ATE344799T1 - Piperidinderivate als antibakterielle mittel - Google Patents

Piperidinderivate als antibakterielle mittel

Info

Publication number
ATE344799T1
ATE344799T1 AT02764786T AT02764786T ATE344799T1 AT E344799 T1 ATE344799 T1 AT E344799T1 AT 02764786 T AT02764786 T AT 02764786T AT 02764786 T AT02764786 T AT 02764786T AT E344799 T1 ATE344799 T1 AT E344799T1
Authority
AT
Austria
Prior art keywords
piperidine derivatives
antibacterial agents
derivatives
piperidine
mammals
Prior art date
Application number
AT02764786T
Other languages
English (en)
Inventor
David Thomas Davies
Graham Elgin Jones
Roger Edward Markwell
Neil David Pearson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE344799T1 publication Critical patent/ATE344799T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT02764786T 2001-07-26 2002-07-25 Piperidinderivate als antibakterielle mittel ATE344799T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0118238.5A GB0118238D0 (en) 2001-07-26 2001-07-26 Medicaments

Publications (1)

Publication Number Publication Date
ATE344799T1 true ATE344799T1 (de) 2006-11-15

Family

ID=9919236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02764786T ATE344799T1 (de) 2001-07-26 2002-07-25 Piperidinderivate als antibakterielle mittel

Country Status (9)

Country Link
US (1) US20040198756A1 (de)
EP (1) EP1419155B1 (de)
JP (1) JP2005504747A (de)
AT (1) ATE344799T1 (de)
AU (1) AU2002328972A1 (de)
DE (1) DE60215951T2 (de)
ES (1) ES2274999T3 (de)
GB (1) GB0118238D0 (de)
WO (1) WO2003010138A2 (de)

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GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
EP1470131A2 (de) 2002-01-29 2004-10-27 Glaxo Group Limited "aminopiperidinverbindugen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen "
US7312212B2 (en) 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
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EP1551829B1 (de) 2002-10-10 2010-04-07 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
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CA2584502A1 (en) 2004-06-24 2006-01-05 Incyte Corporation 2-methylpropanamides and their use as pharmaceuticals
JP2008506695A (ja) 2004-07-13 2008-03-06 グラクソ　グループ　リミテッド 抗細菌剤
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JP2008528586A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006081182A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
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CA2630492C (en) 2005-12-05 2015-04-14 Incyte Corporation Spiro-lactam compounds
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US20070287707A1 (en) * 2006-02-28 2007-12-13 Arrington Mark P Phosphodiesterase 10 inhibitors
WO2007103554A1 (en) * 2006-03-08 2007-09-13 Amgen Inc. Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
EP2001887B1 (de) 2006-04-06 2010-09-15 Glaxo Group Limited Pyrrolochinoxalinonderivate als antibakterielle mittel
WO2007118130A2 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (de) 2007-05-18 2008-11-19 Glaxo Group Limited Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen
AR063275A1 (es) * 2006-10-12 2009-01-14 Epix Delaware Inc Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
AU2008240764C1 (en) * 2007-04-20 2011-10-20 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
CN101679357A (zh) 2007-05-09 2010-03-24 辉瑞大药厂 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
BRPI0820701A2 (pt) 2007-12-11 2015-06-16 Cytopathfinder Inc Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
EP2080761A1 (de) 2008-01-18 2009-07-22 Glaxo Group Limited Verbindungen
NZ589497A (en) * 2008-06-02 2012-09-28 Cipla Ltd Process for the synthesis of arformoterol
EP2352734A1 (de) 2008-10-17 2011-08-10 Glaxo Group Limited Als antibakterielle mittel verwendete tricyclische stickstoffverbindungen
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
TW201209056A (en) * 2010-05-25 2012-03-01 Taisho Pharmaceutical Co Ltd Novel heterocyclic compound or salt thereof
CN102267995A (zh) * 2010-06-04 2011-12-07 艾琪康医药科技（上海）有限公司 一种制备二氮杂螺环化合物的方法
EP2651884A2 (de) * 2010-12-14 2013-10-23 Merck Sharp & Dohme Corp. Verfahren und zwischenprodukte zur herstellung von makrolactamen
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
CA2869453C (en) * 2012-04-27 2021-03-02 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
KR102110355B1 (ko) * 2012-04-27 2020-05-14 얀센 파마슈티카 엔.브이. 항균성 퀴놀린 유도체
US10702521B2 (en) 2014-08-22 2020-07-07 Glaxosmithkline Intellectual Property Development Limited Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
KR20220087497A (ko) 2019-10-18 2022-06-24 더 리전츠 오브 더 유니버시티 오브 캘리포니아 병원성 혈관을 표적화하기 위한 화합물 및 방법
US12590298B2 (en) 2019-10-18 2026-03-31 The Regents Of The University Of California Ex vivo tumor angiogenesis model
CN116102537B (zh) * 2021-11-10 2024-10-01 四川大学 一种喹啉酮类衍生物及其制备方法和用途

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GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
JP2002535323A (ja) * 1999-01-20 2002-10-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー プロテインキナーゼ阻害剤としてのピペリジニルキノリン
GB9914486D0 (en) * 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
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US6803369B1 (en) * 2000-07-25 2004-10-12 Smithkline Beecham Corporation Compounds and methods for the treatment of neoplastic disease
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US7312212B2 (en) * 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
GB0217294D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
DE60215951D1 (de) 2006-12-21
WO2003010138A3 (en) 2003-12-04
EP1419155B1 (de) 2006-11-08
US20040198756A1 (en) 2004-10-07
DE60215951T2 (de) 2007-04-26
AU2002328972A1 (en) 2003-02-17
EP1419155A2 (de) 2004-05-19
GB0118238D0 (en) 2001-09-19
ES2274999T3 (es) 2007-06-01
JP2005504747A (ja) 2005-02-17
WO2003010138A2 (en) 2003-02-06

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties