ATE338044T1 - Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte - Google Patents

Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte

Info

Publication number: ATE338044T1
Authority: AT; Austria
Prior art keywords: quinoline; imidazoc4; production; intermediate products; amines via
Prior art date: 2002-07-23

Application number

AT03766003T

Other languages

English (en)

Inventor

Valeriano Merli

Silvia Mantovani

Stefano Bianchi

Original Assignee

Teva Gyogyszergyar Zartkoeruen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-23

Filing date

2003-07-23

Publication date

2006-09-15

2003-07-23 Application filed by Teva Gyogyszergyar Zartkoeruen filed Critical Teva Gyogyszergyar Zartkoeruen

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE338044T1 publication Critical patent/ATE338044T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 3
HQBUPOAKJGJGCD-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinolin-4-amine Chemical class NC1=NC2=CC=CC=C2C2=C1N=CN2 HQBUPOAKJGJGCD-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
OJLIXSLFKYPKRR-UHFFFAOYSA-N 4-(3h-imidazo[4,5-c]quinolin-4-yl)isoindole-1,3-dione Chemical compound O=C1NC(=O)C2=C1C=CC=C2C1=NC2=CC=CC=C2C2=C1NC=N2 OJLIXSLFKYPKRR-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 abstract 1
229960002751 imiquimod Drugs 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03766003T 2002-07-23 2003-07-23 Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte ATE338044T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39760702P	2002-07-23	2002-07-23

Publications (1)

Publication Number	Publication Date
ATE338044T1 true ATE338044T1 (de)	2006-09-15

Family

ID=30771087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03766003T ATE338044T1 (de)	2002-07-23	2003-07-23	Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte

Country Status (17)

Country	Link
US (3)	US6852861B2 (de)
EP (1)	EP1543002B1 (de)
JP (1)	JP2006502121A (de)
KR (1)	KR20050028047A (de)
CN (1)	CN1315828C (de)
AT (1)	ATE338044T1 (de)
AU (1)	AU2003259226A1 (de)
CA (1)	CA2493227A1 (de)
DE (1)	DE60308040T2 (de)
DK (1)	DK1543002T3 (de)
ES (1)	ES2271650T3 (de)
HR (1)	HRP20050159A2 (de)
IL (1)	IL166309A (de)
MX (1)	MXPA05000893A (de)
PL (1)	PL374884A1 (de)
PT (1)	PT1543002E (de)
WO (1)	WO2004009593A1 (de)

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AU2004270201A1 (en)	2003-09-05	2005-03-17	3M Innovative Properties Company	Treatment for CD5+ B cell lymphoma
EP1668010A2 (de)	2003-10-01	2006-06-14	Taro Pharmaceuticals U.S.A., Inc.	Verfahren zur herstellung von 4-amino-1h-imidazo[4,5-c]chinolinen und säureadditionssalzen davon
US7544697B2 (en) *	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
AR046046A1 (es)	2003-10-03	2005-11-23	3M Innovative Properties Co	Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
KR20060120069A (ko)	2003-10-03	2006-11-24	쓰리엠 이노베이티브 프로퍼티즈 컴파니	피라졸로피리딘 및 그의 유사체
US20090075980A1 (en) *	2003-10-03	2009-03-19	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and Analogs Thereof
CA2545825A1 (en)	2003-11-14	2005-06-02	3M Innovative Properties Company	Hydroxylamine substituted imidazo ring compounds
EP1685129A4 (de) *	2003-11-14	2008-10-22	3M Innovative Properties Co	Oximsubstituierte imidazoringverbindungen
EP1686992A4 (de) *	2003-11-25	2009-11-04	3M Innovative Properties Co	Hydroxylamin- und oxim-substituierte imidazochinoline, imidazopyridine und imidazonaphthyridine
CA2547020C (en) *	2003-11-25	2014-03-25	3M Innovative Properties Company	1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
JP2007513170A (ja) *	2003-12-04	2007-05-24	スリーエムイノベイティブプロパティズカンパニー	スルホン置換イミダゾ環エーテル
JP2007530450A (ja) *	2003-12-29	2007-11-01	スリーエムイノベイティブプロパティズカンパニー	ピペラジン、［１，４］ジアゼパン、［１，４］ジアゾカン、および［１，５］ジアゾカン縮合イミダゾ環化合物
JP2007517035A (ja) *	2003-12-29	2007-06-28	スリーエムイノベイティブプロパティズカンパニー	アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (de) *	2003-12-30	2006-09-13	3M Innovative Properties Company	Imidazochinolinyl-, imidazopyridinyl- und imidazonaphthyridinylsulfonamide
WO2005094531A2 (en) *	2004-03-24	2005-10-13	3M Innovative Properties Company	Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123079A2 (en) *	2004-06-14	2005-12-29	3M Innovative Properties Company	Urea substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) *	2004-06-15	2011-09-13	3M Innovative Properties Company	Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8541438B2 (en) *	2004-06-18	2013-09-24	3M Innovative Properties Company	Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
US7884207B2 (en) *	2004-06-18	2011-02-08	3M Innovative Properties Company	Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
WO2006038923A2 (en)	2004-06-18	2006-04-13	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
WO2006065280A2 (en)	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8026366B2 (en) *	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US20090270443A1 (en) *	2004-09-02	2009-10-29	Doris Stoermer	1-amino imidazo-containing compounds and methods
EP1789042B1 (de) *	2004-09-02	2012-05-02	3M Innovative Properties Company	1-alkoxy 1h-imidazo-ringsysteme und verfahren
WO2006029115A2 (en)	2004-09-02	2006-03-16	3M Innovative Properties Company	2-amino 1h imidazo ring systems and methods
EP1804583A4 (de) *	2004-10-08	2009-05-20	3M Innovative Properties Co	Adjuvans für dna-impfstoffe
EP1819364A4 (de) *	2004-12-08	2010-12-29	3M Innovative Properties Co	Immunmodulatorische zusammensetzungen, kombinationen und verfahren
EA200700244A1 (ru) *	2004-12-27	2007-06-29	Ю Эс Ви ЛИМИТЕД	СПОСОБ ПОЛУЧЕНИЯ 4-АМИНО-1-ИЗОБУТИЛ-1H-ИМИДАЗО-[4,5-c]ХИНОЛИНА (ИМИХИМОД)
JP5543068B2 (ja) *	2004-12-30	2014-07-09	スリーエムイノベイティブプロパティズカンパニー	キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
PL1830876T3 (pl) *	2004-12-30	2015-09-30	Meda Ab	Zastosowanie imikwimodu do leczenia przerzutów do skóry wywodzących się od guza stanowiącego raka piersi
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US8436176B2 (en) *	2004-12-30	2013-05-07	Medicis Pharmaceutical Corporation	Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine
CA2592897A1 (en) *	2004-12-30	2006-07-13	Takeda Pharmaceutical Company Limited	1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate and 1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphthyridin-4-amine methanesulfonate
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AU2006232375A1 (en)	2005-04-01	2006-10-12	Coley Pharmaceutical Group, Inc.	1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
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US8329721B2 (en) *	2006-03-15	2012-12-11	3M Innovative Properties Company	Hydroxy and alkoxy substituted 1H-imidazonaphthyridines and methods
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WO2008048683A2 (en) *	2006-10-16	2008-04-24	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via 1h-imidazo[4,5-c]quinolin-4-phthalimide intermediates
US20080149123A1 (en)	2006-12-22	2008-06-26	Mckay William D	Particulate material dispensing hairbrush with combination bristles
US9242980B2 (en)	2010-08-17	2016-01-26	3M Innovative Properties Company	Lipidated immune response modifier compound compositions, formulations, and methods
JP6460789B2 (ja)	2011-06-03	2019-01-30	スリーエムイノベイティブプロパティズカンパニー	ポリエチレングリコールセグメントを有するヘテロ２官能性リンカー及び該リンカーから調製された免疫反応調節複合体
BR112013031039B1 (pt)	2011-06-03	2020-04-28	3M Innovative Properties Co	compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado
WO2019123178A1 (en)	2017-12-20	2019-06-27	3M Innovative Properties Company	Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier

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2003
- 2003-07-23 AU AU2003259226A patent/AU2003259226A1/en not_active Abandoned
- 2003-07-23 KR KR1020057001185A patent/KR20050028047A/ko not_active Ceased
- 2003-07-23 DE DE60308040T patent/DE60308040T2/de not_active Expired - Fee Related
- 2003-07-23 JP JP2004523380A patent/JP2006502121A/ja active Pending
- 2003-07-23 HR HR20050159A patent/HRP20050159A2/hr not_active Application Discontinuation
- 2003-07-23 MX MXPA05000893A patent/MXPA05000893A/es unknown
- 2003-07-23 CA CA002493227A patent/CA2493227A1/en not_active Abandoned
- 2003-07-23 DK DK03766003T patent/DK1543002T3/da active
- 2003-07-23 EP EP03766003A patent/EP1543002B1/de not_active Expired - Lifetime
- 2003-07-23 PL PL03374884A patent/PL374884A1/xx unknown
- 2003-07-23 AT AT03766003T patent/ATE338044T1/de not_active IP Right Cessation
- 2003-07-23 PT PT03766003T patent/PT1543002E/pt unknown
- 2003-07-23 CN CNB038219174A patent/CN1315828C/zh not_active Expired - Fee Related
- 2003-07-23 US US10/626,036 patent/US6852861B2/en not_active Expired - Fee Related
- 2003-07-23 WO PCT/US2003/023153 patent/WO2004009593A1/en not_active Ceased
- 2003-07-23 ES ES03766003T patent/ES2271650T3/es not_active Expired - Lifetime
2004
- 2004-12-23 US US11/023,021 patent/US7153967B2/en not_active Expired - Fee Related
2005
- 2005-01-14 IL IL166309A patent/IL166309A/en not_active IP Right Cessation
2006
- 2006-11-15 US US11/600,673 patent/US20070060755A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PT1543002E (pt)	2006-11-30
US7153967B2 (en)	2006-12-26
WO2004009593A1 (en)	2004-01-29
EP1543002A1 (de)	2005-06-22
ES2271650T3 (es)	2007-04-16
KR20050028047A (ko)	2005-03-21
DE60308040D1 (de)	2006-10-12
IL166309A0 (en)	2006-01-15
EP1543002B1 (de)	2006-08-30
DK1543002T3 (da)	2006-12-27
PL374884A1 (en)	2005-11-14
HRP20050159A2 (en)	2005-08-31
US20050113404A1 (en)	2005-05-26
IL166309A (en)	2010-04-15
US20040138459A1 (en)	2004-07-15
US6852861B2 (en)	2005-02-08
AU2003259226A1 (en)	2004-02-09
DE60308040T2 (de)	2007-04-19
CN1681814A (zh)	2005-10-12
JP2006502121A (ja)	2006-01-19
US20070060755A1 (en)	2007-03-15
CN1315828C (zh)	2007-05-16
MXPA05000893A (es)	2005-09-30
CA2493227A1 (en)	2004-01-29

Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE338044T1 (de)	2006-09-15	Herstellung von 1h-imidazoc4,5-c)chinolin-4- aminen ber 1h-imidazoc4,5-c)chinolin-4- phthalimidzwischenprodukte
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ATE339512T1 (de)	2006-10-15	Galactosyl-isomalt, verfahren zu seiner herstellung und verwendung
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ATE434598T1 (de)	2009-07-15	Zwischenprodukte für die herstellung von dioxan-2-alkylcarbamaten
ATE308324T1 (de)	2005-11-15	Zolpidem hemitartrat
PL371127A1 (en)	2005-06-13	6-aminomorphinane derivatives, method for the production and use thereof
MXPA03010322A (es)	2004-02-17	PROCEDIMIENTO PARA LA PREPARACIoN DE POLIISOCIANATOS.
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DE60106057D1 (de)	2004-11-04	Verfahren zur herstellung von baccatin iii-derivativen
ATE325794T1 (de)	2006-06-15	Verfahren zur herstellung und zwischenprodukte von pyridin-2-yl-amin
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MXPA04004526A (es)	2004-08-11	N-metil-homocisteinas, su uso y metodo para su produccion.
ATE537160T1 (de)	2011-12-15	Verfahren zur herstellung von 14beta- hydroxybaccatin-iii-1,14-carbonat
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ATE394398T1 (de)	2008-05-15	Verfahren zur herstellung von imidazo(1,2- a)pyridin-3-acetamiden
ATE411999T1 (de)	2008-11-15	Verfahren und zwischenprodukte für die herstellung von olanzapin
IL161800A (en)	2010-11-30	Method for the production of desclarithromycin and intermediate products and their use in the production of desclarithromycin
MXPA03005400A (es)	2004-09-06	Metodo para preparacion de 11 (12)-pentadecen-15-olidos.
ATE458723T1 (de)	2010-03-15	Verfahren zur herstellung von 4,6-dichlor-5- fluorpyrimidin
TW200505413A (en)	2005-02-16	Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same