ATE343645T1 - Verbinden einer gensequenz mit einer genfunktion mittels dreidimensionaler (3d) proteinstrukturbestimmung - Google Patents

Verbinden einer gensequenz mit einer genfunktion mittels dreidimensionaler (3d) proteinstrukturbestimmung

Info

Publication number
ATE343645T1
ATE343645T1 AT99935746T AT99935746T ATE343645T1 AT E343645 T1 ATE343645 T1 AT E343645T1 AT 99935746 T AT99935746 T AT 99935746T AT 99935746 T AT99935746 T AT 99935746T AT E343645 T1 ATE343645 T1 AT E343645T1
Authority
AT
Austria
Prior art keywords
gene
dimensional
linking
protein structure
structure determination
Prior art date
Application number
AT99935746T
Other languages
English (en)
Inventor
Stephen Anderson
Gaetano Montelione
Yuanpeng Huang
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/181,601 external-priority patent/US20010016314A1/en
Application filed by Univ Rutgers filed Critical Univ Rutgers
Application granted granted Critical
Publication of ATE343645T1 publication Critical patent/ATE343645T1/de

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10—Design of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/20—Screening of libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Library & Information Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
AT99935746T 1998-07-21 1999-07-21 Verbinden einer gensequenz mit einer genfunktion mittels dreidimensionaler (3d) proteinstrukturbestimmung ATE343645T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9364198P 1998-07-21 1998-07-21
US09/181,601 US20010016314A1 (en) 1998-10-29 1998-10-29 Linking gene sequence to gene function by three dimesional (3d) protein structure determination

Publications (1)

Publication Number Publication Date
ATE343645T1 true ATE343645T1 (de) 2006-11-15

Family

ID=26787762

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99935746T ATE343645T1 (de) 1998-07-21 1999-07-21 Verbinden einer gensequenz mit einer genfunktion mittels dreidimensionaler (3d) proteinstrukturbestimmung

Country Status (7)

Country Link
EP (1) EP1104488B1 (de)
JP (1) JP2002526745A (de)
AT (1) ATE343645T1 (de)
AU (1) AU5115599A (de)
CA (1) CA2337153A1 (de)
DE (1) DE69933774D1 (de)
WO (1) WO2000005414A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807447B1 (en) 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
JP4586275B2 (ja) * 2001-01-17 2010-11-24 味の素株式会社 複合体の界面を同定する方法
WO2004069989A2 (en) * 2003-02-07 2004-08-19 Affinium Pharmaceuticals, Inc. Novel purified phosphodiesterase polypeptides
DE10323917A1 (de) * 2003-05-23 2004-12-16 Protagen Ag Verfahren und System zur Aufklärung der Primärstruktur von Biopolymeren
JP4555928B2 (ja) * 2004-03-19 2010-10-06 独立行政法人産業技術総合研究所 がん細胞認識破壊活性を発現するように活性化されたパラスポリン−１の結晶、その製造方法、その三次元構造および利用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03500408A (ja) * 1987-09-04 1991-01-31 ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ 増強された安定性を有するペプチド複合体
JP3867863B2 (ja) * 1993-07-13 2007-01-17 富士通株式会社 立体構造処理装置
JP2856306B2 (ja) * 1993-10-08 1999-02-10 アドバンスドテクノロジーインスティテュート株式会社 蛋白質の立体構造の予測演算方法及び予測演算装置
JP2721323B2 (ja) * 1995-09-28 1998-03-04 株式会社蛋白工学研究所 蛋白質結晶化条件スクリーニング用固定化試薬
AU711092B2 (en) * 1995-11-14 1999-10-07 Abbvie Inc. Use of nuclear magnetic resonance to design ligands to target biomolecules

Also Published As

Publication number Publication date
WO2000005414A1 (en) 2000-02-03
CA2337153A1 (en) 2000-02-03
EP1104488A1 (de) 2001-06-06
EP1104488A4 (de) 2003-02-05
JP2002526745A (ja) 2002-08-20
DE69933774D1 (de) 2006-12-07
EP1104488B1 (de) 2006-10-25
AU5115599A (en) 2000-02-14
WO2000005414A9 (en) 2000-07-06

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Legal Events

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