ATE342348T1 - Serum-freies medium für chondrozyt-ähnliche zellen - Google Patents

Serum-freies medium für chondrozyt-ähnliche zellen

Info

Publication number: ATE342348T1
Authority: AT; Austria
Prior art keywords: serum; free medium; chondrocytes; free; cells
Prior art date: 1998-11-09

Application number

AT99971844T

Other languages

English (en)

Inventor

Ranieri Cancedda

Beatrice Dozin

Original Assignee

Consorzio Per La Gestione Del

Istituto Naz Per La Ricerce Su

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-09

Filing date

1999-11-08

Publication date

2006-11-15

1999-11-08 Application filed by Consorzio Per La Gestione Del, Istituto Naz Per La Ricerce Su filed Critical Consorzio Per La Gestione Del

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE342348T1 publication Critical patent/ATE342348T1/de

Links

239000012679 serum free medium Substances 0.000 title abstract 4
210000001612 chondrocyte Anatomy 0.000 abstract 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
102000003974 Fibroblast growth factor 2 Human genes 0.000 abstract 2
108090000379 Fibroblast growth factor 2 Proteins 0.000 abstract 2
230000012010 growth Effects 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
210000002901 mesenchymal stem cell Anatomy 0.000 abstract 2
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 abstract 1
102000009027 Albumins Human genes 0.000 abstract 1
108010088751 Albumins Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 1
102000004338 Transferrin Human genes 0.000 abstract 1
108090000901 Transferrin Proteins 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
229960002685 biotin Drugs 0.000 abstract 1
235000020958 biotin Nutrition 0.000 abstract 1
239000011616 biotin Substances 0.000 abstract 1
230000010261 cell growth Effects 0.000 abstract 1
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
229960003957 dexamethasone Drugs 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
229910052711 selenium Inorganic materials 0.000 abstract 1
239000011669 selenium Substances 0.000 abstract 1
239000004017 serum-free culture medium Substances 0.000 abstract 1
239000012581 transferrin Substances 0.000 abstract 1
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Zoology (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Developmental Biology & Embryology (AREA)
Hematology (AREA)
Immunology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT99971844T 1998-11-09 1999-11-08 Serum-freies medium für chondrozyt-ähnliche zellen ATE342348T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10764698P	1998-11-09	1998-11-09

Publications (1)

Publication Number	Publication Date
ATE342348T1 true ATE342348T1 (de)	2006-11-15

Family

ID=22317692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99971844T ATE342348T1 (de)	1998-11-09	1999-11-08	Serum-freies medium für chondrozyt-ähnliche zellen

Country Status (10)

Country	Link
US (2)	US6617159B1 (de)
EP (1)	EP1131407B1 (de)
JP (1)	JP2002529071A (de)
AT (1)	ATE342348T1 (de)
AU (1)	AU758073B2 (de)
CA (1)	CA2348687A1 (de)
DE (1)	DE69933579D1 (de)
IL (2)	IL142914A0 (de)
RU (1)	RU2272839C2 (de)
WO (1)	WO2000027996A1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001048147A1 (en) *	1999-12-28	2001-07-05	Iso Tis N.V.	Cell culture medium containing growth factors and l-glutamine
ES2328460T3 (es)	2001-04-24	2009-11-13	Dolores Baksh	Poblaciones de celulas progenitoras, expansion de las mismas y crecimiento de tipos de celulas no hematopoyeticas y tejidos provenientes de las mismas.
FR2828401B1 (fr) *	2001-08-10	2003-11-07	Oreal	Composition cosmetique ou dermatologique comprenant une association entre l'igf1 et/ou un compose mimetique de l'igf1, et l'acide ascorbique et/ou au moins l'un de ses derives
JP2003052360A (ja) *	2001-08-20	2003-02-25	Japan Science & Technology Corp	基底膜細胞外基質を用いた間葉系幹細胞の培養方法
US20030109038A1 (en)	2001-12-07	2003-06-12	Thies R. Scott	Chondrocyte precursors derived from human embryonic stem cells
US20070141036A1 (en) *	2002-01-09	2007-06-21	Alberto Gorrochategui Barrueta	Composition and procedure for tissue creation, regeneration and repair by a cell-bearing biological implant enriched with platelet concentrate and supplements
BRPI0307074A2 (pt)	2002-01-25	2017-06-20	Genzyme Corp	meios sem soro para condrócitos e métodos para seu uso
US7741116B2 (en)	2002-03-06	2010-06-22	University Of Cincinnati	Surgical device for skin therapy or testing
WO2003082305A1 (en) *	2002-04-03	2003-10-09	Naohide Yamashita	Drug containing human placenta-origin mesenchymal cells and process for producing vegf using the cells
WO2003097820A1 (en) *	2002-05-22	2003-11-27	Fushimi Pharmaceutical Co.,Ltd.	Method of utilizing physiological activity of rare saccharide and compositions containing rare saccharide
DE10311620A1 (de) *	2003-03-17	2004-10-07	Biotissue Technologies Gmbh	Knorpelzell-Kulturmedium und Verwendung desselben
AU2003903896A0 (en) *	2003-07-28	2003-08-07	Queensland University Of Technology	Skin regeneration system
WO2005065354A2 (en) *	2003-12-31	2005-07-21	The Burnham Institute	Defined media for pluripotent stem cell culture
US20080113434A1 (en) *	2004-03-05	2008-05-15	Davies John E	Serum-Free Suspension Culture System For Mesenchymal Progenitor Cells
WO2005099758A2 (en) *	2004-04-17	2005-10-27	The Board Of Trustees The Leland Standford Junior University	Injectable bioartificial tissue matrix
WO2005113749A2 (en) *	2004-05-14	2005-12-01	Becton, Dickinson And Company	Stem cell populations and methods of use
RU2265445C1 (ru) *	2004-05-14	2005-12-10	ЗАО "РеМеТэкс"	Биотрансплантат, способ его получения (варианты) и способ лечения заболеваний пародонта
WO2006004149A1 (ja) *	2004-07-06	2006-01-12	Kyowa Hakko Kogyo Co., Ltd.	神経細胞の製造方法
US8697139B2 (en)	2004-09-21	2014-04-15	Frank M. Phillips	Method of intervertebral disc treatment using articular chondrocyte cells
JP4646600B2 (ja) *	2004-11-02	2011-03-09	オリンパス株式会社	間葉系幹細胞の培養方法
JP2006136281A (ja) *	2004-11-15	2006-06-01	Olympus Corp	培地および間葉系幹細胞の培養方法
WO2006054448A1 (ja) *	2004-11-19	2006-05-26	Jms Co., Ltd.	細胞培養用ヒト血清
EP2210937A1 (de) *	2005-05-09	2010-07-28	Olympus Corporation	Kulturverfahren für mesenchymale Stammzelle und Verfahren zur Herstellung von Trägermaterial für biologisches Gewebe
US20090169523A1 (en)	2005-06-13	2009-07-02	Catherine Verfaillie	Hsc self-renewal
EP1930413B1 (de) *	2005-08-23	2011-01-12	Oriental Yeast Co., Ltd.	Technik zur kultivierung einer mesenchymalen stammzelle unter verwendung von laminin-5
JP4921083B2 (ja) *	2005-09-13	2012-04-18	タカラバイオ株式会社	レトロウィルス産生用無血清培地
WO2007044418A2 (en) *	2005-10-06	2007-04-19	Moscatello David K	Cell culture media, kits and methods of use
DE102005054577A1 (de) *	2005-11-16	2007-05-24	Cognis Ip Management Gmbh	Verwendung von Estern ungesättigter, physiologisch aktiver Fettsäuren als Nährmedien für Zellkulturen
JP4385076B2 (ja)	2006-01-13	2009-12-16	独立行政法人科学技術振興機構	動物細胞を無血清培養するための培地用添加剤、キット及びこれらの利用
ITTO20060282A1 (it) *	2006-04-14	2007-10-15	Univ Degli Studi Torino	Mezzo di coltura e composizione farmaceutica per la rigenerazione del tessuto cartilagineo relativo procedimento relativi usi e prodotti
BRPI0713572A2 (pt) *	2006-06-20	2012-10-23	Stephen Duguay	meios livres de soro e seus usos para expansão de condrócitos
EP1900810A1 (de) *	2006-09-15	2008-03-19	Celogos	Verfahren zur Zellextraktion und Zellselektion
JP2008099662A (ja)	2006-09-22	2008-05-01	Institute Of Physical & Chemical Research	幹細胞の培養方法
EP1972685B1 (de) *	2007-03-20	2015-09-02	Université Paris Descartes	Kulturmedium für Zahnfleischfibroblasten
US8114668B2 (en) *	2007-05-14	2012-02-14	Cardiac Pacemakers, Inc.	Composition for cold storage of stem cells
RU2351020C1 (ru) *	2007-06-25	2009-03-27	Федеральное государственное учреждение "Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р. Вредена Федерального агентства по высокотехнологичной медицинской помощи" ( ФГУ "РНИИТО им. Р.Р. Вредена Росмедтехнологий")	Способ лечения полнослойных дефектов хряща коленного сустава с использованием культуры аутологичных мезенхимальных стволовых клеток
ITMI20071421A1 (it) *	2007-07-16	2009-01-17	Fond Irccs Istituto Di Ricove	Coltura per espandere cellule staminali ex-vivo
WO2009030092A1 (fr) *	2007-09-05	2009-03-12	Institute Of Basic Medical Sciences Chinese Academy Of Medical Sciences	Milieu de culture et procédé destinés à une culture in vitro de cellules souches mésenchymateuses primaires adultes humaines à grande échelle, cellules souches mésenchymateuses primaires obtenues à l'aide de ce procédé, utilisations correspondantes
WO2009092092A1 (en)	2008-01-18	2009-07-23	Regents Of The University Of Minnesota	Stem cell aggregates and methods for making and using
US20100015710A1 (en) *	2008-04-25	2010-01-21	Sunghoon Jung	Methods and Compositions for Isolating, Maintaining and Serially Expanding Human Mesenchymal Stem Cells
KR101651661B1 (ko) *	2008-06-30	2016-08-26	얀센 바이오테크 인코포레이티드	만능 줄기 세포의 분화
WO2010055616A1 (ja) *	2008-11-11	2010-05-20	独立行政法人科学技術振興機構	分化誘導培地用添加剤およびその利用
EP2456853B1 (de)	2009-07-21	2020-10-28	ABT Holding Company	Verwendung von stammzellen für reduzierte leukozyten-extravasation
US20110020292A1 (en)	2009-07-21	2011-01-27	Abt Holding Company	Use of Stem Cells to Reduce Leukocyte Extravasation
SG10201403202XA (en) *	2009-07-23	2014-08-28	Agency Science Tech & Res	Pre-natal mesenchymal stem cells
US9018010B2 (en) *	2009-11-12	2015-04-28	Technion Research & Development Foundation Limited	Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
CA2791331A1 (en)	2010-02-25	2011-09-01	Abt Holding Company	Modulation of angiogenesis
SG183497A1 (en)	2010-02-25	2012-09-27	Abt Holding Co	Modulation of macrophage activation
JP5804385B2 (ja)	2010-03-10	2015-11-04	株式会社ツーセル	間葉系幹細胞を含む細胞製剤及びその製造方法
AU2011236653B2 (en)	2010-04-08	2016-10-27	The University Court Of The University Of Edinburgh	Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof
DK2568991T6 (en)	2010-05-12	2019-03-18	Abt Holding Co	MODULATION OF SPLENOCYTES IN CELL THERAPY
WO2011158125A2 (en)	2010-06-17	2011-12-22	Katholieke Universiteit Leuven	Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
SG10201914007YA (en)	2010-08-24	2020-03-30	Univ Minnesota	Non-static suspension culture of cell aggregates
US8895291B2 (en)	2010-10-08	2014-11-25	Terumo Bct, Inc.	Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
US9388388B2 (en)	2011-01-31	2016-07-12	Katholieke Universiteit Leuven	Methods for making cells with an extra-embryonic endodermal precursor phenotype
WO2012168295A1 (en)	2011-06-06	2012-12-13	ReGenesys BVBA	Expansion of stem cells in hollow fiber bioreactors
RU2461623C1 (ru) *	2011-06-20	2012-09-20	Борис Карпович Гаврилюк	Способ выращивания культур хрящевых клеток
CA2841985C (en)	2011-07-29	2019-09-17	Cellular Dynamics International, Inc.	Metabolic maturation in stem cell-derived tissue cells
WO2013019857A2 (en)	2011-08-01	2013-02-07	Alnylam Pharmaceuticals, Inc.	Method for improving the success rate of hematopoietic stem cell transplants
GB201119335D0 (en)	2011-11-09	2011-12-21	Univ Leuven Kath	Hepatitis virus infectable stem cells
US9321995B2 (en) *	2012-12-20	2016-04-26	Suzhou Biowisetech Co., Ltd.	Stem cell culture medium and its applications as well as a stem cell culture method
WO2014146057A2 (en) *	2013-03-15	2014-09-18	Cmr Technologies, Llc	Mesenchymal stem cells
PT2983680T (pt)	2013-04-12	2020-10-29	Abt Holding Co	Melhoria de órgãos para transplante
ES2753323T3 (es)	2013-04-30	2020-04-08	Univ Leuven Kath	Terapia celular para síndromes mielodisplásicos
JP6512759B2 (ja) *	2013-08-19	2019-05-15	国立研究開発法人国立循環器病研究センター	羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤
MX2016005824A (es)	2013-11-04	2016-11-18	Isopogen Pty Ltd	Metodo de cultivo celular.
JP6612227B2 (ja)	2013-11-16	2019-11-27	テルモビーシーティー、インコーポレーテッド	バイオリアクターにおける細胞増殖
CN103805562B (zh) *	2014-01-13	2015-08-05	章毅	培养胎盘间充质干细胞的无血清培养基
US11008547B2 (en)	2014-03-25	2021-05-18	Terumo Bct, Inc.	Passive replacement of media
US9669074B2 (en) *	2014-05-23	2017-06-06	Juan Paz Garcia	Formulation for regeneration of bone, cartilage, teeth, and periodontium and treatment of tumors and cysts
US9433629B2 (en)	2014-05-23	2016-09-06	Juan Paz Garcia	Formulation for regeneration of bone, cartilage, teeth, and periodontium and treatment of tumors and cysts
KR102451667B1 (ko) *	2014-05-23	2022-10-06	후안 파스 가르시아	골, 연골, 치아 및 치주의 재생 및 종양 및 낭포의 치료를 위한 제형
WO2016049421A1 (en)	2014-09-26	2016-03-31	Terumo Bct, Inc.	Scheduled feed
EP3536778B1 (de) *	2014-11-14	2021-05-19	Regenesis Science Co., Ltd.	Verfahren zur serumfreien kultur von chondrozyten und serumfreies kulturmedium
CN107567494A (zh) *	2015-03-04	2018-01-09	迈索布拉斯特国际有限公司	间充质干细胞的细胞培养方法
WO2017004592A1 (en)	2015-07-02	2017-01-05	Terumo Bct, Inc.	Cell growth with mechanical stimuli
US10967006B2 (en)	2016-01-21	2021-04-06	Abt Holding Company	Stem cells for wound healing
WO2017205667A1 (en)	2016-05-25	2017-11-30	Terumo Bct, Inc.	Cell expansion
US11685883B2 (en)	2016-06-07	2023-06-27	Terumo Bct, Inc.	Methods and systems for coating a cell growth surface
US11104874B2 (en)	2016-06-07	2021-08-31	Terumo Bct, Inc.	Coating a bioreactor
US11180733B2 (en)	2016-07-04	2021-11-23	Agency For Science, Technology And Research	Method of generating mesenchymal stem cells and uses thereof
US12234441B2 (en)	2017-03-31	2025-02-25	Terumo Bct, Inc.	Cell expansion
WO2018184028A2 (en)	2017-03-31	2018-10-04	Terumo Bct, Inc.	Cell expansion
US11624046B2 (en)	2017-03-31	2023-04-11	Terumo Bct, Inc.	Cell expansion
SG11202003354VA (en)	2017-10-13	2020-05-28	Boehringer Ingelheim Int	Perfusion medium
JP7372518B2 (ja) *	2019-06-27	2023-11-01	国立大学法人山口大学	骨髄由来間葉系幹細胞の培養方法
US20230083026A1 (en) *	2020-02-03	2023-03-16	Mosa Meat B.V.	Serum-free medium for culturing a bovine progenitor cell
JP7690737B2 (ja) *	2021-01-20	2025-06-11	株式会社リジェネシスサイエンス	成熟軟骨細胞の製造方法
GB2619893A (en)	2021-03-23	2023-12-20	Terumo Bct Inc	Cell capture and expansion
US12209689B2 (en)	2022-02-28	2025-01-28	Terumo Kabushiki Kaisha	Multiple-tube pinch valve assembly
USD1099116S1 (en)	2022-09-01	2025-10-21	Terumo Bct, Inc.	Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
JPWO2025018336A1 (de) *	2023-07-20	2025-01-23
WO2025037108A2 (en)	2023-08-15	2025-02-20	Board Of Trustees Of The Leland Stanford Junior University	Modified thrombopoietin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5902741A (en) *	1986-04-18	1999-05-11	Advanced Tissue Sciences, Inc.	Three-dimensional cartilage cultures
US5405772A (en)	1993-06-18	1995-04-11	Amgen Inc.	Medium for long-term proliferation and development of cells
US5908782A (en) *	1995-06-05	1999-06-01	Osiris Therapeutics, Inc.	Chemically defined medium for human mesenchymal stem cells
WO1996040866A1 (en) *	1995-06-07	1996-12-19	Novartis Ag	Serum-free media for primitive hematopoietic cells and methods of use thereof
JP2000507812A (ja) *	1996-03-12	2000-06-27	ライフテクノロジーズ，インコーポレイテッド	造血細胞培養栄養補充成分
EP0920490A2 (de)	1996-07-25	1999-06-09	Genzyme Corporation	Chondrozyten-medien formeln und kulturverfahren
JP4531135B2 (ja) *	1996-12-06	2010-08-25	オシリスセラピューティクス，インコーポレイテッド	ヒト間葉幹細胞の改良された軟骨形成分化

1999
- 1999-11-08 JP JP2000581163A patent/JP2002529071A/ja active Pending
- 1999-11-08 AU AU13804/00A patent/AU758073B2/en not_active Ceased
- 1999-11-08 AT AT99971844T patent/ATE342348T1/de not_active IP Right Cessation
- 1999-11-08 RU RU2001116126/13A patent/RU2272839C2/ru not_active IP Right Cessation
- 1999-11-08 EP EP99971844A patent/EP1131407B1/de not_active Expired - Lifetime
- 1999-11-08 WO PCT/EP1999/008482 patent/WO2000027996A1/en not_active Ceased
- 1999-11-08 US US09/831,161 patent/US6617159B1/en not_active Expired - Fee Related
- 1999-11-08 IL IL14291499A patent/IL142914A0/xx active IP Right Grant
- 1999-11-08 CA CA002348687A patent/CA2348687A1/en not_active Abandoned
- 1999-11-08 DE DE69933579T patent/DE69933579D1/de not_active Expired - Fee Related
2001
- 2001-05-01 IL IL142914A patent/IL142914A/en not_active IP Right Cessation
2003
- 2003-07-08 US US10/614,191 patent/US7109032B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2348687A1 (en)	2000-05-18
JP2002529071A (ja)	2002-09-10
US20050090002A1 (en)	2005-04-28
US6617159B1 (en)	2003-09-09
AU758073B2 (en)	2003-03-13
DE69933579D1 (de)	2006-11-23
IL142914A (en)	2006-07-05
AU1380400A (en)	2000-05-29
EP1131407A1 (de)	2001-09-12
US7109032B2 (en)	2006-09-19
RU2272839C2 (ru)	2006-03-27
EP1131407B1 (de)	2006-10-11
IL142914A0 (en)	2002-04-21
WO2000027996A1 (en)	2000-05-18

Legal Events

Date	Code	Title	Description
2007-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69933579D1 (de)	2006-11-23	Serum-freies medium für chondrozyt-ähnliche zellen
RU2001116126A (ru)	2003-06-10	Бессывороточная среда для хондроцитоподобных клеток
WO1998059035A3 (en)	1999-03-18	Serum-free cell growth medium
AU3808895A (en)	1996-05-15	Active retinoic acid free culture medium for avian totipotential embryonic cells
GB2432846A (en)	2007-06-06	Medium and culture of embryonic stem cells
WO2006047380A3 (en)	2007-03-29	Method and media for single cell serum-fee culture of cho cells
JPH0387174A (ja)	1991-04-11	細胞培養基
WO2003064598A3 (en)	2003-10-16	Serum-free media for chondrocytes and methods of use thereof
WO1998004681A3 (en)	1998-06-18	Chondrocyte media formulations and culture procedures
EP0953354A4 (de)	2002-10-23	Hämatopoietische stammzellen proliferierende wirkstoffe
ATE399855T1 (de)	2008-07-15	Tierzellkulturmedium mit pflanzlichen nährstoffen
DK0703978T3 (da)	2000-01-17	Medium til langtidsproliferation og -udvikling af celler
NZ502712A (en)	2003-01-31	Medium and method for long term culturing of avian primordial germ cells (PGC) in a tissue culture comprising growth factors
WO2000017321A3 (en)	2000-07-13	Use of growth factors and hormones for expansion of mammalian cells and tissue engineering
JP2013510567A5 (de)	2013-12-26
DE502004008542D1 (de)	2009-01-08	Verfahren zur reklonierung von produktionszellen
IL219969A (en)	2017-06-29	Cell culture containing recombinant cho cells expressing protein factor viii
TR199801859T2 (xx)	1999-02-22	Memeli h�creleri i�in h�cre k�lt�r� ortam�.
WO2003038076A1 (en)	2003-05-08	Immortalized mesenchymal cells and utilization thereof
WO2006045064A3 (en)	2006-08-17	Cultured hematopoietic stem cells and method for expansion and analysis thereof
WO1990015877A3 (en)	1991-01-24	Methods, compositions and devices for growing cells
DE60032508D1 (de)	2007-02-01	VERFAHREN ZUR VERMEHRUNG VON NATüRLICHEN KILLERZELLEN
Tarle et al.	2011	Development of a serum‐free system to expand dental‐derived stem cells: PDLSCs and SHEDs
CA3168116A1 (en)	2021-07-29	Utilization of fgf activators in culture media
Gasser et al.	1985	Long-term multiplication of the Chinese hamster ovary (CHO) cell line in a serum-free medium