ATE343789T1 - Biomolekulares kinetik-messverfahren mit hilfe von einem durchfluss-mikroarray - Google Patents
Biomolekulares kinetik-messverfahren mit hilfe von einem durchfluss-mikroarrayInfo
- Publication number
- ATE343789T1 ATE343789T1 AT03740171T AT03740171T ATE343789T1 AT E343789 T1 ATE343789 T1 AT E343789T1 AT 03740171 T AT03740171 T AT 03740171T AT 03740171 T AT03740171 T AT 03740171T AT E343789 T1 ATE343789 T1 AT E343789T1
- Authority
- AT
- Austria
- Prior art keywords
- target
- molecules
- methods
- interaction
- biomolecular
- Prior art date
Links
- 238000002493 microarray Methods 0.000 title abstract 2
- 238000000691 measurement method Methods 0.000 title 1
- 230000003993 interaction Effects 0.000 abstract 4
- 239000012491 analyte Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 238000012544 monitoring process Methods 0.000 abstract 3
- 239000000758 substrate Substances 0.000 abstract 2
- 238000011534 incubation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/40—Flow patterns using back flushing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02447107 | 2002-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE343789T1 true ATE343789T1 (de) | 2006-11-15 |
Family
ID=29595070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03740171T ATE343789T1 (de) | 2002-06-03 | 2003-06-02 | Biomolekulares kinetik-messverfahren mit hilfe von einem durchfluss-mikroarray |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060234229A1 (de) |
| EP (1) | EP1512012B1 (de) |
| JP (1) | JP2005528612A (de) |
| AT (1) | ATE343789T1 (de) |
| AU (1) | AU2003273530A1 (de) |
| CA (1) | CA2487944A1 (de) |
| DE (1) | DE60309317T2 (de) |
| WO (1) | WO2003102585A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538380T1 (de) | 2001-01-23 | 2012-01-15 | Harvard College | Nukleinsäure-programmierbare protein-arrays |
| CA2561411A1 (en) * | 2004-03-31 | 2005-10-13 | Kazuo Shinya | Labeling substance and chimera substance, process for preparing these substances, and method of biosubstance trapping, structural analysis or/and identification with use of the labeling substance |
| US20050260653A1 (en) * | 2004-04-14 | 2005-11-24 | Joshua Labaer | Nucleic-acid programmable protein arrays |
| US8178316B2 (en) | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
| JP4751261B2 (ja) * | 2006-07-18 | 2011-08-17 | セイコーインスツル株式会社 | 解離定数測定装置、解離定数算出方法、及び解離定数算出プログラム |
| US20090269858A1 (en) * | 2006-08-02 | 2009-10-29 | Koninklijke Philips Electronics N.V. | Method of determining the concentration of an analyte using analyte sensor molecules coupled to a porous membrane |
| EP2407783A1 (de) * | 2006-10-27 | 2012-01-18 | Janssen Pharmaceutica, N.V. | Verfahren für das pharmakologische Profiling von Verbindungen |
| WO2009063408A1 (en) * | 2007-11-16 | 2009-05-22 | Nxp B.V. | A biosensor device and a method of manufacturing the same |
| EP2103352A1 (de) | 2008-03-18 | 2009-09-23 | Koninklijke Philips Electronics N.V. | Membranen zur Immobilisierung von Biomolekülen |
| US20120208291A1 (en) * | 2009-05-01 | 2012-08-16 | Univeristy Of Utah Research Foundation | Methods and compositions for measuring high affinity interactions with kinetic imaging of single molecule interaction (kismi) |
| WO2013067322A1 (en) * | 2011-11-03 | 2013-05-10 | Stc Biologics, Inc. | Method for determination of pharmacological properties of recombinant proteins |
| WO2016172121A1 (en) * | 2015-04-20 | 2016-10-27 | Qoolabs, Inc. | Camelid single-domain hcv antibodies and methods of use |
| WO2018045278A1 (en) * | 2016-09-01 | 2018-03-08 | Life Technologies Corporation | Compositions and methods for enhanced fluorescence |
| WO2019023584A1 (en) * | 2017-07-27 | 2019-01-31 | Cornell University | FIXING AND RETENTION OF EXTRACELLULAR VESICLES |
| WO2020061550A1 (en) | 2018-09-21 | 2020-03-26 | Aufbau Medical Innovations Limited | Compositions and methods for glaucoma |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726010A (en) * | 1991-07-31 | 1998-03-10 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
| GB9123903D0 (en) * | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer assay devices |
| US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| GB9416002D0 (en) * | 1994-08-08 | 1994-09-28 | Univ Cranfield | Fluid transport device |
| US6750031B1 (en) * | 1996-01-11 | 2004-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Displacement assay on a porous membrane |
| ATE199663T1 (de) * | 1997-07-11 | 2001-03-15 | Akzo Nobel Nv | Vorrichtung zur durchführung eines tests, verwendung einer membran zur herstellung dieser vorrichtung, kit mit dieser vorrichtung und analyseverfahren unter verwendung dieses gerätes. |
| US6287874B1 (en) * | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Methods for analyzing protein binding events |
| US6303325B1 (en) * | 1998-05-29 | 2001-10-16 | Dade Behring Inc. | Method for detecting analytes |
| US6638760B1 (en) * | 1998-11-25 | 2003-10-28 | Pe Corporation (Ny) | Method and apparatus for flow-through hybridization |
| US6383748B1 (en) * | 1999-09-14 | 2002-05-07 | Pamgene B.V. | Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same |
| US6620625B2 (en) * | 2000-01-06 | 2003-09-16 | Caliper Technologies Corp. | Ultra high throughput sampling and analysis systems and methods |
-
2003
- 2003-06-02 CA CA002487944A patent/CA2487944A1/en not_active Abandoned
- 2003-06-02 US US10/515,302 patent/US20060234229A1/en not_active Abandoned
- 2003-06-02 JP JP2004509419A patent/JP2005528612A/ja not_active Withdrawn
- 2003-06-02 WO PCT/EP2003/005748 patent/WO2003102585A2/en not_active Ceased
- 2003-06-02 AU AU2003273530A patent/AU2003273530A1/en not_active Abandoned
- 2003-06-02 DE DE60309317T patent/DE60309317T2/de not_active Expired - Lifetime
- 2003-06-02 AT AT03740171T patent/ATE343789T1/de active
- 2003-06-02 EP EP03740171A patent/EP1512012B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1512012A2 (de) | 2005-03-09 |
| JP2005528612A (ja) | 2005-09-22 |
| US20060234229A1 (en) | 2006-10-19 |
| DE60309317T2 (de) | 2007-05-31 |
| WO2003102585A2 (en) | 2003-12-11 |
| CA2487944A1 (en) | 2003-12-11 |
| EP1512012B1 (de) | 2006-10-25 |
| AU2003273530A1 (en) | 2003-12-19 |
| WO2003102585A3 (en) | 2004-04-08 |
| DE60309317D1 (de) | 2006-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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