ATE344230T1 - Triphenylbutenderivate zur behandlung von neurologischen störungen - Google Patents
Triphenylbutenderivate zur behandlung von neurologischen störungenInfo
- Publication number
- ATE344230T1 ATE344230T1 AT99954098T AT99954098T ATE344230T1 AT E344230 T1 ATE344230 T1 AT E344230T1 AT 99954098 T AT99954098 T AT 99954098T AT 99954098 T AT99954098 T AT 99954098T AT E344230 T1 ATE344230 T1 AT E344230T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- neurological disorders
- triphenyl
- butene derivatives
- butene
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- HFHRSBKYURPWRU-UHFFFAOYSA-N 1,1-diphenylbut-3-enylbenzene Chemical class C=1C=CC=CC=1C(C=1C=CC=CC=1)(CC=C)C1=CC=CC=C1 HFHRSBKYURPWRU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9824207.6A GB9824207D0 (en) | 1998-11-04 | 1998-11-04 | Neurological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE344230T1 true ATE344230T1 (de) | 2006-11-15 |
Family
ID=10841850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99954098T ATE344230T1 (de) | 1998-11-04 | 1999-10-29 | Triphenylbutenderivate zur behandlung von neurologischen störungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6489481B1 (de) |
| EP (1) | EP1127045B1 (de) |
| JP (1) | JP2002528489A (de) |
| AT (1) | ATE344230T1 (de) |
| AU (1) | AU1054200A (de) |
| DE (1) | DE69933885T2 (de) |
| ES (1) | ES2274645T3 (de) |
| GB (1) | GB9824207D0 (de) |
| WO (1) | WO2000025767A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7710744B2 (en) * | 2004-10-11 | 2010-05-04 | Stmicroelectronics S.R.L. | Method for controlling a full bridge converter with a current-doubler |
| EP1976495A2 (de) * | 2006-01-06 | 2008-10-08 | Aarhus Universitet | Auf den serotonin-transporter wirkende verbindungen |
| US8062588B2 (en) * | 2006-03-22 | 2011-11-22 | Zimek Technologies Ip, Llc | Ultrasonic sanitation device and associated methods |
| JP5382633B2 (ja) * | 2006-05-25 | 2014-01-08 | 学校法人順正学園 | 脳血管性認知症の予防または治療薬 |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| EP3490556A4 (de) | 2016-07-27 | 2020-04-15 | Case Western Reserve University | Verbindungen und verfahren zur förderung der myelinisierung |
| JPWO2018221728A1 (ja) | 2017-06-02 | 2020-04-02 | 富士フイルム富山化学株式会社 | アルツハイマー型認知症予防または治療剤 |
| BR112019024851A2 (pt) | 2017-06-02 | 2020-06-09 | Fujifilm Toyama Chemical Co Ltd | agente para evitar ou tratar atrofia cerebral |
| SG11201911515QA (en) | 2017-06-02 | 2020-01-30 | Fujifilm Toyama Chemical Co Ltd | Agent for preventing or treating spinocerebellar ataxia |
| US11666551B2 (en) | 2017-06-02 | 2023-06-06 | Fujifilm Toyama Chemical Co., Ltd. | Agent for reducing amount of amyloid β protein |
| CN109293519B (zh) * | 2017-07-25 | 2021-09-28 | 北京斯利安药业有限公司 | 一种枸橼酸他莫昔芬晶型a的制备方法 |
| US11548878B2 (en) | 2017-10-30 | 2023-01-10 | Fujifilm Toyama Chemical Co., Ltd. | Emopamil binding protein binding agent and use thereof |
| WO2019103989A1 (en) * | 2017-11-22 | 2019-05-31 | Temple University-Of The Commonwealth System Of Higher Education | Novel functionalized n,n-dialkylamino phenyl ethers and their method of use |
| US20220041629A1 (en) * | 2018-09-12 | 2022-02-10 | Xavier University Of Louisiana | Estrogen receptor targeting antagonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637389A (de) * | 1962-09-13 | |||
| US3288806A (en) * | 1964-03-23 | 1966-11-29 | Parke Davis & Co | Alpha-(aminoethoxyphenyl)-alpha-alkylstilbenes |
| EP0002097B1 (de) * | 1977-08-22 | 1981-08-05 | Imperial Chemical Industries Plc | Triphenylalken-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
| EP0011372B1 (de) * | 1978-11-07 | 1983-02-09 | Imperial Chemical Industries Plc | 1-Acyloxyphenyl-1,2-diphenylalken-Derivate, Verfahren zu deren Herstellung und eine diese Derivate enthaltende pharmazeutische Zusammensetzung |
| DE4311870C2 (de) * | 1993-04-10 | 1998-07-30 | Altramed Holdings Ltd | Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen |
| DE4320896A1 (de) * | 1993-06-24 | 1995-01-05 | Denecke Rainer Dr Med Vet | Präparat zur Therapie und Prophylaxe von Demenz-Erkrankungen |
| JPH11510479A (ja) * | 1995-06-07 | 1999-09-14 | ネオルックス コーポレイション | タモキシフェン類似体による心臓血管疾病の予防及び治療 |
| IL120269A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | 1,1,2-triphenylbut-1-ene derivatives for treating Alzheimer's disease |
| AU7260398A (en) * | 1997-04-28 | 1998-11-24 | University Of British Columbia, The | Method and composition for modulating amyloidosis |
| HUP0002852A3 (en) * | 1997-08-15 | 2001-11-28 | Univ Durham | A method of preventing or treating estrogen-dependent diseases and disorders using triphenil-ethylene derivatives |
| EP0976404A3 (de) * | 1998-07-30 | 2001-06-27 | Pfizer Products Inc. | Pharmazeutische Zubereitung zur Vorbeugung und Behandlung von kognitiven Störungen bei Säugetieren |
-
1998
- 1998-11-04 GB GBGB9824207.6A patent/GB9824207D0/en not_active Ceased
-
1999
- 1999-10-29 DE DE69933885T patent/DE69933885T2/de not_active Expired - Fee Related
- 1999-10-29 AU AU10542/00A patent/AU1054200A/en not_active Abandoned
- 1999-10-29 US US09/831,211 patent/US6489481B1/en not_active Expired - Fee Related
- 1999-10-29 ES ES99954098T patent/ES2274645T3/es not_active Expired - Lifetime
- 1999-10-29 WO PCT/GB1999/003583 patent/WO2000025767A2/en not_active Ceased
- 1999-10-29 AT AT99954098T patent/ATE344230T1/de not_active IP Right Cessation
- 1999-10-29 EP EP99954098A patent/EP1127045B1/de not_active Expired - Lifetime
- 1999-10-29 JP JP2000579208A patent/JP2002528489A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB9824207D0 (en) | 1998-12-30 |
| DE69933885D1 (de) | 2006-12-14 |
| ES2274645T3 (es) | 2007-05-16 |
| WO2000025767A2 (en) | 2000-05-11 |
| WO2000025767A3 (en) | 2000-09-28 |
| JP2002528489A (ja) | 2002-09-03 |
| DE69933885T2 (de) | 2007-05-24 |
| US6489481B1 (en) | 2002-12-03 |
| EP1127045B1 (de) | 2006-11-02 |
| AU1054200A (en) | 2000-05-22 |
| EP1127045A2 (de) | 2001-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |