phosphoproteome analysis and phosphorylated site analysis |
| US20070087448A1 (en) * | 2004-02-16 | 2007-04-19 | Nelsestuen Gary L | Biological profiles and methods of use |
| TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| WO2005087943A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of The University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| WO2005114700A2 (en) * | 2004-05-19 | 2005-12-01 | Applera Corporation | Expression quantification using mass spectrometry |
| US20080206737A1 (en) * | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
| US20070054345A1 (en) * | 2004-05-19 | 2007-03-08 | Hunter Christie L | Expression quantification using mass spectrometry |
| EP1766388A4 (de) * | 2004-06-09 | 2008-08-20 | Anderson Forschung Group Llc | Mit stabilen isotopen markierte polypeptidstandards zur proteinquantifizierung |
| KR100611313B1 (ko) * | 2004-06-30 | 2006-08-10 | 고려대학교 산학협력단 | 폴리펩티드의 n-말단 치환용 화합물, 이를 이용한폴리펩티드 내의 아미노산 서열분석 및 정량방법 |
| SE0401854D0 (sv) * | 2004-07-09 | 2004-07-09 | Amersham Biosciences Ab | Method and kit for peptide analysis |
| WO2006037059A2 (en) * | 2004-09-27 | 2006-04-06 | The Johns Hopkins Universtiy | Point-of-care mass spectrometer system |
| US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
| EP1736480B9 (de) * | 2005-06-02 | 2009-03-04 | Polyquant GmbH | Künstliches Protein, Verfahren für absolute Quantifizierung der Proteine und seine Benutzung |
| TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
| PL1931998T3 (pl) | 2005-09-15 | 2010-11-30 | Alk Abello As | Sposób ilościowego oznaczania alergenów |
| WO2007044935A2 (en) * | 2005-10-13 | 2007-04-19 | Applera Corporation | Methods for the development of a biomolecule assay |
| EP1785729A3 (de) * | 2005-10-17 | 2007-06-13 | Centro De Ingenieria Genetica Y Biotecnologia (Cigb) | Verfahren zur selektiven Isolation von in der quantitativen Proteomik anwendbaren mehrfach-geladenen Peptiden |
| EP1795896A3 (de) * | 2005-11-22 | 2007-06-27 | Centro De Ingenieria Genetica Y Biotecnologia (Cigb) | Verfahren zur Bestimmung und relativen Quantifizierung von Proteinen basierend auf der selektiven Isolation von PRNK-Peptiden zur Vereinfachung von komplexen Proteinmischungen |
| CN100465640C (zh) * | 2005-11-30 | 2009-03-04 | 上海特敏生物医药科技有限公司 | 一种高灵敏血浆总同型半胱氨酸测定试剂盒 |
| WO2007078229A1 (en) * | 2006-01-05 | 2007-07-12 | Ge Healthcare Bio-Sciences Ab | Kit and method for mass labelling |
| DE102006001793A1 (de) * | 2006-01-12 | 2007-07-26 | Forschungsgesellschaft für Arbeitsphysiologie und Arbeitsschutz e.V. | Verfahren und diagnostisches Kit zur simultanen Identifizierung und Quantifizierung von einzelnen oder in Gemischen vorliegenden Biomolekülen und deren Modifikationen |
| US20080026480A1 (en) * | 2006-02-14 | 2008-01-31 | Perkinelmer Las, Inc. | Detection systems for mass labels |
| US8097425B2 (en) | 2006-03-10 | 2012-01-17 | Tethys Bioscience, Inc. | Multiplex protein fractionation |
| EP2021492A2 (de) * | 2006-04-28 | 2009-02-11 | Ludwig Institute For Cancer Research | Quantifizierung von enzymaktivitäten durch massenspektrometrie |
| CN101101283A (zh) * | 2006-07-05 | 2008-01-09 | 中国科学院大连化学物理研究所 | 一种分离富集磷酸化肽的方法 |
| AU2008253573A1 (en) * | 2007-05-17 | 2008-11-27 | Proteomics International Pty Ltd | Fragmentation profile based authentification of protein source |
| WO2008150763A1 (en) * | 2007-05-29 | 2008-12-11 | Waters Investments Limited | Apparatus and methods for multidimensional analysis |
| JP4836875B2 (ja) * | 2007-06-13 | 2011-12-14 | 株式会社日立ハイテクノロジーズ | 修飾ペプチドの分析方法および装置 |
| US8568993B2 (en) * | 2007-07-02 | 2013-10-29 | Purdue Research Foundation | Detection of glycopeptides and glycoproteins for medical diagnostics |
| WO2009050261A1 (en) * | 2007-10-19 | 2009-04-23 | Pronota N.V. | Preparation of samples for proteome analysis |
| KR20100128293A (ko) * | 2008-03-31 | 2010-12-07 | 니뽄 다바코 산교 가부시키가이샤 | 바이러스 정량법 |
| WO2009134439A2 (en) * | 2008-05-02 | 2009-11-05 | Purdue Research Foundation | Group specific internal standard technology (gsist) for simultaneous identification and quantification of small molecules |
| WO2010109022A1 (en) * | 2009-03-27 | 2010-09-30 | Universitetet I Oslo | Quantitative proteomics method |
| US8592216B2 (en) * | 2009-04-15 | 2013-11-26 | Wisconsin Alumni Research Foundation | Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis |
| WO2011072197A2 (en) | 2009-12-11 | 2011-06-16 | Purdue Research Foundation | Detection of oxidized polypeptides |
| US8383417B2 (en) * | 2009-12-22 | 2013-02-26 | Thermo Finnigan, Llc | Assay for monitoring parathyroid hormone (PTH) variants by tandem mass spectrometry |
| WO2011109832A2 (en) * | 2010-03-05 | 2011-09-09 | The Salk Institute For Biological Studies | Methods and compositions for nmr spectroscopic analysis using isotopic labeling schemes |
| CN103038631A (zh) * | 2010-03-10 | 2013-04-10 | 珀菲尼迪生物科学股份有限公司 | 用于在单次分析中识别多种分析物并对其进行定量的方法 |
| US8455202B2 (en) | 2010-03-10 | 2013-06-04 | Perfinity Biosciences, Inc. | Affinity selector based recognition and quantification system and method for multiple analytes in a single analysis |
| US8772043B2 (en) | 2010-12-23 | 2014-07-08 | Pioneer Hi Bred International Inc | Universal peptide tags for transgene polypeptide analysis by mass spectrometry |
| JP2014526685A (ja) | 2011-09-08 | 2014-10-06 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 代謝流量測定、画像化、および顕微鏡法 |
| JP6294233B2 (ja) | 2011-12-07 | 2018-03-14 | グラクソスミスクライン エルエルシー | 全身骨格筋量の定量方法 |
| WO2013094579A1 (ja) * | 2011-12-20 | 2013-06-27 | 日本ケミカルリサーチ株式会社 | ホルミルグリシン残基の分析法 |
| GB201204723D0 (en) * | 2012-03-19 | 2012-05-02 | Micromass Ltd | Improved time of flight quantitation using alternative characteristic ions |
| GB2503538B (en) * | 2012-03-27 | 2015-09-09 | Micromass Ltd | A method of mass spectrometry and a mass spectrometer |
| EP2909618B1 (de) * | 2012-10-22 | 2021-02-17 | President and Fellows of Harvard College | Präzise und interferenzfreie multiplexierte quantitative proteomik mittels massenspektrometrie |
| WO2014120890A1 (en) | 2013-01-31 | 2014-08-07 | Perfinity Biosciences, Inc. | Robust, easy to use immobilized enzyme reactors |
| US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
| JP6079587B2 (ja) * | 2013-11-27 | 2017-02-15 | 株式会社島津製作所 | 糖ペプチド解析装置 |
| US10551358B2 (en) * | 2013-12-03 | 2020-02-04 | Perfinity Bioscices, Inc. | Single reactor for simplified sample preparation workflows |
| US10018635B2 (en) | 2014-07-30 | 2018-07-10 | Novilytic, LLC | Method for analyzing samples of a biological fluid |
| US9786478B2 (en) | 2014-12-05 | 2017-10-10 | Purdue Research Foundation | Zero voltage mass spectrometry probes and systems |
| CN113725063B (zh) | 2015-02-06 | 2024-09-20 | 普度研究基金会 | 探针、盒、系统和样本分析的方法 |
| WO2016164530A1 (en) * | 2015-04-07 | 2016-10-13 | University Of Maryland, College Park | Compositions and methods for high throughput protein sequencing |
| US10352942B2 (en) | 2015-05-29 | 2019-07-16 | Cedars-Sinai Medical Center | Correlated peptides for quantitative mass spectrometry |
| WO2017210427A1 (en) | 2016-06-03 | 2017-12-07 | President And Fellows Of Harvard College | Techniques for high throughput targeted proteomic analysis and related systems and methods |
| EP3734268B1 (de) * | 2017-12-28 | 2022-07-13 | Shimadzu Corporation | Vereinfachtes verfahren zur quantifizierung von monoklonalen antikörpern |
| MX2021008822A (es) * | 2019-01-25 | 2021-09-08 | Regeneron Pharma | Cromatografia en linea y espectrometro de masas de ionizacion por electrospray. |
| EP3892989A1 (de) * | 2020-04-07 | 2021-10-13 | Ares Trading S.A. | Kapillargelelektrophorese und ihre verwendung mit komplexen biologischen molekülen |
| CA3179958A1 (en) * | 2020-06-11 | 2021-12-16 | Thierry Le Bihan | Reagents and methods for antibody sequencing |
| JP7667684B2 (ja) * | 2021-04-06 | 2025-04-23 | 株式会社日立製作所 | 検体の分析前処理方法および検体前処理装置 |
| CN113804897A (zh) * | 2021-09-17 | 2021-12-17 | 中国食品药品检定研究院 | 一种冬虫夏草及各发酵虫草制剂特征肽段的序列鉴定方法 |
| US20240036055A1 (en) * | 2022-06-15 | 2024-02-01 | Wisconsin Alumni Research Foundation | Multiplexed DiLeu-Biotin-Azide (DBA) Tag Enabled Isobaric Tandem Orthogonal Proteolysis Activity-Based Protein Profiling (isoBOP-ABPP) Platform For High-Throughput Quantitative Pan-PTM Analysis |
| CN117030899A (zh) * | 2023-08-28 | 2023-11-10 | 中信湘雅生殖与遗传专科医院有限公司 | 蛋白样品的处理方法及蛋白组分析方法 |
| WO2025057852A1 (ja) * | 2023-09-14 | 2025-03-20 | 株式会社島津製作所 | 代謝物の分析前処理方法 |
| CN117347531B (zh) * | 2023-12-05 | 2024-02-13 | 天津医科大学总医院 | 一种采用双重内标定量检测蛋白质的方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340966C (en) * | 1989-05-19 | 2000-04-18 | Thomas R. Covey | Method of protein analysis |
| US5652128A (en) | 1993-01-05 | 1997-07-29 | Jarvik; Jonathan Wallace | Method for producing tagged genes, transcripts, and proteins |
| US5393669A (en) * | 1993-02-05 | 1995-02-28 | Martek Biosciences Corp. | Compositions and methods for protein structural determinations |
| DE69817211T2 (de) * | 1997-01-23 | 2004-06-03 | Xzillion Gmbh & Co. Kg | Charakterisierung von polypeptiden |
| DE69933679T2 (de) | 1998-08-12 | 2007-08-23 | Zycos Inc., Cambridge | Darstellung des profils und katalogisierung von exprimierten proteinmarkern |
| ATE253126T1 (de) * | 1998-08-25 | 2003-11-15 | Univ Washington | Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen |
| GB9821669D0 (en) * | 1998-10-05 | 1998-12-02 | Glaxo Group Ltd | Chemical constructs and their uses |
| US6629040B1 (en) * | 1999-03-19 | 2003-09-30 | University Of Washington | Isotope distribution encoded tags for protein identification |
| US6391649B1 (en) * | 1999-05-04 | 2002-05-21 | The Rockefeller University | Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy |
| JP2003532900A (ja) * | 2000-05-05 | 2003-11-05 | パーデュー・リサーチ・ファウンデーション | タンパク質を同定及び定量化するための親和性により選択されるサインペプチド |
| EP1295123A4 (de) * | 2000-06-12 | 2005-02-02 | Univ Washington | Selektives markieren und isolieren von phosphopeptiden und anwendungen in proteomischen analysen |
| US6905879B2 (en) | 2000-10-23 | 2005-06-14 | Genetics Institute, Inc. | Isotope-coded ionization-enhancing reagents (ICIER) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry |
| US20020119490A1 (en) * | 2000-12-26 | 2002-08-29 | Aebersold Ruedi H. | Methods for rapid and quantitative proteome analysis |
| US7045296B2 (en) * | 2001-05-08 | 2006-05-16 | Applera Corporation | Process for analyzing protein samples |
| US7183116B2 (en) * | 2001-05-14 | 2007-02-27 | The Institute For Systems Biology | Methods for isolation and labeling of sample molecules |
| SE0101683D0 (sv) * | 2001-05-14 | 2001-05-14 | Torkel Klingberg | New method |
| WO2003027682A2 (en) * | 2001-09-27 | 2003-04-03 | Purdue Research Foundation | Controlling isotope effects during fractionation of analytes |
| US6970630B2 (en) * | 2002-05-23 | 2005-11-29 | Rutgers, The State University Of New Jersey | Fiber optic cable and process for manufacturing |
| CA2487314A1 (en) * | 2002-06-03 | 2003-12-11 | The Institute For Systems Biology | Methods for quantitative proteome analysis of glycoproteins |
| US20070269895A1 (en) * | 2002-06-03 | 2007-11-22 | The Institute For Systems Biology | Methods for quantitative proteome analysis of glycoproteins |
| AU2003259029A1 (en) * | 2002-06-04 | 2003-12-19 | The Institute For Systems Biology | Methods for high throughput and quantitative proteome analysis |
| US7473535B2 (en) * | 2002-08-20 | 2009-01-06 | The Institute For Systems Biology | Chemical reagents and methods for detection and quantification of proteins in complex mixtures |
| WO2005007677A2 (en) * | 2003-07-10 | 2005-01-27 | The Institute For Systems Biology | Affinity capture of peptides by microarray and related methods |
| DE602005013670D1 (de) * | 2004-05-21 | 2009-05-14 | Inst Systems Biology | Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen |
| AU2006304605A1 (en) * | 2005-10-17 | 2007-04-26 | Institute For Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
-
2001
- 2001-05-04 JP JP2001583198A patent/JP2003532900A/ja active Pending
- 2001-05-04 AT AT01932999T patent/ATE344456T1/de not_active IP Right Cessation
- 2001-05-04 DE DE60124265T patent/DE60124265D1/de not_active Expired - Lifetime
- 2001-05-04 WO PCT/US2001/014418 patent/WO2001086306A2/en not_active Ceased
- 2001-05-04 US US09/849,924 patent/US6864099B2/en not_active Expired - Fee Related
- 2001-05-04 IL IL152620A patent/IL152620A/en not_active IP Right Cessation
- 2001-05-04 AU AU2001259470A patent/AU2001259470A1/en not_active Abandoned
- 2001-05-04 EP EP01932999A patent/EP1311858B1/de not_active Expired - Lifetime
- 2001-05-04 CA CA2402871A patent/CA2402871C/en not_active Expired - Fee Related
-
2002
- 2002-09-16 US US10/244,784 patent/US6872575B2/en not_active Expired - Fee Related
- 2002-09-16 US US10/244,709 patent/US20030129769A1/en not_active Abandoned
-
2005
- 2005-09-09 AU AU2005209637A patent/AU2005209637B2/en not_active Ceased
-
2007
- 2007-04-12 US US11/786,748 patent/US20080145863A1/en not_active Abandoned
-
2008
- 2008-09-11 AU AU2008213716A patent/AU2008213716B2/en not_active Ceased
-
2009
- 2009-09-14 IL IL200933A patent/IL200933A/en not_active IP Right Cessation
-
2010
- 2010-02-01 US US12/658,057 patent/US20100273178A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001259470A1 (en) | 2001-11-20 |
| JP2003532900A (ja) | 2003-11-05 |
| US20080145863A1 (en) | 2008-06-19 |
| US20100273178A1 (en) | 2010-10-28 |
| WO2001086306A2 (en) | 2001-11-15 |
| IL200933A (en) | 2011-04-28 |
| US20030092076A1 (en) | 2003-05-15 |
| US20020037532A1 (en) | 2002-03-28 |
| WO2001086306A3 (en) | 2003-03-13 |
| AU2005209637B2 (en) | 2008-06-12 |
| AU2005209637A1 (en) | 2005-09-29 |
| US6872575B2 (en) | 2005-03-29 |
| DE60124265D1 (de) | 2006-12-14 |
| IL152620A (en) | 2010-05-17 |
| IL152620A0 (en) | 2003-06-24 |
| US20030129769A1 (en) | 2003-07-10 |
| US6864099B2 (en) | 2005-03-08 |
| EP1311858B1 (de) | 2006-11-02 |
| CA2402871C (en) | 2011-08-23 |
| AU2008213716A1 (en) | 2008-10-02 |
| AU2008213716B2 (en) | 2012-03-15 |
| CA2402871A1 (en) | 2001-11-15 |
| EP1311858A2 (de) | 2003-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE344456T1 (de) | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen | |
| Orvisky et al. | Enrichment of low molecular weight fraction of serum for MS analysis of peptides associated with hepatocellular carcinoma | |
| DE60217328D1 (de) | Verfahren zur analyse von proteinproben | |
| JP2003532900A5 (de) | ||
| WO2002042427A3 (en) | Mass tags for quantitative analysis | |
| DE60029572D1 (de) | Isolierung und analyse von proteinen | |
| ATE508361T1 (de) | Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie | |
| WO2004031730A3 (en) | High sensitivity quantitation of peptides by mass spectrometry | |
| ATE377756T1 (de) | Verfahren und gerät für die identifikation und zuordnung von biomolekülen | |
| WO2001084140A3 (de) | Verfahren und vorrichtung zur qualitativen und/oder quantitativen bestimmung eines protein- und/oder peptidmusters einer flüssigkeitsprobe, die dem menschlichen oder tierischen körper entnommen wird | |
| WO2002008767A3 (en) | Methods and kits for sequencing polypeptides | |
| WO2004111636A3 (en) | Peptide combos and their uses | |
| JP2009531679A5 (ja) | 複合タンパク質混合物中の被分析タンパク質および/または被分析ペプチドを検出および/または濃縮するための方法 | |
| DE60129239D1 (de) | Kit und verfahren zur bestimmung von protein esm-1 | |
| DE60215498D1 (de) | Verfahren zur bestimmung von polypeptiden | |
| TW200420491A (en) | Integrated microfluidic electro-spray chip system and the analysis method thereof | |
| JP2019088213A (ja) | コラーゲン由来材料の動物種を判定する方法 | |
| DE50105263D1 (de) | Verfahren zur analyse von proteinen | |
| ATE225942T1 (de) | Peptidereagenz zum nachweis von humanem cytomegalovirus (cmv) | |
| ATE274190T1 (de) | Methoden und kits zum sequenzieren von polypeptiden | |
| WO2003056343A3 (en) | Method for protein expression analysis | |
| WO2003027681A3 (en) | A method of protein analysis | |
| WO2000007024A3 (en) | Method of protein analysis | |
| EP1589341A3 (de) | Methode zur selektiven Isolierung von Peptiden zwecks Identifizierung und quantitativer Analyse der Proteine in komplexen Mischungen | |
| WO2002029414A3 (en) | A method for the quantitative determination of one or more compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |