ATE342263T1 - Salze von benzimidazol-derivaten und deren verwendung - Google Patents

Salze von benzimidazol-derivaten und deren verwendung

Info

Publication number
ATE342263T1
ATE342263T1 AT01954427T AT01954427T ATE342263T1 AT E342263 T1 ATE342263 T1 AT E342263T1 AT 01954427 T AT01954427 T AT 01954427T AT 01954427 T AT01954427 T AT 01954427T AT E342263 T1 ATE342263 T1 AT E342263T1
Authority
AT
Austria
Prior art keywords
salt
salts
benzimidazole derivatives
benzimidazole
äää3
Prior art date
Application number
AT01954427T
Other languages
English (en)
Inventor
Keiji Kamiyama
Hideo Hashimoto
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE342263T1 publication Critical patent/ATE342263T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01954427T 2000-08-04 2001-08-03 Salze von benzimidazol-derivaten und deren verwendung ATE342263T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000236651 2000-08-04

Publications (1)

Publication Number Publication Date
ATE342263T1 true ATE342263T1 (de) 2006-11-15

Family

ID=18728661

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01954427T ATE342263T1 (de) 2000-08-04 2001-08-03 Salze von benzimidazol-derivaten und deren verwendung

Country Status (8)

Country Link
US (3) US7271182B2 (de)
EP (1) EP1306375B1 (de)
JP (1) JP5412023B2 (de)
AT (1) ATE342263T1 (de)
AU (1) AU2001276721A1 (de)
CA (2) CA2417311C (de)
DE (1) DE60123800T2 (de)
WO (1) WO2002012225A1 (de)

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EA200500673A1 (ru) * 2002-10-22 2005-12-29 Рэнбакси Лабораториз Лимитед Аморфная форма соли эзомепразола, способ ее получения и фармацевтическая композиция на её основе
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US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
EP1607395B1 (de) * 2003-03-24 2011-05-04 Eisai R&D Management Co., Ltd. Verfahren zur herstellung von amorphem rabeprazole-natrium-salz
CN1842525A (zh) 2003-05-05 2006-10-04 兰贝克赛实验室有限公司 苯并咪唑衍生物的钡盐
WO2004111029A2 (en) 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
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WO2005076987A2 (en) * 2004-02-10 2005-08-25 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent
GB0403165D0 (en) * 2004-02-12 2004-03-17 Ct Novel uses for proton pump inhibitors
WO2005082888A1 (en) * 2004-03-01 2005-09-09 Milen Merkez Ilac Endustrisi A.S. Process for the preparation of magnesium salt of omeprazole
EP1742630A4 (de) * 2004-04-16 2010-01-20 Santarus Inc Kombination aus protonenpumpenhemmer, puffermittel und prokinetischem wirkstoff
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8461187B2 (en) * 2004-06-16 2013-06-11 Takeda Pharmaceuticals U.S.A., Inc. Multiple PPI dosage form
FR2871800B1 (fr) * 2004-06-17 2006-08-25 Sidem Pharma Sa Sa Sel de sodium monohydrate du s-tenatoprazole et application en therapeutique
WO2006001753A1 (en) 2004-06-24 2006-01-05 Astrazeneca Ab New process for the preparation of crystal modifications for use in the preparation of esomeprazole sodium salt
US7244765B2 (en) * 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
ES2342090T3 (es) 2004-08-25 2010-07-01 Essentialis, Inc. Formulaciones farmaceuticas de agentes de apertura de canales de potasio dependientes de atp y usos de los mismos.
US20090030044A1 (en) * 2005-06-07 2009-01-29 Takeda Pharmaceutical Company Limited Crystal of Salt of Benzimidazole Compound
WO2006131338A2 (en) * 2005-06-08 2006-12-14 Lek Pharmaceuticals D.D. Crystalline solvate of omeprazole sodium
WO2007041790A1 (en) * 2005-10-14 2007-04-19 Jon Pty Limited Salts of proton pump inhibitors and process for preparing same
CN101868239B (zh) 2006-01-05 2015-06-10 伊森舍丽斯有限公司 钾atp通道开放剂的盐及其用途
US20080177076A1 (en) * 2006-11-06 2008-07-24 Lilach Hedvanti Processes for preparing substantially pure pantoprazole magnesium
WO2009049160A1 (en) * 2007-10-12 2009-04-16 Takeda Pharmaceuticals North America Methods of treating gastrointestinal disorders independent of the intake of food
US20100280077A1 (en) * 2007-12-18 2010-11-04 Watson Pharma Private Limited Process for Preparation of Stable Amorphous R-Lansoprazole
CN101250182B (zh) * 2008-03-26 2010-09-01 江苏奥赛康药业有限公司 兰索拉唑钠
EP2303868A2 (de) * 2008-05-14 2011-04-06 Watson Pharma Private Limited Stabiles r(+)-lansoprazolaminsalz und verfahren zu seiner herstellung
US20110009637A1 (en) * 2009-02-10 2011-01-13 Dario Braga Crystals of Dexlansoprazole
WO2011004387A2 (en) 2009-06-18 2011-01-13 Matrix Laboratories Ltd Process for the preparation of dexlansoprazole polymorphic forms
CA2771790A1 (en) * 2009-08-19 2011-02-24 Apotex Pharmachem Inc. Forms of dexlansoprazole and processes for the preparation thereof
CA2795056C (en) 2010-03-31 2015-03-24 Ranbaxy Laboratories Limited Salts of dexlansoprazole and their preparation
WO2011121548A1 (en) 2010-03-31 2011-10-06 Ranbaxy Laboratories Limited Process for the preparation of dexlansoprazole
CN102399212B (zh) * 2010-08-23 2014-07-16 江苏豪森医药集团有限公司 一种右兰索拉唑晶型及其制备方法
WO2012095859A1 (en) * 2011-01-12 2012-07-19 Hetero Research Foundation Polymorphs of dexlansoprazole salts
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WO2013140120A1 (en) 2012-03-22 2013-09-26 Cipla Limited Glycerol solvate forms of (r) - 2 - [ [ [3 -methyl -4 (2,2, 2 - trifluoroethoxy) pyridin- 2 - yl] methyl] sulphinyl] - 1h - ben zimidazole
WO2013179194A1 (en) 2012-05-31 2013-12-05 Ranbaxy Laboratories Limited Process for the preparation of crystalline dexlansoprazole
CN102942557A (zh) * 2012-11-26 2013-02-27 北京阜康仁生物制药科技有限公司 右兰索拉唑的新药用盐
US9011934B2 (en) 2013-06-14 2015-04-21 SatisPharma, LLC Multi-purpose anti-itch treatment
CN103788068B (zh) * 2014-02-26 2016-04-06 南京海融医药科技有限公司 高熔点的手性苯并咪唑类化合物钠盐、制备方法及其用途
CN105017216A (zh) * 2014-04-16 2015-11-04 天津药物研究院 右兰索拉唑晶型iii及其制备方法和用途
US9452178B1 (en) 2014-10-22 2016-09-27 SatisPharma, LLC Acne formulations, treatments, and pressure sensitive patches for delivery of acne formulations

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SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
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DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
SE9302396D0 (sv) 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE504459C2 (sv) 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
HRP960232A2 (en) 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
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TW385306B (en) * 1996-11-14 2000-03-21 Takeda Chemical Industries Ltd Method for producing crystals of benzimidazole derivatives
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Also Published As

Publication number Publication date
JP5412023B2 (ja) 2014-02-12
CA2775616A1 (en) 2002-02-14
CA2775616C (en) 2013-09-17
US20070254924A1 (en) 2007-11-01
US20030181487A1 (en) 2003-09-25
WO2002012225A1 (en) 2002-02-14
JP2002114779A (ja) 2002-04-16
CA2417311A1 (en) 2003-01-27
AU2001276721A1 (en) 2002-02-18
US20130281704A1 (en) 2013-10-24
DE60123800D1 (de) 2006-11-23
EP1306375A1 (de) 2003-05-02
DE60123800T2 (de) 2007-10-11
CA2417311C (en) 2012-07-10
EP1306375A4 (de) 2004-03-31
US8809542B2 (en) 2014-08-19
EP1306375B1 (de) 2006-10-11
US7271182B2 (en) 2007-09-18

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties