ATE537160T1 - Verfahren zur herstellung von 14beta- hydroxybaccatin-iii-1,14-carbonat - Google Patents

Verfahren zur herstellung von 14beta- hydroxybaccatin-iii-1,14-carbonat

Info

Publication number: ATE537160T1
Authority: AT; Austria
Prior art keywords: 14beta; carbonate; producing; hydroxybaccatin iii; iii
Prior art date: 2001-10-19

Application number

AT02764721T

Other languages

English (en)

Inventor

Ezio Bombardelli

Gabriele Fontana

Maria Gelmi

Donato Pocar

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-19

Filing date

2002-07-18

Publication date

2011-12-15

2002-07-18 Application filed by Indena Spa filed Critical Indena Spa

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE537160T1 publication Critical patent/ATE537160T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02764721T 2001-10-19 2002-07-18 Verfahren zur herstellung von 14beta- hydroxybaccatin-iii-1,14-carbonat ATE537160T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI002186A ITMI20012186A1 (it)	2001-10-19	2001-10-19	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
PCT/EP2002/008005 WO2003035633A1 (en)	2001-10-19	2002-07-18	A process for the preparation of the 14beta-hydroxy-baccatin iii-1,14-carbonate

Publications (1)

Publication Number	Publication Date
ATE537160T1 true ATE537160T1 (de)	2011-12-15

Family

ID=11448529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02764721T ATE537160T1 (de)	2001-10-19	2002-07-18	Verfahren zur herstellung von 14beta- hydroxybaccatin-iii-1,14-carbonat

Country Status (19)

Country	Link
US (1)	US7078432B2 (de)
EP (1)	EP1436277B1 (de)
JP (1)	JP4454310B2 (de)
KR (1)	KR100896542B1 (de)
CN (1)	CN1271061C (de)
AT (1)	ATE537160T1 (de)
AU (1)	AU2002328918B2 (de)
BR (1)	BR0213360B1 (de)
CA (1)	CA2463915C (de)
DK (1)	DK1436277T3 (de)
ES (1)	ES2376162T3 (de)
HU (1)	HUP0401989A3 (de)
IL (1)	IL161443A0 (de)
IT (1)	ITMI20012186A1 (de)
MX (1)	MXPA04003519A (de)
NO (1)	NO328562B1 (de)
PL (1)	PL368122A1 (de)
RU (1)	RU2291866C2 (de)
WO (1)	WO2003035633A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20021921A1 (it) *	2002-09-10	2004-03-11	Indena Spa	Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
DK2080764T3 (da)	2008-01-18	2012-09-24	Indena Spa	Faste former af ortataxel
CN103450118A (zh) *	2013-09-18	2013-12-18	江苏红豆杉药业有限公司	一种半合成法制备紫杉醇的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1254517B (it)	1992-03-06	1995-09-25	Indena Spa	14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
FR2718137B1 (fr) *	1994-04-05	1996-04-26	Rhone Poulenc Rorer Sa	Procédé de préparation de trialcoylsilyl-7 baccatine III.
IT1275936B1 (it)	1995-03-17	1997-10-24	Indena Spa	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
FR2732341A1 (fr)	1995-03-27	1996-10-04	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
IT1275435B (it) *	1995-05-19	1997-08-07	Indena Spa	Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
IT1283633B1 (it)	1996-05-10	1998-04-23	Indena Spa	Derivati tassanici loro sintesi e formulazioni che li contengono
US5811452A (en)	1997-01-08	1998-09-22	The Research Foundation Of State University Of New York	Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
IT1318678B1 (it) *	2000-08-10	2003-08-27	Indena Spa	Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) *	2000-11-28	2003-11-18	Indena Spa	Procedimento per la preparazione di derivati tassanici.
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato

2001
- 2001-10-19 IT IT2001MI002186A patent/ITMI20012186A1/it unknown
2002
- 2002-07-18 PL PL02368122A patent/PL368122A1/xx not_active Application Discontinuation
- 2002-07-18 DK DK02764721.3T patent/DK1436277T3/da active
- 2002-07-18 AU AU2002328918A patent/AU2002328918B2/en not_active Ceased
- 2002-07-18 HU HU0401989A patent/HUP0401989A3/hu unknown
- 2002-07-18 WO PCT/EP2002/008005 patent/WO2003035633A1/en not_active Ceased
- 2002-07-18 RU RU2004111669/04A patent/RU2291866C2/ru active
- 2002-07-18 KR KR1020047004621A patent/KR100896542B1/ko not_active Expired - Fee Related
- 2002-07-18 IL IL16144302A patent/IL161443A0/xx active IP Right Grant
- 2002-07-18 US US10/492,986 patent/US7078432B2/en not_active Expired - Lifetime
- 2002-07-18 ES ES02764721T patent/ES2376162T3/es not_active Expired - Lifetime
- 2002-07-18 AT AT02764721T patent/ATE537160T1/de active
- 2002-07-18 EP EP02764721A patent/EP1436277B1/de not_active Expired - Lifetime
- 2002-07-18 BR BRPI0213360-1B1A patent/BR0213360B1/pt not_active IP Right Cessation
- 2002-07-18 JP JP2003538149A patent/JP4454310B2/ja not_active Expired - Fee Related
- 2002-07-18 CA CA002463915A patent/CA2463915C/en not_active Expired - Lifetime
- 2002-07-18 CN CNB028205227A patent/CN1271061C/zh not_active Expired - Fee Related
- 2002-07-18 MX MXPA04003519A patent/MXPA04003519A/es active IP Right Grant
2004
- 2004-04-15 NO NO20041537A patent/NO328562B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1571779A (zh)	2005-01-26
DK1436277T3 (da)	2012-01-23
HUP0401989A2 (hu)	2005-01-28
IL161443A0 (en)	2004-09-27
ITMI20012186A1 (it)	2003-04-19
EP1436277B1 (de)	2011-12-14
JP4454310B2 (ja)	2010-04-21
MXPA04003519A (es)	2004-07-23
PL368122A1 (en)	2005-03-21
AU2002328918B2 (en)	2008-09-04
NO328562B1 (no)	2010-03-22
WO2003035633A1 (en)	2003-05-01
KR100896542B1 (ko)	2009-05-07
NO20041537L (no)	2004-04-15
EP1436277A1 (de)	2004-07-14
JP2005512977A (ja)	2005-05-12
CA2463915C (en)	2009-11-24
BR0213360A (pt)	2004-10-26
HK1069170A1 (en)	2005-05-13
CN1271061C (zh)	2006-08-23
RU2291866C2 (ru)	2007-01-20
US20040266859A1 (en)	2004-12-30
ES2376162T3 (es)	2012-03-09
CA2463915A1 (en)	2003-05-01
BR0213360B1 (pt)	2014-04-15
KR20040045023A (ko)	2004-05-31
RU2004111669A (ru)	2005-04-20
HUP0401989A3 (en)	2007-05-29
US7078432B2 (en)	2006-07-18

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