ATE344966T1 - Verfahren und vorrichtung zur erzeugung vom fluor-isotop f-18 - Google Patents
Verfahren und vorrichtung zur erzeugung vom fluor-isotop f-18Info
- Publication number
- ATE344966T1 ATE344966T1 AT02731883T AT02731883T ATE344966T1 AT E344966 T1 ATE344966 T1 AT E344966T1 AT 02731883 T AT02731883 T AT 02731883T AT 02731883 T AT02731883 T AT 02731883T AT E344966 T1 ATE344966 T1 AT E344966T1
- Authority
- AT
- Austria
- Prior art keywords
- superscript
- water
- target
- loop
- isotope
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Particle Accelerators (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/878,770 US6567492B2 (en) | 2001-06-11 | 2001-06-11 | Process and apparatus for production of F-18 fluoride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE344966T1 true ATE344966T1 (de) | 2006-11-15 |
Family
ID=25372803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02731883T ATE344966T1 (de) | 2001-06-11 | 2002-05-21 | Verfahren und vorrichtung zur erzeugung vom fluor-isotop f-18 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6567492B2 (de) |
| EP (1) | EP1397812B1 (de) |
| JP (1) | JP4486811B2 (de) |
| AT (1) | ATE344966T1 (de) |
| DE (1) | DE60215939T2 (de) |
| WO (1) | WO2002101758A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6599484B1 (en) * | 2000-05-12 | 2003-07-29 | Cti, Inc. | Apparatus for processing radionuclides |
| US6567492B2 (en) * | 2001-06-11 | 2003-05-20 | Eastern Isotopes, Inc. | Process and apparatus for production of F-18 fluoride |
| WO2003099208A2 (en) * | 2002-05-21 | 2003-12-04 | Duke University | Recirculating target and method for producing radionuclide |
| US7018614B2 (en) * | 2002-11-05 | 2006-03-28 | Eastern Isotopes, Inc. | Stabilization of radiopharmaceuticals labeled with 18-F |
| EP1429345A1 (de) * | 2002-12-10 | 2004-06-16 | Ion Beam Applications S.A. | Radioisotopen Herstellungsverfahren und -vorrichtung |
| WO2004093652A2 (en) * | 2003-04-22 | 2004-11-04 | Molecular Technologies, Inc. | System and method for synthesis of molecular imaging probes including fdg |
| WO2005009928A2 (en) * | 2003-07-24 | 2005-02-03 | The Queen's Medical Center | Preparation and use of alkylating agents |
| WO2005025519A2 (en) * | 2003-09-11 | 2005-03-24 | Mayo Foundation For Medical Education And Research | Radiolabeled thymidine solid-phase extraction purification method |
| US7831009B2 (en) * | 2003-09-25 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Tantalum water target body for production of radioisotopes |
| EP1569243A1 (de) * | 2004-02-20 | 2005-08-31 | Ion Beam Applications S.A. | Targetvorrichtung zum Erzeugen eines Radioisotops |
| US7734331B2 (en) * | 2004-03-02 | 2010-06-08 | General Electric Company | Systems, methods and apparatus for preparation, delivery and monitoring of radioisotopes in positron emission tomography |
| US20050232861A1 (en) * | 2004-04-20 | 2005-10-20 | Buchanan Charles R | Microfluidic apparatus and method for synthesis of molecular imaging probes including FDG |
| US20050232387A1 (en) * | 2004-04-20 | 2005-10-20 | Padgett Henry C | Microfluidic apparatus and method for synthesis of molecular imaging probes |
| US20050279130A1 (en) * | 2004-06-18 | 2005-12-22 | General Electric Company | 18O[O2] oxygen refilling technique for the production of 18[F2] fluorine |
| KR20070042922A (ko) * | 2004-06-29 | 2007-04-24 | 트라이엄프,오퍼레이팅애즈어조인트벤쳐바이더거버너스 오브더유니버시티오브알버타더유니버시티오브브리티시콜롬비아 칼레톤유니버시티시몬프레이저유니버시티더유니버시티 오브토론토앤드더유니버시티오브빅토리아 | 강제 대류 타겟 어셈블리 |
