ATE340189T1 - Impfkristalle zur herstellung von peptiden oder proteinen - Google Patents

Impfkristalle zur herstellung von peptiden oder proteinen

Info

Publication number: ATE340189T1
Authority: AT; Austria
Prior art keywords: insulin; proteins; microcrystals; human; production
Prior art date: 1998-06-30

Application number

AT99931016T

Other languages

English (en)

Inventor

Flemming Manique

Christian Ilsoe

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-30

Filing date

1999-06-30

Publication date

2006-10-15

1999-06-30 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2006-10-15 Application granted granted Critical

2006-10-15 Publication of ATE340189T1 publication Critical patent/ATE340189T1/de

Links

102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000004169 proteins and genes Human genes 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 title abstract 3
239000013078 crystal Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 10
102000004877 Insulin Human genes 0.000 abstract 5
108090001061 Insulin Proteins 0.000 abstract 5
229940125396 insulin Drugs 0.000 abstract 5
239000013081 microcrystal Substances 0.000 abstract 5
238000004519 manufacturing process Methods 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
238000010899 nucleation Methods 0.000 abstract 3
239000000725 suspension Substances 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
102400000321 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
102100040918 Pro-glucagon Human genes 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
238000000265 homogenisation Methods 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Crystallography & Structural Chemistry (AREA)
Zoology (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Metallurgy (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99931016T 1998-06-30 1999-06-30 Impfkristalle zur herstellung von peptiden oder proteinen ATE340189T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98610020		1998-06-30
US9288298P	1998-07-15	1998-07-15

Publications (1)

Publication Number	Publication Date
ATE340189T1 true ATE340189T1 (de)	2006-10-15

Family

ID=26151840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99931016T ATE340189T1 (de)	1998-06-30	1999-06-30	Impfkristalle zur herstellung von peptiden oder proteinen

Country Status (15)

Country	Link
EP (1)	EP1091979B1 (de)
JP (1)	JP2002519437A (de)
KR (1)	KR20010071666A (de)
CN (1)	CN1307589A (de)
AT (1)	ATE340189T1 (de)
AU (1)	AU758496B2 (de)
BR (1)	BR9911678A (de)
CA (1)	CA2336112A1 (de)
DE (1)	DE69933296T2 (de)
ES (1)	ES2273501T3 (de)
HU (1)	HUP0102577A3 (de)
IL (1)	IL140341A0 (de)
NO (1)	NO20006701L (de)
PL (1)	PL345260A1 (de)
WO (1)	WO2000001727A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
JP3421739B2 (ja)	2000-03-01	2003-06-30	大阪大学長	有機単結晶の形成方法
EP2213743A1 (de)	2000-04-12	2010-08-04	Human Genome Sciences, Inc.	Albuminfusionsproteine
AU2002228608A1 (en) *	2000-12-13	2002-06-24	Eli Lilly And Company	Amidated glucagon-like peptide-1
WO2005003296A2 (en)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Albumin fusion proteins
AU2002364586A1 (en)	2001-12-21	2003-07-30	Delta Biotechnology Limited	Albumin fusion proteins
EP2158927A1 (de) *	2008-08-25	2010-03-03	Debiotech S.A.	Verabreichungsvorrichtung mit einem Modul um Fibrillen stromabwärts von dem Behälter zu vermeiden
RU2407540C1 (ru) *	2009-06-22	2010-12-27	Общество с ограниченной ответственностью "Завод Медсинтез"	Способ промышленного получения рекомбинантного инсулина человека

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB766994A (en) *	1953-11-13	1957-01-30	Novo Terapeutisk Labortorium A	Improved process in crystallization of insulin
GB766995A (en) *	1953-11-14	1957-01-30	Novo Terapeutisk Labor As	Improvements in or relating to the production of insulin crystals
FR2527903A1 (fr) *	1982-06-03	1983-12-09	Noelle Ancenis Coop Agricole	Procede et installation pour l'obtention d'un produit gras en tout point comparable au beurre
FI882921A7 (fi) *	1986-10-20	1988-06-17	Novo Ind A/S	Protamiinisinkki-insuliinivalmisteet.
BR8803345A (pt) *	1988-06-30	1990-02-13	Biobras Bioquimica Do Brasil S	Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada
JP2554784B2 (ja) *	1991-03-15	1996-11-13	杏林製薬株式会社	懸濁シロップ剤
NL9201408A (nl) *	1992-08-05	1994-03-01	Holland Sweetener Co	Werkwijze voor het kristalliseren van aspartaam.

1999
- 1999-06-30 IL IL14034199A patent/IL140341A0/xx unknown
- 1999-06-30 PL PL99345260A patent/PL345260A1/xx not_active Application Discontinuation
- 1999-06-30 DE DE69933296T patent/DE69933296T2/de not_active Expired - Lifetime
- 1999-06-30 CA CA002336112A patent/CA2336112A1/en not_active Abandoned
- 1999-06-30 BR BR9911678-2A patent/BR9911678A/pt not_active IP Right Cessation
- 1999-06-30 HU HU0102577A patent/HUP0102577A3/hu unknown
- 1999-06-30 AT AT99931016T patent/ATE340189T1/de not_active IP Right Cessation
- 1999-06-30 JP JP2000558128A patent/JP2002519437A/ja active Pending
- 1999-06-30 AU AU47685/99A patent/AU758496B2/en not_active Ceased
- 1999-06-30 EP EP99931016A patent/EP1091979B1/de not_active Expired - Lifetime
- 1999-06-30 KR KR1020007014921A patent/KR20010071666A/ko not_active Withdrawn
- 1999-06-30 WO PCT/DK1999/000371 patent/WO2000001727A1/en not_active Ceased
- 1999-06-30 ES ES99931016T patent/ES2273501T3/es not_active Expired - Lifetime
- 1999-06-30 CN CN99807953A patent/CN1307589A/zh active Pending
2000
- 2000-12-29 NO NO20006701A patent/NO20006701L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2000001727A1 (en)	2000-01-13
AU4768599A (en)	2000-01-24
NO20006701D0 (no)	2000-12-29
BR9911678A (pt)	2001-03-20
JP2002519437A (ja)	2002-07-02
EP1091979B1 (de)	2006-09-20
HUP0102577A2 (hu)	2002-01-28
CN1307589A (zh)	2001-08-08
KR20010071666A (ko)	2001-07-31
AU758496B2 (en)	2003-03-20
DE69933296T2 (de)	2007-05-03
DE69933296D1 (de)	2006-11-02
HUP0102577A3 (en)	2002-02-28
ES2273501T3 (es)	2007-05-01
CA2336112A1 (en)	2000-01-13
PL345260A1 (en)	2001-12-03
IL140341A0 (en)	2002-02-10
EP1091979A1 (de)	2001-04-18
NO20006701L (no)	2000-12-29

Legal Events

Date	Code	Title	Description
2007-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE59601880D1 (de)	1999-06-17	Verfahren zur herstellung hydrophiler oder teilweise hydrophiler, anorganischer aerogele
RU95110107A (ru)	1997-05-10	Способ получения стабильного кристаллического аналога цинк-инсулина
DE59410052D1 (de)	2002-03-21	Verwendung von nona- und dekapeptiden zur herstellung eines arzneimittels zur bekämpfung von aids
EP0295959A3 (de)	1990-01-10	Schwefelreiches Protein aus Bertholletia excelsa H.B.K.
DE69113386D1 (de)	1995-11-02	Herstellung von Medikamenten zur Behandlung von Asthma, unter Verwendung von (S)-Alpha-Fluoromethyl-Histidin und dessen Estern.
AU2273795A (en)	1995-10-23	Reduction of endogenous seed protein levels in plants
DE69935978D1 (de)	2007-06-14	Kulturmedium zur kultivierung tierischer zellen und verfahren zur herstellung von proteinen durch dessen verwendung
ATE340189T1 (de)	2006-10-15	Impfkristalle zur herstellung von peptiden oder proteinen
DE69409518D1 (de)	1998-05-14	Polyarminearme nähr- und/oder heilmittelzusammensetzung und therapeutische verwendung derselben
ATE440144T1 (de)	2009-09-15	Die verwendung von abc transporter kodierenden genen zur stimulierung der herstellung von sekundärmetaboliten in biologischen zellen
ATE459355T1 (de)	2010-03-15	Verfahren zur behandlung von erkrankungen mit mangel an thiolhaltiger verbindung
FI942442A0 (fi)	1994-05-25	Proteiinien tuotto 7B2-proteiinia käyttäen
ATE308334T1 (de)	2005-11-15	Verfahren zur herstellung von tocotrienol- angereicherten präparationen
ATE342062T1 (de)	2006-11-15	Angiotensin ii zur verbesserung der befruchtung
SE9402331D0 (sv)	1994-07-01	New use
DE59409413D1 (de)	2000-08-03	Verwendung von n,s-diacetylcystein-ethylester (dacee) zur herstellung eines medikaments zur behandlung viraler erkrankungen
KR890008166A (ko)	1989-07-10	융합 단백질의 선택적 분해 방법
DE68914660D1 (de)	1994-05-19	Verfahren zur Herstellung von den Safranblütennarben ähnlichem Gewebe sowie Verfahren zur Herstellung von nützlichen Stoffen aus safranblütennarbenähnlichem Gewebe.
ATE363524T1 (de)	2007-06-15	Brennstoff in form von presslingen mit gehalt an pflanzenmaterial und ein verfahren zur herstellung eines solchen brennstoffes
WO2003076595A3 (en)	2004-02-19	Production of insulin and insulin-like proteins in plants
DE69214804D1 (de)	1996-11-28	Methode zur extraktion einer biologischen substanz aus lepidoptera-larven und eine solch erhaltene substanz
AU7571301A (en)	2002-02-13	Organ transplant rejection and associated conditions
ATE147988T1 (de)	1997-02-15	Authentischen igf-1 und hypokalorische menge von nährstoffen enthaltendes produkt und dessen verwendung zur behandlung kataboler zustände
MD1094G2 (ro)	1999-06-30	Metodă de dermatoplastie a plăgilor
DE19541345C2 (de)	1997-09-25	Verfahren zur Kultivierung eukariotischer Zellen