ATE405251T1 - Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung - Google Patents

Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung

Info

Publication number
ATE405251T1
ATE405251T1 AT01999357T AT01999357T ATE405251T1 AT E405251 T1 ATE405251 T1 AT E405251T1 AT 01999357 T AT01999357 T AT 01999357T AT 01999357 T AT01999357 T AT 01999357T AT E405251 T1 ATE405251 T1 AT E405251T1
Authority
AT
Austria
Prior art keywords
drug
compositions
composition
production
delayed release
Prior art date
Application number
AT01999357T
Other languages
English (en)
Inventor
Min-Hyo Seo
Yil-Woong Yi
Sang-Jun Lee
Jae-Hong Kim
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE405251T1 publication Critical patent/ATE405251T1/de

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
AT01999357T 2000-12-07 2001-12-07 Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung ATE405251T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20000074098 2000-12-07

Publications (1)

Publication Number Publication Date
ATE405251T1 true ATE405251T1 (de) 2008-09-15

Family

ID=19702771

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01999357T ATE405251T1 (de) 2000-12-07 2001-12-07 Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung

Country Status (10)

Country Link
US (1) US7153520B2 (de)
EP (1) EP1339389B1 (de)
JP (1) JP2004514734A (de)
KR (1) KR100446101B1 (de)
CN (1) CN1234416C (de)
AT (1) ATE405251T1 (de)
AU (2) AU2273302A (de)
CA (1) CA2430481C (de)
DE (1) DE60135486D1 (de)
WO (1) WO2002045689A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
WO2003017987A1 (en) * 2001-08-31 2003-03-06 Mcgill University Biodegradable polymeric nanocapsules and uses thereof
NZ532198A (en) * 2001-10-18 2006-03-31 Samyang Corp Polymeric micelle composition of an amphiphilic block copolymer and a polylactic acid derivative
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US8501215B2 (en) * 2002-07-31 2013-08-06 Guohua Chen Injectable multimodal polymer depot compositions and uses thereof
US8986737B2 (en) 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
MXPA05002589A (es) * 2002-09-05 2005-09-20 Ambrose Catherine G Microesferas antibioticas para el tratamiento de infecciones y osteomelitis.
DE60319727T2 (de) * 2002-10-21 2009-03-12 L'oreal Verfahren zum auflösen lipophiler verbindungen, und kosmetische zusammensetzung.
AU2004241830B9 (en) 2003-05-26 2010-04-22 Hiroshi Maeda Antitumor agent and process for producing the same
ES2379466T3 (es) 2003-06-26 2012-04-26 Psivida Us, Inc. Sistema de suministro de fármacos de liberación sostenida bioerosionables
JP5229768B2 (ja) * 2003-06-26 2013-07-03 シヴィダ・ユーエス・インコーポレイテッド In−Situゲル化薬物輸送システム
JP4939936B2 (ja) * 2003-06-27 2012-05-30 株式會社アモーレパシフィック 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物
KR100967113B1 (ko) 2003-12-03 2010-07-05 (주)아모레퍼시픽 코엔자임 q10을 함유한 자기회합성 고분자 나노입자 및이를 함유한 피부 외용제 조성물
CN100539988C (zh) * 2003-06-27 2009-09-16 株式会社太平洋 含有生理活性成分的自聚集聚合物纳米颗粒和含有该纳米颗粒的外用搽剂
KR101054728B1 (ko) 2004-06-16 2011-08-05 (주)아모레퍼시픽 난용성 발모 및 육모 생리활성 물질인 사이클로스포린을포함하는 나노입자 및 이를 함유하는 피부 외용제 조성물
WO2005000258A1 (en) * 2003-06-27 2005-01-06 Amorepacific Corporation Self-assembled polymeric nanoparticles containing physiologically active ingredients and external application containing the nanoparticles
KR20050064075A (ko) * 2003-12-23 2005-06-29 주식회사 삼양사 이트라코나졸을 유효성분으로 하는 약학적 조성물
GB0412866D0 (en) * 2004-06-09 2004-07-14 Novartis Ag Organic compounds
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US20060034889A1 (en) * 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
JP2008519076A (ja) * 2004-11-02 2008-06-05 テルアビブ ユニバーシティ フューチャー テクノロジー デベロップメント エル.ピー. 脂質化グリコサミノグリカン粒子中の水不溶性又は水難溶性薬物の処方、並びに診断及び治療のためのこれらの使用
