ATE304006T1 - Aminopiperidinderivate als antibakterielles arzneimittel - Google Patents

Aminopiperidinderivate als antibakterielles arzneimittel

Info

Publication number
ATE304006T1
ATE304006T1 AT00945938T AT00945938T ATE304006T1 AT E304006 T1 ATE304006 T1 AT E304006T1 AT 00945938 T AT00945938 T AT 00945938T AT 00945938 T AT00945938 T AT 00945938T AT E304006 T1 ATE304006 T1 AT E304006T1
Authority
AT
Austria
Prior art keywords
antibacterial drug
aminopiperidine derivatives
derivatives
aminopiperidine
antibacterial
Prior art date
Application number
AT00945938T
Other languages
English (en)
Inventor
David Davies
Andrew Lightfoot
Roger Edward Markwell
Neil David Pearson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE304006T1 publication Critical patent/ATE304006T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00945938T 1999-07-23 2000-07-17 Aminopiperidinderivate als antibakterielles arzneimittel ATE304006T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9917408.8A GB9917408D0 (en) 1999-07-23 1999-07-23 Compounds
PCT/EP2000/006938 WO2001007432A2 (en) 1999-07-23 2000-07-17 Aminopiperidine derivatives as antibacterials

Publications (1)

Publication Number Publication Date
ATE304006T1 true ATE304006T1 (de) 2005-09-15

Family

ID=10857877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00945938T ATE304006T1 (de) 1999-07-23 2000-07-17 Aminopiperidinderivate als antibakterielles arzneimittel

Country Status (9)

Country Link
US (2) US7001913B1 (de)
EP (1) EP1214314B1 (de)
JP (1) JP2003505455A (de)
AT (1) ATE304006T1 (de)
AU (1) AU5986200A (de)
DE (1) DE60022523T2 (de)
ES (1) ES2246244T3 (de)
GB (1) GB9917408D0 (de)
WO (1) WO2001007432A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
ES2228842T3 (es) 2000-04-04 2005-04-16 Colgate-Palmolive Company Producto solido blando, estable y eficaz.
NZ523749A (en) * 2000-07-26 2005-03-24 Smithkline Beecham P Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
EP1719770A3 (de) * 2000-09-21 2008-03-05 Smithkline Beecham Plc Chinolinderivate als antibakterielle Mittel
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
US7312212B2 (en) * 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
WO2003064431A2 (en) * 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
GB0217294D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments
EP1551829B1 (de) * 2002-10-10 2010-04-07 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
AU2003291227A1 (en) 2002-11-05 2004-06-07 Smithkline Beecham Corporation Antibacterial agents
ES2340484T3 (es) * 2002-11-05 2010-06-04 Glaxo Group Limited Agentes antibacterianos.
ATE411312T1 (de) 2002-12-04 2008-10-15 Glaxo Group Ltd Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
US7232833B2 (en) 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
FR2852954B1 (fr) * 2003-03-28 2006-07-14 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
DK1667991T3 (da) 2003-09-16 2008-08-18 Astrazeneca Ab Quinazolinderivater som tyrosinkinaseinhibitorer
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
ATE444068T1 (de) 2004-01-23 2009-10-15 Janssen Pharmaceutica Nv Chinolinderivate und ihre verwendung als mycobakterielle inhibitoren
ATE413389T1 (de) 2004-02-03 2008-11-15 Astrazeneca Ab Chinazolinderivate
JP2008502689A (ja) * 2004-06-15 2008-01-31 グラクソ　グループ　リミテッド 抗菌剤
EP1773831A1 (de) * 2004-07-08 2007-04-18 Glaxo Group Limited Antibakterielle mittel
EP1846416A4 (de) 2005-01-25 2009-07-01 Glaxo Group Ltd Antibakterielle wirkstoffe
WO2006081264A1 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1846411A4 (de) 2005-01-25 2010-08-04 Glaxo Group Ltd Antibakterielle wirkstoffe
EP1845995A4 (de) 2005-01-25 2010-03-03 Glaxo Group Ltd Antibakterielle wirkstoffe
JP2008528588A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
CN101374831B (zh) 2006-01-26 2011-04-27 埃科特莱茵药品有限公司 四氢吡喃抗生素
WO2007118130A2 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
KR100760148B1 (ko) 2006-07-19 2007-09-18 주식회사 엘지생활건강 알파-리포산을 안정화시킨 화장료 조성물
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
WO2008095847A1 (de) 2007-02-06 2008-08-14 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
GB0707706D0 (en) * 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
EP2005995A1 (de) * 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclische Verbindungen für die Behandlung von Tuberkulose
US8497369B2 (en) 2008-02-07 2013-07-30 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
EP2276766A1 (de) 2008-04-15 2011-01-26 Actelion Pharmaceuticals Ltd. Tricyclische antibiotika
NZ589883A (en) 2008-05-13 2012-06-29 Astrazeneca Ab Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy} quinazoline
EP2313397B1 (de) 2008-08-08 2016-04-20 Boehringer Ingelheim International GmbH Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
EP2332939A1 (de) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Neuartige Naphthyridinderivate und ihre Verwendung als Kinasehemmer
US20220106308A1 (en) 2019-02-19 2022-04-07 Univerza V Ljubljani Antibacterials based on monocyclic fragments coupled to aminopiperidine naphthyridine scaffold

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB296560A (en) 1927-09-13 1928-09-06 Frank Staines Improvements in shades and/or reflectors for electric lamps
GB449186A (en) 1934-12-21 1936-06-22 American Optical Corp Improvements in or relating to lenses
GB572963A (en) 1942-06-08 1945-10-31 Shell Dev Conversion of vinyl type halides to aldehydes or ketones
GB742207A (en) 1952-11-29 1955-12-21 Alfred Abrum Fain Process and apparatus for the manufacture of printed fabrics
US3362875A (en) 1965-06-04 1968-01-09 Richardson Merrell Inc N4, n4'-decamethylene-bis(4-amino)-quinaldine diacetate compositions for controllingtopical infections
US3505339A (en) * 1966-11-23 1970-04-07 Sterling Drug Inc Piperidine intermediates for 4-(4-piperidinyl-methyl or -1-ethyl)amino-7-chloroquinolines
FR2177511A1 (en) 1972-03-28 1973-11-09 Omnium Chimique Sa Quinolyl pipiridylethyl ketones - with vasodilatory and antispasmodic activity
NL7908031A (nl) 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
NL7908030A (nl) 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
FR2471981A1 (fr) * 1979-12-21 1981-06-26 Pharmindustrie Nouveaux derives de la (piperidyl-4)-2 (quinolyl-4)-1 ethanone, produits intermediaires et procedes pour leur preparation, et leur utilisation comme medicaments
FR2485014A1 (fr) 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments
FR2495470A1 (fr) 1980-12-05 1982-06-11 Pharmindustrie Nouveaux medicaments a base de derives de (quinolyl-4)-1 (piperidyl-4)-2 ethanol ou (quinolyl-4)-1 (piperidyl-4)-3 propanol
US4925877A (en) 1986-02-25 1990-05-15 Zaidanhojin Biseibutsu Kagaku Kenkyukai Physiologically active erbstatin analogue compounds and compositions
US4971996A (en) 1987-03-11 1990-11-20 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors
DK662188A (da) 1987-11-27 1989-05-28 Eisai Co Ltd Cykliske aminer og farmakologiske praeparater med indhold af saadanne
ZA899436B (en) 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
JP2777159B2 (ja) 1988-12-22 1998-07-16 エーザイ株式会社 環状アミン誘導体を含有する医薬
US5109002A (en) 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
ES2188584T3 (es) 1991-03-28 2003-07-01 Eisai Co Ltd Derivados heterociclicos de amina.
US5721237A (en) 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
MY110227A (en) 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
EP0541486A1 (de) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclische Konjugate
US5728708A (en) 1993-10-01 1998-03-17 Novartis Corporation Pharmacologically active pyridine derivatives and processes for the preparation thereof
JPH07179407A (ja) 1993-11-12 1995-07-18 Green Cross Corp:The 新規縮合環系化合物またはその塩、およびその医薬用途
MX9702245A (es) 1994-11-14 1997-06-28 Warner Lambert Co Seis-aril-pirido(2,3-d)pirimidinas y naftiridinas para inhibir la proliferacion celular mediada por la proteina cinasa tirosina.
ES2149468T3 (es) 1995-04-26 2000-11-01 Kyowa Hakko Kogyo Kk Derivados de radicicol.
US5620997A (en) 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
US5707990A (en) 1996-01-30 1998-01-13 Ortho Pharmaceutical Corporation 2-substituted amino and thio alkyl benzoxazine antimicrobial agents
WO1997045119A1 (en) 1996-05-24 1997-12-04 Novartis Ag Use of substance p antagonists for treating social phobia
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
US5965572A (en) 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
DE69908555T2 (de) 1998-01-26 2004-05-06 Smithkline Beecham P.L.C., Brentford Chinolinderivate als antibakterielles arzneimittel
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9914486D0 (en) * 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US6403610B1 (en) * 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
FR2798656B1 (fr) 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
NZ523749A (en) * 2000-07-26 2005-03-24 Smithkline Beecham P Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity

Also Published As

Publication number Publication date
JP2003505455A (ja) 2003-02-12
ES2246244T3 (es) 2006-02-16
AU5986200A (en) 2001-02-13
EP1214314A2 (de) 2002-06-19
US7001913B1 (en) 2006-02-21
WO2001007432A3 (en) 2001-05-25
GB9917408D0 (en) 1999-09-22
DE60022523D1 (de) 2005-10-13
US20060079546A1 (en) 2006-04-13
EP1214314B1 (de) 2005-09-07
DE60022523T2 (de) 2006-06-29
WO2001007432A8 (en) 2001-09-07
WO2001007432A2 (en) 2001-02-01

Similar Documents

Publication Publication Date Title
DE60022523D1 (de) Aminopiperidinderivate als antibakterielles arzneimittel
DE60006823D1 (de) Quinolin-derivate und deren verwendung als antibakterielle wirkstoffe
ATE344799T1 (de) Piperidinderivate als antibakterielle mittel
DE60119939D1 (de) Chinolinderivate als antibakterielle mittel
GB0112836D0 (en) Medicaments
IL154107A0 (en) Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0031088D0 (en) Medicaments
GB9822450D0 (en) Medicaments
AU6339599A (en) Quinoline derivatives and their use as antibacterial agents
GB0031086D0 (en) Medicaments
GB0217294D0 (en) Medicaments
DE60221969D1 (de) Durch piperidine-enthaltende gruppen substituierte chinoline und deren stickstoff-enthaltende derivate und ihre verwendung als antibakterielle wirkstoffe
ECSP993176A (es) Nuevos compuestos y composiciones antibacterianas

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties