ATE338762T1 - Zusammensetzungen und methoden für die verknüpfung von endothelzellen - Google Patents
Zusammensetzungen und methoden für die verknüpfung von endothelzellenInfo
- Publication number
- ATE338762T1 ATE338762T1 AT92911299T AT92911299T ATE338762T1 AT E338762 T1 ATE338762 T1 AT E338762T1 AT 92911299 T AT92911299 T AT 92911299T AT 92911299 T AT92911299 T AT 92911299T AT E338762 T1 ATE338762 T1 AT E338762T1
- Authority
- AT
- Austria
- Prior art keywords
- sialyl
- methods
- compositions
- endothelial cells
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68803791A | 1991-04-19 | 1991-04-19 | |
| US72177191A | 1991-06-25 | 1991-06-25 | |
| US72116091A | 1991-06-26 | 1991-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE338762T1 true ATE338762T1 (de) | 2006-09-15 |
Family
ID=27418500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92911299T ATE338762T1 (de) | 1991-04-19 | 1992-04-17 | Zusammensetzungen und methoden für die verknüpfung von endothelzellen |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0580763B1 (de) |
| JP (1) | JPH0826045B2 (de) |
| AT (1) | ATE338762T1 (de) |
| AU (1) | AU1926692A (de) |
| CA (1) | CA2108786A1 (de) |
| DE (1) | DE69233654D1 (de) |
| WO (1) | WO1992018610A2 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| EP0557424A4 (en) * | 1990-11-16 | 1994-06-08 | Univ Leland Stanford Junior | Skin-associated lymphocytes and markers |
| CA2097617A1 (en) * | 1990-11-23 | 1992-05-23 | Brian Seed | Inhibition of cell adhesion protein-carbohydrate interactions |
| AU667813B2 (en) * | 1991-05-03 | 1996-04-18 | Rockefeller University, The | Amino-acid sequence homologies between selectins and B pertussis toxin-peptides derived therefrom antibodies thereto pharmaceutical compositions |
| WO1993005803A1 (en) * | 1991-09-25 | 1993-04-01 | Genetics Institute, Inc. | Anti-inflammatory selectin inhibitors |
| US5326752A (en) * | 1991-11-27 | 1994-07-05 | Glycomed Incorporated | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
| US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
| US5648458A (en) * | 1992-05-06 | 1997-07-15 | Affymax Technologies N.V. | Peptides and compounds that bind to ELAM-1 |
| US5728802A (en) * | 1992-05-06 | 1998-03-17 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) |
| GB9300989D0 (en) * | 1993-01-19 | 1993-03-10 | British Bio Technology | Disaccharide ligands |
| CA2157489A1 (en) * | 1993-03-04 | 1994-09-15 | Masaaki Numata | Lewis-associated compound, process for producing the same, and anti-inflammatory |
| US5658880A (en) * | 1993-06-16 | 1997-08-19 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
| US5837689A (en) * | 1993-06-16 | 1998-11-17 | Glycomed Incorporated | Sialyl lewis-x mimetics containing naphthyl backbones |
| US5750508A (en) * | 1993-06-16 | 1998-05-12 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
| US5789385A (en) * | 1993-06-16 | 1998-08-04 | Glycomed Incorporated | Sialyl Lewisx mimetics containing phenyl backbones |
| US5679321A (en) * | 1993-06-17 | 1997-10-21 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
| EP0671409A3 (de) * | 1994-03-11 | 1996-06-12 | Hoechst Ag | Malonsäurederivate mit antiadhäsiven Eigenschaften. |
| DE4408248A1 (de) * | 1994-03-11 | 1995-09-14 | Hoechst Ag | Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung |
| EP1428832A3 (de) * | 1995-08-03 | 2004-09-22 | The Board of Regents for the University of Oklahoma | Peptid-und O-Glycaninhibitoren von Selectin vermittelten Entzündungen |
| WO1997028807A1 (fr) * | 1996-02-08 | 1997-08-14 | Ngk Insulators, Ltd. | Substance anticancereuse inhibant le processus metastatique cancereux |
| JP4599027B2 (ja) * | 2002-10-30 | 2010-12-15 | 東洋水産株式会社 | L−セレクチン結合阻害剤 |
| WO2009033011A1 (en) | 2007-09-07 | 2009-03-12 | Children's Hospital Medical Center | Use of secretor, lewis and sialyl antigen levels as predictors for disease |
| ES2651067T3 (es) | 2009-07-06 | 2018-01-24 | Children's Hospital Medical Center | Inhibición de la inflamación con oligosacáridos de la leche |
| US10626460B2 (en) | 2013-02-21 | 2020-04-21 | Children's Hospital Medical Center | Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease |
| EP3288389A4 (de) | 2015-04-28 | 2018-10-10 | Children's Hospital Medical Center | Verwendung von oligosaccharidzusammensetzungen zur verstärkung der gewichtszunahme |
| KR20190110127A (ko) * | 2017-02-03 | 2019-09-27 | 스미또모 가가꾸 가부시키가이샤 | 췌장암의 검사 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851511A (en) * | 1986-01-30 | 1989-07-25 | Fred Hutchinson Cancer Research Center | Monoclonal antibody that specifically binds to disialosyl Lea |
| EP0381310A1 (de) * | 1989-01-30 | 1990-08-08 | The Biomembrane Institute | Monoklonale Antikörper gegen Tumor-assoziierte Ganglioside und Fucoganglioside sowie Produktionsmethode |
| US5272263A (en) * | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
| EP0585963A1 (de) * | 1989-05-23 | 1994-03-09 | Otsuka Pharmaceutical Co., Ltd. | Monoklonale Antikörper gegen CMP-170 Antigen auf aktivierten endothelialen Zellen |
| AU8007791A (en) * | 1990-06-15 | 1992-01-07 | Cytel Corporation | Intercellular adhesion mediators |
| ES2183851T3 (es) * | 1990-07-17 | 2003-04-01 | Univ Oklahoma | Ligando de gmp-140. |
| NZ240316A (en) * | 1990-10-25 | 1996-12-20 | Univ Michigan | Compound for treating disease mediated by the elaboration of elam-1 on endothelial cells |
-
1992
- 1992-04-17 AT AT92911299T patent/ATE338762T1/de not_active IP Right Cessation
- 1992-04-17 CA CA002108786A patent/CA2108786A1/en not_active Abandoned
- 1992-04-17 WO PCT/US1992/003192 patent/WO1992018610A2/en not_active Ceased
- 1992-04-17 AU AU19266/92A patent/AU1926692A/en not_active Abandoned
- 1992-04-17 EP EP92911299A patent/EP0580763B1/de not_active Expired - Lifetime
- 1992-04-17 DE DE69233654T patent/DE69233654D1/de not_active Expired - Lifetime
- 1992-12-17 JP JP5511410A patent/JPH0826045B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06507927A (ja) | 1994-09-08 |
| CA2108786A1 (en) | 1992-10-20 |
| EP0580763B1 (de) | 2006-09-06 |
| WO1992018610A2 (en) | 1992-10-29 |
| AU1926692A (en) | 1992-11-17 |
| JPH0826045B2 (ja) | 1996-03-13 |
| DE69233654D1 (de) | 2006-10-19 |
| EP0580763A1 (de) | 1994-02-02 |
| WO1992018610A3 (en) | 1993-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |