ATE338036T1 - Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate - Google Patents

Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate

Info

Publication number: ATE338036T1
Authority: AT; Austria
Prior art keywords: treatment; benzofuran; hyperproliferative diseases; benzothiophene derivatives; derivatives suitable
Prior art date: 2002-02-22

Application number

AT03709265T

Other languages

English (en)

Inventor

Chengzhi Zhang

Michael Burke

Zhi Chen

Jacques Dumas

Dongping Fan

Jianmei Fan

Holia Hatoum-Mokdad

Benjamin D Jones

Gaetan Ladouceur

Wendy Lee

Barton Phillips

Original Assignee

Bayer Pharmaceuticals Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-22

Filing date

2003-02-21

Publication date

2006-09-15

2003-02-21 Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE338036T1 publication Critical patent/ATE338036T1/de

Links

IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title abstract 4
FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title abstract 2
230000003463 hyperproliferative effect Effects 0.000 title abstract 2
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT03709265T 2002-02-22 2003-02-21 Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate ATE338036T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35901102P	2002-02-22	2002-02-22
US39988602P	2002-07-31	2002-07-31

Publications (1)

Publication Number	Publication Date
ATE338036T1 true ATE338036T1 (de)	2006-09-15

Family

ID=27767558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03709265T ATE338036T1 (de)	2002-02-22	2003-02-21	Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate

Country Status (23)

Country	Link
US (2)	US7351735B2 (de)
EP (2)	EP1487813B1 (de)
JP (3)	JP2005518446A (de)
KR (3)	KR100965021B1 (de)
CN (2)	CN1319961C (de)
AT (1)	ATE338036T1 (de)
AU (2)	AU2003213219B2 (de)
BR (2)	BR0307894A (de)
CA (2)	CA2474510C (de)
CO (1)	CO5611124A2 (de)
DE (1)	DE60307998T2 (de)
ES (1)	ES2271537T3 (de)
HK (2)	HK1080467B (de)
HR (1)	HRP20040874A2 (de)
HU (1)	HUP0600156A2 (de)
IL (2)	IL163026A (de)
MA (1)	MA27111A1 (de)
MX (2)	MXPA04007031A (de)
NO (1)	NO329185B1 (de)
NZ (1)	NZ534255A (de)
PL (2)	PL373373A1 (de)
RU (1)	RU2350609C2 (de)
WO (2)	WO2003072566A1 (de)

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US7329764B2 (en)	2003-07-31	2008-02-12	Boehringer Ingelheim Pharmaceuticals, Inc.	Substitute benzothiophene compounds
JP4709757B2 (ja) *	2003-08-07	2011-06-22	ニツポネツクス・インコーポレーテツド	過剰増殖性障害の処置に有用なベンゾフラン誘導体
JP4557984B2 (ja) *	2003-12-05	2010-10-06	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	Ｉｋｋインヒビターとしての置換３−アミノ−チエノ−［２，３−ｂ］ピリジン−２−カルボン酸アミド化合物
JP4805166B2 (ja) *	2003-12-22	2011-11-02	バジリアファルマスーチカアーゲー	アロイルフランおよびアロイルチオフェン
WO2005087778A1 (en) *	2004-02-16	2005-09-22	Bayer Pharmaceuticals Corporation	Tricyclic furopyridine derivatives useful in the treatment of hyper-proliferative disorders
US7449481B2 (en)	2004-04-13	2008-11-11	Cephalon, Inc.	Thio-substituted biaryl-methanesulfinyl derivatives
JP5049124B2 (ja) *	2004-07-09	2012-10-17	メディスィンテクノロジーズ，インコーポレイテッド	治療化合物および処置
WO2006036031A1 (ja) *	2004-09-30	2006-04-06	Takeda Pharmaceutical Company Limited	縮合フラン誘導体およびその用途
CA2653654A1 (en)	2006-06-06	2007-12-21	Boehringer Ingelheim International Gmbh	Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use
CA2666469A1 (en) *	2006-09-01	2008-03-06	Bayer Healthcare Ag	Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system
US8173666B2 (en)	2007-03-12	2012-05-08	Nektar Therapeutics	Oligomer-opioid agonist conjugates
US10512644B2 (en)	2007-03-12	2019-12-24	Inheris Pharmaceuticals, Inc.	Oligomer-opioid agonist conjugates
AU2008226822B2 (en) *	2007-03-12	2013-08-01	Nektar Therapeutics	Oligomer-opioid agonist conjugates
AU2011202542A1 (en)	2010-07-14	2012-02-02	Indian Institute Of Science	Benzothiophene carboxamide compounds, composition and applications thereof
WO2012011314A1 (ja)	2010-07-22	2012-01-26	扶桑薬品工業株式会社	ベンゾフラノン化合物およびそれを含む医薬組成物
SG11202003807RA (en)	2017-11-03	2020-05-28	Univ Montreal	Compounds and use thereof in the expansion of stem cells and/or progenitor cells
SG11202106124UA (en)	2018-12-20	2021-07-29	Life Technologies Corp	Modified rhodamine dye and use thereof in biological assays
CN112574189B (zh) *	2019-09-27	2024-05-31	海创药业股份有限公司	一种ep300/cbp抑制剂
CN113173928B (zh) *	2021-04-25	2022-05-27	武汉国粹医药科技有限公司	萜类化合物、其制备方法和其应用以及抗菌剂
US20250145637A1 (en) *	2021-08-10	2025-05-08	Jiangsu Hengrui Pharmaceuticals Co. Ltd.	Sulfonamide derivative, preparation method therefor and medical use thereof
CN116621859A (zh) *	2022-02-18	2023-08-22	山东轩竹医药科技有限公司	三并环类kat6抑制剂

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JPS6072880A (ja) *	1983-09-29	1985-04-24	Kaken Pharmaceut Co Ltd	ベンゾフラン誘導体およびその製造法
GB9200623D0 (en)	1992-01-13	1992-03-11	Bayer Ag	Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives
GB9309324D0 (en) *	1993-05-06	1993-06-16	Bayer Ag	Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
ES2127966T3 (es) *	1994-05-31	1999-05-01	Bayer Ag	Derivados de amino-benzofurilo y -benzotienilo.
HRP950288A2 (en) *	1994-05-31	1997-08-31	Bayer Ag	Oxalylamino-benzofuran- and benzothienyl-derivatives
GB9410877D0 (en) *	1994-05-31	1994-07-20	Bayer Ag	Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives
US5466810A (en) *	1994-06-10	1995-11-14	Eli Lilly And Company	2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
GB9504460D0 (en) *	1995-03-06	1995-04-26	Bayer Ag	N-(3-Benzofuranyl)urea-derivatives
DE19527568A1 (de) *	1995-07-28	1997-01-30	Merck Patent Gmbh	Endothelin-Rezeptor-Antagonisten
GB9525262D0 (en) *	1995-12-11	1996-02-07	Bayer Ag	Heterocyclylcarbonyl substituted benzofuranyl-ureas
CN1211977A (zh) *	1996-02-19	1999-03-24	明治制果株式会社	新的四氢萘并呋喃酮衍生物及其制备方法
EP0801066A1 (de)	1996-03-12	1997-10-15	Eli Lilly And Company	Heterozyklisch substituierte Benzothiophene und pharmazeutische Zusammensetzungen
US5688796A (en) *	1996-03-12	1997-11-18	Eli Lilly And Company	Heterocyclic substituted benzothiophenes, compositions, and methods
GB9614718D0 (en)	1996-07-12	1996-09-04	Bayer Ag	3-ureido-pyridofurans and -pyridothiophenes
GB2350109A (en)	1999-05-17	2000-11-22	Bayer Ag	Pharmaceutically active benzofuranyl sulfonates
GB2350111A (en)	1999-05-17	2000-11-22	Bayer Ag	Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
GB2350112A (en)	1999-05-17	2000-11-22	Bayer Ag	Pharmaceutically active cycloalkyl ketones
GB2350110A (en)	1999-05-17	2000-11-22	Bayer Ag	Pharmaceutically active benzofurans

2003
- 2003-02-21 KR KR1020047013061A patent/KR100965021B1/ko not_active Expired - Fee Related
- 2003-02-21 BR BR0307894-9A patent/BR0307894A/pt not_active IP Right Cessation
- 2003-02-21 KR KR1020107004368A patent/KR20100029280A/ko not_active Ceased
- 2003-02-21 US US10/501,689 patent/US7351735B2/en not_active Expired - Fee Related
- 2003-02-21 KR KR10-2004-7013069A patent/KR20040094720A/ko not_active Ceased
- 2003-02-21 HU HU0600156A patent/HUP0600156A2/hu unknown
- 2003-02-21 WO PCT/US2003/005395 patent/WO2003072566A1/en not_active Ceased
- 2003-02-21 JP JP2003571272A patent/JP2005518446A/ja active Pending
- 2003-02-21 AU AU2003213219A patent/AU2003213219B2/en not_active Ceased
- 2003-02-21 AT AT03709265T patent/ATE338036T1/de not_active IP Right Cessation
- 2003-02-21 RU RU2004128393/04A patent/RU2350609C2/ru not_active IP Right Cessation
- 2003-02-21 EP EP03709265A patent/EP1487813B1/de not_active Expired - Lifetime
- 2003-02-21 ES ES03709265T patent/ES2271537T3/es not_active Expired - Lifetime
- 2003-02-21 EP EP03711205A patent/EP1478639A1/de not_active Withdrawn
- 2003-02-21 CN CNB038044420A patent/CN1319961C/zh not_active Expired - Fee Related
- 2003-02-21 WO PCT/US2003/005396 patent/WO2003072561A1/en not_active Ceased
- 2003-02-21 PL PL03373373A patent/PL373373A1/xx not_active Application Discontinuation
- 2003-02-21 BR BRPI0307905-8A patent/BR0307905A/pt not_active IP Right Cessation
- 2003-02-21 DE DE60307998T patent/DE60307998T2/de not_active Expired - Lifetime
- 2003-02-21 NZ NZ534255A patent/NZ534255A/en not_active IP Right Cessation
- 2003-02-21 MX MXPA04007031A patent/MXPA04007031A/es active IP Right Grant
- 2003-02-21 AU AU2003215380A patent/AU2003215380B2/en not_active Ceased
- 2003-02-21 CN CNA038044366A patent/CN1639146A/zh active Pending
- 2003-02-21 CA CA002474510A patent/CA2474510C/en not_active Expired - Fee Related
- 2003-02-21 MX MXPA04007391A patent/MXPA04007391A/es active IP Right Grant
- 2003-02-21 CA CA002474511A patent/CA2474511C/en not_active Expired - Fee Related
- 2003-02-21 PL PL03372179A patent/PL372179A1/xx not_active Application Discontinuation
- 2003-02-21 JP JP2003571267A patent/JP2006507215A/ja not_active Withdrawn
- 2003-02-21 HR HR20040874A patent/HRP20040874A2/hr not_active Application Discontinuation
- 2003-02-21 HK HK06100208.2A patent/HK1080467B/zh not_active IP Right Cessation
- 2003-02-21 HK HK06100207.3A patent/HK1080466A1/zh unknown
2004
- 2004-07-15 IL IL163026A patent/IL163026A/en not_active IP Right Cessation
- 2004-07-15 IL IL163027A patent/IL163027A/en not_active IP Right Cessation
- 2004-09-15 CO CO04091831A patent/CO5611124A2/es not_active Application Discontinuation
- 2004-09-21 NO NO20043952A patent/NO329185B1/no not_active IP Right Cessation
- 2004-09-22 MA MA27873A patent/MA27111A1/fr unknown
2008
- 2008-03-31 US US12/059,984 patent/US7585888B2/en not_active Expired - Fee Related
2010
- 2010-06-17 JP JP2010138437A patent/JP5153830B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2003215380B2 (en)	2008-10-02
JP2005518446A (ja)	2005-06-23
KR20040096600A (ko)	2004-11-16
NO20043952L (no)	2004-10-22
HK1080467B (zh)	2008-02-01
BR0307905A (pt)	2006-04-04
AU2003213219A1 (en)	2003-09-09
US20050139814A1 (en)	2005-06-30
CN1639146A (zh)	2005-07-13
US7351735B2 (en)	2008-04-01
HUP0600156A2 (en)	2006-06-28
EP1478639A1 (de)	2004-11-24
JP5153830B2 (ja)	2013-02-27
DE60307998D1 (de)	2006-10-12
JP2010229152A (ja)	2010-10-14
CN1319961C (zh)	2007-06-06
MXPA04007031A (es)	2004-10-11
US20090054514A1 (en)	2009-02-26
EP1487813B1 (de)	2006-08-30
CO5611124A2 (es)	2006-02-28
IL163026A (en)	2009-09-01
PL372179A1 (en)	2005-07-11
CA2474510C (en)	2009-11-03
RU2004128393A (ru)	2005-05-10
JP2006507215A (ja)	2006-03-02
KR20040094720A (ko)	2004-11-10
HK1080467A1 (en)	2006-04-28
CA2474511C (en)	2008-07-22
CA2474510A1 (en)	2003-09-04
KR100965021B1 (ko)	2010-06-21
PL373373A1 (en)	2005-08-22
AU2003213219B2 (en)	2009-02-26
HRP20040874A2 (en)	2006-05-31
BR0307894A (pt)	2004-12-07
WO2003072566A1 (en)	2003-09-04
IL163027A (en)	2009-07-20
MXPA04007391A (es)	2004-10-11
AU2003215380A1 (en)	2003-09-09
RU2350609C2 (ru)	2009-03-27
DE60307998T2 (de)	2007-04-05
EP1487813A1 (de)	2004-12-22
KR20100029280A (ko)	2010-03-16
US7585888B2 (en)	2009-09-08
ES2271537T3 (es)	2007-04-16
MA27111A1 (fr)	2004-12-20
CA2474511A1 (en)	2003-09-04
NZ534255A (en)	2007-06-29
CN1639145A (zh)	2005-07-13
HK1080466A1 (zh)	2006-04-28
NO329185B1 (no)	2010-09-06
WO2003072561A1 (en)	2003-09-04

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Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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