ATE345355T1 - Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz - Google Patents

Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz

Info

Publication number
ATE345355T1
ATE345355T1 AT02764797T AT02764797T ATE345355T1 AT E345355 T1 ATE345355 T1 AT E345355T1 AT 02764797 T AT02764797 T AT 02764797T AT 02764797 T AT02764797 T AT 02764797T AT E345355 T1 ATE345355 T1 AT E345355T1
Authority
AT
Austria
Prior art keywords
magnetic resonance
derivatives
resonance imaging
metal complexes
peptide conjugates
Prior art date
Application number
AT02764797T
Other languages
English (en)
Inventor
Silvio Aime
Eliana Gianolio
Giancarlo Morelli
Carlo Pedone
Diego Tesauro
Luciano Lattuada
Massimo Visigalli
Pier Lucio Anelli
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE345355T1 publication Critical patent/ATE345355T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02764797T 2001-08-03 2002-07-26 Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz ATE345355T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI001708A ITMI20011708A1 (it) 2001-08-03 2001-08-03 Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m

Publications (1)

Publication Number Publication Date
ATE345355T1 true ATE345355T1 (de) 2006-12-15

Family

ID=11448231

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02764797T ATE345355T1 (de) 2001-08-03 2002-07-26 Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz

Country Status (8)

Country Link
US (1) US20050008573A1 (de)
EP (1) EP1412383B9 (de)
JP (1) JP4216715B2 (de)
AT (1) ATE345355T1 (de)
AU (1) AU2002328981A1 (de)
DE (1) DE60216111T2 (de)
IT (1) ITMI20011708A1 (de)
WO (1) WO2003014157A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD20030174A1 (it) * 2003-07-31 2003-10-29 Univ Padova Coniugati polimerici per diagnostica e terapia
WO2006002873A2 (en) 2004-07-02 2006-01-12 Bracco Imaging Spa 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri )
WO2006128643A2 (en) * 2005-05-31 2006-12-07 Inbios S.R.L. Supramolecular aggregates containing chelating agents and bioactive peptides as effective and selective delivery tools for drugs and contrast agents in mri or nuclear medicine
JP5377965B2 (ja) 2005-09-09 2013-12-25 ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド 標的化された造影剤および造影剤を標的化するための方法
EP1928507B1 (de) * 2005-09-09 2015-11-11 Georgia State University Research Foundation, Inc. Gezielte kontrastmittel und verfahren für kontrastmittel-targeting
US20090110640A1 (en) * 2006-03-29 2009-04-30 Oskar Axelsson Contrast agents for magnetic resonance imaging and spectroscopy consisting of a cyclic oligoamid core of 3 to 4 identicial monomer units with 3 to 4 paramagnetic chelate side chains
US8481272B2 (en) 2006-08-04 2013-07-09 Georgia State University Research Foundation, Inc. Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity
WO2008070384A2 (en) * 2006-11-06 2008-06-12 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method of preparing macromolecular contrast agents and uses thereof
EP2097507B1 (de) 2006-12-14 2015-05-06 Georgia State University Research Foundation, Inc. Analytsensoren und verwendung davon für den nachweis von analytaktivität
WO2009146099A2 (en) * 2008-04-02 2009-12-03 Georgia State University Research Foundation, Inc. Contrast agents, methods for preparing contrast agents, and methods of imaging
EP2279190A1 (de) * 2008-04-18 2011-02-02 Ge Healthcare As Paramagnetische, um einen zentralen kern angeordnete chelate enthaltende verbindungen und ihre verwendung in der magnetresonanzbilddarstellung und spektroskopie
ES2354320B2 (es) * 2008-06-24 2011-10-11 Universidade De Santiago De Compostela Ciclopéptidos marcados magnéticamente con complejos de lantánidos.
US10610608B2 (en) 2013-08-01 2020-04-07 Rochester Institute Of Technology Modular imaging agents containing amino acids and peptides
US10265013B2 (en) * 2013-09-06 2019-04-23 Somnology, Inc. System and method for sleep disorder diagnosis and treatment
US10265014B2 (en) * 2013-09-06 2019-04-23 Somnology, Inc. System and method for sleep disorder diagnosis and treatment
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
EP3389478B1 (de) 2015-12-15 2021-03-31 Mayo Foundation for Medical Education and Research Systeme und verfahren zum linearen zeitlichen clustering für begrenzte, wiederholbare, seltene ereignisse in physiologischen signalen
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
GB9215780D0 (en) * 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
NO940080L (no) * 1993-01-12 1994-07-13 Sandoz Ag Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav
GB9404208D0 (en) * 1994-03-04 1994-04-20 Nycomed Salutar Inc Chelants
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5762909A (en) * 1995-08-31 1998-06-09 General Electric Company Tumor targeting with polymeric molecules having extended conformation
AT405906B (de) * 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
US6342598B1 (en) * 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
IT1315263B1 (it) * 1999-12-21 2003-02-03 Bracco Spa Composti chelanti,loro chelati con ioni metallici paramagnetici, loropreparazione ed uso

Also Published As

Publication number Publication date
JP4216715B2 (ja) 2009-01-28
ITMI20011708A0 (it) 2001-08-03
WO2003014157A2 (en) 2003-02-20
EP1412383A2 (de) 2004-04-28
ITMI20011708A1 (it) 2003-02-03
EP1412383B1 (de) 2006-11-15
WO2003014157A3 (en) 2003-11-13
US20050008573A1 (en) 2005-01-13
DE60216111D1 (de) 2006-12-28
DE60216111T2 (de) 2007-04-05
AU2002328981A1 (en) 2003-02-24
EP1412383B9 (de) 2007-10-03
JP2005510461A (ja) 2005-04-21

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