ATE342306T1 - Polymere zusammensetzung zur lösung von schwer wasserlöslichen medikamenten und verfahren zu deren herstellung - Google Patents

Polymere zusammensetzung zur lösung von schwer wasserlöslichen medikamenten und verfahren zu deren herstellung

Info

Publication number
ATE342306T1
ATE342306T1 AT00952029T AT00952029T ATE342306T1 AT E342306 T1 ATE342306 T1 AT E342306T1 AT 00952029 T AT00952029 T AT 00952029T AT 00952029 T AT00952029 T AT 00952029T AT E342306 T1 ATE342306 T1 AT E342306T1
Authority
AT
Austria
Prior art keywords
poorly water
production
polymeric composition
composition
dissolving poorly
Prior art date
Application number
AT00952029T
Other languages
English (en)
Inventor
Min-Hyo Seo
In-Ja Choi
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE342306T1 publication Critical patent/ATE342306T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00Compositions of unspecified macromolecular compounds
    • C08L101/12Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
    • C08L101/14Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/05Polymer mixtures characterised by other features containing polymer components which can react with one another
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00952029T 1999-08-14 2000-08-10 Polymere zusammensetzung zur lösung von schwer wasserlöslichen medikamenten und verfahren zu deren herstellung ATE342306T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019990033500A KR100360827B1 (ko) 1999-08-14 1999-08-14 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법

Publications (1)

Publication Number Publication Date
ATE342306T1 true ATE342306T1 (de) 2006-11-15

Family

ID=19607214

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00952029T ATE342306T1 (de) 1999-08-14 2000-08-10 Polymere zusammensetzung zur lösung von schwer wasserlöslichen medikamenten und verfahren zu deren herstellung

Country Status (13)

Country Link
US (1) US6616941B1 (de)
EP (1) EP1226212B1 (de)
JP (1) JP3363142B1 (de)
KR (1) KR100360827B1 (de)
CN (1) CN1164675C (de)
AT (1) ATE342306T1 (de)
AU (1) AU763154B2 (de)
CA (1) CA2381729C (de)
DE (1) DE60031286T2 (de)
ES (1) ES2269168T3 (de)
MX (1) MXPA02001527A (de)
NZ (1) NZ517036A (de)
WO (1) WO2001012718A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
KR100416242B1 (ko) * 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
KR100358027B1 (ko) * 2000-02-14 2002-10-25 한국과학기술연구원 의료용 생분해성 삼중블록 공중합체 및 그의 제조 방법
CA2408548C (en) * 2000-05-12 2008-03-11 Samyang Corporation Method for the preparation of polymeric micelle via phase separation of block copolymer
KR100446101B1 (ko) * 2000-12-07 2004-08-30 주식회사 삼양사 수난용성 약물의 서방성 제형 조성물
CA2440935A1 (en) * 2001-03-13 2002-09-19 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
DE60220519T2 (de) * 2001-04-20 2007-09-27 The University Of British Columbia, Vancouver Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
KR100488002B1 (ko) * 2001-06-20 2005-05-09 주식회사 삼양사 수용성 폴리알킬렌글리콜로 이루어진 친수성 블록과,방향족 기 함유 α-하이드록시산 유도체와 락타이드의불규칙 공중합체인 소수성 블록으로 이루어진 양친성 블록공중합체
KR100773078B1 (ko) * 2001-06-21 2007-11-02 주식회사 삼양사 결정성이 높은 난용성 약물을 함유하는 고분자 미셀형약물 조성물
KR100492805B1 (ko) * 2001-10-18 2005-06-07 주식회사 삼양사 안정성이 향상된 고분자 미셀 조성물
EP1448707B1 (de) * 2001-10-18 2007-08-22 Samyang Corporation Polymermicellenzusammensetzung mit verbesserter stabilität
KR100531269B1 (ko) * 2001-12-04 2005-11-28 주식회사 삼양사 수용액에서 안정한 미셀 또는 나노 파티클을 형성하는고분자 조성물
US8158145B2 (en) * 2002-02-19 2012-04-17 Hisamitsu Pharmaceutical Co., Inc. Percutaneous absorption type plaster
AU2003230761A1 (en) * 2002-03-29 2003-10-13 Abbott Laboratories Polymeric micelle formulations of hydrophobic compounds and methods
US20060165987A1 (en) * 2002-04-05 2006-07-27 Patrice Hildgen Stealthy polymeric biodegradable nanospheres and uses thereof
US20030203000A1 (en) * 2002-04-24 2003-10-30 Schwarz Marlene C. Modulation of therapeutic agent release from a polymeric carrier using solvent-based techniques
JP2003342168A (ja) * 2002-05-24 2003-12-03 Nano Career Kk 注射用薬物含有ポリマーミセル製剤の製造方法
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
KR100502840B1 (ko) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 약물 담지능력이 우수한 블록 공중합체 미셀 조성물
FR2845930B1 (fr) * 2002-10-21 2006-05-26 Oreal Procede de solubilisation de composes lipophiles en solution aqueuse par des copolymeres blocs amphiphiles et composition cosmetique
WO2004035013A2 (en) * 2002-10-21 2004-04-29 L'oreal Process for dissolving lipophilic compounds, and cosmetic composition
KR100560069B1 (ko) * 2002-11-29 2006-03-13 주식회사 태평양 생분해성 양친성 블록공중합체 및 이의 제조방법
DK1611884T3 (da) * 2003-03-18 2012-12-10 Hisamitsu Pharmaceutical Co Plaster, indeholdende diclofenac
US20040258754A1 (en) * 2003-06-18 2004-12-23 Valery Alakhov Compositions for oral administration of camptothecin and its analogs
EP1661556A4 (de) * 2003-08-20 2010-05-19 Ajinomoto Kk Medizinisches präparat mit verbesserten auflösungseigenschaften
CN100471886C (zh) * 2003-10-10 2009-03-25 株式会社三养社 两亲嵌段共聚物以及包含它的用于给药的聚合组合物
US7311901B2 (en) * 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
US7179867B2 (en) * 2003-11-26 2007-02-20 Industrial Technology Research Institute Thermosensitive biodegradable copolymer
US20050226932A1 (en) * 2004-04-09 2005-10-13 Samyang Corporation Pharmaceutical formulations for itraconazole
CN1320927C (zh) * 2005-01-27 2007-06-13 浙江大学 仿细胞膜的聚合物胶束载药体系
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
CN1299776C (zh) * 2005-04-18 2007-02-14 武汉大学 两亲三嵌段共聚物纳米粒及其制备方法和用途
US8283352B2 (en) * 2005-06-13 2012-10-09 Dainippon Sumitomo Pharma Co., Ltd. Solubilization preparation
PT1920786E (pt) 2005-07-25 2011-12-28 Otsuka Pharma Co Ltd Preparação oral para avaliar a capacidade metabólica da pirimidina
SG170823A1 (en) * 2006-04-13 2011-05-30 Otsuka Pharma Co Ltd Test agent for diagnosing dyspepsia
WO2008035229A2 (en) * 2006-09-22 2008-03-27 Labopharm, Inc. Compositions and methods for ph targeted drug delivery
US20100008998A1 (en) * 2006-09-26 2010-01-14 Samyang Corporation Submicron nanoparticle of poorly water soluble camptothecin derivatives and process for preparation thereof
AU2013203271B2 (en) * 2007-01-19 2016-05-12 Hananja Ehf Methods and compositions for the delivery of a therapeutic agent
CN101678112B (zh) * 2007-01-19 2016-08-31 哈南亚有限公司 用于递送治疗剂的方法和组合物
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
CN102895668A (zh) 2007-04-30 2013-01-30 新加坡科技研究局 一种将蛋白质递送到细胞中的方法
