ATE344246T1 - Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer - Google Patents
Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmerInfo
- Publication number
- ATE344246T1 ATE344246T1 AT98962838T AT98962838T ATE344246T1 AT E344246 T1 ATE344246 T1 AT E344246T1 AT 98962838 T AT98962838 T AT 98962838T AT 98962838 T AT98962838 T AT 98962838T AT E344246 T1 ATE344246 T1 AT E344246T1
- Authority
- AT
- Austria
- Prior art keywords
- alkoxyguanidine
- aminoguanidine
- heteroaryl
- derivatives
- protease inhibitors
- Prior art date
Links
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 title 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6647597P | 1997-11-26 | 1997-11-26 | |
| US6732497P | 1997-12-05 | 1997-12-05 | |
| US7910798P | 1998-03-23 | 1998-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE344246T1 true ATE344246T1 (de) | 2006-11-15 |
Family
ID=27370979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98962838T ATE344246T1 (de) | 1997-11-26 | 1998-11-25 | Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US6037356A (de) |
| EP (1) | EP1036063B1 (de) |
| JP (1) | JP2001524467A (de) |
| AR (1) | AR016702A1 (de) |
| AT (1) | ATE344246T1 (de) |
| AU (1) | AU751412B2 (de) |
| BR (1) | BR9815325A (de) |
| CA (1) | CA2311969A1 (de) |
| DE (1) | DE69836346T2 (de) |
| EA (1) | EA004180B1 (de) |
| ES (1) | ES2274587T3 (de) |
| PL (1) | PL340560A1 (de) |
| TW (1) | TWI222441B (de) |
| WO (1) | WO1999026926A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037356A (en) * | 1997-11-26 | 2000-03-14 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
| AU750561B2 (en) * | 1998-04-24 | 2002-07-25 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
| NZ508669A (en) * | 1998-06-11 | 2003-06-30 | Dimensional Pharm Inc | Pyrazinone protease inhibitors |
| US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| KR20010113970A (ko) * | 1999-05-19 | 2001-12-28 | 추후보정 | 응고 캐스케이드의 선택적 억제에 유용한 치환 폴리시클릭아릴 및 헤테로아릴 피리돈 |
| US6653316B1 (en) * | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) * | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6908919B2 (en) * | 1999-05-19 | 2005-06-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
| WO2000073302A1 (en) | 1999-05-27 | 2000-12-07 | 3-Dimensional Pharmaceuticals, Inc. | Oxazaheterocycles as protease inhibitors |
| DE60005351D1 (de) * | 1999-07-09 | 2003-10-23 | Dimensional Pharm Inc | Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel |
| ATE253558T1 (de) * | 1999-09-13 | 2003-11-15 | Dimensional Pharm Inc | Azazykloalkanone serin-protease-hemmer |
| EP1127884A1 (de) * | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Neue Malonsäure Derivaie, Verfahren zu ihrer Herstellung, ihre Verwendung als Inhibitor der Faktor XA Aktivtät und pharmazeutische Zusammensetzungen diese enthaltend |
| WO2001068605A1 (en) * | 2000-03-13 | 2001-09-20 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| AU2001251315A1 (en) * | 2000-04-05 | 2001-10-23 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| ATE289299T1 (de) | 2000-04-05 | 2005-03-15 | Pharmacia Corp | Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess |
| EP1274676A2 (de) * | 2000-04-17 | 2003-01-15 | Pharmacia Corporation | Polycyclische aryl- und heteroaryl- substuierte 1,4-chinone zur selektiven hemmung des blutgerinnungsprozesses |
| WO2001087842A1 (en) * | 2000-05-18 | 2001-11-22 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| MXPA03000512A (es) | 2000-07-17 | 2003-10-06 | Dimensional Pharm Inc | Oxiguanidina-pirazinonas ciclicas como inhibidores de proteasas. |
| JP2004505956A (ja) | 2000-08-04 | 2004-02-26 | ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド | 環式オキシグアニジンプロテアーゼインヒビター |
| US20020037897A1 (en) * | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| CA2430037A1 (en) | 2000-11-20 | 2002-05-30 | Michael S. South | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| US20030236257A1 (en) * | 2001-04-04 | 2003-12-25 | South Michael S. | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade |
| DE10133786A1 (de) * | 2001-07-16 | 2003-02-06 | Boehringer Ingelheim Pharma | Verwendung von Thrombin-Inhibitoren zur Behandlung von Arthritis |
| US20040082585A1 (en) * | 2001-10-03 | 2004-04-29 | Pharmacia Corporation | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade |
| BR0213092A (pt) * | 2001-10-03 | 2004-10-19 | Pharmacia Corp | Compostos heterocìclicos de 6 elementos úteis para a inibição seletiva da cascata de coagulação |
| CA2462647A1 (en) * | 2001-10-03 | 2003-04-10 | Michael S. South | 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| MXPA04003170A (es) | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion. |
| WO2003048127A1 (en) | 2001-12-04 | 2003-06-12 | Corvas International, Inc. | Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation |
| CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
| US7550474B2 (en) | 2003-04-10 | 2009-06-23 | Johnson & Johnson Pharmaceuticals Research & Development, L.L.C. | Substituted phenyl acetamides and their use as protease inhibitors |
| US7087622B2 (en) | 2004-05-07 | 2006-08-08 | Janssen Pharmaceutica N.V. | Pyridone compounds as inhibitors of bacterial type III protein secreation systems |
| US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
| US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
| US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
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| US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
| CA2570261C (en) | 2004-07-08 | 2014-06-10 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
| US20070255177A1 (en) * | 2006-04-27 | 2007-11-01 | Pronovost Allan D | Devices and methods for collecting oral samples of enriched serous fluid |
| US7758001B2 (en) * | 2006-09-13 | 2010-07-20 | Premier Mounts | Mount with magnetic attachment and automatic safety latching |
| US20100297218A1 (en) * | 2006-09-20 | 2010-11-25 | Pneumrx, Inc. | Tissue adhesive compositions and methods thereof |
| US7591075B2 (en) | 2006-09-28 | 2009-09-22 | Techtronic Power Tools Technology Limited | Self-leveling mechanism |
| WO2008137779A2 (en) | 2007-05-03 | 2008-11-13 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| EP2164325B1 (de) | 2007-05-31 | 2013-04-24 | Shionogi&Co., Ltd. | Oxyiminoverbindungen und ihre verwendung |
| WO2009151152A1 (en) | 2008-06-11 | 2009-12-17 | Shionogi & Co., Ltd. | Oxycarbamoyl compounds and the use thereof |
| CA2762611C (en) * | 2009-05-20 | 2017-03-28 | Sekisui Medical Co., Ltd. | Blood coagulation time prolonging agent |
| US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
| US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
| EP2655399B1 (de) | 2010-12-21 | 2017-09-27 | The Medicines Company (Leipzig) GmbH | Trypsin-ähnliche serinproteasehemmer, ihre herstellung und verwendung als selektive inhibitoren der gerinnungsfaktoren iia und xa |
| RU2019121905A (ru) | 2010-12-31 | 2019-09-03 | Астразенека Юкей Лимитед | Ингибиторы аргиназы и способы их применения |
| WO2012158983A2 (en) | 2011-05-17 | 2012-11-22 | Qiyong Peter Liu | Improved platelet storage using a sialidase inhibitor |
| US9788539B2 (en) | 2011-05-17 | 2017-10-17 | Velico Medical, Inc. | Platelet protection solution having beta-galactosidase and sialidase inhibitors |
| EP2903430A1 (de) | 2012-10-05 | 2015-08-12 | Velico Medical, Inc. | Plättchenadditivlösung mit beta-galactosidase-inhibitor |
| WO2014120886A1 (en) | 2013-01-30 | 2014-08-07 | Velico Medical, Inc. | Platelet additive solution having a self-assembling hydrogel-forming peptide |
| US20150365084A1 (en) * | 2014-06-13 | 2015-12-17 | Infineon Technologies Austria Ag | Circuits and methods for operating a circuit |
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|---|---|---|---|---|
| US4097472A (en) | 1974-11-08 | 1978-06-27 | Mitsubishi Chemical Industries Limited | N2 -arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof |
| SU328634A1 (ru) | 1971-01-05 | 1978-01-05 | Butyrin V G | Устройство дл забора проб крови у животных |
| SU938739A3 (ru) | 1977-01-19 | 1982-06-23 | Мицубиси Кемикал Индастриз Лимитед(Фирма) | Способ получени N -арилсульфонил-L-аргининамидов или их солей |
| US4418052A (en) * | 1980-08-12 | 1983-11-29 | Wong Dennis W | Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body |
| US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
| US5011686A (en) * | 1987-09-21 | 1991-04-30 | Creative Biomolecules, Inc. | Thrombus specific conjugates |
| ZA897514B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
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| GB9318637D0 (en) | 1993-09-08 | 1993-10-27 | Ferring Res Ltd | Enzyme inhibitors |
| US5466811A (en) * | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
| HUT77888A (hu) * | 1994-12-13 | 1998-09-28 | Corvas International, Inc. | Enzim inhibitor hatású aromás heterociklusos származékok |
| US5656645A (en) * | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
| US5658930A (en) * | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
| JPH11508558A (ja) * | 1995-06-27 | 1999-07-27 | メルク エンド カンパニー インコーポレーテッド | ピリジノン トロンビン阻害剤 |
| JP2000512616A (ja) * | 1996-02-22 | 2000-09-26 | メルク エンド カンパニー インコーポレーテッド | ピリジノントロンビンインヒビター |
| ES2273365T3 (es) | 1996-03-29 | 2007-05-01 | Ortho-Mcneil Pharmaceutical, Inc. | Amidinohidrazonas utiles como inhibidores de proteasa. |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| US6037356A (en) * | 1997-11-26 | 2000-03-14 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
| NZ508669A (en) * | 1998-06-11 | 2003-06-30 | Dimensional Pharm Inc | Pyrazinone protease inhibitors |
| WO2000073302A1 (en) | 1999-05-27 | 2000-12-07 | 3-Dimensional Pharmaceuticals, Inc. | Oxazaheterocycles as protease inhibitors |
| DE60005351D1 (de) | 1999-07-09 | 2003-10-23 | Dimensional Pharm Inc | Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel |
| US6236492B1 (en) * | 1999-08-03 | 2001-05-22 | Crystal Corporation | Electrode with a balanced centroid, soft edges and an apodization ratio greater than one |
-
1998
- 1998-11-25 US US09/199,167 patent/US6037356A/en not_active Expired - Lifetime
- 1998-11-25 ES ES98962838T patent/ES2274587T3/es not_active Expired - Lifetime
- 1998-11-25 BR BR9815325-0A patent/BR9815325A/pt not_active Application Discontinuation
- 1998-11-25 EP EP98962838A patent/EP1036063B1/de not_active Expired - Lifetime
- 1998-11-25 DE DE69836346T patent/DE69836346T2/de not_active Expired - Fee Related
- 1998-11-25 EA EA200000578A patent/EA004180B1/ru not_active IP Right Cessation
- 1998-11-25 JP JP2000522084A patent/JP2001524467A/ja active Pending
- 1998-11-25 TW TW087119488A patent/TWI222441B/zh not_active IP Right Cessation
- 1998-11-25 AU AU17991/99A patent/AU751412B2/en not_active Ceased
- 1998-11-25 WO PCT/US1998/025185 patent/WO1999026926A1/en not_active Ceased
- 1998-11-25 CA CA002311969A patent/CA2311969A1/en not_active Abandoned
- 1998-11-25 PL PL98340560A patent/PL340560A1/xx not_active Application Discontinuation
- 1998-11-25 AT AT98962838T patent/ATE344246T1/de not_active IP Right Cessation
- 1998-11-26 AR ARP980106006A patent/AR016702A1/es unknown
-
2000
- 2000-01-14 US US09/482,540 patent/US6245763B1/en not_active Expired - Lifetime
-
2001
- 2001-04-06 US US09/827,292 patent/US6350764B2/en not_active Expired - Lifetime
- 2001-12-12 US US10/012,445 patent/US6472399B2/en not_active Expired - Lifetime
-
2002
- 2002-09-12 US US10/241,513 patent/US6566379B1/en not_active Expired - Lifetime
-
2003
- 2003-03-27 US US10/400,073 patent/US6706021B2/en not_active Expired - Lifetime
- 2003-11-17 US US10/714,988 patent/US7029654B2/en not_active Expired - Lifetime
-
2005
- 2005-10-19 US US11/254,086 patent/US7402586B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6706021B2 (en) | 2004-03-16 |
| TWI222441B (en) | 2004-10-21 |
| BR9815325A (pt) | 2001-12-26 |
| DE69836346T2 (de) | 2007-05-24 |
| US20030087921A1 (en) | 2003-05-08 |
| US6566379B1 (en) | 2003-05-20 |
| PL340560A1 (en) | 2001-02-12 |
| JP2001524467A (ja) | 2001-12-04 |
| US6350764B2 (en) | 2002-02-26 |
| DE69836346D1 (de) | 2006-12-14 |
| US20020086872A1 (en) | 2002-07-04 |
| AU1799199A (en) | 1999-06-15 |
| EA200000578A1 (ru) | 2001-02-26 |
| US20030225115A1 (en) | 2003-12-04 |
| CA2311969A1 (en) | 1999-06-03 |
| US6472399B2 (en) | 2002-10-29 |
| ES2274587T3 (es) | 2007-05-16 |
| EA004180B1 (ru) | 2004-02-26 |
| US7402586B2 (en) | 2008-07-22 |
| US6245763B1 (en) | 2001-06-12 |
| AR016702A1 (es) | 2001-07-25 |
| US20060211719A1 (en) | 2006-09-21 |
| AU751412B2 (en) | 2002-08-15 |
| EP1036063B1 (de) | 2006-11-02 |
| EP1036063A1 (de) | 2000-09-20 |
| US20040106633A1 (en) | 2004-06-03 |
| US7029654B2 (en) | 2006-04-18 |
| WO1999026926A1 (en) | 1999-06-03 |
| US6037356A (en) | 2000-03-14 |
| US20020007070A1 (en) | 2002-01-17 |
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