ATE338044T1 - Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte - Google Patents

Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte

Info

Publication number: ATE338044T1
Authority: AT; Austria
Prior art keywords: quinoline; imidazoc4; production; intermediate products; amines via
Prior art date: 2002-07-23

Application number

AT03766003T

Other languages

English (en)

Inventor

Valeriano Merli

Silvia Mantovani

Stefano Bianchi

Original Assignee

Teva Gyogyszergyar Zartkoeruen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-23

Filing date

2003-07-23

Publication date

2006-09-15

2003-07-23 Application filed by Teva Gyogyszergyar Zartkoeruen filed Critical Teva Gyogyszergyar Zartkoeruen

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE338044T1 publication Critical patent/ATE338044T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 3
HQBUPOAKJGJGCD-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinolin-4-amine Chemical class NC1=NC2=CC=CC=C2C2=C1N=CN2 HQBUPOAKJGJGCD-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
OJLIXSLFKYPKRR-UHFFFAOYSA-N 4-(3h-imidazo[4,5-c]quinolin-4-yl)isoindole-1,3-dione Chemical compound O=C1NC(=O)C2=C1C=CC=C2C1=NC2=CC=CC=C2C2=C1NC=N2 OJLIXSLFKYPKRR-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 abstract 1
229960002751 imiquimod Drugs 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Virology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03766003T 2002-07-23 2003-07-23 Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte ATE338044T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39760702P	2002-07-23	2002-07-23

Publications (1)

Publication Number	Publication Date
ATE338044T1 true ATE338044T1 (de)	2006-09-15

Family

ID=30771087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03766003T ATE338044T1 (de)	2002-07-23	2003-07-23	Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte

Country Status (17)

