ATE335743T1 - Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid - Google Patents

Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid

Info

Publication number: ATE335743T1
Authority: AT; Austria
Prior art keywords: valacyclovir hydrochloride; reducing residual; crystalline valacyclovir; residual carbons; residual process
Prior art date: 2002-10-16

Application number

AT03809127T

Other languages

English (en)

Inventor

Ben-Zion Dolitzky

Igor Lifshitz

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-16

Filing date

2003-10-16

Publication date

2006-09-15

2003-10-16 Application filed by Teva Pharma filed Critical Teva Pharma

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE335743T1 publication Critical patent/ATE335743T1/de

Links

ZCDDBUOENGJMLV-QRPNPIFTSA-N Valacyclovir hydrochloride Chemical compound Cl.N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 ZCDDBUOENGJMLV-QRPNPIFTSA-N 0.000 title abstract 3
229940064636 valacyclovir hydrochloride Drugs 0.000 title abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
-1 isopropanol) Chemical compound 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

AT03809127T 2002-10-16 2003-10-16 Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid ATE335743T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41927002P	2002-10-16	2002-10-16
US42732002P	2002-11-18	2002-11-18

Publications (1)

Publication Number	Publication Date
ATE335743T1 true ATE335743T1 (de)	2006-09-15

Family

ID=32110230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03809127T ATE335743T1 (de)	2002-10-16	2003-10-16	Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid

Country Status (8)

Country	Link
US (1)	US20050070711A1 (de)
EP (1)	EP1551838B1 (de)
AT (1)	ATE335743T1 (de)
AU (1)	AU2003277433A1 (de)
CA (1)	CA2501557A1 (de)
DE (1)	DE60307494D1 (de)
ES (1)	ES2270172T3 (de)
WO (1)	WO2004035583A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003041647A2 (en) *	2001-11-14	2003-05-22	Teva Pharmaceutical Industries Ltd.	Synthesis and purification of valacyclovir
AU2002348022B2 (en) *	2001-11-05	2006-06-15	Glaxo Group Limited	Anhydrous crystal form of valaciclovir hydrochloride
US20050059684A1 (en) *	2002-10-16	2005-03-17	Ben-Zion Dolitzky	Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US7786302B2 (en) *	2003-05-30	2010-08-31	Eczacibasi-Zentiva Kimyasal Urunler Sanayi Ve Ticaret A.S.	Crystalline forms of valacyclovir hydrochloride
WO2005000850A2 (en) *	2003-06-02	2005-01-06	Teva Pharmaceutical Industries, Ltd.	Novel crystalline forms of valacyclovir hydrochloride
EP1761535A1 (de) *	2004-06-30	2007-03-14	Teva Pharmaceutical Industries Ltd	Verfahren zur verminderung von restalkoholen in kristallinem valacyclovir-hydrochlorid
KR100890595B1 (ko) *	2004-09-04	2009-03-25	테바 파마슈티컬 인더스트리즈 리미티드	단리된 발라시클로버 불순물, 발라시클로버 불순물 제조방법 및 참조 표준 물질로서의 용도
EP1746098A1 (de) *	2005-07-21	2007-01-24	SOLMAG S.p.A.	Valacyclovir Polymorphe und Verfahren zu deren Herstellung
WO2021034962A1 (en) *	2019-08-19	2021-02-25	Modis Therapeutics, Inc.	Polymorphic forms of deoxycytidine, compositions comprising the same and uses

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR5161M (de) *	1965-03-25	1967-06-12
US3989849A (en) *	1973-03-23	1976-11-02	General Foods Corporation	Improving the flavor of decaffeinated coffee by radio frequency heating to rapidly dry coffee beans
GB8719367D0 (en) *	1987-08-15	1987-09-23	Wellcome Found	Therapeutic compounds
US5270267A (en) *	1989-05-31	1993-12-14	Mitel Corporation	Curing and passivation of spin on glasses by a plasma process wherein an external polarization field is applied to the substrate
DE69513313T2 (de) *	1994-02-01	2000-07-13	Ajinomoto Co., Inc.	Verfahren zur Herstellung von Nukleinsäurebasenderivaten
JP2723088B2 (ja) *	1994-09-07	1998-03-09	藤沢薬品工業株式会社	セファロスポリン化合物の新規な結晶
GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative
GB9501127D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Tablet
GB9717629D0 (en) *	1997-08-21	1997-10-22	Johnson Matthey Plc	Removal of residual organic solvents
US6258371B1 (en) *	1998-04-03	2001-07-10	Medtronic Inc	Method for making biocompatible medical article
WO2003041647A2 (en) *	2001-11-14	2003-05-22	Teva Pharmaceutical Industries Ltd.	Synthesis and purification of valacyclovir
CZ2004446A3 (cs) *	2001-09-07	2005-01-12	Teva Pharmaceutical Industries Ltd.	Krystalické formy valaciklovir hydrochloridu
US20050059684A1 (en) *	2002-10-16	2005-03-17	Ben-Zion Dolitzky	Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US7199144B2 (en) *	2003-04-21	2007-04-03	Teva Pharmaceuticals Industries, Ltd.	Process for the preparation of valsartan and intermediates thereof

2003
- 2003-10-16 AT AT03809127T patent/ATE335743T1/de not_active IP Right Cessation
- 2003-10-16 ES ES03809127T patent/ES2270172T3/es not_active Expired - Lifetime
- 2003-10-16 DE DE60307494T patent/DE60307494D1/de not_active Expired - Lifetime
- 2003-10-16 CA CA002501557A patent/CA2501557A1/en not_active Abandoned
- 2003-10-16 EP EP03809127A patent/EP1551838B1/de not_active Expired - Lifetime
- 2003-10-16 US US10/688,538 patent/US20050070711A1/en not_active Abandoned
- 2003-10-16 WO PCT/US2003/032995 patent/WO2004035583A1/en not_active Ceased
- 2003-10-16 AU AU2003277433A patent/AU2003277433A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1551838B1 (de)	2006-08-09
US20050070711A1 (en)	2005-03-31
CA2501557A1 (en)	2004-04-29
ES2270172T3 (es)	2007-04-01
AU2003277433A1 (en)	2004-05-04
DE60307494D1 (de)	2006-09-21
WO2004035583A1 (en)	2004-04-29
EP1551838A1 (de)	2005-07-13

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Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties