ATE337094T1 - Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür - Google Patents

Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür

Info

Publication number
ATE337094T1
ATE337094T1 AT02732596T AT02732596T ATE337094T1 AT E337094 T1 ATE337094 T1 AT E337094T1 AT 02732596 T AT02732596 T AT 02732596T AT 02732596 T AT02732596 T AT 02732596T AT E337094 T1 ATE337094 T1 AT E337094T1
Authority
AT
Austria
Prior art keywords
binding
substrate
shear
field generating
target molecules
Prior art date
Application number
AT02732596T
Other languages
English (en)
Inventor
Gert Desmet
Gino Baron
Original Assignee
Univ Bruxelles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bruxelles filed Critical Univ Bruxelles
Application granted granted Critical
Publication of ATE337094T1 publication Critical patent/ATE337094T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4317Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/43197Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
    • B01F25/431971Mounted on the wall
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/29Mixing by periodically deforming flexible tubular members through which the material is flowing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • B01F31/311Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted the motion being a linear movement to one part of the receptacle
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/92Construction of the plate
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0636Integrated biosensor, microarrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0803Disc shape
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0812Bands; Tapes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/086Passive control of flow resistance using baffles or other fixed flow obstructions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/38Flow patterns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6095Micromachined or nanomachined, e.g. micro- or nanosize
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Discharge Heating (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
AT02732596T 2001-04-26 2002-04-11 Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür ATE337094T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01870091 2001-04-26

Publications (1)

Publication Number Publication Date
ATE337094T1 true ATE337094T1 (de) 2006-09-15

Family

ID=8184962

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02732596T ATE337094T1 (de) 2001-04-26 2002-04-11 Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür

Country Status (10)

Country Link
US (2) US20040171002A1 (de)
EP (2) EP1383603B1 (de)
JP (1) JP2004536694A (de)
AT (1) ATE337094T1 (de)
CY (1) CY1105742T1 (de)
DE (1) DE60214155T2 (de)
DK (1) DK1383603T3 (de)
ES (1) ES2271256T3 (de)
PT (1) PT1383603E (de)
WO (1) WO2002087761A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1383603B1 (de) * 2001-04-26 2006-08-23 Vrije Universiteit Brussel Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür
JP2004357698A (ja) * 2003-05-09 2004-12-24 Aloka Co Ltd 処理装置
JP5016638B2 (ja) * 2003-05-09 2012-09-05 日立アロカメディカル株式会社 処理装置
WO2005036139A1 (en) * 2003-10-03 2005-04-21 Vrije Universiteit Brussel Method and device for size-separating particles present in a fluid
US8105845B2 (en) * 2003-11-12 2012-01-31 Bio-Rad Haifa Ltd. System and method for carrying out multiple binding reactions in an array format
DE10354806A1 (de) * 2003-11-21 2005-06-02 Boehringer Ingelheim Microparts Gmbh Probenträger
JP4441599B2 (ja) * 2005-01-12 2010-03-31 多摩川精機株式会社 蛋白質スクリーニング装置
EP1965921A2 (de) * 2005-12-21 2008-09-10 Koninklijke Philips Electronics N.V. Sensor für biomoleküle und analyseverfahren unter verwendung des sensors
WO2007105140A2 (en) * 2006-03-15 2007-09-20 Koninklijke Philips Electronics N. V. Microelectronic device with controllable reference substance supply
US8303915B2 (en) 2006-10-30 2012-11-06 Ventana Medical Systems, Inc. Thin film apparatus and method
EP1944080A1 (de) * 2007-01-11 2008-07-16 F.Hoffmann-La Roche Ag Vorrichtung und Verfahren zum Bewegen einer Flüssigkeit in einer Kavität
DE102008010436A1 (de) * 2008-02-21 2009-09-03 Berthold Technologies Gmbh & Co. Kg Vorrichtung und Verfahren zur Messung von Lumineszenz und Fluoreszenz von transfizierten Zellen oder Organteilen
EP2274613B1 (de) 2008-04-02 2014-06-04 Abbott Point Of Care, Inc. Verfahren für serologische agglutinierungsverfahren welche in einer dünnfilm-flüssigkeitsprobe durchgeführt werden
US20100075863A1 (en) * 2008-09-25 2010-03-25 Northrop Grumman Systems Corporation Rotary array module for multiplexing spot-based optical readouts
WO2014150853A1 (en) * 2013-03-15 2014-09-25 Inanovate, Inc. Analyte measurement using longitudinal assay
KR101817122B1 (ko) * 2015-12-14 2018-01-10 경희대학교 산학협력단 분자 통신 시스템, 분자 통신 방법, 분자 송신기 및 분자 수신기
US11499962B2 (en) 2017-11-17 2022-11-15 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
US12239980B2 (en) * 2018-12-07 2025-03-04 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US11118223B2 (en) 2019-03-14 2021-09-14 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US10900078B2 (en) 2019-03-14 2021-01-26 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis

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WO1985004112A1 (en) * 1984-03-21 1985-09-26 Mclaughlin, William, Francis Method and apparatus for filtration
US4874507A (en) * 1986-06-06 1989-10-17 Whitlock David R Separating constituents of a mixture of particles
DE4108820A1 (de) * 1991-03-18 1992-09-24 Karl Dr Reuter Kontinuierliche chromatographie
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
IL106330A (en) * 1993-07-14 1998-01-04 Univ Ramot Method and instrument for determining the activity of their plaques in the initial coagulation system
EP0670489A3 (de) * 1994-03-03 1996-03-06 Ciba Geigy Ag Vorrichtung und Verfahren zur Trennung fluider Substanzen.
EP0882982A1 (de) * 1997-06-04 1998-12-09 Vrije Universiteit Brussel Verfahren und Vorrichtung zur Trennung eines Fluids
US6843963B1 (en) * 1998-05-25 2005-01-18 Herbert Peter Jennissen Flow-through shear analyzer for biologically active molecules in liquid layers on surfaces
EP1383603B1 (de) * 2001-04-26 2006-08-23 Vrije Universiteit Brussel Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür

Also Published As

Publication number Publication date
US20040171002A1 (en) 2004-09-02
PT1383603E (pt) 2007-01-31
WO2002087761A1 (en) 2002-11-07
CY1105742T1 (el) 2010-12-22
DK1383603T3 (da) 2007-01-02
DE60214155T2 (de) 2007-07-19
EP1383603A1 (de) 2004-01-28
DE60214155D1 (de) 2006-10-05
US20060078934A1 (en) 2006-04-13
EP1383603B1 (de) 2006-08-23
JP2004536694A (ja) 2004-12-09
EP1627686A1 (de) 2006-02-22
ES2271256T3 (es) 2007-04-16

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