ATE342260T1 - Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen - Google Patents

Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen

Info

Publication number
ATE342260T1
ATE342260T1 AT00936038T AT00936038T ATE342260T1 AT E342260 T1 ATE342260 T1 AT E342260T1 AT 00936038 T AT00936038 T AT 00936038T AT 00936038 T AT00936038 T AT 00936038T AT E342260 T1 ATE342260 T1 AT E342260T1
Authority
AT
Austria
Prior art keywords
paclitaxel
synthesis
dialkyldichlorosilanes
semi
dialkylalkoxysilyl
Prior art date
Application number
AT00936038T
Other languages
English (en)
Inventor
Purushotham Vemishetti
Francis S Gibson
John L Dillon Jr
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE342260T1 publication Critical patent/ATE342260T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Silicon Polymers (AREA)
  • Paper (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT00936038T 1999-05-28 2000-05-18 Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen ATE342260T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13655999P 1999-05-28 1999-05-28

Publications (1)

Publication Number Publication Date
ATE342260T1 true ATE342260T1 (de) 2006-11-15

Family

ID=22473365

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00936038T ATE342260T1 (de) 1999-05-28 2000-05-18 Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen

Country Status (17)

Country Link
US (1) US6242614B1 (de)
EP (1) EP1183250B1 (de)
JP (1) JP2003502290A (de)
KR (1) KR100603877B1 (de)
AT (1) ATE342260T1 (de)
AU (1) AU776216B2 (de)
CA (1) CA2375253A1 (de)
CY (1) CY1105837T1 (de)
DE (1) DE60031269T2 (de)
DK (1) DK1183250T3 (de)
ES (1) ES2273698T3 (de)
HU (1) HUP0201266A3 (de)
IL (1) IL145869A (de)
MX (1) MXPA01012177A (de)
PT (1) PT1183250E (de)
TW (1) TW593300B (de)
WO (1) WO2000073293A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ298333B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy 7-trialkylsilylbaccatinu III
GB0701523D0 (en) * 2007-01-26 2007-03-07 Chatham Biotec Ltd Semi-synthetic process for the preparation of taxane derivatives
CN101835769A (zh) * 2007-08-22 2010-09-15 6570763加拿大有限公司 将9-二氢-13-乙酰基浆果赤霉素ⅲ转化为多烯紫杉醇或太平洋紫杉醇的方法
CA2723654A1 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US9375484B2 (en) * 2011-05-31 2016-06-28 Regents Of The University Of Minnesota Taxane silicate prodrugs and nanoparticles
KR101378537B1 (ko) * 2011-09-30 2014-03-28 주식회사 삼양바이오팜 10-디아세틸파클리탁셀로부터 파클리탁셀을 제조하는 방법
CN103145654A (zh) * 2013-04-12 2013-06-12 江苏斯威森生物医药工程研究中心有限公司 一种多西他赛的半合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
ATE258171T1 (de) 1991-09-23 2004-02-15 Univ Florida State Metallalkoxide
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
ATE253563T1 (de) * 1993-02-05 2003-11-15 Bryn Mawr College Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
US6005120A (en) * 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
JPH1192468A (ja) * 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6136988A (en) * 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法

Also Published As

Publication number Publication date
US6242614B1 (en) 2001-06-05
AU776216B2 (en) 2004-09-02
KR100603877B1 (ko) 2006-07-25
CY1105837T1 (el) 2011-02-02
IL145869A (en) 2005-07-25
KR20020032426A (ko) 2002-05-03
DE60031269D1 (de) 2006-11-23
EP1183250A1 (de) 2002-03-06
AU5140800A (en) 2000-12-18
EP1183250A4 (de) 2002-11-13
EP1183250B1 (de) 2006-10-11
PT1183250E (pt) 2006-12-29
MXPA01012177A (es) 2002-07-22
CA2375253A1 (en) 2000-12-07
JP2003502290A (ja) 2003-01-21
WO2000073293A1 (en) 2000-12-07
DK1183250T3 (da) 2007-01-08
TW593300B (en) 2004-06-21
HK1042301A1 (en) 2002-08-09
DE60031269T2 (de) 2007-05-31
IL145869A0 (en) 2002-07-25
HUP0201266A3 (en) 2005-02-28
ES2273698T3 (es) 2007-05-16
HUP0201266A2 (en) 2002-08-28

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