WO2009002425A2 (en) * 2007-06-22 2008-12-31 Scidose Llc Solubilized formulation of docetaxel without tween 80
EP2200613B1 (de) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazin-derivate und ihre verwendungen
GB0720716D0 (en) * 2007-10-23 2007-12-05 York Pharma Plc Novel formulation
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
CN101910246B (zh) * 2007-12-31 2013-01-02 株式会社三养生物制药 包含源自α-羟酸的疏水嵌段的高纯两亲共聚物及其制备方法
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
WO2009091622A1 (en) * 2008-01-18 2009-07-23 Dow Global Technologies Inc. Method to enhance aqueous solubility of poorly soluble actives using methoxypolyethylene glycol
WO2009105692A1 (en) * 2008-02-21 2009-08-27 Rutgers, The State University Of New Jersey Compositions and methods for treating ophthalmic diseases
US20110257253A1 (en) * 2008-12-26 2011-10-20 Samyang Corporation Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
EP2201935B1 (de) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymere Mizellenzusammensetzung, die ein schlecht lösliches Arzneimittel enthält, und zugehöriges Herstellungsverfahren
CN101444510B (zh) * 2008-12-31 2011-03-09 南京卡文迪许生物工程技术有限公司 含有伏立康唑的药物制剂及其制备方法
EP2210584A1 (de) 2009-01-27 2010-07-28 Bayer Schering Pharma Aktiengesellschaft Stabile Polymerzusammensetzung mit einem Epothilon und einem amphiphilischen Blockpolymer
CA2756072A1 (en) * 2009-03-30 2010-10-14 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
CN102348468B (zh) * 2009-07-31 2014-11-05 西安力邦医药科技有限责任公司 微球药物载体、其制备方法、组合物及应用
AU2010278601A1 (en) * 2009-07-31 2012-02-23 Xi'an Libang Medical Technology Co., Ltd Nanosphere or microsphere drug carrier, preparation method, composition and use thereof
EP2498835B1 (de) * 2009-11-13 2017-05-24 Nanyang Technological University Biologisch abbaubare thermoplastische elastomere
WO2011070436A2 (en) 2009-12-11 2011-06-16 Council Of Scientific & Industrial Research In situ cross linked biodegradable gel with hydrophobic pockets
KR101267813B1 (ko) 2009-12-30 2013-06-04 주식회사 삼양바이오팜 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물
CN103857440B (zh) 2011-06-22 2018-09-25 维奥姆生物科学有限公司 基于缀合物的抗真菌和抗细菌前药
KR101286854B1 (ko) 2011-09-29 2013-07-17 중앙대학교 산학협력단 폴리락트산(a)과 폴리에틸렌글리콜(b)로 이루어진 bab형 삼중 블록 공중합체, 이의 제조방법 및 이를 이용한 약물전달체
CA2882528A1 (en) 2012-08-20 2014-02-27 Otsuka Pharmaceutical Co., Ltd. Method for measuring carbohydrate metabolism ability, and composition for use in said method
KR20210014204A (ko) 2013-03-15 2021-02-08 오츠카 세이야쿠 가부시키가이샤 지방산 연소에 의한 인슐린 저항성의 측정 방법, 및 그에 사용하는 조성물
US20160128944A1 (en) 2013-06-04 2016-05-12 Vyome Biosciences Pvt. Ltd. Coated particles and compositions comprising same
CN104758256B (zh) * 2014-02-14 2016-05-04 苏州海特比奥生物技术有限公司 一种多西他赛纳米聚合物胶束冻干制剂及其制备方法
WO2016094594A1 (en) 2014-12-09 2016-06-16 Sweetwater Energy, Inc. Rapid pretreatment
KR101748191B1 (ko) * 2015-07-28 2017-06-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
CN105250219A (zh) * 2015-11-12 2016-01-20 济南大学 一种酮康唑载药胶束及其制备方法
CN106727306A (zh) * 2016-12-12 2017-05-31 温州医科大学 一种高载药量曲安奈德胶束的制备方法
KR102358377B1 (ko) 2016-12-28 2022-02-03 히사미쓰 세이야꾸 가부시키가이샤 첩부제
US11821047B2 (en) 2017-02-16 2023-11-21 Apalta Patent OÜ High pressure zone formation for pretreatment
AU2018285975B2 (en) * 2017-06-13 2023-11-16 The University Of British Columbia Polymeric paste compositions for drug delivery
JP7017770B2 (ja) * 2017-07-31 2022-02-09 国立大学法人 東京大学 解重合性を有する両親媒性ブロック共重合体
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device
BR112022012348A2 (pt) 2019-12-22 2022-09-13 Sweetwater Energy Inc Métodos de fazer lignina especializada e produtos de lignina da biomassa
BR112022020991A2 (pt) * 2020-08-31 2023-03-07 Vaim Co Ltd Dispersão de polímero biodegradável, composição compreendendo a mesma e sistema de melhoria da pele
KR102317559B1 (ko) * 2021-02-16 2021-10-27 주식회사 유머스트알엔디 암을 치료하기 위한 신규 화합물, 이를 포함하는 약제학적 조성물 및 이의 제조방법
US11872320B2 (en) 2021-02-25 2024-01-16 Hisamitsu Pharmaceutical Co., Inc. Method for treating osteoarthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US566428A (en) * 1896-08-25 terry
CA2087125A1 (en) 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
WO1995010265A1 (en) * 1993-10-15 1995-04-20 Cytrx Corporation Therapeutic delivery compositions and methods of use thereof
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5665428A (en) 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
JP4189889B2 (ja) 1996-07-29 2008-12-03 株式会社ヴァーユ ポリ(2―ヒドロキシエチル(メタ)アクリレート)セグメントを分子中に含有する改質ポリマー
KR100289074B1 (ko) * 1998-02-04 2001-07-12 김윤 난용성약물함유시스템
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법

Also Published As

Publication number Publication date
CN1164675C (zh) 2004-09-01
US6616941B1 (en) 2003-09-09
CA2381729C (en) 2008-07-29
DE60031286T2 (de) 2007-05-24
JP3363142B1 (ja) 2003-01-08
CA2381729A1 (en) 2001-02-22
DE60031286D1 (de) 2006-11-23
ES2269168T3 (es) 2007-04-01
AU6479200A (en) 2001-03-13
AU763154B2 (en) 2003-07-17
KR20010017804A (ko) 2001-03-05
CN1370201A (zh) 2002-09-18
EP1226212B1 (de) 2006-10-11
EP1226212A4 (de) 2005-01-12
JP2003507514A (ja) 2003-02-25
NZ517036A (en) 2003-07-25
KR100360827B1 (ko) 2002-11-18
EP1226212A1 (de) 2002-07-31
MXPA02001527A (es) 2002-07-02
WO2001012718A1 (en) 2001-02-22

Similar Documents

Publication Publication Date Title
ATE342306T1 (de) Polymere zusammensetzung zur lösung von schwer wasserlöslichen medikamenten und verfahren zu deren herstellung
DE60135486D1 (de) Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung
Parhi Cross-linked hydrogel for pharmaceutical applications: a review
ATE358160T1 (de) Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffen
US20080199431A1 (en) Self-Assembling Membranes And Related Methods Thereof
WO2004112748A3 (en) Rate controlled release of a pharmaceutical agent in a biodegradable device
DK1638539T3 (da) Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikament
NO20025759D0 (no) Formulering basert på heparin, glykosaminoglykan eller heparinoid, anvendelse av formuleringen og formuleringsbasen
WO2002031025A3 (en) Biodegradable poly(beta-amino esters) and uses thereof
KR940003540A (ko) 수용성 약제의 마이크로캡슐의 제조방법
DE60041978D1 (de) Auf äussere bedingungen ansprechende polymere hohle partikel
ATE267842T1 (de) Mit bioaktiven mitteln beladene polymeren
SE0202619D0 (sv) New Polymers and Applications
KR102409490B1 (ko) 국소피부용 마이크로니들 및 이의 제조방법
ATE141788T1 (de) Mikrosphäre enthaltende pharmazeutische zusammensetzung mit kontrollierter freigabe und verfahren zur herstellung
DE60229249D1 (de) Verfahren zur erzeugung von emulsionen
WO2002085337B1 (en) Micellar drug delivery systems for hydrophobic drugs
BR0012972A (pt) Modos para criar uma massa tendo integridade estrutural
ATE427760T1 (de) Erodierbare polymere zur injektion
DE68904922D1 (de) Piroxicam in waessrigen loesungen enthaltende arzneizubereitungen und verfahren zu deren herstellung.
ATE345780T1 (de) Lyophilisierende zusammensetzung von wirkstoff- verkapselnder polymer-mizelle und verfahren zu ihrer herstellung
DE60001640D1 (de) Dreidimensionale struktur enthaltend hyaluronsäurederivat, hergestellt durch die technik von superkritischen antilösungsmitteln
Zhou et al. Thermoresponsive macroporous scaffolds prepared by emulsion templating
EP1514560A4 (de) Verfahren zur herstellung eines blockcopolymer/arzneimittel-komposits
Jang et al. Effect of surface interactions on microsphere loading in dissolving microneedle patches

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties