ATE342507T1 - PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN - Google Patents

PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN

Info

Publication number
ATE342507T1
ATE342507T1 AT99914218T AT99914218T ATE342507T1 AT E342507 T1 ATE342507 T1 AT E342507T1 AT 99914218 T AT99914218 T AT 99914218T AT 99914218 T AT99914218 T AT 99914218T AT E342507 T1 ATE342507 T1 AT E342507T1
Authority
AT
Austria
Prior art keywords
ßleadß
identifying
compounds
small molecule
molecule drugs
Prior art date
Application number
AT99914218T
Other languages
English (en)
Inventor
Jonathan A Ellman
Ingrid Choong
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE342507T1 publication Critical patent/ATE342507T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99914218T 1998-03-27 1999-03-26 PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN ATE342507T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/049,754 US6344330B1 (en) 1998-03-27 1998-03-27 Pharmacophore recombination for the identification of small molecule drug lead compounds

Publications (1)

Publication Number Publication Date
ATE342507T1 true ATE342507T1 (de) 2006-11-15

Family

ID=21961533

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99914218T ATE342507T1 (de) 1998-03-27 1999-03-26 PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN

Country Status (9)

Country Link
US (5) US6344330B1 (de)
EP (1) EP1066522B1 (de)
JP (1) JP2002507748A (de)
AT (1) ATE342507T1 (de)
AU (1) AU759327B2 (de)
CA (1) CA2326341C (de)
DE (1) DE69933549T2 (de)
IL (1) IL138717A0 (de)
WO (1) WO1999049314A1 (de)

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US20030194745A1 (en) * 1998-06-26 2003-10-16 Mcdowell Robert S. Cysteine mutants and methods for detecting ligand binding to biological molecules
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
EP1441228B1 (de) * 2000-11-21 2006-06-28 Sunesis Pharmaceuticals, Inc. Erweiterter "thethering" Ansatz zum schnellen Auffinden von Liganden
US20020172967A1 (en) * 2001-02-13 2002-11-21 Gadek Thomas R. Identification of non-covalent complexes by mass spectrometry
US20040017884A1 (en) * 2002-07-25 2004-01-29 Havrilla George J. Flow method and apparatus for screening chemicals using micro x-ray fluorescence
US6858148B2 (en) * 2003-07-16 2005-02-22 The Regents Of The University Of California Method and apparatus for detecting chemical binding
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
MXPA04001074A (es) * 2001-08-07 2004-07-08 Sunesis Pharmaceuticals Inc Ligandos de bisulfuro y tiosulfonato y colecciones que comprenden estos ligandos.
NZ532579A (en) * 2001-11-21 2006-11-30 Sunesis Pharmaceuticals Inc Methods for ligand discovery based on tethering process
CN1668918A (zh) 2002-07-24 2005-09-14 基德姆生物科学有限公司 药物发现的方法
US7519145B2 (en) * 2002-07-25 2009-04-14 Los Alamos National Security, Llc Flow method and apparatus for screening chemicals using micro x-ray fluorescence
WO2004042353A2 (en) * 2002-10-30 2004-05-21 Galileo Pharmaceuticals, Inc. Identifying therapeutic compounds based on their physical-chemical properties
US7149280B2 (en) 2002-12-23 2006-12-12 Astex Therapeutics Limited Synthesis and screening of ligands using X-ray crystallography
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
AU2004230519A1 (en) * 2003-04-11 2004-10-28 Sgx Pharmaceuticals, Inc. Compound libraries and methods for drug discovery
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
CA2619457C (en) * 2005-10-04 2016-09-06 Alchemia Ltd. Method of drug design
WO2008013569A2 (en) * 2006-01-03 2008-01-31 The President And Fellows Of Harvard College Small molecule printing
JP5143841B2 (ja) 2006-10-10 2013-02-13 ロス アラモス ナショナル セキュリティー，エルエルシー 高度な薬物開発及び製造
DE102007023102A1 (de) * 2006-12-19 2008-06-26 Bayer Cropscience Ag Bisoxime als Fungizide
EP2201353A4 (de) 2007-09-28 2011-01-26 Caldera Pharmaceuticals Inc Verfahren und vorrichtung zur messung posttranslationaler proteinmodifikation
CA2719579C (en) * 2008-03-25 2020-07-21 Sunesis Pharmaceuticals, Inc. Methods of chemotype evolution
EP2435827A1 (de) * 2009-05-29 2012-04-04 The Board of Regents of The University of Texas System Peptoidliganden zur isolierung und behandlung von t-autoimmunzellen
CA2764153C (en) * 2009-06-02 2021-07-27 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
TW201124726A (en) * 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
WO2012001040A1 (en) 2010-07-02 2012-01-05 Syngenta Participations Ag Novel microbiocidal dioxime ether derivatives
AR082405A1 (es) 2010-07-29 2012-12-05 Syngenta Participations Ag Derivados microbicidas de eteres de dioximas
KR20140027174A (ko) 2011-03-24 2014-03-06 옵코 파마슈티칼스, 엘엘씨 비드 또는 입자 기초 라이브러리들, 진단적 키트들을 및 치료제들을 사용한 복합 생물학적 유체에서 바이오마커 발견
WO2013024040A2 (en) 2011-08-12 2013-02-21 B.S.R.C. Alexander Fleming Tnf superfamily trimerization inhibitors
WO2013092460A1 (en) 2011-12-20 2013-06-27 Syngenta Participations Ag Cyclic bisoxime microbicides
CN102731450A (zh) * 2012-07-04 2012-10-17 中山大学 一种苯并呋喃或吲哚的制备方法
US10782295B2 (en) 2013-08-13 2020-09-22 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
CN104897826B (zh) * 2015-06-16 2016-06-22 广西师范大学 一种用于细胞原位检测小分子化合物与靶蛋白相互作用的方法
JP7054674B2 (ja) 2015-08-11 2022-04-14 アーチ バイオパートナーズ， インコーポレイテッド Ｄｐｅｐ－１結合組成物および使用の方法
JP6953400B2 (ja) 2015-10-22 2021-10-27 ザ スクリプス リサーチ インスティテュート システイン反応性プローブとその使用
CN109641935A (zh) 2016-03-25 2019-04-16 莫拉利达尔·瑞迪·穆拉 组合合成和生物标志物开发
WO2018136555A2 (en) * 2017-01-18 2018-07-26 The Scripps Research Institute Photoreactive ligands and uses thereof

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Also Published As

Publication number Publication date
JP2002507748A (ja) 2002-03-12
AU3211399A (en) 1999-10-18
US6344334B1 (en) 2002-02-05
WO1999049314A1 (en) 1999-09-30
DE69933549D1 (de) 2006-11-23
US20040063157A1 (en) 2004-04-01
WO1999049314A9 (en) 1999-11-18
AU759327B2 (en) 2003-04-10
US6344330B1 (en) 2002-02-05
DE69933549T2 (de) 2007-06-21
EP1066522A1 (de) 2001-01-10
IL138717A0 (en) 2001-10-31
CA2326341A1 (en) 1999-09-30
US7001727B2 (en) 2006-02-21
CA2326341C (en) 2009-02-17
US20040132100A1 (en) 2004-07-08
EP1066522A4 (de) 2005-02-02
US20020115107A1 (en) 2002-08-22
EP1066522B1 (de) 2006-10-11

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