ATE336486T1 - Cyklisierungsverfahren für benzothiazolderivate - Google Patents

Cyklisierungsverfahren für benzothiazolderivate

Info

Publication number: ATE336486T1
Authority: AT; Austria
Prior art keywords: sup; lower alkyl; sub; hydrogen; formula
Prior art date: 2003-01-07

Application number

AT03799511T

Other languages

English (en)

Inventor

Paul Spurr

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-07

Filing date

2003-12-29

Publication date

2006-09-15

2003-12-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE336486T1 publication Critical patent/ATE336486T1/de

Links

238000000034 method Methods 0.000 title abstract 2
238000007363 ring formation reaction Methods 0.000 title abstract 2
IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
-1 amino substituted benzothiazole derivatives Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

AT03799511T 2003-01-07 2003-12-29 Cyklisierungsverfahren für benzothiazolderivate ATE336486T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03000048		2003-01-07

Publications (1)

Publication Number	Publication Date
ATE336486T1 true ATE336486T1 (de)	2006-09-15

Family

ID=32695583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03799511T ATE336486T1 (de)	2003-01-07	2003-12-29	Cyklisierungsverfahren für benzothiazolderivate

Country Status (15)

Country	Link
US (1)	US7087761B2 (de)
EP (1)	EP1583752B1 (de)
JP (1)	JP4381311B2 (de)
KR (1)	KR100712747B1 (de)
CN (1)	CN100420678C (de)
AT (1)	ATE336486T1 (de)
AU (1)	AU2003300234A1 (de)
CA (1)	CA2512361A1 (de)
DE (1)	DE60307682T2 (de)
DK (1)	DK1583752T3 (de)
ES (1)	ES2270167T3 (de)
IL (1)	IL169368A (de)
MX (1)	MXPA05007387A (de)
TW (1)	TWI284127B (de)
WO (1)	WO2004060879A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1677791A4 (de) *	2003-10-31	2007-08-15	Takeda Pharmaceutical	Stickstoffhaltige kondensierte heterocyclische verbindungen
US7429589B2 (en) *	2006-04-27	2008-09-30	Hoffmann-La Roche Inc.	Mono-nitration of aromatic compounds via nitrate salts
EP2099445B1 (de) *	2006-09-04	2010-11-17	University Court of The University of Dundee	P53 aktivierende benzoylharnstoff- und benzoylthioharnstoff-verbindungen
US8779154B2 (en) *	2006-09-26	2014-07-15	Qinglin Che	Fused ring compounds for inflammation and immune-related uses
WO2008052930A2 (en) *	2006-11-03	2008-05-08	F. Hoffmann-La Roche Ag	Preparation of 4-alk0xy-7- (tetrahydropyran-4-yl) benzothiazol-2-amine derivatives
US7902248B2 (en) *	2006-12-14	2011-03-08	Hoffmann-La Roche Inc.	Oxime glucokinase activators
FR2930552B1 (fr) *	2008-04-24	2012-10-12	Centre Nat Rech Scient	N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog
GB0909912D0 (en)	2009-06-09	2009-07-22	Univ Dundee	Compounds
CN102391207B (zh) *	2011-07-26	2014-04-09	贵州大学	N-(2-(取代苯并噻唑-2-氨基甲酰基)-苯基)-苯甲酰胺及其制备方法和用途
GB201416754D0 (en)	2014-09-23	2014-11-05	Mission Therapeutics Ltd	Novel compounds

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH505543A (de)	1968-11-01	1971-04-15	Ciba Geigy Ag	Schädlingsbekämpfungsmittel
NL7109150A (de)	1970-07-06	1972-01-10
US4028374A (en)	1975-11-03	1977-06-07	Morton-Norwich Products, Inc.	Antibacterial thiocyanatobenzothiazoles
DE2656468A1 (de)	1976-12-14	1978-06-15	Boehringer Mannheim Gmbh	N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung
KR930005004B1 (ko)	1985-04-15	1993-06-11	쟈안센 파아마슈우티카 엔. 부이.	치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
US4826860A (en)	1987-03-16	1989-05-02	Warner-Lambert Company	Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
FI91859C (fi)	1987-06-17	1994-08-25	Eisai Co Ltd	Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
IL90337A0 (en)	1988-05-24	1989-12-15	Pfizer	Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
WO1990015801A1 (en)	1989-06-22	1990-12-27	Pfizer Inc.	Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases
EP0427963B1 (de)	1989-11-10	1994-03-30	Agrolinz Agrarchemikalien Gesellschaft M.B.H.	Verfahren zur Herstellung reiner, unsymmetrisch disubstituierter Harnstoffe
EP0529600B1 (de)	1991-08-30	1996-11-06	Hoechst Aktiengesellschaft	Verfahren zur Herstellung von 2-Aminobenzthiazolen
DE69327572T2 (de)	1992-05-21	2000-06-21	Otsuka Pharmaceutical Factory, Inc.	Phosphonsäurediester-derivat
FR2753970B1 (fr)	1996-10-01	1998-10-30	Synthelabo	Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
JPH11130761A (ja)	1997-10-24	1999-05-18	Otsuka Pharmaceut Co Ltd	ベンゾチアゾール誘導体
ATE315394T1 (de)	1997-11-10	2006-02-15	Bristol Myers Squibb Co	Benzothiazole als protein tyrosin-kinase inhibitoren
BR9907183A (pt)	1998-01-23	2003-06-10	Versicor Inc	Colet neas combinatórias de oxazolidinona, composições e processos de preparação
AU6280199A (en)	1998-09-30	2000-04-17	Neurogen Corporation	2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands
UA71587C2 (uk)	1998-11-10	2004-12-15	Шерінг Акцієнгезелльшафт	Аміди антранілової кислоти та їхнє застосування як лікарських засобів
IL133680A0 (en)	1999-09-10	2001-04-30	Can Fite Technologies Ltd	Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
AU2001281817B2 (en)	2000-06-21	2005-11-24	F. Hoffmann-La Roche Ag	Benzothiazole derivatives

2003
- 2003-12-22 US US10/743,613 patent/US7087761B2/en not_active Expired - Fee Related
- 2003-12-29 CN CNB2003801084061A patent/CN100420678C/zh not_active Expired - Fee Related
- 2003-12-29 ES ES03799511T patent/ES2270167T3/es not_active Expired - Lifetime
- 2003-12-29 MX MXPA05007387A patent/MXPA05007387A/es active IP Right Grant
- 2003-12-29 AU AU2003300234A patent/AU2003300234A1/en not_active Abandoned
- 2003-12-29 DK DK03799511T patent/DK1583752T3/da active
- 2003-12-29 DE DE60307682T patent/DE60307682T2/de not_active Expired - Lifetime
- 2003-12-29 WO PCT/EP2003/014928 patent/WO2004060879A2/en not_active Ceased
- 2003-12-29 AT AT03799511T patent/ATE336486T1/de active
- 2003-12-29 EP EP03799511A patent/EP1583752B1/de not_active Expired - Lifetime
- 2003-12-29 KR KR1020057012640A patent/KR100712747B1/ko not_active Expired - Fee Related
- 2003-12-29 CA CA002512361A patent/CA2512361A1/en not_active Abandoned
- 2003-12-29 TW TW092137300A patent/TWI284127B/zh not_active IP Right Cessation
- 2003-12-29 JP JP2004564226A patent/JP4381311B2/ja not_active Expired - Lifetime
2005
- 2005-06-23 IL IL169368A patent/IL169368A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US7087761B2 (en)	2006-08-08
US20040138465A1 (en)	2004-07-15
KR20050091061A (ko)	2005-09-14
JP2006513228A (ja)	2006-04-20
DK1583752T3 (da)	2006-12-27
MXPA05007387A (es)	2005-09-12
IL169368A (en)	2010-05-31
EP1583752A2 (de)	2005-10-12
WO2004060879A2 (en)	2004-07-22
DE60307682D1 (de)	2006-09-28
IL169368A0 (en)	2007-07-04
TWI284127B (en)	2007-07-21
KR100712747B1 (ko)	2007-04-30
TW200424184A (en)	2004-11-16
CA2512361A1 (en)	2004-07-22
ES2270167T3 (es)	2007-04-01
WO2004060879A3 (en)	2004-11-18
JP4381311B2 (ja)	2009-12-09
CN100420678C (zh)	2008-09-24
DE60307682T2 (de)	2007-09-06
AU2003300234A8 (en)	2004-07-29
AU2003300234A1 (en)	2004-07-29
EP1583752B1 (de)	2006-08-16
CN1738808A (zh)	2006-02-22

Similar Documents

Publication	Publication Date	Title
DE60311821D1 (de)	2007-03-29	Dibenzylaminverbindung und deren medizinische verwendung
HUP0301671A2 (hu)	2003-08-28	4-Fenil-piridin-származékok, mint neurokinin-1-receptor antagonisták, eljárás az előállításukra és alkalmazásuk
RU2000119731A (ru)	2002-05-10	Новые тетрациклические аналоги камптотецинов, способы их получения, их применение в качестве лекарств и фармацевтические композиции, их содержащие
MY140528A (en)	2009-12-31	Spiroketal derivatives and their use as therapeutic agents for diabetes
CA2427576A1 (en)	2002-05-23	Benzodiazepine derivatives as gaba a receptor modulators
RU2004122094A (ru)	2005-03-27	Производные азаиндолилалкиламина и применение указанных соединений в качестве лигандов 5-гидрокситриптамина-6
WO2008145839A8 (fr)	2009-11-19	Dérivés de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur préparation et leur application en thérapeutique
MX2009003927A (es)	2009-04-23	Derivado espirocetal de tioglucosa y uso del mismo como un agente terapeutico para la diabetes.
ATE336486T1 (de)	2006-09-15	Cyklisierungsverfahren für benzothiazolderivate
JP4065604B2 (ja)	2008-03-26	新規なクロメン化合物、それらの製造方法及びそれらを含む医薬組成物
CA2479097A1 (en)	2003-09-25	Amides of acetic and propionic acids
BR0205683A (pt)	2004-07-06	Processo para a preparação de derivados de piperazina, e, mesilato de um composto
EA200200523A1 (ru)	2002-12-26	Новые разветвленные замещенные аминопроизводные 3-амино-1-фенил-1h[1,2,4]триазола, способы их получения и содержащие их фармацевтические композиции
MXPA04003278A (es)	2004-07-23	Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina.
MXPA02011464A (es)	2003-04-25	Derivados 1,4-diazepan-2,5-diona y su uso como antagonistas del receptor de la nk-1.
ATE453621T1 (de)	2010-01-15	Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer
DK1178047T3 (da)	2004-05-24	Diazabicyclooctanderivater og terapeutiske anvendelser deraf
DE60103752D1 (de)	2004-07-15	Verfahren zur herstellung von pyrazolopyridinderivaten
MY139258A (en)	2009-09-30	Carbamoyl-type benzofuran derivatives
HUP0300392A2 (hu)	2003-07-28	Benzo[a]fenazin-11-karboxamid-származékok és alkalmazásuk közös topoizomeráz I és II inhibitor hatású gyógyszerkészítmények előállítására, eljárás az előállításukra és intermedierjeik
TW200612912A (en)	2006-05-01	Benzyloxy derivatives as maob inhibitors
LV10957A (lv)	1995-12-20	16, 17 -Acetalaizvietoti androstan-17-karbonskabes esteri to iegusanas panemiens to starpprodukti un so starpproduktu iegusanas panemiens farmaceitiskie preparati
GB9407637D0 (en)	1994-06-08	Serotoninergic abeo-ergoline derivatives
NO20065057L (no)	2006-11-21	benzoksazociner og terapeutisk anvendelse derav som monoamin reopptaks inhibitorer
DE60214554D1 (de)	2006-10-19	Derivate von 3-phenyl-n-(2-(4-benzyl)piperidin-1-yl)ethyl) acrylamid mit ccr-3-rezeptor antagonistischer wirkung zur verwendung bei der behandlung von entzündungen und allergischen leiden

Legal Events

Date

Code

Title

Description

2007-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1583752

Country of ref document: EP