Country	Link
US (3)	US6852861B2 (de)
EP (1)	EP1543002B1 (de)
JP (1)	JP2006502121A (de)
KR (1)	KR20050028047A (de)
CN (1)	CN1315828C (de)
AT (1)	ATE338044T1 (de)
AU (1)	AU2003259226A1 (de)
CA (1)	CA2493227A1 (de)
DE (1)	DE60308040T2 (de)
DK (1)	DK1543002T3 (de)
ES (1)	ES2271650T3 (de)
HR (1)	HRP20050159A2 (de)
IL (1)	IL166309A (de)
MX (1)	MXPA05000893A (de)
PL (1)	PL374884A1 (de)
PT (1)	PT1543002E (de)
WO (1)	WO2004009593A1 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
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EP1668010A2 (de) *	2003-10-01	2006-06-14	Taro Pharmaceuticals U.S.A., Inc.	Verfahren zur herstellung von 4-amino-1h-imidazo[4,5-c]chinolinen und säureadditionssalzen davon
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US7544697B2 (en) *	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
AR046046A1 (es) *	2003-10-03	2005-11-23	3M Innovative Properties Co	Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
US20090075980A1 (en) *	2003-10-03	2009-03-19	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and Analogs Thereof
CA2545825A1 (en)	2003-11-14	2005-06-02	3M Innovative Properties Company	Hydroxylamine substituted imidazo ring compounds
US7897767B2 (en) *	2003-11-14	2011-03-01	3M Innovative Properties Company	Oxime substituted imidazoquinolines
MXPA06005910A (es)	2003-11-25	2006-08-23	3M Innovative Properties Co	Sistemas de anillo imidazo sustituido y metodos.
EP1686992A4 (de) *	2003-11-25	2009-11-04	3M Innovative Properties Co	Hydroxylamin- und oxim-substituierte imidazochinoline, imidazopyridine und imidazonaphthyridine
JP2007513170A (ja) *	2003-12-04	2007-05-24	スリーエムイノベイティブプロパティズカンパニー	スルホン置換イミダゾ環エーテル
US7888349B2 (en) *	2003-12-29	2011-02-15	3M Innovative Properties Company	Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds
EP1701955A1 (de) *	2003-12-29	2006-09-20	3M Innovative Properties Company	Arylalkenyl- und arylalkinylsubstituierte imidazochinoline
WO2005066169A2 (en) *	2003-12-30	2005-07-21	3M Innovative Properties Company	Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
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US20080015184A1 (en) *	2004-06-14	2008-01-17	3M Innovative Properties Company	Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines
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US8541438B2 (en) *	2004-06-18	2013-09-24	3M Innovative Properties Company	Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
US8026366B2 (en) *	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
EP1765348B1 (de) *	2004-06-18	2016-08-03	3M Innovative Properties Company	Substituierte imidazochinoline, imidazopyridine sowie imidazonaphthyridine
WO2006065280A2 (en) *	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US7897609B2 (en)	2004-06-18	2011-03-01	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
WO2006026760A2 (en) *	2004-09-02	2006-03-09	3M Innovative Properties Company	1-amino imidazo-containing compounds and methods
US7579359B2 (en) *	2004-09-02	2009-08-25	3M Innovative Properties Company	1-alkoxy 1H-imidazo ring systems and methods
US8143270B2 (en)	2004-09-02	2012-03-27	3M Innovative Properties Company	2-amino 1H-in-imidazo ring systems and methods
WO2006042254A2 (en) *	2004-10-08	2006-04-20	3M Innovative Properties Company	Adjuvant for dna vaccines
EP1819364A4 (de) *	2004-12-08	2010-12-29	3M Innovative Properties Co	Immunmodulatorische zusammensetzungen, kombinationen und verfahren
WO2006070379A1 (en) *	2004-12-27	2006-07-06	Usv Limited	A process for preparation of 4-amino-1-isobutyl-1h-imidazo[4,5-c]-quinoline (imiquimod)
JP5543068B2 (ja) *	2004-12-30	2014-07-09	スリーエムイノベイティブプロパティズカンパニー	キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
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US8436176B2 (en) *	2004-12-30	2013-05-07	Medicis Pharmaceutical Corporation	Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine
BRPI0519302A2 (pt) *	2004-12-30	2009-01-06	Takeda Pharmaceutical	etanossulfonato de sais de 1-(2-metilpropil)-1h-imidazo[4,5-c][1,5]naftiridin-4-amin o e metanossulfonato de 1-(2-metilpropil)-1h-imidazo[4,5-c][1,5]naftiridin-4-amin a, composiÇÕes contendo os mesmos, processos de preparaÇço e uso
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WO2007120121A2 (en)	2005-02-09	2007-10-25	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted thiazolo[4,5-c] ring compounds and methods
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US8658666B2 (en) *	2005-02-11	2014-02-25	3M Innovative Properties Company	Substituted imidazoquinolines and imidazonaphthyridines
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AU2006216686A1 (en) *	2005-02-23	2006-08-31	Coley Pharmaceutical Group, Inc.	Method of preferentially inducing the biosynthesis of interferon
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JP2008538550A (ja)	2005-04-01	2008-10-30	コーリーファーマシューティカルグループ，インコーポレイテッド	ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
US7943610B2 (en)	2005-04-01	2011-05-17	3M Innovative Properties Company	Pyrazolopyridine-1,4-diamines and analogs thereof
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CA2621831A1 (en) *	2005-09-09	2007-03-15	Coley Pharmaceutical Group, Inc.	Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods
ZA200803029B (en) *	2005-09-09	2009-02-25	Coley Pharm Group Inc	Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
JP5247458B2 (ja) *	2005-11-04	2013-07-24	スリーエム・イノベイティブ・プロパティーズ・カンパニー	ヒドロキシ及びアルコキシ置換１ｈ−イミダゾキノリン及び方法
EP1988896A4 (de)	2006-02-22	2011-07-27	3M Innovative Properties Co	Konjugate zur modifizierung von immunreaktionen
US8329721B2 (en) *	2006-03-15	2012-12-11	3M Innovative Properties Company	Hydroxy and alkoxy substituted 1H-imidazonaphthyridines and methods
WO2008008432A2 (en) *	2006-07-12	2008-01-17	Coley Pharmaceutical Group, Inc.	Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
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EP1966205A2 (de) *	2006-10-16	2008-09-10	Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság	Erstellung von 1h-imidazo[4,5-c]quinolin-4-aminen mithilfe von 1h-imidazo[4,5-c]quinolin-4-phthalimid-vermittlern
US20080149123A1 (en)	2006-12-22	2008-06-26	Mckay William D	Particulate material dispensing hairbrush with combination bristles
CA2808624C (en)	2010-08-17	2019-05-14	3M Innovative Properties Company	Lipidated immune response modifier compound compositions, formulations, and methods
CA2838158C (en)	2011-06-03	2019-07-16	3M Innovative Properties Company	Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
EP3366311B1 (de)	2011-06-03	2020-02-26	3M Innovative Properties Co.	Hydrazino-1h-imidazochinolin-4-amine und daraus hergestellte konjugate
CA3086439A1 (en)	2017-12-20	2019-06-27	3M Innovative Properties Company	Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier

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2003
- 2003-07-23 JP JP2004523380A patent/JP2006502121A/ja active Pending
- 2003-07-23 AT AT03766003T patent/ATE338044T1/de not_active IP Right Cessation
- 2003-07-23 WO PCT/US2003/023153 patent/WO2004009593A1/en not_active Ceased
- 2003-07-23 MX MXPA05000893A patent/MXPA05000893A/es unknown
- 2003-07-23 CA CA002493227A patent/CA2493227A1/en not_active Abandoned
- 2003-07-23 EP EP03766003A patent/EP1543002B1/de not_active Expired - Lifetime
- 2003-07-23 PL PL03374884A patent/PL374884A1/xx unknown
- 2003-07-23 DE DE60308040T patent/DE60308040T2/de not_active Expired - Fee Related
- 2003-07-23 HR HR20050159A patent/HRP20050159A2/hr not_active Application Discontinuation
- 2003-07-23 US US10/626,036 patent/US6852861B2/en not_active Expired - Fee Related
- 2003-07-23 AU AU2003259226A patent/AU2003259226A1/en not_active Abandoned
- 2003-07-23 CN CNB038219174A patent/CN1315828C/zh not_active Expired - Fee Related
- 2003-07-23 PT PT03766003T patent/PT1543002E/pt unknown
- 2003-07-23 DK DK03766003T patent/DK1543002T3/da active
- 2003-07-23 ES ES03766003T patent/ES2271650T3/es not_active Expired - Lifetime
- 2003-07-23 KR KR1020057001185A patent/KR20050028047A/ko not_active Ceased
2004
- 2004-12-23 US US11/023,021 patent/US7153967B2/en not_active Expired - Fee Related
2005
- 2005-01-14 IL IL166309A patent/IL166309A/en not_active IP Right Cessation
2006
- 2006-11-15 US US11/600,673 patent/US20070060755A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2003259226A1 (en)	2004-02-09
US20070060755A1 (en)	2007-03-15
DK1543002T3 (da)	2006-12-27
EP1543002B1 (de)	2006-08-30
KR20050028047A (ko)	2005-03-21
MXPA05000893A (es)	2005-09-30
US20050113404A1 (en)	2005-05-26
CA2493227A1 (en)	2004-01-29
US7153967B2 (en)	2006-12-26
WO2004009593A1 (en)	2004-01-29
ES2271650T3 (es)	2007-04-16
DE60308040D1 (de)	2006-10-12
CN1681814A (zh)	2005-10-12
US6852861B2 (en)	2005-02-08
IL166309A (en)	2010-04-15
IL166309A0 (en)	2006-01-15
HRP20050159A2 (en)	2005-08-31
EP1543002A1 (de)	2005-06-22
PL374884A1 (en)	2005-11-14
PT1543002E (pt)	2006-11-30
JP2006502121A (ja)	2006-01-19
CN1315828C (zh)	2007-05-16
US20040138459A1 (en)	2004-07-15
DE60308040T2 (de)	2007-04-19

Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE338044T1 (de)	2006-09-15	Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte
ATE339512T1 (de)	2006-10-15	Galactosyl-isomalt, verfahren zu seiner herstellung und verwendung
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