ATE337318T1 - Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren - Google Patents

Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren

Info

Publication number: ATE337318T1
Authority: AT; Austria
Prior art keywords: adhesion molecule; molecule inhibitors; active ingredients; spiro compounds; inhibitors containing
Prior art date: 2000-09-25

Application number

AT01967819T

Other languages

English (en)

Inventor

Toshiya Takahashi

Takeshi Ishigaki

Miyuki Funahashi

Koji Taniguchi

Masayuki Kaneko

Mie Kainoh

Hiroyuki Meguro

Original Assignee

Toray Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-25

Filing date

2001-09-25

Publication date

2006-09-15

2001-09-25 Application filed by Toray Industries filed Critical Toray Industries

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE337318T1 publication Critical patent/ATE337318T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title 1
150000003413 spiro compounds Chemical class 0.000 title 1
125000003003 spiro group Chemical group 0.000 abstract 2
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT01967819T 2000-09-25 2001-09-25 Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren ATE337318T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000289658		2000-09-25

Publications (1)

Publication Number	Publication Date
ATE337318T1 true ATE337318T1 (de)	2006-09-15

Family

ID=18773016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01967819T ATE337318T1 (de)	2000-09-25	2001-09-25	Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren

Country Status (11)

Country	Link
US (1)	US6919349B2 (de)
EP (1)	EP1329451B1 (de)
JP (1)	JP4997684B2 (de)
KR (1)	KR20030027076A (de)
CN (1)	CN1247577C (de)
AT (1)	ATE337318T1 (de)
AU (2)	AU8811401A (de)
CA (1)	CA2423007C (de)
DE (1)	DE60122555T2 (de)
ES (1)	ES2271071T3 (de)
WO (1)	WO2002024697A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003080611A1 (en) *	2002-03-22	2003-10-02	Toray Industries, Inc.	Spiro derivatives and adhesion molecule inhibitors comprising the same as the active ingredient
FR2870538B1 (fr) *	2004-05-19	2006-07-14	Servier Lab	Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2008219007A1 (en)	2007-02-20	2008-08-28	Merrimack Pharmaceuticals, Inc.	Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
JP5639039B2 (ja)	2008-04-11	2014-12-10	メリマックファーマシューティカルズインコーポレーティッド	ヒト血清アルブミンリンカーおよびそのコンジュゲート
CN102282168A (zh)	2008-11-18	2011-12-14	梅里麦克制药股份有限公司	人血清白蛋白接头以及其结合物
CN102958311A (zh) *	2011-08-25	2013-03-06	深圳富泰宏精密工业有限公司	装饰性外壳及其制作方法
US9345766B2 (en)	2012-08-30	2016-05-24	Merrimack Pharmaceuticals, Inc.	Combination therapies comprising anti-ERBB3 agents
WO2016065603A1 (en) *	2014-10-31	2016-05-06	Merck Sharp & Dohme Corp.	Inhibitors of the renal outer medullary potassium channel
CN107849044B (zh) *	2015-07-03	2021-06-25	豪夫迈·罗氏有限公司	作为ddr1抑制剂的三氮杂-螺癸酮类化合物
CN108884096B (zh)	2016-02-08	2022-03-22	豪夫迈·罗氏有限公司	作为ddr1抑制剂的螺二氢吲哚酮
ES2987796T3 (es)	2018-10-30	2024-11-18	Gilead Sciences Inc	Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias
DK3873884T3 (da)	2018-10-30	2025-02-17	Gilead Sciences Inc	3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme
WO2020092394A1 (en)	2018-10-30	2020-05-07	Gilead Sciences, Inc.	Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
WO2020092401A1 (en)	2018-10-30	2020-05-07	Gilead Sciences, Inc.	COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN
US11338626B2 (en)	2018-11-06	2022-05-24	Peter Vogelpohl	Devices and systems for controlling tire pressure
CN109541237A (zh) *	2018-12-28	2019-03-29	吴江近岸蛋白质科技有限公司	纤维连接蛋白的生物学活性测定方法
AU2020329207B2 (en)	2019-08-14	2024-02-29	Gilead Sciences, Inc.	Compounds for inhibition of alpha 4 beta 7 integrin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11500100A (ja) *	1993-09-09	1999-01-06	サイオスノバインコーポレイテッド	偽ペプチドおよび非ペプチドブラジキニンレセプターアンタゴニスト
JPH08337569A (ja)	1995-06-15	1996-12-24	Sankyo Co Ltd	鎮痛活性物質
ZA972195B (en) *	1996-03-15	1998-09-14	Du Pont Merck Pharma	Spirocycle integrin inhibitors
KR100554815B1 (ko) *	1997-08-22	2006-02-22	에프. 호프만-라 로슈 아게	엔-아로일페닐알라닌 유도체
AU4242100A (en)	1999-04-14	2000-11-14	American Home Products Corporation	Methods for solid phase combinatorial synthesis of integrin inhibitors
EP1214292B1 (de) *	1999-09-24	2007-06-13	Genentech, Inc.	Tyrosinderivate

2001
- 2001-09-25 AU AU8811401A patent/AU8811401A/xx active Pending
- 2001-09-25 KR KR10-2003-7002669A patent/KR20030027076A/ko not_active Ceased
- 2001-09-25 WO PCT/JP2001/008290 patent/WO2002024697A1/ja not_active Ceased
- 2001-09-25 JP JP2002529107A patent/JP4997684B2/ja not_active Expired - Fee Related
- 2001-09-25 CN CNB018162274A patent/CN1247577C/zh not_active Expired - Fee Related
- 2001-09-25 CA CA2423007A patent/CA2423007C/en not_active Expired - Fee Related
- 2001-09-25 EP EP01967819A patent/EP1329451B1/de not_active Expired - Lifetime
- 2001-09-25 US US10/381,367 patent/US6919349B2/en not_active Expired - Fee Related
- 2001-09-25 AT AT01967819T patent/ATE337318T1/de not_active IP Right Cessation
- 2001-09-25 ES ES01967819T patent/ES2271071T3/es not_active Expired - Lifetime
- 2001-09-25 DE DE60122555T patent/DE60122555T2/de not_active Expired - Lifetime
- 2001-09-25 AU AU2001288114A patent/AU2001288114B2/en not_active Ceased

Also Published As

Publication number	Publication date
CA2423007A1 (en)	2003-03-24
WO2002024697A1 (en)	2002-03-28
CN1466586A (zh)	2004-01-07
US20040087574A1 (en)	2004-05-06
ES2271071T3 (es)	2007-04-16
JPWO2002024697A1 (ja)	2004-01-29
EP1329451A1 (de)	2003-07-23
JP4997684B2 (ja)	2012-08-08
DE60122555T2 (de)	2007-07-12
AU2001288114B2 (en)	2006-04-27
CA2423007C (en)	2010-06-01
EP1329451A4 (de)	2004-06-16
CN1247577C (zh)	2006-03-29
AU8811401A (en)	2002-04-02
DE60122555D1 (de)	2006-10-05
EP1329451B1 (de)	2006-08-23
KR20030027076A (ko)	2003-04-03
US6919349B2 (en)	2005-07-19

Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60122555D1 (de)	2006-10-05	Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren
DE60204452D1 (de)	2005-07-07	Pyrazolo[1,5]pyridinderivate
EA200200708A1 (ru)	2003-02-27	Производные бензазола и их применение в качестве модуляторов jnk
DE60003949D1 (de)	2003-08-21	5-aryl-1h-1,2,4 triazolverbindungen als cyclooxygenase -2 inhibitoren und dieseenthaltende pharmazeutische zusammensetzungen
MEP45308A (en)	2011-02-10	[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
NO20053645L (no)	2002-10-22	(4R)- og (4S)-diastereoisomerer av (2S)-2-[ 2-oksy-4-propylpyrrolidinyl]butanamid og farmasoytisk preparat inneholdende disse
DE60131967D1 (de)	2008-01-31	Nr1h4-kern-rezeptor-bindende verbindungen
MA27769A1 (fr)	2006-02-01	Dérivées de 2-acylamino-4-phenylthiazole, leur préparation et leur application en thérapeutique
CY1107747T1 (el)	2013-04-18	Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
ATE331519T1 (de)	2006-07-15	Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten
ES2243579T3 (es)	2005-12-01	Derivados de pirazolopirideno.
ATE433971T1 (de)	2009-07-15	Neue azolderivate
BRPI0406801A (pt)	2006-01-17	Derivados de tieno-pirimidinodiona e uso dos mesmos na modulação de doenças autoimunes
SE9804212D0 (sv)	1998-12-04	Compounds
DK0903347T3 (da)	2005-11-21	Hidtil ukendte cyclodepsipeptid PF1022-derivater
ATE498600T1 (de)	2011-03-15	Inden derivate als pharmazeutika
ATE420853T1 (de)	2009-01-15	5-amidino-2-hydroxybenzolsulfonamidderivate, pharmazeutischen zusammensetzungen, die diese verbindungen enthalten, und zwischenprodukte zu deren herstellung
ATE223376T1 (de)	2002-09-15	Bisarylcyclobutenderivate als cyclooxygenasehemmer
ATE373000T1 (de)	2007-09-15	Pyrazolopyridin-derivate als antiherpesmittel
EE200200326A (et)	2003-10-15	Asendatud homopiperidüülbensimidasooli analoog, meetod selle valmistamiseks ning seda sisaldav farmatseutiline kompositsioon
ATE433450T1 (de)	2009-06-15	Substituierte 1,4,8-triazaspiro 4.5 decan-2-on- verbindungen
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
ATE284882T1 (de)	2005-01-15	Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
ATE228134T1 (de)	2002-12-15	Kondensierte pyrimidinderivate und diese enthaltende pharmazeutische zubereitungen
ATE374751T1 (de)	2007-10-15	3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern