ATE228520T1 - Lactamverbindungen als inhibitoren der cholesterin-esterase - Google Patents

Lactamverbindungen als inhibitoren der cholesterin-esterase

Info

Publication number
ATE228520T1
ATE228520T1 AT95922309T AT95922309T ATE228520T1 AT E228520 T1 ATE228520 T1 AT E228520T1 AT 95922309 T AT95922309 T AT 95922309T AT 95922309 T AT95922309 T AT 95922309T AT E228520 T1 ATE228520 T1 AT E228520T1
Authority
AT
Austria
Prior art keywords
cholesterol esterase
lactam compounds
esterase inhibitors
alkyl
compounds
Prior art date
Application number
AT95922309T
Other languages
English (en)
Inventor
Byron Rubin
Kenneth C Mattes
Terrence C Mungal
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of ATE228520T1 publication Critical patent/ATE228520T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT95922309T 1994-06-14 1995-06-13 Lactamverbindungen als inhibitoren der cholesterin-esterase ATE228520T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/259,593 US5474993A (en) 1994-06-14 1994-06-14 Lactam inhibitors of cholesterol esterase
PCT/US1995/007450 WO1995034566A1 (en) 1994-06-14 1995-06-13 Lactam inhibitors of cholesterol esterase

Publications (1)

Publication Number Publication Date
ATE228520T1 true ATE228520T1 (de) 2002-12-15

Family

ID=22985566

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95922309T ATE228520T1 (de) 1994-06-14 1995-06-13 Lactamverbindungen als inhibitoren der cholesterin-esterase

Country Status (9)

Country Link
US (1) US5474993A (de)
EP (1) EP0765330B1 (de)
JP (1) JPH10504283A (de)
AT (1) ATE228520T1 (de)
AU (1) AU693565B2 (de)
CA (1) CA2192984A1 (de)
DE (1) DE69528978D1 (de)
HU (1) HU221426B (de)
WO (1) WO1995034566A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264937B1 (en) * 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
CA2324801A1 (en) * 1999-11-10 2001-05-10 Andrew Gordon Swick Use of apo b secretion/mtp inhibitors and anti-obesity agents
IL139449A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Use of apo b secretion/mtp inhibitors
CA2324800A1 (en) * 1999-11-10 2001-05-10 Mary Anne Hickman Use of apo b secretion/mtp inhibitors
IL139450A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
US7115279B2 (en) * 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3311638A (en) * 1961-08-16 1967-03-28 Bristol Myers Co Anhydropenicillins
JPS608117B2 (ja) * 1977-02-08 1985-02-28 財団法人微生物化学研究会 新生理活性物質エステラスチンおよびその製造法
GB2023604B (en) * 1978-05-25 1982-07-28 Microbial Chem Res Found Physiologically active derivatives of esterastin and production thereof
US4202284A (en) * 1978-12-29 1980-05-13 Parsons Joe T Sr Sewing machine table
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US5132300A (en) * 1989-06-01 1992-07-21 Pfizer Inc. Beta-lactam elastase inhibitors
US5093371A (en) * 1990-07-02 1992-03-03 University Of Iowa Research Foundation Naphthyl ketone inhibitors of cholesterol esterase and their use as hypolipidemic and hypocaloric agents

Also Published As

Publication number Publication date
CA2192984A1 (en) 1995-12-21
HUT76612A (en) 1997-10-28
AU2704095A (en) 1996-01-05
AU693565B2 (en) 1998-07-02
EP0765330A4 (de) 2000-04-26
JPH10504283A (ja) 1998-04-28
HU221426B (en) 2002-10-28
EP0765330A1 (de) 1997-04-02
EP0765330B1 (de) 2002-11-27
US5474993A (en) 1995-12-12
WO1995034566A1 (en) 1995-12-21
DE69528978D1 (de) 2003-01-09
HU9603451D0 (en) 1997-02-28

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties