ATE337396T1 - Kombinatorische bibliotheken heteromerer cytotoxischer proteine - Google Patents

Kombinatorische bibliotheken heteromerer cytotoxischer proteine

Info

Publication number
ATE337396T1
ATE337396T1 AT98959689T AT98959689T ATE337396T1 AT E337396 T1 ATE337396 T1 AT E337396T1 AT 98959689 T AT98959689 T AT 98959689T AT 98959689 T AT98959689 T AT 98959689T AT E337396 T1 ATE337396 T1 AT E337396T1
Authority
AT
Austria
Prior art keywords
heteromeric
proteins
cytotoxic proteins
target cell
combinatory libraries
Prior art date
Application number
AT98959689T
Other languages
English (en)
Inventor
Jean Gariepy
Mark Robert Bray
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Application granted granted Critical
Publication of ATE337396T1 publication Critical patent/ATE337396T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT98959689T 1998-02-04 1998-12-08 Kombinatorische bibliotheken heteromerer cytotoxischer proteine ATE337396T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002222993A CA2222993A1 (en) 1998-02-04 1998-02-04 A method for using a ribosome-inactivating protein complex as a structural template and a molecular search engine in the design, construction and screening of combinatorial protein libraries

Publications (1)

Publication Number Publication Date
ATE337396T1 true ATE337396T1 (de) 2006-09-15

Family

ID=4161822

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98959689T ATE337396T1 (de) 1998-02-04 1998-12-08 Kombinatorische bibliotheken heteromerer cytotoxischer proteine

Country Status (8)

Country Link
US (1) US7713915B1 (de)
EP (1) EP1051482B1 (de)
JP (1) JP4339511B2 (de)
AT (1) ATE337396T1 (de)
AU (1) AU769824B2 (de)
CA (1) CA2222993A1 (de)
DE (1) DE69835695T2 (de)
WO (1) WO1999040185A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1727827B1 (de) * 2004-03-26 2010-05-12 Molecular Templates, Inc. Bibliothek von toxin mutanten und deren verwendung
EP1945660B1 (de) 2005-09-26 2014-05-07 Molecular Templates, Inc. Bibliothek aus toxinmutanten und verfahren zu deren anwendung
US20100298238A1 (en) * 2007-10-08 2010-11-25 Rutgers, The State University Nontoxic shiga-like toxin mutant compositions and methods
EP2786147B1 (de) * 2012-12-04 2017-02-01 Scinopharm Taiwan Ltd. Verfahren zur auswahl einer sammlung von molekülen
EP3666795A1 (de) 2013-03-12 2020-06-17 Molecular Templates, Inc. Zytotoxische proteine mit zellgerichteten bindungsregionen und shigatoxin-a-untereinheitsregionen zur selektiven tötung von spezifischen zellarten
CN112851769A (zh) 2014-01-27 2021-05-28 分子模板公司 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
WO2015120058A2 (en) * 2014-02-05 2015-08-13 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
CN106604934A (zh) 2014-06-11 2017-04-26 分子模板公司 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子
EP3253799B1 (de) 2015-02-05 2020-12-02 Molecular Templates, Inc. Multivalente cd20-bindende moleküle mit shigatoxin-a-untereinheiteffektorregionen und angereicherte zusammensetzungen davon
EP3303373B1 (de) 2015-05-30 2020-04-08 Molecular Templates, Inc. Deimmunisierte shigatoxin-a-untereinheitsgerüste und zellgerichtete moleküle damit
KR20180030085A (ko) 2015-07-26 2018-03-21 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
WO2018106895A1 (en) 2016-12-07 2018-06-14 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
MX2019008840A (es) 2017-01-25 2019-09-09 Molecular Templates Inc Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+.
CN110612117B (zh) 2018-04-17 2024-04-12 分子模板公司 包含去免疫化的志贺毒素a亚基支架的her2靶向分子

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
US5047513A (en) 1986-07-10 1991-09-10 Hoffmann-La Roche Inc. Metal chelate resins
CA1340522C (en) 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB9109478D0 (en) * 1991-05-02 1991-06-26 Therapeutic Antibodies Inc Antivenoms
JP3398957B2 (ja) * 1991-12-24 2003-04-21 ザ・プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ Ｄｎａの特定部位の突然変異誘発
US5659123A (en) * 1994-08-26 1997-08-19 Plant Genetic Systems, N.V. Diabrotica toxins
US5869250A (en) * 1996-12-02 1999-02-09 The University Of North Carolina At Chapel Hill Method for the identification of peptides that recognize specific DNA sequences
US6086900A (en) 1997-03-26 2000-07-11 Board Of Regents, The University Of Texas Systems Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
US5888750A (en) 1997-05-30 1999-03-30 Synsorb Biotech, Inc. Method of recovering shiga-like toxins and vaccines comprising inactivated shiga-like toxin
US20020161203A1 (en) * 2000-08-14 2002-10-31 Sheppard Paul O. Rattlesnake venom gland proteins
US20030188326A1 (en) * 2000-11-03 2003-10-02 Dana Farber Cancer Institute Methods and compositions for the diagnosis of cancer susceptibilities and defective DNA repair mechanisms and treatment thereof

Also Published As

Publication number Publication date
WO1999040185A1 (en) 1999-08-12
US7713915B1 (en) 2010-05-11
DE69835695D1 (de) 2006-10-05
DE69835695T2 (de) 2007-08-23
CA2222993A1 (en) 1999-08-04
JP2002503453A (ja) 2002-02-05
AU769824B2 (en) 2004-02-05
EP1051482B1 (de) 2006-08-23
JP4339511B2 (ja) 2009-10-07
EP1051482A1 (de) 2000-11-15
AU1553099A (en) 1999-08-23

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