ATE339423T1 - Verfahren zur herstellung von 4'-o-substituierten 4'-demethyl-1 desoxypodophyllotoxinderivaten und geometrischen isomeren davon ,und antikrebspräparat, das diese enthält - Google Patents

Verfahren zur herstellung von 4'-o-substituierten 4'-demethyl-1 desoxypodophyllotoxinderivaten und geometrischen isomeren davon ,und antikrebspräparat, das diese enthält

Info

Publication number
ATE339423T1
ATE339423T1 AT01996542T AT01996542T ATE339423T1 AT E339423 T1 ATE339423 T1 AT E339423T1 AT 01996542 T AT01996542 T AT 01996542T AT 01996542 T AT01996542 T AT 01996542T AT E339423 T1 ATE339423 T1 AT E339423T1
Authority
AT
Austria
Prior art keywords
demethyl
substituted
deoxypodophyllotoxine
derivatives
producing
Prior art date
Application number
AT01996542T
Other languages
English (en)
Inventor
Song-Bae Kim
Byung-Zun Ahn
Yong Kim
Young-Jae You
Original Assignee
Song-Bae Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR10-2001-0040806A external-priority patent/KR100433679B1/ko
Application filed by Song-Bae Kim filed Critical Song-Bae Kim
Application granted granted Critical
Publication of ATE339423T1 publication Critical patent/ATE339423T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01996542T 2000-11-20 2001-11-19 Verfahren zur herstellung von 4'-o-substituierten 4'-demethyl-1 desoxypodophyllotoxinderivaten und geometrischen isomeren davon ,und antikrebspräparat, das diese enthält ATE339423T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20000069004 2000-11-20
KR10-2001-0040806A KR100433679B1 (ko) 2000-11-20 2001-07-09 신규의 4'-데메틸-4'-ｏ-치환-1-데옥시포도필로톡신유도체 및 그의 기하 이성체, 그의 제조방법 및 그를포함하는 항암제

Publications (1)

Publication Number Publication Date
ATE339423T1 true ATE339423T1 (de) 2006-10-15

Family

ID=26638551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01996542T ATE339423T1 (de) 2000-11-20 2001-11-19 Verfahren zur herstellung von 4'-o-substituierten 4'-demethyl-1 desoxypodophyllotoxinderivaten und geometrischen isomeren davon ,und antikrebspräparat, das diese enthält

Country Status (10)

Country Link
US (1) US6894075B2 (de)
EP (1) EP1335922B1 (de)
JP (1) JP4024148B2 (de)
CN (1) CN1256336C (de)
AT (1) ATE339423T1 (de)
AU (1) AU2002222695A1 (de)
DE (1) DE60123105T2 (de)
DK (1) DK1335922T3 (de)
ES (1) ES2271120T3 (de)
WO (1) WO2002040489A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102168D0 (sv) 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
JP2013530993A (ja) 2010-07-02 2013-08-01 アンジオケム インコーポレーテッド 治療用コンジュゲートのための短く且つｄ−アミノ酸を含有するポリペプチドおよびその使用
CN102070645B (zh) * 2011-01-07 2015-04-22 兰州大学 一种脱氧鬼臼毒素类化合物及其制备与应用
CN102260273B (zh) * 2011-05-13 2015-04-22 兰州大学 脱氧鬼臼与5-氟尿嘧啶的拼合物及其制备与用途
CN103214495A (zh) * 2013-03-29 2013-07-24 西南交通大学 抗癌用4’-去甲基-4’-氧-环丁甲酰基-去氧鬼臼毒及其制备方法
KR102378151B1 (ko) * 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH454169A (de) * 1964-08-12 1968-04-15 Sandoz Ag Verfahren zur Herstellung von neuen Podophyllotoxin-Derivaten
ES2191733T3 (es) * 1995-12-04 2003-09-16 Nippon Kayaku Kk Procedimiento para producir etoposido.
US6051721A (en) * 1997-10-02 2000-04-18 The Board Of Regents Of The University Of Nebraska Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis

Also Published As

Publication number Publication date
US20040044058A1 (en) 2004-03-04
EP1335922B1 (de) 2006-09-13
US6894075B2 (en) 2005-05-17
EP1335922A4 (de) 2004-08-11
CN1474822A (zh) 2004-02-11
EP1335922A1 (de) 2003-08-20
JP4024148B2 (ja) 2007-12-19
ES2271120T3 (es) 2007-04-16
DE60123105T2 (de) 2007-04-26
AU2002222695A1 (en) 2002-05-27
CN1256336C (zh) 2006-05-17
WO2002040489A1 (en) 2002-05-23
JP2004513949A (ja) 2004-05-13
DE60123105D1 (de) 2006-10-26
DK1335922T3 (da) 2007-01-15

Similar Documents

Publication Publication Date Title
EE200000318A (et) Uudsed ühendid
DE69006951D1 (de) Verfahren zur Herstellung von 1,1,1,2-Tetrafluorethan.
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
DE69504162D1 (de) Verfahren zur Herstellung von 2-Methyl-1,4-naphthochinon
DE60239842D1 (de) Verfahren zur Herstellung von 10,11-dihydro-10-oxo-5h-dibenzoÄb,fÜazepin-5-carboxamid
ATE339423T1 (de) Verfahren zur herstellung von 4'-o-substituierten 4'-demethyl-1 desoxypodophyllotoxinderivaten und geometrischen isomeren davon ,und antikrebspräparat, das diese enthält
DE69800901D1 (de) Verfahren zur Herstellung von Trans 1,4-Cyclohexan-bis-(methylamin)
DE10085452T1 (de) Verfahren zur Herstellung von 1,1,1,2-Tetrafluorethan
DE60222806D1 (de) Verfahren zur herstellung von (1,4,5)-oxadiazepinderivaten
DE69013132D1 (de) Verfahren zur Herstellung von Octa-2,7-dien-1-ol.
DE59907526D1 (de) Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethyl-cyclohexanon
DE69514122D1 (de) Lösungsmittelfreies verfahren zur herstellung von 2,6 difluorbenzonitril
DE69300920D1 (de) Verfahren zur Herstellung von 1,1,1,2-Tetrafluorethan.
DE59200298D1 (de) Verfahren zur Herstellung von 2,4-Dichlorfluorbenzol.
DE69009394D1 (de) Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethyl-1-cyclohexanon.
DE69205601D1 (de) Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethylcyclohexanon.
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
DE69913635D1 (de) Verfahren zur Herstellung von 1,3-Dialkyl-2-Imidazolinonderivaten
DE60104789D1 (de) Verfahren zur Herstellung von 2,4,5-Trialkylbenzaldehyden
DE60004931D1 (de) Kontinuierliches Verfahren zur Herstellung von 3,5,5-Trimethylcyclohexa-3-en-1-on(beta-Isophoron)
DE59802620D1 (de) Verfahren zur Herstellung von trans-(R,R)-Actinol
DE60114482D1 (de) Verfahren zur Herstellung von 1,1,1-Trifluoraceton
DE69802329D1 (de) Verfahren zur Herstellung von 3,4 disubstituirten Dinitroanilinen
DE60230097D1 (de) Verfahren zur herstellung von 1,5-diaminonaphthalinen
DE69018028D1 (de) Verfahren zur Herstellung von 2-substituierten-1,4-Naphtochinonen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1335922

Country of ref document: EP

REN Ceased due to non-payment of the annual fee