ATE336277T1 - Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngen - Google Patents
Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngenInfo
- Publication number
- ATE336277T1 ATE336277T1 AT03742313T AT03742313T ATE336277T1 AT E336277 T1 ATE336277 T1 AT E336277T1 AT 03742313 T AT03742313 T AT 03742313T AT 03742313 T AT03742313 T AT 03742313T AT E336277 T1 ATE336277 T1 AT E336277T1
- Authority
- AT
- Austria
- Prior art keywords
- drugs
- devices
- surface coating
- transdermal administration
- coated microprojections
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39260902P | 2002-06-28 | 2002-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE336277T1 true ATE336277T1 (de) | 2006-09-15 |
Family
ID=30000902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03742313T ATE336277T1 (de) | 2002-06-28 | 2003-06-27 | Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngen |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040062813A1 (de) |
| EP (1) | EP1517722B1 (de) |
| JP (1) | JP2006500974A (de) |
| KR (1) | KR20050054483A (de) |
| CN (1) | CN100464800C (de) |
| AR (1) | AR040302A1 (de) |
| AT (1) | ATE336277T1 (de) |
| AU (1) | AU2003279641B2 (de) |
| BR (1) | BR0312268A (de) |
| CA (1) | CA2490545A1 (de) |
| DE (1) | DE60307640T2 (de) |
| ES (1) | ES2271613T3 (de) |
| MX (1) | MXPA05000205A (de) |
| WO (1) | WO2004002566A1 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
| ATE416692T1 (de) * | 2000-10-13 | 2008-12-15 | Alza Corp | Mikronadelelementhalter für schlagapplikator |
| DE60138411D1 (de) * | 2000-10-13 | 2009-05-28 | Alza Corp | Vorrichtung und verfahren zum durchstechen der haut mit micronadeln |
| NZ525551A (en) * | 2000-10-26 | 2005-09-30 | Alza Corp | Transdermal drug delivery devices having coated microprotrusions |
| WO2002074173A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| AR040819A1 (es) * | 2002-08-08 | 2005-04-20 | Alza Corp | Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas |
| EP1590033A2 (de) * | 2002-09-30 | 2005-11-02 | Alza Corporation | Wirkstoffabgabesystem mit vasokonstriktor enthaltenden überzogenen mikroprojektionen |
| AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
| KR20060038407A (ko) * | 2003-06-30 | 2006-05-03 | 알자 코포레이션 | 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제 |
| CN1845708A (zh) * | 2003-07-02 | 2006-10-11 | 阿尔扎公司 | 微突出物阵列免疫贴剂和方法 |
| JP2007501071A (ja) * | 2003-08-04 | 2007-01-25 | アルザ・コーポレーシヨン | 経皮作用剤流率を向上させる方法および装置 |
| US8961477B2 (en) * | 2003-08-25 | 2015-02-24 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| WO2005042702A2 (en) * | 2003-10-23 | 2005-05-12 | Alza Corporation | Compositions of stabilized dna for coating microprojections |
| BRPI0415466A (pt) * | 2003-10-24 | 2006-12-19 | Alza Corp | método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos |
| AU2004285481A1 (en) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Apparatus and method for enhancing transdermal drug delivery |
| AU2004287412A1 (en) * | 2003-10-28 | 2005-05-19 | Alza Corporation | Method and apparatus for reducing the incidence of tobacco use |
| ES2377647T3 (es) | 2003-10-31 | 2012-03-29 | Alza Corporation | Aplicador auto-actuado para ordenamiento de microproyecciones |
| KR20060135931A (ko) * | 2004-04-01 | 2006-12-29 | 알자 코포레이션 | 인플루엔자 백신의 경피전달 장치 및 방법 |
| CN101120101A (zh) * | 2004-04-13 | 2008-02-06 | 阿尔扎公司 | 多联疫苗透皮释放的装置和方法 |
| US7556821B2 (en) | 2004-05-13 | 2009-07-07 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
| US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
| TW200626177A (en) * | 2004-09-28 | 2006-08-01 | Alza Corp | Method and formulation for stabilizing alum-adsorbed vaccines |
| US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| WO2006055844A2 (en) * | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| AU2006291157A1 (en) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
| CA2629193C (en) * | 2005-11-18 | 2016-03-29 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
| US8554317B2 (en) * | 2005-11-30 | 2013-10-08 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
| US8632801B2 (en) * | 2005-12-28 | 2014-01-21 | Alza Corporation | Stable therapeutic formulations |
| AU2007225056A1 (en) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia |
| US20070299388A1 (en) * | 2006-04-25 | 2007-12-27 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
| US20070293816A1 (en) * | 2006-04-25 | 2007-12-20 | Alza Corporation | Microprojection Array Application with Grouped Microprojections for High Drug Loading |
| ES2817249T3 (es) | 2007-04-16 | 2021-04-06 | Corium Inc | Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo |
| AU2014200648B2 (en) * | 2007-04-16 | 2015-09-24 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
| AU2008283929B2 (en) * | 2007-08-06 | 2013-10-10 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
| US9549746B2 (en) | 2007-09-28 | 2017-01-24 | The Queen's University Of Belfast | Delivery device and method |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| US20090136554A1 (en) * | 2007-10-23 | 2009-05-28 | Alza Corporation | Transdermal sustained release drug delivery |
| GB0725017D0 (en) * | 2007-12-21 | 2008-01-30 | Univ Cardiff | Aerosol coating of microneedles |
| EP2429627B1 (de) * | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Verfahren zur herstellung von mikroprojektionsarrays |
| EP2566501B1 (de) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Verfahren und vorrichtung zur transdermalen verabreichung von parathormon mithilfe eines mikroprojektions-arrays |
| GB201019577D0 (en) | 2010-11-18 | 2010-12-29 | Univ Cork | Method |
| CN104602752A (zh) * | 2012-08-30 | 2015-05-06 | 帝人株式会社 | 涂布有药物组合物的微针阵列 |
| EP2934660B1 (de) | 2012-12-21 | 2019-07-17 | Corium, Inc. | Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur herstellung davon |
| EP4094799A1 (de) | 2013-03-12 | 2022-11-30 | Corium, Inc. | Mikroprojektionsapplikatoren |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| EP2968119B1 (de) | 2013-03-15 | 2019-09-18 | Corium International, Inc. | Mikroarray zur freisetzung therapeutischer wirkstoffe, verfahren zur verwendung und verfahren zur herstellung |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| JP6906885B2 (ja) | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| KR20170115429A (ko) * | 2016-04-07 | 2017-10-17 | 랩앤피플주식회사 | 생체분해성 금속을 이용한 마이크로 니들 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3123212A (en) * | 1964-03-03 | Multiple disposable intracutaneous injector package | ||
| USRE25637E (en) * | 1964-09-08 | Means for vaccinating | ||
| US2619962A (en) * | 1948-02-19 | 1952-12-02 | Res Foundation | Vaccination appliance |
| US2893392A (en) * | 1958-01-08 | 1959-07-07 | American Cyanamid Co | Article of manufacture for intracutaneous injections |
| US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
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| US3221739A (en) * | 1962-03-26 | 1965-12-07 | Rosenthal Sol Roy | Injection device |
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| OA05448A (fr) * | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Dispositif vaccinateur multipénétrant. |
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| EP0429842B1 (de) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten |
| US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
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| JPH06346255A (ja) * | 1993-06-10 | 1994-12-20 | Hino Motors Ltd | ステンレス鋼の表面処理方法 |
| US5457041A (en) * | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
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| JP2002532165A (ja) * | 1998-12-18 | 2002-10-02 | メドトロニック ミニメド インコーポレイテッド | 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法 |
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| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| DE10036832C1 (de) * | 2000-07-28 | 2001-12-13 | Schott Glas | Verfahren und Vorrichtung zum Aufbringen einer hitzefixierten Gleitmittelschicht auf die Innenwandung von zylindrischen Behältern für medizinische Zwecke |
| DE60138411D1 (de) * | 2000-10-13 | 2009-05-28 | Alza Corp | Vorrichtung und verfahren zum durchstechen der haut mit micronadeln |
| US7556821B2 (en) * | 2004-05-13 | 2009-07-07 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
-
2003
- 2003-06-27 AU AU2003279641A patent/AU2003279641B2/en not_active Ceased
- 2003-06-27 KR KR1020047021384A patent/KR20050054483A/ko not_active Ceased
- 2003-06-27 ES ES03742313T patent/ES2271613T3/es not_active Expired - Lifetime
- 2003-06-27 US US10/608,304 patent/US20040062813A1/en not_active Abandoned
- 2003-06-27 CN CNB038204878A patent/CN100464800C/zh not_active Expired - Fee Related
- 2003-06-27 WO PCT/US2003/020471 patent/WO2004002566A1/en not_active Ceased
- 2003-06-27 JP JP2004518065A patent/JP2006500974A/ja not_active Withdrawn
- 2003-06-27 CA CA002490545A patent/CA2490545A1/en not_active Abandoned
- 2003-06-27 MX MXPA05000205A patent/MXPA05000205A/es active IP Right Grant
- 2003-06-27 BR BR0312268-9A patent/BR0312268A/pt not_active IP Right Cessation
- 2003-06-27 DE DE60307640T patent/DE60307640T2/de not_active Revoked
- 2003-06-27 EP EP03742313A patent/EP1517722B1/de not_active Revoked
- 2003-06-27 AT AT03742313T patent/ATE336277T1/de not_active IP Right Cessation
- 2003-06-27 AR ARP030102342A patent/AR040302A1/es unknown
-
2008
- 2008-10-31 US US12/290,678 patent/US20090186147A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0312268A (pt) | 2005-04-26 |
| KR20050054483A (ko) | 2005-06-10 |
| CN100464800C (zh) | 2009-03-04 |
| AR040302A1 (es) | 2005-03-23 |
| CN1678367A (zh) | 2005-10-05 |
| MXPA05000205A (es) | 2005-09-30 |
| EP1517722A1 (de) | 2005-03-30 |
| WO2004002566A1 (en) | 2004-01-08 |
| JP2006500974A (ja) | 2006-01-12 |
| AU2003279641A1 (en) | 2004-01-19 |
| DE60307640D1 (de) | 2006-09-28 |
| US20090186147A1 (en) | 2009-07-23 |
| EP1517722B1 (de) | 2006-08-16 |
| CA2490545A1 (en) | 2004-01-08 |
| AU2003279641B2 (en) | 2009-06-18 |
| DE60307640T2 (de) | 2007-09-13 |
| ES2271613T3 (es) | 2007-04-16 |
| US20040062813A1 (en) | 2004-04-01 |
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| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |