ATE335513T1 - Photosensitizer-konjugate zur zielrichtung von intrazellulare pathogene - Google Patents

Photosensitizer-konjugate zur zielrichtung von intrazellulare pathogene

Info

Publication number
ATE335513T1
ATE335513T1 AT99953191T AT99953191T ATE335513T1 AT E335513 T1 ATE335513 T1 AT E335513T1 AT 99953191 T AT99953191 T AT 99953191T AT 99953191 T AT99953191 T AT 99953191T AT E335513 T1 ATE335513 T1 AT E335513T1
Authority
AT
Austria
Prior art keywords
intracellular pathogens
targeting
intracellular pathogen
targeting intracellular
photosensitizer
Prior art date
Application number
AT99953191T
Other languages
English (en)
Inventor
Tayyaba Hasan
Jerome Gross
Gerard J Nau
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE335513T1 publication Critical patent/ATE335513T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99953191T 1998-10-16 1999-10-15 Photosensitizer-konjugate zur zielrichtung von intrazellulare pathogene ATE335513T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10458498P 1998-10-16 1998-10-16
US11597699P 1999-01-15 1999-01-15

Publications (1)

Publication Number Publication Date
ATE335513T1 true ATE335513T1 (de) 2006-09-15

Family

ID=26801704

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99953191T ATE335513T1 (de) 1998-10-16 1999-10-15 Photosensitizer-konjugate zur zielrichtung von intrazellulare pathogene

Country Status (7)

Country Link
US (2) US6610298B2 (de)
EP (1) EP1133319B1 (de)
JP (1) JP2002527494A (de)
AT (1) ATE335513T1 (de)
CA (1) CA2347045A1 (de)
DE (1) DE69932733T2 (de)
WO (1) WO2000023117A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020137901A1 (en) * 2001-01-22 2002-09-26 Cavanaugh Philip Gerard Synthesis, and photodynamic therapy-mediated anti-cancer, and other uses of chlorin e6-transferrin
US8703146B2 (en) * 2001-04-20 2014-04-22 Institute For Systems Biology Toll-like receptor 5 ligands and methods of use
ATE463505T1 (de) * 2001-04-20 2010-04-15 Inst Systems Biology Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren
US20040116350A1 (en) * 2001-09-17 2004-06-17 Paul Wentworth Jr Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
US20030176326A1 (en) * 2002-03-15 2003-09-18 Ceramoptec Industries Inc. Photosensitzers for photodynamic therapy of microbial infections
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
EP1585548B1 (de) 2002-12-09 2018-06-27 Abraxis BioScience, LLC Zusammensetzungen, pharmakologisch wirksame agenzien enthaltend und wirkstofffreigabemethoden
KR20140148502A (ko) * 2002-12-09 2014-12-31 아브락시스 바이오사이언스, 엘엘씨 약리학적 물질의 조성물 및 그 전달방법
WO2004080284A2 (en) * 2003-03-07 2004-09-23 Board Of Regents, The University Of Texas System Antibody-targeted photodynamic therapy
WO2007038201A1 (en) * 2005-09-23 2007-04-05 Bioenvision, Inc. Methylene blue therapy of parasitic infections
US8999933B2 (en) * 2006-01-18 2015-04-07 Biolitec Pharma Marketing Ltd Photodynamic cosmetic procedure and healing method
US20090030257A1 (en) * 2007-07-25 2009-01-29 Ceramoptec Industries Inc. Anti-microbial photodynamic therapy
WO2008098100A2 (en) * 2007-02-07 2008-08-14 Perscitus Biosciences, Llc Detection of molecule proximity
JP2012504553A (ja) 2008-07-29 2012-02-23 フロンティア サイエンティフィック インコーポレイテッド 微生物の殺滅または増殖抑制のためのテトラキス（ｎ−アルキルピリジニウム）−ポルフィリン誘導体の使用
US8859760B2 (en) 2008-07-29 2014-10-14 Frontier Scientific, Inc. Compositions for killing or preventing the growth of microbes
KR101265525B1 (ko) * 2010-11-12 2013-05-21 서울대학교병원 (분사무소) 광역학적 치료를 통한 결핵균 활성 억제 방법
US9023092B2 (en) 2011-08-23 2015-05-05 Anthony Natale Endoscopes enhanced with pathogenic treatment
US8668727B2 (en) 2011-08-23 2014-03-11 Anthony Natale Systems and methods for treating pathogenic infection
HUE032791T2 (en) * 2011-09-05 2017-11-28 Hiroshi Maeda Polymer-type fluorescent molecule probe
US12109429B2 (en) 2015-07-28 2024-10-08 Know Bio, Llc Phototherapeutic light for treatment of pathogens
CN108136196B (zh) 2015-07-28 2020-07-17 诺欧生物有限责任公司 用于对一氧化氮的光疗调节的系统和方法
GB201718631D0 (en) 2017-11-10 2017-12-27 Pci Biotech As Method
WO2020251933A1 (en) 2019-06-10 2020-12-17 The University Of Massachusetts Compositions comprising fullerenyl mesochlorin nano-photosensitizers with covalently bound antibiotics and their uses in combination therapy
US11986666B2 (en) 2020-03-19 2024-05-21 Know Bio, Llc Illumination devices for inducing biological effects
US12011611B2 (en) 2020-03-19 2024-06-18 Know Bio, Llc Illumination devices for inducing biological effects
US11147984B2 (en) 2020-03-19 2021-10-19 Know Bio, Llc Illumination devices for inducing biological effects
US12447354B2 (en) 2020-03-19 2025-10-21 Know Bio, Llc Illumination devices for inducing biological effects
US12347337B2 (en) 2020-12-10 2025-07-01 Know Bio, Llc Enhanced testing and characterization techniques for phototherapeutic light treatments
US11654294B2 (en) 2021-03-15 2023-05-23 Know Bio, Llc Intranasal illumination devices
US12115384B2 (en) 2021-03-15 2024-10-15 Know Bio, Llc Devices and methods for illuminating tissue to induce biological effects
CA3235252A1 (en) 2021-10-26 2023-05-04 Duane GRANT Magnetostrictive piezoelectric nanoassembly as cancer chemotherapeutic
CN117660337A (zh) * 2023-10-31 2024-03-08 大连理工大学 一类工程细胞及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091385A (en) 1988-09-30 1992-02-25 Baylor Research Institute Pre-activated therapeutic agents derived from photoactive compounds
US5177073A (en) * 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
US5332567A (en) 1989-08-24 1994-07-26 Immunomedics Detection and treatment of infections with immunoconjugates
CA2047969A1 (en) 1990-08-17 1992-02-18 Thomas D. Madden Benzoporphyrin vesicles
US5405957A (en) * 1992-10-30 1995-04-11 The University Of British Columbia Wavelength-specific photosensitive compounds and expanded porphyrin-like compounds and methods of use
DE19514087A1 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforsch Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein

Also Published As

Publication number Publication date
EP1133319A1 (de) 2001-09-19
WO2000023117A1 (en) 2000-04-27
DE69932733D1 (de) 2006-09-21
US20030224002A1 (en) 2003-12-04
CA2347045A1 (en) 2000-04-27
US20020122805A1 (en) 2002-09-05
JP2002527494A (ja) 2002-08-27
US6610298B2 (en) 2003-08-26
EP1133319A4 (de) 2002-04-03
EP1133319B1 (de) 2006-08-09
US6977075B2 (en) 2005-12-20
DE69932733T2 (de) 2007-08-16

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