ATE346145T1 - Verfahren zur stabilisierung von thrombin - Google Patents

Verfahren zur stabilisierung von thrombin

Info

Publication number
ATE346145T1
ATE346145T1 AT00961196T AT00961196T ATE346145T1 AT E346145 T1 ATE346145 T1 AT E346145T1 AT 00961196 T AT00961196 T AT 00961196T AT 00961196 T AT00961196 T AT 00961196T AT E346145 T1 ATE346145 T1 AT E346145T1
Authority
AT
Austria
Prior art keywords
thrombin
containing composition
stabilized
stabilization
effective amount
Prior art date
Application number
AT00961196T
Other languages
English (en)
Inventor
Masahiro Okuda
Norihiro Kikukawa
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Application granted granted Critical
Publication of ATE346145T1 publication Critical patent/ATE346145T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00961196T 1999-09-27 2000-09-22 Verfahren zur stabilisierung von thrombin ATE346145T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27209299 1999-09-27
JP2000212924 2000-07-13

Publications (1)

Publication Number Publication Date
ATE346145T1 true ATE346145T1 (de) 2006-12-15

Family

ID=26550026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00961196T ATE346145T1 (de) 1999-09-27 2000-09-22 Verfahren zur stabilisierung von thrombin

Country Status (7)

Country Link
US (1) US20060246052A1 (de)
EP (1) EP1221479B1 (de)
JP (1) JP4399615B2 (de)
AT (1) ATE346145T1 (de)
AU (1) AU7320300A (de)
DE (1) DE60032001T2 (de)
WO (1) WO2001023536A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101413027B (zh) * 2001-01-31 2014-12-31 旭化成制药株式会社 测定糖化蛋白质的组合物
DK1766003T3 (da) 2004-06-22 2008-12-08 Zymogenetics Inc Thrombinpræparater
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
TW200718785A (en) 2005-11-10 2007-05-16 Toyo Boseki A process for improving the thermal stability of a composition containing a soluble coenzyme conjugated glucose dehydrogenase (GDH)
ES2382758T3 (es) * 2006-12-21 2012-06-13 Sekisui Medical Co., Ltd. Procedimiento para estabilizar la alfa-trombina en solución que contiene trombina
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
JP6174367B2 (ja) * 2013-04-26 2017-08-02 株式会社Ｌｓｉメディエンス トロンビン含有試薬及び測定方法
CN104630325B (zh) * 2015-02-04 2018-03-02 上海长岛生物技术有限公司 一种液体型纤维蛋白原检测试剂及其制备方法
CN104569446A (zh) * 2015-02-04 2015-04-29 上海长岛生物技术有限公司 一种液体型凝血酶时间检测试剂及其制备方法
EA026104B1 (ru) * 2015-04-02 2017-03-31 Общество С Ограниченной Ответственностью "Тектум" Кровоостанавливающее и ранозаживляющее средство
CN105548564B (zh) * 2015-12-28 2017-03-22 青岛古高生物科技有限公司 原花青素的应用及含原花青素的纤维蛋白原测定试剂
CN112578130A (zh) * 2019-09-30 2021-03-30 积水医疗科技(苏州)有限公司 凝血酶溶液、试剂盒、凝血酶的稳定化方法、检测试剂以及凝血酶时间的测定方法
CN112941143A (zh) * 2021-01-28 2021-06-11 南京可诺医疗技术有限公司 一种简单便捷的检测凝血和血小板功能的试剂及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5639782A (en) * 1979-09-04 1981-04-15 Dai Ichi Pure Chem Co Ltd Stabilization of thrombin
DE3019612A1 (de) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes thrombinpraeparat
DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
ATE177781T1 (de) * 1990-02-20 1999-04-15 Baxter Int Gereinigtes, virusfreies menschliches thrombin
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
DE59005286D1 (de) * 1990-10-04 1994-05-11 Kallies Import Export Vertrieb Stabilisiertes Thrombin, seine Herstellung und seine Verwendung als Thrombinzeitreagens.
JPH0513899A (ja) * 1991-07-02 1993-01-22 Mitsubishi Electric Corp プリント基板
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT399055B (de) * 1992-05-15 1995-03-27 Immuno Ag Verfahren zur bestimmung von fibrinogen
JP2994557B2 (ja) * 1994-09-02 1999-12-27 株式会社アズウェル フィブリノゲン測定方法およびその測定試薬
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
GB9503750D0 (en) * 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
WO1996033263A1 (en) * 1995-04-17 1996-10-24 JAPAN, represented by DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms
CA2251475C (en) * 1996-04-04 2006-09-05 Immuno Aktiengesellschaft Hemostatic sponge based on collagen

Also Published As

Publication number Publication date
WO2001023536A1 (en) 2001-04-05
AU7320300A (en) 2001-04-30
DE60032001T2 (de) 2007-05-31
EP1221479A4 (de) 2004-06-16
EP1221479B1 (de) 2006-11-22
US20060246052A1 (en) 2006-11-02
DE60032001D1 (de) 2007-01-04
EP1221479A1 (de) 2002-07-10
JP4399615B2 (ja) 2010-01-20

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