ATE467641T1 - Bibliothek von toxin mutanten und deren verwendung - Google Patents

Bibliothek von toxin mutanten und deren verwendung

Info

Publication number
ATE467641T1
ATE467641T1 AT04785852T AT04785852T ATE467641T1 AT E467641 T1 ATE467641 T1 AT E467641T1 AT 04785852 T AT04785852 T AT 04785852T AT 04785852 T AT04785852 T AT 04785852T AT E467641 T1 ATE467641 T1 AT E467641T1
Authority
AT
Austria
Prior art keywords
library
toxin mutants
mutants
toxin
libraries
Prior art date
Application number
AT04785852T
Other languages
English (en)
Inventor
Jean Gariepy
Xin Wei
Original Assignee
Molecular Templates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Application granted granted Critical
Publication of ATE467641T1 publication Critical patent/ATE467641T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04785852T 2004-03-26 2004-03-26 Bibliothek von toxin mutanten und deren verwendung ATE467641T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2004/000443 WO2005092917A1 (en) 2004-03-26 2004-03-26 Library of toxin mutants, and methods of using same

Publications (1)

Publication Number Publication Date
ATE467641T1 true ATE467641T1 (de) 2010-05-15

Family

ID=34957323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04785852T ATE467641T1 (de) 2004-03-26 2004-03-26 Bibliothek von toxin mutanten und deren verwendung

Country Status (9)

Country Link
US (1) US20070298434A1 (de)
EP (2) EP1727827B1 (de)
JP (1) JP4934761B2 (de)
AT (1) ATE467641T1 (de)
AU (1) AU2004317555B2 (de)
CA (1) CA2559536A1 (de)
DE (1) DE602004027168D1 (de)
ES (2) ES2344844T3 (de)
WO (1) WO2005092917A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1945660B1 (de) * 2005-09-26 2014-05-07 Molecular Templates, Inc. Bibliothek aus toxinmutanten und verfahren zu deren anwendung
WO2007071061A1 (en) * 2005-12-23 2007-06-28 Viventia Biotech Inc. Methods for generating and screening fusion protein libraries and uses thereof
EP3666795A1 (de) 2013-03-12 2020-06-17 Molecular Templates, Inc. Zytotoxische proteine mit zellgerichteten bindungsregionen und shigatoxin-a-untereinheitsregionen zur selektiven tötung von spezifischen zellarten
CN112851769A (zh) 2014-01-27 2021-05-28 分子模板公司 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
WO2015120058A2 (en) 2014-02-05 2015-08-13 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
CN106604934A (zh) 2014-06-11 2017-04-26 分子模板公司 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子
EP3253799B1 (de) 2015-02-05 2020-12-02 Molecular Templates, Inc. Multivalente cd20-bindende moleküle mit shigatoxin-a-untereinheiteffektorregionen und angereicherte zusammensetzungen davon
EP3303373B1 (de) 2015-05-30 2020-04-08 Molecular Templates, Inc. Deimmunisierte shigatoxin-a-untereinheitsgerüste und zellgerichtete moleküle damit
KR20180030085A (ko) 2015-07-26 2018-03-21 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
WO2018106895A1 (en) 2016-12-07 2018-06-14 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
MX2019008840A (es) 2017-01-25 2019-09-09 Molecular Templates Inc Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+.
CN110612117B (zh) 2018-04-17 2024-04-12 分子模板公司 包含去免疫化的志贺毒素a亚基支架的her2靶向分子
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
MX2022003195A (es) 2019-09-18 2022-04-11 Molecular Templates Inc Moleculas de union a pd-l1 que comprenden andamios de la subunidad a de la toxina shiga.
WO2021102445A1 (en) 2019-11-24 2021-05-27 Molecular Templates, Inc. Uses of cd20-binding molecules and additional therapeutic agents
EP4262858A1 (de) 2020-12-16 2023-10-25 Molecular Templates, Inc. Klinische verfahren zur verwendung eines pd-l1-bindenden moleküls mit einem shigatoxineffektor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5552144A (en) 1992-01-22 1996-09-03 Microcarb, Inc. Immunogenic shiga-like toxin II variant mutants
CA2218601A1 (en) * 1995-03-24 1996-10-03 Ophidian Pharmaceuticals, Inc. Treatment for verotoxin-producing escherichia coli
AU7023798A (en) * 1997-04-30 1998-11-24 De Novo Enzyme Corporation Ricin-like toxin variants for treatment of cancer, viral or parasitic infections
US7314632B1 (en) * 1997-07-11 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pseudomonas exotoxin A-like chimeric immunogens
CA2222993A1 (en) * 1998-02-04 1999-08-04 The Ontario Cancer Institute A method for using a ribosome-inactivating protein complex as a structural template and a molecular search engine in the design, construction and screening of combinatorial protein libraries
AU2001238501A1 (en) * 2000-02-16 2001-08-27 Bechtel Bwxt Idaho, Llc Selective destruction of cells infected with human immunodeficiency virus
WO2001068679A2 (en) * 2000-03-16 2001-09-20 University Of Pittsburgh Peptides targeting specifically tumor-derived endothelial cells
EP1945660B1 (de) * 2005-09-26 2014-05-07 Molecular Templates, Inc. Bibliothek aus toxinmutanten und verfahren zu deren anwendung

Also Published As

Publication number Publication date
CA2559536A1 (en) 2005-10-06
WO2005092917A1 (en) 2005-10-06
EP2228383B1 (de) 2012-05-23
AU2004317555A1 (en) 2005-10-06
EP1727827A1 (de) 2006-12-06
US20070298434A1 (en) 2007-12-27
EP1727827B1 (de) 2010-05-12
JP4934761B2 (ja) 2012-05-16
AU2004317555B2 (en) 2011-12-01
DE602004027168D1 (de) 2010-06-24
ES2344844T3 (es) 2010-09-08
JP2007531716A (ja) 2007-11-08
EP2228383A1 (de) 2010-09-15
ES2386338T3 (es) 2012-08-17

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