ATE342510T1 - Komplementierungsassay für den nachweis von protein-löslichkeit und -faltung - Google Patents

Komplementierungsassay für den nachweis von protein-löslichkeit und -faltung

Info

Publication number
ATE342510T1
ATE342510T1 AT01909281T AT01909281T ATE342510T1 AT E342510 T1 ATE342510 T1 AT E342510T1 AT 01909281 T AT01909281 T AT 01909281T AT 01909281 T AT01909281 T AT 01909281T AT E342510 T1 ATE342510 T1 AT E342510T1
Authority
AT
Austria
Prior art keywords
protein
folding
detection
improper
marker protein
Prior art date
Application number
AT01909281T
Other languages
English (en)
Inventor
Philip Jordan Thomas
John F Hunt
William Christian Wigley
Rhesa D Stidham
Original Assignee
Univ Texas
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Univ Columbia filed Critical Univ Texas
Application granted granted Critical
Publication of ATE342510T1 publication Critical patent/ATE342510T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT01909281T 2000-02-14 2001-02-14 Komplementierungsassay für den nachweis von protein-löslichkeit und -faltung ATE342510T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18228300P 2000-02-14 2000-02-14
US09/775,051 US6727070B2 (en) 2000-02-14 2001-01-31 Protein/solubility folding assessed by structural complementation

Publications (1)

Publication Number Publication Date
ATE342510T1 true ATE342510T1 (de) 2006-11-15

Family

ID=56290109

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01909281T ATE342510T1 (de) 2000-02-14 2001-02-14 Komplementierungsassay für den nachweis von protein-löslichkeit und -faltung

Country Status (9)

Country Link
US (3) US6727070B2 (de)
EP (1) EP1257829B1 (de)
JP (1) JP4772247B2 (de)
AT (1) ATE342510T1 (de)
AU (2) AU2001237055B2 (de)
CA (1) CA2398834C (de)
DE (1) DE60123755T2 (de)
DK (1) DK1257829T3 (de)
ES (1) ES2273809T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727070B2 (en) * 2000-02-14 2004-04-27 The Board Of Regents, The University Of Texas System Protein/solubility folding assessed by structural complementation
US8088586B2 (en) * 2000-03-17 2012-01-03 Oxford Radcliffe Hospital Nhs Trust Method of producing a body fluid sample depleted of anti-MHC antibodies
US8609436B2 (en) * 2000-03-17 2013-12-17 Guy's & St Thomas' Hospital NHS Trust (“GST”) Method
US20060105377A1 (en) * 2001-08-30 2006-05-18 Eglen Richard M Screening to optimize RNAi
US20040137480A1 (en) * 2001-08-30 2004-07-15 Eglen Richard M. Monitoring intracellular proteins
EP2400030B1 (de) 2004-05-18 2016-01-20 The Board of Trustees of the Leland Stanford Junior University Detektion von Proteintranslokation durch Beta-Galactosidase-Reporter-Fragmentkomplementierung
CA2638888A1 (en) * 2004-12-04 2006-06-15 The Regents Of The University Of California Protein subcellular localization assays using split fluorescent proteins
EP1683868A1 (de) * 2005-01-21 2006-07-26 Medizinische Universität Graz Kringle Domäne in einem Calcium-sensitiven Fusionsprotein
WO2006091638A2 (en) * 2005-02-22 2006-08-31 The Regents Of University Of California Circular permutant gfp insertion folding reporters
US7355920B2 (en) * 2006-02-16 2008-04-08 Micron Technology, Inc. Write latency tracking using a delay lock loop in a synchronous DRAM
EP2309860B1 (de) 2008-07-22 2014-01-08 Trustees of Dartmouth College Monocyclische cyanoenone und anwendungsverfahren
DE102008048036A1 (de) * 2008-09-19 2010-03-25 Meurer, Heinrich, Dr. Verfahren zur Detektion ionisierender Strahlung
US8892184B2 (en) 2010-10-18 2014-11-18 Siemens Medical Solutions Usa, Inc. Systems and methods for reducing interference in a dual modality imaging system
EP3623371A1 (de) 2014-12-16 2020-03-18 Axovant Sciences GmbH Geminale substituierte chinuklidinamidverbindungen als agonisten von alpha-7-nikotinischen acetylcholinrezeptoren
CN107847494A (zh) 2015-06-10 2018-03-27 阿考温特科学股份有限公司 作为α7‑烟碱乙酰胆碱受体激动剂的氨基苯并异噁唑化合物
JP2018523707A (ja) 2015-08-12 2018-08-23 アクソバント サイエンシズ ゲーエムベーハー α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120653A (en) 1985-04-08 1992-06-09 Microgenics Corporation Vector comprising DNA sequence coding for enzyme-donor polypeptide
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
US6294330B1 (en) * 1997-01-31 2001-09-25 Odyssey Pharmaceuticals Inc. Protein fragment complementation assays for the detection of biological or drug interactions
US6342345B1 (en) 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
US6727070B2 (en) * 2000-02-14 2004-04-27 The Board Of Regents, The University Of Texas System Protein/solubility folding assessed by structural complementation

Also Published As

Publication number Publication date
DK1257829T3 (da) 2007-02-12
ES2273809T3 (es) 2007-05-16
US6727070B2 (en) 2004-04-27
AU3705501A (en) 2001-08-27
DE60123755T2 (de) 2007-10-18
JP2004500092A (ja) 2004-01-08
DE60123755D1 (de) 2006-11-23
US20040002065A1 (en) 2004-01-01
US20050019829A1 (en) 2005-01-27
CA2398834A1 (en) 2001-08-23
JP4772247B2 (ja) 2011-09-14
EP1257829A2 (de) 2002-11-20
US7455978B2 (en) 2008-11-25
AU2001237055B2 (en) 2006-09-14
EP1257829B1 (de) 2006-10-11
US20070178498A1 (en) 2007-08-02
CA2398834C (en) 2010-08-10
US7635569B2 (en) 2009-12-22

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