ATE338044T1 - Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte - Google Patents

Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte

Info

Publication number: ATE338044T1
Authority: AT; Austria
Prior art keywords: quinoline; imidazoc4; production; intermediate products; amines via
Prior art date: 2002-07-23

Application number

AT03766003T

Other languages

English (en)

Inventor

Valeriano Merli

Silvia Mantovani

Stefano Bianchi

Original Assignee

Teva Gyogyszergyar Zartkoeruen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-23

Filing date

2003-07-23

Publication date

2006-09-15

2003-07-23 Application filed by Teva Gyogyszergyar Zartkoeruen filed Critical Teva Gyogyszergyar Zartkoeruen

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE338044T1 publication Critical patent/ATE338044T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 3
HQBUPOAKJGJGCD-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinolin-4-amine Chemical class NC1=NC2=CC=CC=C2C2=C1N=CN2 HQBUPOAKJGJGCD-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
OJLIXSLFKYPKRR-UHFFFAOYSA-N 4-(3h-imidazo[4,5-c]quinolin-4-yl)isoindole-1,3-dione Chemical compound O=C1NC(=O)C2=C1C=CC=C2C1=NC2=CC=CC=C2C2=C1NC=N2 OJLIXSLFKYPKRR-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 abstract 1
229960002751 imiquimod Drugs 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03766003T 2002-07-23 2003-07-23 Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte ATE338044T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39760702P	2002-07-23	2002-07-23

Publications (1)

Publication Number	Publication Date
ATE338044T1 true ATE338044T1 (de)	2006-09-15

Family

ID=30771087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03766003T ATE338044T1 (de)	2002-07-23	2003-07-23	Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte

Country Status (17)

Country	Link
US (3)	US6852861B2 (de)
EP (1)	EP1543002B1 (de)
JP (1)	JP2006502121A (de)
KR (1)	KR20050028047A (de)
CN (1)	CN1315828C (de)
AT (1)	ATE338044T1 (de)
AU (1)	AU2003259226A1 (de)
CA (1)	CA2493227A1 (de)
DE (1)	DE60308040T2 (de)
DK (1)	DK1543002T3 (de)
ES (1)	ES2271650T3 (de)
HR (1)	HRP20050159A2 (de)
IL (1)	IL166309A (de)
MX (1)	MXPA05000893A (de)
PL (1)	PL374884A1 (de)
PT (1)	PT1543002E (de)
WO (1)	WO2004009593A1 (de)

Families Citing this family (65)

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RU2006105101A (ru) *	2003-08-27	2007-10-10	3М Инновейтив Пропертиз Компани (US)	Арилокси и арилалкиленокси замещенные имидазохинолины
WO2005023190A2 (en)	2003-09-05	2005-03-17	3M Innovative Properties Company	Treatment for cd5+ b cell lymphoma
WO2005033049A2 (en)	2003-10-01	2005-04-14	Taro Pharmaceuticals U.S.A., Inc.	METHOD OF PREPARING 4-AMINO-1H-IMIDAZO(4,5-c)QUINOLINES AND ACID ADDITION SALTS THEREOF
AR046172A1 (es)	2003-10-03	2005-11-30	3M Innovative Properties Co	Pirazolopiridinas y sus analogos; composiciones farmaceuticas que los contienen y su uso en la inhibicion de la biosintesis de citocinas
US20090075980A1 (en) *	2003-10-03	2009-03-19	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and Analogs Thereof
US7544697B2 (en) *	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
US8871782B2 (en)	2003-10-03	2014-10-28	3M Innovative Properties Company	Alkoxy substituted imidazoquinolines
CA2545774A1 (en) *	2003-11-14	2005-06-02	3M Innovative Properties Company	Oxime substituted imidazo ring compounds
US8598192B2 (en)	2003-11-14	2013-12-03	3M Innovative Properties Company	Hydroxylamine substituted imidazoquinolines
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AR046781A1 (es)	2003-11-25	2005-12-21	3M Innovative Properties Co	Derivados de imidazoquinolinas. composiciones farmaceuticas.
EP1694674A4 (de) *	2003-12-04	2010-07-07	3M Innovative Properties Co	Sulfonsubstituierte imidazoringether
WO2005066170A1 (en) *	2003-12-29	2005-07-21	3M Innovative Properties Company	Arylalkenyl and arylalkynyl substituted imidazoquinolines
EP1699792A1 (de) *	2003-12-29	2006-09-13	3M Innovative Properties Company	Piperazin-, [1,4]diazepan-, [1,4]diazocan- und [1,5]diazocan-kondensierte imidazoringverbindungen
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AU2005228150A1 (en) *	2004-03-24	2005-10-13	3M Innovative Properties Company	Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US20080015184A1 (en) *	2004-06-14	2008-01-17	3M Innovative Properties Company	Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines
WO2005123080A2 (en)	2004-06-15	2005-12-29	3M Innovative Properties Company	Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8541438B2 (en) *	2004-06-18	2013-09-24	3M Innovative Properties Company	Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
EP1765348B1 (de) *	2004-06-18	2016-08-03	3M Innovative Properties Company	Substituierte imidazochinoline, imidazopyridine sowie imidazonaphthyridine
WO2006038923A2 (en) *	2004-06-18	2006-04-13	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
US8026366B2 (en) *	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) *	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
CA2578975A1 (en)	2004-09-02	2006-03-16	3M Innovative Properties Company	2-amino 1h imidazo ring systems and methods
US20090270443A1 (en) *	2004-09-02	2009-10-29	Doris Stoermer	1-amino imidazo-containing compounds and methods
WO2006028962A2 (en) *	2004-09-02	2006-03-16	3M Innovative Properties Company	1-alkoxy 1h-imidazo ring systems and methods
JP2008515928A (ja) *	2004-10-08	2008-05-15	スリーエムイノベイティブプロパティズカンパニー	Ｄｎａワクチンのためのアジュバント
EP1819364A4 (de) *	2004-12-08	2010-12-29	3M Innovative Properties Co	Immunmodulatorische zusammensetzungen, kombinationen und verfahren
EP1831214A1 (de) *	2004-12-27	2007-09-12	Usv Limited	Verfahren zur herstellung von 4-amino-1-isobutyl-1h-imidazo[4,5-c]chinolin (imiquimod)
EP1831226B1 (de)	2004-12-30	2012-08-08	3M Innovative Properties Company	Chirale tetracyklische verbindungen, die interferon biosyntheze induzieren
US8436176B2 (en) *	2004-12-30	2013-05-07	Medicis Pharmaceutical Corporation	Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine
KR20070107685A (ko) *	2004-12-30	2007-11-07	다케다 야쿠힌 고교 가부시키가이샤	１-(２-메틸프로필)-１Ｈ-이미다조[４,５-ｃ][１,５]나프티리딘-４-아민 에탄술포네이트 및１-(２-메틸프로필)-１Ｈ-이미다조[４,５-ｃ][１,５]나프티리딘-４-아민 메탄술포네이트
JP2008526765A (ja) *	2004-12-30	2008-07-24	スリーエムイノベイティブプロパティズカンパニー	皮膚転移の処置
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AU2006210392A1 (en) *	2005-02-04	2006-08-10	Coley Pharmaceutical Group, Inc.	Aqueous gel formulations containing immune response modifiers
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AU2006212765B2 (en) *	2005-02-09	2012-02-02	3M Innovative Properties Company	Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines
JP2008532933A (ja) *	2005-02-11	2008-08-21	コーリーファーマシューティカルグループ，インコーポレイテッド	置換イミダゾキノリン類および置換イミダゾナフチリジン類
CA2597587A1 (en)	2005-02-11	2006-08-17	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
EP1850849A2 (de) *	2005-02-23	2007-11-07	Coley Pharmaceutical Group, Inc.	Verfahren zur vorzugsweisen herbeiführung der biosynthese von interferon
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US8158794B2 (en) *	2005-02-23	2012-04-17	3M Innovative Properties Company	Hydroxyalkyl substituted imidazoquinoline compounds and methods
EP1851224A2 (de) *	2005-02-23	2007-11-07	3M Innovative Properties Company	Hydroxyalkyl-substituierte imidazochinoline
WO2006107853A2 (en)	2005-04-01	2006-10-12	Coley Pharmaceutical Group, Inc.	Pyrazolopyridine-1,4-diamines and analogs thereof
US7943636B2 (en)	2005-04-01	2011-05-17	3M Innovative Properties Company	1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
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AU2006287270A1 (en) *	2005-09-09	2007-03-15	Coley Pharmaceutical Group, Inc.	Amide and carbamate derivatives of N-{2-[4-amino-2- (ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods
ZA200803029B (en) *	2005-09-09	2009-02-25	Coley Pharm Group Inc	Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
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US8329721B2 (en) *	2006-03-15	2012-12-11	3M Innovative Properties Company	Hydroxy and alkoxy substituted 1H-imidazonaphthyridines and methods
US7906506B2 (en)	2006-07-12	2011-03-15	3M Innovative Properties Company	Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8178539B2 (en) *	2006-09-06	2012-05-15	3M Innovative Properties Company	Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods
EP1966205A2 (de) *	2006-10-16	2008-09-10	Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság	Erstellung von 1h-imidazo[4,5-c]quinolin-4-aminen mithilfe von 1h-imidazo[4,5-c]quinolin-4-phthalimid-vermittlern
US20080149123A1 (en)	2006-12-22	2008-06-26	Mckay William D	Particulate material dispensing hairbrush with combination bristles
DK2606047T3 (en)	2010-08-17	2017-03-27	3M Innovative Properties Co	COMPOSITIONS AND FORMULATIONS WITH LIPIDIZED IMMUNE RESPONSE-MODIFIING COMPOUND AND PROCEDURES THEREOF
BR112013031028A2 (pt)	2011-06-03	2016-11-29	3M Innovative Properties Co	conectores heterobifuncionais com segmentos de polietileno glicol e conjugados de modificadores de resposta imunológica feitos a partir deles
EP3153180A1 (de)	2011-06-03	2017-04-12	3M Innovative Properties Company	Heterobifunktionale binder mit polyethylenglykolsegmenten und daraus hergestellte immunantwort-modifizierende konjugate
CA3086439A1 (en)	2017-12-20	2019-06-27	3M Innovative Properties Company	Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier

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2003
- 2003-07-23 MX MXPA05000893A patent/MXPA05000893A/es unknown
- 2003-07-23 DK DK03766003T patent/DK1543002T3/da active
- 2003-07-23 CA CA002493227A patent/CA2493227A1/en not_active Abandoned
- 2003-07-23 WO PCT/US2003/023153 patent/WO2004009593A1/en not_active Ceased
- 2003-07-23 AT AT03766003T patent/ATE338044T1/de not_active IP Right Cessation
- 2003-07-23 DE DE60308040T patent/DE60308040T2/de not_active Expired - Fee Related
- 2003-07-23 ES ES03766003T patent/ES2271650T3/es not_active Expired - Lifetime
- 2003-07-23 AU AU2003259226A patent/AU2003259226A1/en not_active Abandoned
- 2003-07-23 JP JP2004523380A patent/JP2006502121A/ja active Pending
- 2003-07-23 HR HR20050159A patent/HRP20050159A2/hr not_active Application Discontinuation
- 2003-07-23 EP EP03766003A patent/EP1543002B1/de not_active Expired - Lifetime
- 2003-07-23 CN CNB038219174A patent/CN1315828C/zh not_active Expired - Fee Related
- 2003-07-23 PL PL03374884A patent/PL374884A1/xx unknown
- 2003-07-23 KR KR1020057001185A patent/KR20050028047A/ko not_active Ceased
- 2003-07-23 US US10/626,036 patent/US6852861B2/en not_active Expired - Fee Related
- 2003-07-23 PT PT03766003T patent/PT1543002E/pt unknown
2004
- 2004-12-23 US US11/023,021 patent/US7153967B2/en not_active Expired - Fee Related
2005
- 2005-01-14 IL IL166309A patent/IL166309A/en not_active IP Right Cessation
2006
- 2006-11-15 US US11/600,673 patent/US20070060755A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20050113404A1 (en)	2005-05-26
CA2493227A1 (en)	2004-01-29
IL166309A0 (en)	2006-01-15
DE60308040D1 (de)	2006-10-12
ES2271650T3 (es)	2007-04-16
IL166309A (en)	2010-04-15
JP2006502121A (ja)	2006-01-19
US6852861B2 (en)	2005-02-08
KR20050028047A (ko)	2005-03-21
US20070060755A1 (en)	2007-03-15
EP1543002B1 (de)	2006-08-30
HRP20050159A2 (en)	2005-08-31
DK1543002T3 (da)	2006-12-27
US7153967B2 (en)	2006-12-26
DE60308040T2 (de)	2007-04-19
PL374884A1 (en)	2005-11-14
PT1543002E (pt)	2006-11-30
CN1681814A (zh)	2005-10-12
WO2004009593A1 (en)	2004-01-29
EP1543002A1 (de)	2005-06-22
US20040138459A1 (en)	2004-07-15
CN1315828C (zh)	2007-05-16
AU2003259226A1 (en)	2004-02-09
MXPA05000893A (es)	2005-09-30

Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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