ATE374196T1 - Dihydrobenzodiazepin-2-on-derivative für die behandlung von neurologischen erkrankungen - Google Patents

Dihydrobenzodiazepin-2-on-derivative für die behandlung von neurologischen erkrankungen

Info

Publication number
ATE374196T1
ATE374196T1 AT03702549T AT03702549T ATE374196T1 AT E374196 T1 ATE374196 T1 AT E374196T1 AT 03702549 T AT03702549 T AT 03702549T AT 03702549 T AT03702549 T AT 03702549T AT E374196 T1 ATE374196 T1 AT E374196T1
Authority
AT
Austria
Prior art keywords
dihydrobenzodiazepine
derivatives
treatment
neurological diseases
neurological
Prior art date
Application number
AT03702549T
Other languages
English (en)
Inventor
Geo Adam
Erwin Goetschi
Juergen Wichmann
Thomas Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE374196T1 publication Critical patent/ATE374196T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03702549T 2002-02-06 2003-01-28 Dihydrobenzodiazepin-2-on-derivative für die behandlung von neurologischen erkrankungen ATE374196T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02002012 2002-02-06

Publications (1)

Publication Number Publication Date
ATE374196T1 true ATE374196T1 (de) 2007-10-15

Family

ID=27675598

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03702549T ATE374196T1 (de) 2002-02-06 2003-01-28 Dihydrobenzodiazepin-2-on-derivative für die behandlung von neurologischen erkrankungen

Country Status (30)

Country Link
US (1) US6949542B2 (de)
EP (1) EP1474416B1 (de)
JP (1) JP4077411B2 (de)
KR (1) KR20040081486A (de)
CN (1) CN100497333C (de)
AR (1) AR038481A1 (de)
AT (1) ATE374196T1 (de)
AU (1) AU2003205695B8 (de)
BR (1) BR0307474A (de)
CA (1) CA2474219C (de)
DE (1) DE60316538T2 (de)
DK (1) DK1474416T3 (de)
ES (1) ES2294264T3 (de)
GT (1) GT200300028A (de)
HR (1) HRP20040678A2 (de)
IL (1) IL163102A (de)
MX (1) MXPA04007516A (de)
MY (1) MY176608A (de)
NO (1) NO327697B1 (de)
NZ (1) NZ534122A (de)
PA (1) PA8565901A1 (de)
PE (1) PE20031011A1 (de)
PL (1) PL372425A1 (de)
PT (1) PT1474416E (de)
RU (1) RU2315764C2 (de)
SI (1) SI1474416T1 (de)
TW (1) TWI326599B (de)
UY (1) UY27654A1 (de)
WO (1) WO2003066623A1 (de)
ZA (1) ZA200406032B (de)

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TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
JP2010524879A (ja) * 2007-04-19 2010-07-22 エフ．ホフマン−ラ ロシュ アーゲー ジヒドロ−ベンゾ［ｂ］［１，４］ジアゼピン−２−オンスルホンアミド誘導体
JP5204232B2 (ja) 2007-08-27 2013-06-05 エフ．ホフマン−ラ ロシュ アーゲー Ｆｘｒアゴニストとして使用されるベンゾイミダゾール誘導体
CA2696948C (en) 2007-09-14 2013-04-30 Jose Maria Cid-Nunez 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
KR20100080597A (ko) 2007-09-14 2010-07-09 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 １,３-이치환된-４-페닐-1ｈ-피리딘-2-온
KR20100065191A (ko) 2007-09-14 2010-06-15 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
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CA2735764C (en) 2008-09-02 2016-06-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
BRPI0921333A2 (pt) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
NZ596078A (en) 2009-05-12 2013-06-28 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
EA020671B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
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CN102811620B (zh) 2010-01-25 2015-03-25 Chdi基金会股份有限公司 一些犬尿氨酸-3-单加氧酶抑制剂、药物组合物及其使用方法
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BR112014004741B1 (pt) 2011-08-30 2021-10-13 Chdi Foundation, Inc Entidade química, seu uso e composição farmacêutica compreendendo a mesma
JP6337255B2 (ja) 2012-07-27 2018-06-06 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. ヒストンデアセチラーゼの阻害剤
KR20150070187A (ko) 2012-10-23 2015-06-24 에프. 호프만-라 로슈 아게 자폐 장애의 치료를 위한 ｍｇｌｕ２／３ 길항제
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JP6552061B2 (ja) * 2014-06-10 2019-07-31 サンフォード−バーンハム メディカル リサーチ インスティテュート 代謝型グルタミン酸受容体の負のアロステリックモジュレーター（ｎａｍｓ）とその使用
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MXPA02003740A (es) 1999-10-15 2002-09-30 Hoffmann La Roche Derivados de benzodiazepina.

Also Published As

Publication number Publication date
SI1474416T1 (sl) 2008-02-29
IL163102A (en) 2011-07-31
EP1474416B1 (de) 2007-09-26
NO327697B1 (no) 2009-09-14
ES2294264T3 (es) 2008-04-01
RU2315764C2 (ru) 2008-01-27
PA8565901A1 (es) 2003-09-05
US20030166639A1 (en) 2003-09-04
WO2003066623A1 (en) 2003-08-14
RU2004126945A (ru) 2005-06-27
TWI326599B (en) 2010-07-01
US6949542B2 (en) 2005-09-27
GT200300028A (es) 2004-06-11
HK1078858A1 (zh) 2006-03-24
MXPA04007516A (es) 2004-11-10
AR038481A1 (es) 2005-01-19
PL372425A1 (en) 2005-07-25
CN1633430A (zh) 2005-06-29
DE60316538D1 (de) 2007-11-08
EP1474416A1 (de) 2004-11-10
AU2003205695B8 (en) 2008-05-01
ZA200406032B (en) 2005-10-12
MY176608A (en) 2020-08-18
AU2003205695B2 (en) 2008-04-03
AU2003205695A1 (en) 2003-09-02
UY27654A1 (es) 2003-08-29
CA2474219C (en) 2010-04-13
JP2005522440A (ja) 2005-07-28
PT1474416E (pt) 2007-12-27
NO20043237L (no) 2004-08-02
KR20040081486A (ko) 2004-09-21
NZ534122A (en) 2006-12-22
HRP20040678A2 (en) 2005-10-31
CN100497333C (zh) 2009-06-10
DK1474416T3 (da) 2008-01-14
PE20031011A1 (es) 2003-11-29
DE60316538T2 (de) 2008-08-21
CA2474219A1 (en) 2003-08-14
JP4077411B2 (ja) 2008-04-16
BR0307474A (pt) 2004-11-09
TW200302730A (en) 2003-08-16

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