ATE423780T1 - Makrozyclen zur behandlung von krebserkrankungen - Google Patents

Makrozyclen zur behandlung von krebserkrankungen

Info

Publication number
ATE423780T1
ATE423780T1 AT03763870T AT03763870T ATE423780T1 AT E423780 T1 ATE423780 T1 AT E423780T1 AT 03763870 T AT03763870 T AT 03763870T AT 03763870 T AT03763870 T AT 03763870T AT E423780 T1 ATE423780 T1 AT E423780T1
Authority
AT
Austria
Prior art keywords
treatment
macrocycles
cancer diseases
cancer
diseases
Prior art date
Application number
AT03763870T
Other languages
English (en)
Inventor
Gerhard Hoefle
Wolfgang Richter
Original Assignee
Biotechnolog Forschung Gmbh
Wolfgang Richter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10232094A external-priority patent/DE10232094A1/de
Priority claimed from DE10255660A external-priority patent/DE10255660A1/de
Application filed by Biotechnolog Forschung Gmbh, Wolfgang Richter filed Critical Biotechnolog Forschung Gmbh
Application granted granted Critical
Publication of ATE423780T1 publication Critical patent/ATE423780T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26Radicals substituted by sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03763870T 2002-07-15 2003-07-15 Makrozyclen zur behandlung von krebserkrankungen ATE423780T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10232094A DE10232094A1 (de) 2002-07-15 2002-07-15 5-Thiaepothilone und 15-disubstituierte Epothilone
DE10255660A DE10255660A1 (de) 2002-11-28 2002-11-28 Neue Makrocyclen zur Behandlung von Krebserkrankungen

Publications (1)

Publication Number Publication Date
ATE423780T1 true ATE423780T1 (de) 2009-03-15

Family

ID=30116646

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03763870T ATE423780T1 (de) 2002-07-15 2003-07-15 Makrozyclen zur behandlung von krebserkrankungen

Country Status (10)

Country Link
US (1) US7553859B2 (de)
EP (1) EP1521752B1 (de)
JP (1) JP4597667B2 (de)
AT (1) ATE423780T1 (de)
AU (1) AU2003252540B2 (de)
CA (1) CA2491943C (de)
DE (1) DE60326348D1 (de)
DK (1) DK1521752T3 (de)
ES (1) ES2323956T3 (de)
WO (1) WO2004007492A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1567524B1 (de) * 2002-11-28 2009-07-22 Wolfgang Richter Thia-epothilon derivate zur krebsbehandlung
CN104116736A (zh) 2008-04-24 2014-10-29 百时美施贵宝公司 埃坡霉素D在治疗包括阿尔茨海默病的τ相关疾病中的用途
EP2394640A1 (de) 2010-05-21 2011-12-14 MediGene AG Verbesserte liposomale Formulierungen von lipophilen Verbindungen
EP2708243A1 (de) 2012-09-17 2014-03-19 OntoChem GmbH Rezeptor-Ligand-verbundene zytotoxische Moleküle

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001243372A1 (en) * 2000-03-01 2001-09-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6699997B2 (en) * 2000-06-28 2004-03-02 Teva Pharmaceutical Industries Ltd. Carvedilol
EP1567524B1 (de) * 2002-11-28 2009-07-22 Wolfgang Richter Thia-epothilon derivate zur krebsbehandlung

Also Published As

Publication number Publication date
US7553859B2 (en) 2009-06-30
JP2005537263A (ja) 2005-12-08
DK1521752T3 (da) 2009-06-22
AU2003252540B2 (en) 2008-11-20
EP1521752B1 (de) 2009-02-25
AU2003252540A1 (en) 2004-02-02
US20060004065A1 (en) 2006-01-05
CA2491943C (en) 2012-06-19
EP1521752A1 (de) 2005-04-13
ES2323956T3 (es) 2009-07-28
DE60326348D1 (de) 2009-04-09
JP4597667B2 (ja) 2010-12-15
WO2004007492A1 (de) 2004-01-22
CA2491943A1 (en) 2004-01-22

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