ATE336492T1 - Methonocarbacycloalkylanaloga von nucleosiden - Google Patents
Methonocarbacycloalkylanaloga von nucleosidenInfo
- Publication number
- ATE336492T1 ATE336492T1 AT01903043T AT01903043T ATE336492T1 AT E336492 T1 ATE336492 T1 AT E336492T1 AT 01903043 T AT01903043 T AT 01903043T AT 01903043 T AT01903043 T AT 01903043T AT E336492 T1 ATE336492 T1 AT E336492T1
- Authority
- AT
- Austria
- Prior art keywords
- receptors
- present
- uracil
- cycloalkyl group
- useful
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 4
- 108020003175 receptors Proteins 0.000 abstract 3
- 102000005962 receptors Human genes 0.000 abstract 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical class NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229940035893 uracil Drugs 0.000 abstract 2
- 101150007969 ADORA1 gene Proteins 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- 101150051188 Adora2a gene Proteins 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000002294 Purinergic P2X Receptors Human genes 0.000 abstract 1
- 108010000836 Purinergic P2X Receptors Proteins 0.000 abstract 1
- 102000001744 Purinergic P2Y2 Receptors Human genes 0.000 abstract 1
- 108010029812 Purinergic P2Y2 Receptors Proteins 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17637300P | 2000-01-14 | 2000-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE336492T1 true ATE336492T1 (de) | 2006-09-15 |
Family
ID=22644097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01903043T ATE336492T1 (de) | 2000-01-14 | 2001-01-12 | Methonocarbacycloalkylanaloga von nucleosiden |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7087589B2 (de) |
| EP (1) | EP1252160B1 (de) |
| AT (1) | ATE336492T1 (de) |
| AU (2) | AU3091301A (de) |
| CA (1) | CA2397366C (de) |
| DE (1) | DE60122285D1 (de) |
| WO (1) | WO2001051490A1 (de) |
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| US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
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| WO2007002634A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
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| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
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2001
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- 2001-01-12 EP EP01903043A patent/EP1252160B1/de not_active Expired - Lifetime
- 2001-01-12 AU AU3091301A patent/AU3091301A/xx active Pending
- 2001-01-12 DE DE60122285T patent/DE60122285D1/de not_active Expired - Lifetime
- 2001-01-12 AU AU2001230913A patent/AU2001230913B2/en not_active Expired
- 2001-01-12 WO PCT/US2001/000981 patent/WO2001051490A1/en not_active Ceased
- 2001-01-12 CA CA2397366A patent/CA2397366C/en not_active Expired - Lifetime
- 2001-01-12 AT AT01903043T patent/ATE336492T1/de not_active IP Right Cessation
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2006
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Also Published As
| Publication number | Publication date |
|---|---|
| US20030216412A1 (en) | 2003-11-20 |
| DE60122285D1 (de) | 2006-09-28 |
| WO2001051490A1 (en) | 2001-07-19 |
| EP1252160B1 (de) | 2006-08-16 |
| CA2397366C (en) | 2011-03-15 |
| EP1252160A1 (de) | 2002-10-30 |
| AU2001230913B2 (en) | 2005-06-30 |
| US7087589B2 (en) | 2006-08-08 |
| CA2397366A1 (en) | 2001-07-19 |
| US20060270629A1 (en) | 2006-11-30 |
| US7790735B2 (en) | 2010-09-07 |
| AU3091301A (en) | 2001-07-24 |
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