ATE342962T1 - Zusammensetzungen und verfahren für verbesserte zellkultur - Google Patents

Zusammensetzungen und verfahren für verbesserte zellkultur

Info

Publication number
ATE342962T1
ATE342962T1 AT00959455T AT00959455T ATE342962T1 AT E342962 T1 ATE342962 T1 AT E342962T1 AT 00959455 T AT00959455 T AT 00959455T AT 00959455 T AT00959455 T AT 00959455T AT E342962 T1 ATE342962 T1 AT E342962T1
Authority
AT
Austria
Prior art keywords
cell culture
methods
compositions
improved cell
igf
Prior art date
Application number
AT00959455T
Other languages
English (en)
Inventor
Arvia E Morris
Pranhitha Reddy
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of ATE342962T1 publication Critical patent/ATE342962T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0043—Medium free of human- or animal-derived components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00959455T 1999-08-25 2000-08-25 Zusammensetzungen und verfahren für verbesserte zellkultur ATE342962T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15064599P 1999-08-25 1999-08-25
US16894899P 1999-12-03 1999-12-03
US17194999P 1999-12-23 1999-12-23

Publications (1)

Publication Number Publication Date
ATE342962T1 true ATE342962T1 (de) 2006-11-15

Family

ID=27387011

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00959455T ATE342962T1 (de) 1999-08-25 2000-08-25 Zusammensetzungen und verfahren für verbesserte zellkultur

Country Status (14)

Country Link
US (3) US6413744B1 (de)
EP (1) EP1210411B1 (de)
JP (1) JP2003507058A (de)
AT (1) ATE342962T1 (de)
AU (1) AU784506B2 (de)
CA (1) CA2383073A1 (de)
CY (1) CY1105772T1 (de)
DE (1) DE60031419T2 (de)
DK (1) DK1210411T3 (de)
ES (1) ES2272318T3 (de)
IL (2) IL148060A0 (de)
NZ (2) NZ517215A (de)
PT (1) PT1210411E (de)
WO (1) WO2001014529A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US7115231B1 (en) 1998-06-09 2006-10-03 Symyx Technologies, Inc. Parallel reactor with knife-edge seal
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
EP1210411B1 (de) * 1999-08-25 2006-10-18 Immunex Corporation Zusammensetzungen und verfahren für verbesserte zellkultur
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US6455007B1 (en) 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
US6439036B1 (en) 2000-06-13 2002-08-27 Symyx Technologics, Inc. Method for evaluating a test fluid
US7018589B1 (en) 2000-07-19 2006-03-28 Symyx Technologies, Inc. High pressure parallel reactor
US7091004B1 (en) 2001-06-08 2006-08-15 Immunex Corporation Regulation of translation for recombinant protein production
US20050271663A1 (en) * 2001-06-28 2005-12-08 Domantis Limited Compositions and methods for treating inflammatory disorders
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
PT1600510E (pt) * 2001-07-04 2007-06-25 Chromagenics Bv Sequências de adn com actividade anti-repressora.
EP1438385A1 (de) * 2001-10-25 2004-07-21 Bar-Ilan University Interaktiver transparenter biochip-prozessor für einzeln adressierbare zellen
US20030166147A1 (en) * 2001-12-14 2003-09-04 Lee Chichang Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media
EP2287288B1 (de) 2002-07-09 2012-11-07 Baxter International Inc. Tierproteinfreies Zellkulturmedium
ATE354645T1 (de) * 2002-12-20 2007-03-15 Chromagenics Bv Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
EP1654347B1 (de) * 2003-06-26 2014-06-04 Seng Enterprises Limited Verbesserte Materialien zur Konstruktion von Zellchips, Zellchip-Abdeckungen, Zellchip-Hüllen, prozessierte Zellchips und Verwendungen davon
US7888110B2 (en) * 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US8597597B2 (en) * 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
WO2005008626A1 (en) * 2003-07-11 2005-01-27 University Of North Carolina At Chapel Hill Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
WO2005074893A1 (en) * 2004-02-03 2005-08-18 Chemagis Ltd. Stable amorphous forms of montelukast sodium
US20080063251A1 (en) * 2004-07-07 2008-03-13 Mordechai Deutsch Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing
US7403647B2 (en) * 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
US20080009051A1 (en) * 2004-08-25 2008-01-10 Seng Enterprises Ltd. Method and Device for Isolating Cells
US7488599B2 (en) * 2004-10-15 2009-02-10 Monell Chemical Senses Center Methods for culturing mammalian taste cells
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
ES2384391T3 (es) 2004-11-08 2012-07-04 Chromagenics B.V. Selección de células hospedantes que expresan proteína a altos niveles
US8999667B2 (en) * 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
KR101271884B1 (ko) * 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
CA2595676A1 (en) * 2005-01-25 2006-08-03 Apollo Life Sciences Limited Molecules and chimeric molecules thereof
DE602005023534D1 (de) 2005-01-25 2010-10-21 Seng Entpr Ltd Mikrofluidische vorrichtung zur untersuchung zellen
EP1707634A1 (de) * 2005-03-29 2006-10-04 Octapharma AG Verfahren zur Isolierung von rekombinant hergestellten Proteinen
US20060232821A1 (en) * 2005-04-15 2006-10-19 Sridharan Ranganathan Parallel architecture for vector color error diffusion
WO2007002210A2 (en) * 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
EP1739179A1 (de) 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
DE102005034043B4 (de) * 2005-07-18 2019-12-12 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
US8288120B2 (en) * 2005-11-03 2012-10-16 Seng Enterprises Ltd. Method for studying floating, living cells
ES2474573T3 (es) 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
US7655191B2 (en) 2007-05-14 2010-02-02 Symyx Solutions, Inc. Methods for chemical reactions in a parallel batch reactor
US7807109B2 (en) 2007-05-14 2010-10-05 Freeslate, Inc. Parallel batch reactor with pressure monitoring
JP2010528647A (ja) * 2007-06-06 2010-08-26 ドマンティス リミテッド ポリペプチド、抗体可変ドメインおよびアンタゴニスト
RU2010102810A (ru) * 2007-06-29 2011-08-10 Ф.Хоффманн-Ля Рош Аг (Ch) Клетки сно
PT2592148T (pt) * 2007-10-12 2018-11-12 Hoffmann La Roche Expressão proteica de múltiplos ácidos nucleicos
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
EP2237887A2 (de) 2007-12-26 2010-10-13 Seng Enterprises Ltd. Vorrichtung zur untersuchung von lebenden zellen
EP2257620A1 (de) * 2008-03-19 2010-12-08 Boehringer Ingelheim Pharma GmbH & Co. KG Methode zur steigerung der reklonierungseffizienz
MX2011003241A (es) * 2008-09-26 2011-04-21 Schering Corp Produccion de anticuerpos con alto titulo.
JP2013512674A (ja) * 2009-12-02 2013-04-18 アクセルロン ファーマ， インコーポレイテッド Ｆｃ融合タンパク質の血清半減期を増加させるための組成物および方法
HUE042314T2 (hu) 2011-02-07 2019-06-28 Cerenis Therapeutics Holding Sa Lipoprotein komplexek és azok gyártása és alkalmazásai
EP2718328A4 (de) 2011-06-08 2014-12-24 Acceleron Pharma Inc Zusammensetzungen und verfahren zur erhöhung der halbwertszeit von serum
JP2015531244A (ja) 2012-10-15 2015-11-02 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ タンパク質を製造するための哺乳動物細胞培養方法
US20160160270A1 (en) * 2013-07-19 2016-06-09 Markus J. Herrgard Methods for modeling chinese hamster ovary (cho) cell metabolism
DK3303396T5 (da) 2015-05-29 2024-10-07 Bristol Myers Squibb Co Antistoffer mod ox40 og anvendelser deraf
CN113493770A (zh) * 2020-03-18 2021-10-12 苏州大学 人源glut5稳定转染细胞株及其在筛选glut5抑制剂中的应用
KR20230124578A (ko) 2020-12-22 2023-08-25 암젠 인크 세포 배양 방법
WO2023081455A2 (en) * 2021-11-08 2023-05-11 Memorial Sloan-Kettering Cancer Center Immune cells expressing glucose transporter 5 (gluts) and compositions and methods including the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
AU6432090A (en) * 1989-09-01 1991-04-08 Genentech Inc. Cells transfected with nucleic acid encoding gtp
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
EP0496453A1 (de) * 1991-01-23 1992-07-29 Merck & Co. Inc. Menschlicher glut4 Genpromotor
US5262308A (en) * 1992-01-28 1993-11-16 Thomas Jefferson University Cell lines which constitutively express IGF-1 and IGF-1 R
WO1993020200A1 (en) 1992-04-02 1993-10-14 Imperial Cancer Research Technology Limited Modified cells and method of treatment
US5663314A (en) 1992-11-20 1997-09-02 The Board Of Regents Of The University Of Washington Human signal transduction MAPK kinase
EP0666312A1 (de) * 1994-02-08 1995-08-09 Wolfgang A. Renner Verfahren zur Förderung des Wachstums von Säugetierzellen
US5597719A (en) * 1994-07-14 1997-01-28 Onyx Pharmaceuticals, Inc. Interaction of RAF-1 and 14-3-3 proteins
AUPN442295A0 (en) 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
CA2298854A1 (en) * 1997-09-26 1999-04-08 Onyx Pharmaceuticals, Inc. Compositions and methods for identifying pkb kinase inhibitors
EP1210411B1 (de) * 1999-08-25 2006-10-18 Immunex Corporation Zusammensetzungen und verfahren für verbesserte zellkultur

Also Published As

Publication number Publication date
CY1105772T1 (el) 2011-02-02
CA2383073A1 (en) 2001-03-01
AU784506B2 (en) 2006-04-13
PT1210411E (pt) 2006-12-29
NZ529329A (en) 2005-06-24
IL148060A (en) 2009-07-20
DE60031419D1 (de) 2006-11-30
EP1210411B1 (de) 2006-10-18
US20050170462A1 (en) 2005-08-04
EP1210411A1 (de) 2002-06-05
DE60031419T2 (de) 2007-09-27
AU7077800A (en) 2001-03-19
IL148060A0 (en) 2002-09-12
ES2272318T3 (es) 2007-05-01
WO2001014529A9 (en) 2002-09-06
NZ517215A (en) 2004-01-30
US6413744B1 (en) 2002-07-02
JP2003507058A (ja) 2003-02-25
US6897040B2 (en) 2005-05-24
WO2001014529A1 (en) 2001-03-01
US7166445B2 (en) 2007-01-23
US20020160455A1 (en) 2002-10-31
DK1210411T3 (da) 2007-02-19

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