NZ556290A (en) * 2005-01-04 2010-11-26 Intezyne Technologies Inc Synthesis of hybrid block copolymers and uses thereof
JP2007023023A (ja) * 2005-06-15 2007-02-01 Kanagawa Acad Of Sci & Technol 組織接着性薬剤放出ゲル形成用組成物
US20090306339A1 (en) * 2006-09-19 2009-12-10 Van Boxtel Huibert Albertus Preparation of Fine Particles
CA2699184A1 (en) * 2006-09-22 2008-03-27 Labopharm Inc. Compositions and methods for ph targeted drug delivery
CA2663558C (en) * 2006-09-26 2013-05-28 Samyang Corporation Submicron nanoparticle of poorly water soluble camptothecin derivatives and process for preparation thereof
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
GB0720716D0 (en) * 2007-10-23 2007-12-05 York Pharma Plc Novel formulation
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
WO2009064442A1 (en) * 2007-11-13 2009-05-22 Brookwood Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
KR101187487B1 (ko) * 2007-12-31 2012-10-02 주식회사 삼양바이오팜 고순도의 폴리 알파(α)-히드록시산의 소수성 고분자 블록을 포함하는 양친성 블록 공중합체 및 그의 제조방법
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
BRPI0905707B1 (pt) 2008-01-18 2024-02-27 Dow Global Technologies Inc Método para aumentar a solubilidade aquosa de um composto ativo e composição compreendendo um composto ativo
AU2009216216B2 (en) 2008-02-22 2013-11-07 Toray Industries, Inc. Microparticles and pharmaceutical compositions thereof
US8858995B2 (en) * 2008-03-10 2014-10-14 University Of Louisville Research Foundation, Inc. Methods and compositions for controlled delivery of phytochemical agents
EP2103313A1 (de) * 2008-03-19 2009-09-23 Koninklijke Philips Electronics N.V. Verfahren für die Synthese von Hohlkugeln
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US8916188B2 (en) 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
EA020753B1 (ru) 2008-06-16 2015-01-30 Бинд Терапьютикс, Инк. Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение
WO2010005726A2 (en) 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
ES2765240T3 (es) 2008-06-16 2020-06-08 Pfizer Nanopartículas poliméricas cargadas de fármaco y procedimientos de fabricación y uso de las mismas
EP2323623B1 (de) 2008-08-12 2016-07-27 Novartis AG Pharmazeutische zusammensetzungen
EP2172189A1 (de) * 2008-10-01 2010-04-07 Novartis AG Pharmazeutische Zusammensetzungen
JP2010065067A (ja) * 2008-09-08 2010-03-25 Tokyo Univ Of Agriculture & Technology 粒子およびその製造方法、ならびにゲル
AU2009296394B2 (en) * 2008-09-25 2014-01-09 Invivo Therapeutics Corporation Spinal cord injury, inflammation, and immune-disease: local controlled release of therapeutic agents
TWI372057B (en) * 2008-12-11 2012-09-11 Dev Center Biotechnology Sustained release implant for granisetron
WO2010068827A1 (en) * 2008-12-11 2010-06-17 A.P. Pharma, Inc. Methods for enhancing stability of polyorthoesters and their formulations
ES2776126T3 (es) 2008-12-15 2020-07-29 Pfizer Nanopartículas de circulación prolongada para la liberación sostenida de agentes terapéuticos
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US8951546B2 (en) 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US9480643B2 (en) * 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US20100158978A1 (en) * 2008-12-23 2010-06-24 Peter Markland Bioactive spray coating compositions and methods of making and uses thereof
US9415197B2 (en) 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
EP2201935B1 (de) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymere Mizellenzusammensetzung, die ein schlecht lösliches Arzneimittel enthält, und zugehöriges Herstellungsverfahren
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
US20100203150A1 (en) * 2009-02-06 2010-08-12 National Tsing Hua University Novel amphiphilic copolymers and fabrication method thereof
EA201171195A8 (ru) * 2009-03-30 2014-08-29 Серулин Фарма Инк. Конъюгаты, частицы, композиции "полимер-агент" и способы их применения
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
CN106421797A (zh) 2009-10-01 2017-02-22 艾戴尔医药公司 口服给予的皮质类固醇组合物
WO2011072218A2 (en) 2009-12-11 2011-06-16 Bind Biosciences Stable formulations for lyophilizing therapeutic particles
WO2011084513A2 (en) 2009-12-15 2011-07-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
WO2012030821A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Terpolymer blends and their use as pressure-sensitive adhesives
EA027046B1 (ru) 2010-12-29 2017-06-30 Мединселл Биоразлагаемая композиция для доставки лекарственных средств, способ ее получения и ее применение
CN103889434B (zh) 2011-06-21 2017-02-15 Bvw控股公司 含有乳香酸的医疗装置
WO2013148682A1 (en) * 2012-03-26 2013-10-03 University Of Louisville Research Foundation, Inc. Methods and compositions for controlled delivery of phytochemical agents
WO2014001904A1 (en) * 2012-06-27 2014-01-03 Medincell Biodegradable drug delivery for hydrophobic compositions
PT2895156T (pt) 2012-09-17 2019-06-28 Pfizer Processo para a preparação de nanopartículas terapêuticas
WO2014165842A2 (en) * 2013-04-05 2014-10-09 Igdrasol Nanoparticle formulations in biomarker detection
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
CN104761710B (zh) * 2014-02-14 2016-06-29 苏州海特比奥生物技术有限公司 一种聚乙二醇单甲醚-聚乳酸嵌段共聚物及其制备方法
SI3116547T1 (sl) 2014-03-14 2019-08-30 Pfizer, Inc. Terapevtski nanodelci, ki obsegajo terapevtsko stredstvo, in postopek izdelave ter uporabe le-teh
WO2016205652A1 (en) 2015-06-18 2016-12-22 Acuitybio Corporation Implantable drug delivery compositions and methods of use thereof
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
CN106727306A (zh) * 2016-12-12 2017-05-31 温州医科大学 一种高载药量曲安奈德胶束的制备方法
CN107596380B (zh) * 2017-09-03 2020-09-11 河南师范大学 基于聚乙二醇-聚碳酸酯的还原敏感性喜树碱前药及其制备方法和应用
KR102072419B1 (ko) * 2018-04-19 2020-02-03 중앙대학교 산학협력단 항암제 봉입 마이셀 제제 조성물
EP4090353A4 (de) 2020-01-13 2023-08-09 Durect Corporation Arzneimittelabgabesysteme mit verzögerter freisetzung mit reduzierten verunreinigungen und verwandte verfahren
KR102905790B1 (ko) * 2020-08-31 2026-01-08 주식회사 바임 생분해성 고분자 분산체, 이를 포함하는 조성물 및 피부 개선용 시스템
CN115427012B (zh) * 2020-08-31 2024-07-02 株式会社百艺 生物降解性高分子分散体、包含其的组合物和皮肤改善用系统
JP2024503402A (ja) 2021-01-12 2024-01-25 デュレクト コーポレーション 徐放性薬物送達システム及び関連の方法
CN114903904B (zh) * 2021-02-08 2024-02-09 宜昌人福药业有限责任公司 瑞马唑仑药用盐和阿片样物质的注射用药物组合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2080682B (en) * 1980-07-30 1984-03-28 Ciba Geigy Ag Antiherpetically active lipstick
CA2050067C (en) * 1990-08-30 2000-05-30 Yasushi Morita Controlled drug release composition
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JPH08176016A (ja) * 1994-12-19 1996-07-09 Univ Miami 生分解可能で注射可能な薬物運搬ポリマー
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
KR100289074B1 (ko) * 1998-02-04 2001-07-12 김윤 난용성약물함유시스템
US7128927B1 (en) * 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
KR100274842B1 (ko) * 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
AU5887201A (en) * 2000-05-12 2001-11-20 Samyang Corp Method for the preparation of polymeric micelle via phase separation of block copolymer
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof

Also Published As

Publication number Publication date
WO2002045689A1 (en) 2002-06-13
EP1339389B1 (de) 2008-08-20
DE60135486D1 (de) 2008-10-02
US20040037885A1 (en) 2004-02-26
CN1477952A (zh) 2004-02-25
KR20020045569A (ko) 2002-06-19
AU2273302A (en) 2002-06-18
AU2002222733B2 (en) 2006-03-30
EP1339389A4 (de) 2007-08-08
CA2430481A1 (en) 2002-06-13
CN1234416C (zh) 2006-01-04
US7153520B2 (en) 2006-12-26
CA2430481C (en) 2008-07-22
EP1339389A1 (de) 2003-09-03
KR100446101B1 (ko) 2004-08-30
JP2004514734A (ja) 2004-05-20

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