ATE343221T1 - Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspek rometriesystem - Google Patents

Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspek rometriesystem

Info

Publication number
ATE343221T1
ATE343221T1 AT04726409T AT04726409T ATE343221T1 AT E343221 T1 ATE343221 T1 AT E343221T1 AT 04726409 T AT04726409 T AT 04726409T AT 04726409 T AT04726409 T AT 04726409T AT E343221 T1 ATE343221 T1 AT E343221T1
Authority
AT
Austria
Prior art keywords
mass
output
ion
current
fragmenting
Prior art date
Application number
AT04726409T
Other languages
English (en)
Inventor
Blanc Yves Le
Original Assignee
Mds Inc Dbt Mds Sciex Division
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Inc Dbt Mds Sciex Division, Applera Corp filed Critical Mds Inc Dbt Mds Sciex Division
Application granted granted Critical
Publication of ATE343221T1 publication Critical patent/ATE343221T1/de

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • G01N30/8689—Peak purity of co-eluting compounds
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8641—Baseline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Library & Information Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
AT04726409T 2003-04-09 2004-04-08 Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspek rometriesystem ATE343221T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46112603P 2003-04-09 2003-04-09

Publications (1)

Publication Number Publication Date
ATE343221T1 true ATE343221T1 (de) 2006-11-15

Family

ID=33159818

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04726409T ATE343221T1 (de) 2003-04-09 2004-04-08 Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspek rometriesystem

Country Status (7)

Country Link
US (1) US7009174B2 (de)
EP (1) EP1611595B1 (de)
JP (1) JP4676955B2 (de)
AT (1) ATE343221T1 (de)
CA (1) CA2518568C (de)
DE (1) DE602004002856T2 (de)
WO (1) WO2004090933A2 (de)

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JP4896518B2 (ja) * 2002-12-13 2012-03-14 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド ニコチンアミド系キナーゼ阻害薬
US7498568B2 (en) 2005-04-29 2009-03-03 Agilent Technologies, Inc. Real-time analysis of mass spectrometry data for identifying peptidic data of interest
US7297941B2 (en) * 2005-06-02 2007-11-20 Thermo Finnigan Llc Methods for improved data dependent acquisition
CA2611183A1 (en) * 2005-06-08 2006-12-14 Mds Inc., Doing Business Through Its Mds Sciex Division Dynamic background signal exclusion in chromatography/mass spectrometry data-dependent data acquisition
TWI422044B (zh) * 2005-06-30 2014-01-01 克立公司 封裝發光裝置之晶片尺度方法及經晶片尺度封裝之發光裝置
US7417223B2 (en) * 2005-10-28 2008-08-26 Mds Inc. Method, system and computer software product for specific identification of reaction pairs associated by specific neutral differences
US7548818B2 (en) * 2005-12-07 2009-06-16 Mds Analytical Technologies Automated analysis of complex matrices using mass spectrometer
US7541575B2 (en) 2006-01-11 2009-06-02 Mds Inc. Fragmenting ions in mass spectrometry
JP4577266B2 (ja) * 2006-05-16 2010-11-10 株式会社島津製作所 クロマトグラフ質量分析装置
EP2052255A2 (de) * 2006-08-18 2009-04-29 Huntington Medical Research Institutes Verfahren zur bestimmung von freien aminosäuren und dipeptiden und zur diagnose der alzheimer krankheit
EP2062284B1 (de) * 2006-08-25 2018-08-15 Thermo Finnigan LLC Datenabhängige auswahl des dissoziationstyps in einem massenspektrometer
US7511267B2 (en) * 2006-11-10 2009-03-31 Thermo Finnigan Llc Data-dependent accurate mass neutral loss analysis
US7943899B2 (en) * 2006-12-21 2011-05-17 Thermo Finnigan Llc Method and apparatus for identifying the apex of a chromatographic peak
EP2232524A4 (de) * 2007-12-04 2016-06-08 Dh Technologies Dev Pte Ltd Systeme und verfahren zum analysieren von substanzen unter verwendung eines massenspektrometers
US7982181B1 (en) 2008-01-15 2011-07-19 Thermo Finnigan Llc Methods for identifying an apex for improved data-dependent acquisition
US8304719B2 (en) * 2009-02-22 2012-11-06 Xin Wang Precise and thorough background subtraction
US8987662B2 (en) * 2009-05-14 2015-03-24 Agilent Technologies, Inc. System and method for performing tandem mass spectrometry analysis
WO2010138120A1 (en) * 2009-05-27 2010-12-02 Thermo Finnigan Llc Methods for identifying an apex for improved data-dependent acquisition
GB0919870D0 (en) * 2009-11-13 2009-12-30 Micromass Ltd A method to detect and quantitatively profile organic species using a mass spectrometer
JP5505110B2 (ja) * 2010-06-14 2014-05-28 株式会社島津製作所 クロマトグラフ質量分析装置
US20140374583A1 (en) * 2013-06-24 2014-12-25 Agilent Technologies, Inc. Electron ionization (ei) utilizing different ei energies
CN107148572A (zh) * 2014-10-30 2017-09-08 Dh科技发展私人贸易有限公司 用于选择离子进行离子碎裂的方法和系统
US10176977B2 (en) 2014-12-12 2019-01-08 Agilent Technologies, Inc. Ion source for soft electron ionization and related systems and methods
US10217619B2 (en) * 2015-03-12 2019-02-26 Thermo Finnigan Llc Methods for data-dependent mass spectrometry of mixed intact protein analytes
US9779922B1 (en) * 2017-01-17 2017-10-03 Advion Inc. Generation of discovery ion currents and mass spectrometry and uses thereof
US11371971B2 (en) 2020-01-31 2022-06-28 Regeneron Pharmaceuticals, Inc. High confidence compound identification by liquid chromatography-mass spectrometry
WO2023031870A1 (en) * 2021-09-03 2023-03-09 Dh Technologies Development Pte. Ltd. Prediction of precursor charge state in dm-swath analysis
CN115860692B (zh) * 2022-12-28 2026-04-17 武汉市三藏科技有限责任公司 一种在线环境数据采集及分析系统和方法
GB2619405B (en) * 2023-04-12 2024-05-08 Methuselah Health Uk Ltd Mass spectrometry
CN119601113B (zh) * 2024-11-20 2025-10-21 中国科学院生态环境研究中心 环境中含磷有机化合物全面识别及综合风险评估的方法

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Also Published As

Publication number Publication date
DE602004002856D1 (de) 2006-11-30
US20040251409A1 (en) 2004-12-16
JP2006522999A (ja) 2006-10-05
CA2518568C (en) 2012-09-25
EP1611595A2 (de) 2006-01-04
JP4676955B2 (ja) 2011-04-27
WO2004090933A3 (en) 2005-07-21
CA2518568A1 (en) 2004-10-21
US7009174B2 (en) 2006-03-07
EP1611595B1 (de) 2006-10-18
WO2004090933A2 (en) 2004-10-21
DE602004002856T2 (de) 2007-05-16

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