| US7663119B2 (en) | 2004-08-12 | 2010-02-16 | John Sved | Process for neutron interrogation of objects in relative motion or of large extent |
| EP1800315B1 (de) * | 2004-08-12 | 2008-04-02 | John Sved | Protonengeneratorvorrichtung für isotopproduktion |
| US20060039522A1 (en) * | 2004-08-18 | 2006-02-23 | Research Foundation Of The State University Of New York | Cyclotron target, apparatus for handling fluids with respect thereto and for recovering irradiated fluids, and methods of operating same |
| US20060062342A1 (en) * | 2004-09-17 | 2006-03-23 | Cyclotron Partners, L.P. | Method and apparatus for the production of radioisotopes |
| GB0506041D0 (en) * | 2005-03-24 | 2005-04-27 | Ge Healthcare Ltd | Stripping method |
| US7235216B2 (en) * | 2005-05-01 | 2007-06-26 | Iba Molecular North America, Inc. | Apparatus and method for producing radiopharmaceuticals |
| US7556780B1 (en) * | 2006-09-11 | 2009-07-07 | Atomic Energy Council-Institute Of Nuclear Energy Research | Device for 123I-ADAM and automatic manufacturing device thereof |
| KR100855106B1 (ko) * | 2007-02-02 | 2008-08-29 | 한국원자력연구원 | 0-18 농축표적의 유기불순물 정제 방법 및 장치 |
| US8340058B2 (en) * | 2007-10-29 | 2012-12-25 | Nvidia Corporation | Headphone with enhanced voice communication |
| EP2056303B1 (de) | 2007-10-29 | 2011-10-19 | Atomic Energy Council - Institute of Nuclear Energy Research | Freisetzungssystem für Flüssigisotope |
| US20100243082A1 (en) * | 2007-10-31 | 2010-09-30 | Atomic Energy Council - Institute Of Nuclear Energy Research | Liquid isotope delivery system |
| EP2063039A1 (de) * | 2007-11-26 | 2009-05-27 | Technical University of Denmark | Leichte Tragstruktur |
| WO2009135163A2 (en) | 2008-05-02 | 2009-11-05 | Phoenix Nuclear Labs Llc | Device and method for producing medical isotopes |
| US8825015B2 (en) * | 2008-09-18 | 2014-09-02 | Nvidia Corporation | Accessing web pages on communication paths with low bandwidth |
| US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
| US9415392B2 (en) | 2009-03-24 | 2016-08-16 | The University Of Chicago | Slip chip device and methods |
| US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
| US8670513B2 (en) * | 2009-05-01 | 2014-03-11 | Bti Targetry, Llc | Particle beam target with improved heat transfer and related apparatus and methods |
| US8435454B2 (en) * | 2009-07-09 | 2013-05-07 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
| US8273300B2 (en) * | 2009-07-09 | 2012-09-25 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
| WO2012003009A2 (en) | 2010-01-28 | 2012-01-05 | Shine Medical Technologies, Inc. | Segmented reaction chamber for radioisotope production |
| US9336916B2 (en) * | 2010-05-14 | 2016-05-10 | Tcnet, Llc | Tc-99m produced by proton irradiation of a fluid target system |
| BE1019556A3 (fr) | 2010-10-27 | 2012-08-07 | Ion Beam Applic Sa | Dispositif destine a la production de radioisotopes. |
| WO2012092394A1 (en) | 2010-12-29 | 2012-07-05 | Cardinal Health 414, Llc | Closed vial fill system for aseptic dispensing |
| US10734126B2 (en) | 2011-04-28 | 2020-08-04 | SHINE Medical Technologies, LLC | Methods of separating medical isotopes from uranium solutions |
| US9269467B2 (en) | 2011-06-02 | 2016-02-23 | Nigel Raymond Stevenson | General radioisotope production method employing PET-style target systems |
| WO2013012822A1 (en) * | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc | Systems, methods, and devices for producing, manufacturing, and control of radiopharmaceuticals |
| US9417332B2 (en) | 2011-07-15 | 2016-08-16 | Cardinal Health 414, Llc | Radiopharmaceutical CZT sensor and apparatus |
| WO2013012813A1 (en) | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc | Modular cassette synthesis unit |
| EP2581914B1 (de) * | 2011-10-10 | 2014-12-31 | Ion Beam Applications S.A. | Verfahren und Anlage für die Herstellung eines Radioisotops |
| CN104321623B (zh) | 2012-04-05 | 2018-11-30 | 阳光医疗技术公司 | 水性组件及控制方法 |
| KR101443512B1 (ko) * | 2013-03-27 | 2014-09-22 | 조선대학교산학협력단 | O-18 농축수의 자동 공급 및 회수 기능을 갖는 방사성 동위원소 생산용 표적장치 |
| JP2017528509A (ja) * | 2014-06-06 | 2017-09-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自己遮蔽ベンチトップ型ケミストリシステム |
| NL2014828B1 (en) | 2015-05-20 | 2017-01-31 | Out And Out Chemistry S P R L | Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method. |
| KR102233112B1 (ko) * | 2019-07-25 | 2021-03-29 | 한국원자력의학원 | 액체 타겟을 이용한 핵종 생산 장치 |
| RU2724108C1 (ru) * | 2019-08-20 | 2020-06-22 | Акционерное общество "Государственный научный центр-Научно-исследовательский институт атомных реакторов" | Мишень для наработки радиоактивных изотопов и способ ее изготовления |
| CN113828259A (zh) * | 2021-09-24 | 2021-12-24 | 上海安迪科正电子技术有限公司 | 一种氟-18离子的生产方法及应用 |
| CN117062296B (zh) * | 2023-08-14 | 2024-02-02 | 北京恒益德科技有限公司 | 一种18f氟化钠半自动制备装置 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981769A (en) | 1972-04-26 | 1976-09-21 | Medi-Physics, Inc. | Process for preparing fluorine-18 |
| US3993538A (en) * | 1976-01-27 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Production of high purity radiothallium |
| US4818468A (en) | 1977-08-03 | 1989-04-04 | The Regents Of The University Of California | Continuous flow radioactive production |
| US4252668A (en) * | 1979-02-22 | 1981-02-24 | The United States Of America As Represented By The United States Department Of Energy | Process for preparation of potassium-38 |
| JPS57142600A (en) * | 1981-02-28 | 1982-09-03 | Japan Steel Works Ltd | Target device |
| US4436717A (en) | 1981-05-29 | 1984-03-13 | The United States Of America As Represented By The United States Department Of Energy | 18 F-4-Fluoroantipyrine |
| JPS603600A (ja) * | 1983-06-21 | 1985-01-09 | 住友重機械工業株式会社 | 強制循環式の放射性同位体連続合成方法とそれに用いる装置 |
| JPH0640160B2 (ja) * | 1985-04-25 | 1994-05-25 | 住友重機械工業株式会社 | 放射性同位元素18f製造用ターゲット装置 |
| US5037602A (en) | 1989-03-14 | 1991-08-06 | Science Applications International Corporation | Radioisotope production facility for use with positron emission tomography |
| US5082980A (en) | 1990-06-13 | 1992-01-21 | Case Western Reserve University | Process and apparatus for synthesizing oxygen-15 labelled butanol for positron emission tomography |
| MC2260A1 (fr) | 1990-06-18 | 1993-04-26 | Dow Chemical Co | Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation |
| JPH0778558B2 (ja) * | 1990-07-20 | 1995-08-23 | 日本鋼管株式会社 | ▲上13▼nh▲上+▼▲下4▼,▲上18▼f−同時製造用ターゲット箱 |
| CA2055297C (en) | 1990-11-13 | 1996-10-08 | Iwao Kanno | Apparatus and method for producing and automatically injecting h--o |
| US5280505A (en) | 1991-05-03 | 1994-01-18 | Science Research Laboratory, Inc. | Method and apparatus for generating isotopes |
| WO1993004702A1 (en) | 1991-08-29 | 1993-03-18 | Mallinckrodt Medical, Inc. | Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins |
| WO1994021653A1 (en) | 1993-03-22 | 1994-09-29 | General Electric Company | Method for making 2-fluoro-2-deoxyglucose |
| US5425063A (en) | 1993-04-05 | 1995-06-13 | Associated Universities, Inc. | Method for selective recovery of PET-usable quantities of [18 F] fluoride and [13 N] nitrate/nitrite from a single irradiation of low-enriched [18 O] water |
| US5468355A (en) | 1993-06-04 | 1995-11-21 | Science Research Laboratory | Method for producing radioisotopes |
| WO1995018668A1 (de) | 1994-01-11 | 1995-07-13 | Forschungszentrum Jülich GmbH | Verfahren zur abtrennung von trägerfreien radionukliden aus targetflüssigkeit, dessen anwendung und dafür geeignete anordnung |
| US5482865A (en) | 1994-06-10 | 1996-01-09 | Associated Universities, Inc. | Apparatus and method for preparing oxygen-15 labeled water H2 [15 O] in an injectable form for use in positron emission tomography |
| JP3008329B2 (ja) | 1995-01-26 | 2000-02-14 | 信彦 中澤 | ラジオアイソトープ標識試薬調整用プレフィルドキット |
| US5573747A (en) | 1995-05-19 | 1996-11-12 | Lacy; Jeffrey L. | Method for preparing a physiological isotonic pet radiopharmaceutical of 62 Cu |
| US5586153A (en) | 1995-08-14 | 1996-12-17 | Cti, Inc. | Process for producing radionuclides using porous carbon |
| JPH0954196A (ja) | 1995-08-17 | 1997-02-25 | Nihon Medi Physics Co Ltd | 18−f製造ターゲット部材及びターゲットシステム |
| US6066309A (en) | 1996-02-02 | 2000-05-23 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| US5932178A (en) | 1996-03-29 | 1999-08-03 | Nkk Plant Engineering Corporation | FDG synthesizer using columns |
| BE1010280A3 (fr) | 1996-05-02 | 1998-05-05 | Coincidence S A | Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose. |
| US6027710A (en) | 1996-09-18 | 2000-02-22 | Nihon Medi-Physiscs Co., Ltd. | Radiation-protecting agent |
| JPH10206597A (ja) * | 1997-01-23 | 1998-08-07 | Rikagaku Kenkyusho | 低速陽電子ビーム発生方法及び装置 |
| US5917874A (en) | 1998-01-20 | 1999-06-29 | Brookhaven Science Associates | Accelerator target |
| JPH11295494A (ja) * | 1998-04-08 | 1999-10-29 | Nippon Meji Physics Kk | [f−18]−フッ化物イオンの製造方法 |
| JP2001074891A (ja) * | 1999-09-03 | 2001-03-23 | Hitachi Ltd | 放射線同位体製造装置および方法 |
| ATE430368T1 (de) * | 2000-02-23 | 2009-05-15 | Univ Alberta The University Of | Verfahren und vorrichtung zur erzeugung von 18f- fluorid |
| US6567492B2 (en) * | 2001-06-11 | 2003-05-20 | Eastern Isotopes, Inc. | Process and apparatus for production of F-18 fluoride |
-
2001
- 2001-06-11 US US09/878,770 patent/US6567492B2/en not_active Expired - Lifetime
-
2002
- 2002-05-21 WO PCT/US2002/016017 patent/WO2002101758A1/en not_active Ceased
- 2002-05-21 EP EP02731883A patent/EP1397812B1/de not_active Expired - Lifetime
- 2002-05-21 JP JP2003504417A patent/JP4486811B2/ja not_active Expired - Lifetime
- 2002-05-21 AT AT02731883T patent/ATE344966T1/de not_active IP Right Cessation
- 2002-05-21 DE DE60215939T patent/DE60215939T2/de not_active Expired - Lifetime
-
2003
- 2003-05-06 US US10/429,990 patent/US20030194039A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005505751A (ja) | 2005-02-24 |
| DE60215939D1 (de) | 2006-12-21 |
| US20030007588A1 (en) | 2003-01-09 |
| EP1397812B1 (de) | 2006-11-08 |
| JP4486811B2 (ja) | 2010-06-23 |
| US20030194039A1 (en) | 2003-10-16 |
| DE60215939T2 (de) | 2007-09-13 |
| WO2002101758A1 (en) | 2002-12-19 |
| EP1397812A1 (de) | 2004-03-17 |
| US6567492B2 (en) | 2003-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |