DK1054893T3 - Syntetiske polymerer og fremgangsmåder, kit eller sammensætninger til modulering af deres oplöselighed - Google Patents
Syntetiske polymerer og fremgangsmåder, kit eller sammensætninger til modulering af deres oplöselighedInfo
- Publication number
- DK1054893T3 DK1054893T3 DK99904123T DK99904123T DK1054893T3 DK 1054893 T3 DK1054893 T3 DK 1054893T3 DK 99904123 T DK99904123 T DK 99904123T DK 99904123 T DK99904123 T DK 99904123T DK 1054893 T3 DK1054893 T3 DK 1054893T3
- Authority
- DK
- Denmark
- Prior art keywords
- kits
- compositions
- solubility
- modulating
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229920001059 synthetic polymer Polymers 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 3
- 108091093037 Peptide nucleic acid Proteins 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 1
- 229920002647 polyamide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyamides (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7277298P | 1998-01-27 | 1998-01-27 | |
| US09/225,048 US6326479B1 (en) | 1998-01-27 | 1999-01-04 | Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
| PCT/US1999/001024 WO1999037670A1 (en) | 1998-01-27 | 1999-01-19 | Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1054893T3 true DK1054893T3 (da) | 2007-07-23 |
Family
ID=26753724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99904123T DK1054893T3 (da) | 1998-01-27 | 1999-01-19 | Syntetiske polymerer og fremgangsmåder, kit eller sammensætninger til modulering af deres oplöselighed |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6326479B1 (da) |
| EP (1) | EP1054893B1 (da) |
| AT (1) | ATE356827T1 (da) |
| AU (1) | AU2459199A (da) |
| DE (1) | DE69935502T2 (da) |
| DK (1) | DK1054893T3 (da) |
| WO (1) | WO1999037670A1 (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999049293A2 (en) | 1998-03-24 | 1999-09-30 | Boston Probes, Inc. | Methods, kits and compositions pertaining to detection complexes |
| US6962906B2 (en) | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| AU2001247414A1 (en) | 2000-03-14 | 2001-09-24 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| US20040014644A1 (en) * | 2000-03-14 | 2004-01-22 | Vladimir Efimov | Oligonucleotide analogues and methods of use for modulating gene expression |
| DE10019135A1 (de) | 2000-04-18 | 2001-10-31 | Aventis Pharma Gmbh | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
| EP1349958B1 (en) | 2000-09-26 | 2009-06-03 | Boston Probes, Inc. | Probes, probe sets, methods and kits pertaining to the detection, identification and/or enumeration of bacteria |
| WO2002057493A2 (en) | 2000-12-15 | 2002-07-25 | Boston Probes, Inc. | Methods for determining organisms |
| US7256275B2 (en) * | 2001-03-09 | 2007-08-14 | Boston Probes, Inc. | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation |
| US20030129626A1 (en) * | 2001-09-24 | 2003-07-10 | Nielsen Kirsten Vang | Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid |
| WO2003080857A2 (en) * | 2002-03-21 | 2003-10-02 | Boston Probes,Inc. | Pna oligomers, oligomers sets, methods and kits pertaining to the detection of bacillus anthracis |
| US20040219685A1 (en) * | 2003-01-30 | 2004-11-04 | Applera Corporation | Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents |
| US7282331B2 (en) * | 2003-03-18 | 2007-10-16 | Advandx, Inc. | Method for improved specificity in probe based assays |
| US20070259445A1 (en) * | 2006-05-05 | 2007-11-08 | Blas Cerda | Quantitative analysis of surface-derived samples using mass spectrometry |
| US9051601B2 (en) | 2006-08-01 | 2015-06-09 | Gen-Probe Incorporated | Methods of nonspecific target capture of nucleic acids |
| FR2908415B1 (fr) * | 2006-11-10 | 2009-01-23 | Abr Dev Sarl | Acide hyaluronique reticule et son procede de preparation |
| ES2794401T3 (es) * | 2008-10-15 | 2020-11-18 | Axolabs Gmbh | Método de detección de oligonucleótidos |
| WO2014093291A1 (en) | 2012-12-10 | 2014-06-19 | Advandx, Inc. | Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest |
| GB201415864D0 (en) * | 2014-09-08 | 2014-10-22 | Univ Edinburgh | Methods of detecting of multidrug resistant bacteria |
| JP2019508037A (ja) | 2016-02-16 | 2019-03-28 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ | 標的化遺伝子編集を増強するための組成物およびその使用方法 |
| WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
| US20210189431A1 (en) | 2018-08-10 | 2021-06-24 | Yale University | Compositions and methods for embryonic gene editing in vitro |
| EP3844287B1 (en) | 2018-08-31 | 2024-05-22 | Yale University | Compositions and methods for enhancing donor oligonucleotide-based gene editing |
| CA3111186A1 (en) | 2018-08-31 | 2020-03-05 | Yale University | Compositions and methods for enhancing triplex and nuclease-based gene editing |
| WO2020112195A1 (en) | 2018-11-30 | 2020-06-04 | Yale University | Compositions, technologies and methods of using plerixafor to enhance gene editing |
| WO2020257779A1 (en) | 2019-06-21 | 2020-12-24 | Yale University | Hydroxymethyl-modified gamma-pna compositions and methods of use thereof |
| WO2020257776A1 (en) | 2019-06-21 | 2020-12-24 | Yale University | Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof |
| US12496357B2 (en) | 2019-07-31 | 2025-12-16 | Yale University | Compositions and methods for treating sickle cell disease |
| WO2021042060A1 (en) | 2019-08-30 | 2021-03-04 | Yale University | Compositions and methods for delivery of nucleic acids to cells |
| US20220339294A1 (en) | 2019-09-09 | 2022-10-27 | Yale University | Nanoparticles for selective tissue or cellular uptake |
| WO2021211786A1 (en) * | 2020-04-17 | 2021-10-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thyclotides |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US5198540A (en) | 1982-10-28 | 1993-03-30 | Hubert Koster | Process for the preparation of oligonucleotides in solution |
| DE3329892A1 (de) | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| USRE34069E (en) | 1983-08-18 | 1992-09-15 | Biosyntech Gmbh | Process for the preparation of oligonucleotides |
| US4786724A (en) | 1984-10-11 | 1988-11-22 | Northwestern University | Nucleoside trichlorodimethylethyl phosphite esters |
| US5118605A (en) | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| WO1986005519A1 (en) | 1985-03-15 | 1986-09-25 | James Summerton | Polynucleotide assay reagent and method |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
| FR2596761B1 (fr) | 1986-04-08 | 1988-05-20 | Commissariat Energie Atomique | Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides |
| US5204456A (en) | 1986-04-08 | 1993-04-20 | Commissariat A L'energie Atomique | Derivatives of nucleosides and their use for the synthesis of oligonucleotides |
| US5071974A (en) | 1986-10-31 | 1991-12-10 | Amoco Corporation | Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini |
| US5243038A (en) | 1986-11-04 | 1993-09-07 | Protein Polymer Technologies, Inc. | Construction of synthetic DNA and its use in large polypeptide synthesis |
| US5175209A (en) | 1987-01-06 | 1992-12-29 | Baylor College Of Medicine | Porous wafer for segmented synthesis of biopolymers |
| US4923901A (en) | 1987-09-04 | 1990-05-08 | Millipore Corporation | Membranes with bound oligonucleotides and peptides |
| US5268306A (en) | 1988-02-29 | 1993-12-07 | Boehringer Mannheim Gmbh | Preparation of a solid phase matrix containing a bound specific binding pair |
| US5218103A (en) | 1988-05-26 | 1993-06-08 | University Patents, Inc. | Nucleoside thiophosphoramidites |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US5047524A (en) | 1988-12-21 | 1991-09-10 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| US5262530A (en) | 1988-12-21 | 1993-11-16 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| DE3900648A1 (de) | 1989-01-11 | 1990-07-12 | Boehringer Mannheim Gmbh | Neue cobalamin-saeurehydrazide und davon abgeleitete cobalamin-konjugate |
| US5112962A (en) | 1989-04-19 | 1992-05-12 | Northwestern University | Labile anchors for solid phase polynucleotide synthesis |
| US5391723A (en) | 1989-05-31 | 1995-02-21 | Neorx Corporation | Oligonucleotide conjugates |
| US5164491A (en) | 1989-06-15 | 1992-11-17 | Gilead Sciences | Large scale synthesis of oligonucleotides and their associated analogs |
| US5204455A (en) | 1989-06-15 | 1993-04-20 | Froehler Brian C | Monomethoxytrityl protected oligonucleotides bound to a solid support |
| DE4011084A1 (de) | 1990-04-05 | 1991-10-10 | Boehringer Mannheim Gmbh | Saccharid-modifizierte, wasserloesliche proteine |
| DE4011601A1 (de) | 1990-04-10 | 1991-10-17 | Boehringer Mannheim Gmbh | Hapten-biotin-konjugate und ihre verwendung |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5419966A (en) | 1991-06-10 | 1995-05-30 | Microprobe Corporation | Solid support for synthesis of 3'-tailed oligonucleotides |
| US5281701A (en) | 1991-07-12 | 1994-01-25 | Applied Biosystems, Inc. | Process and compounds for RNA synthesis |
| US5348868A (en) | 1992-04-24 | 1994-09-20 | Beckman Instruments, Inc. | Methods and reagents for cleaving and deprotecting oligonucleotides |
| US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
| US5391667A (en) | 1993-03-04 | 1995-02-21 | Isis Pharmaceuticals | Copolymers of N-vinyl-lactams suitable for oligomer solid phase synthesis |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| JPH10500310A (ja) | 1994-05-19 | 1998-01-13 | ダコ アクティーゼルスカブ | 淋菌及びトラコーマ クラミジアの検出のためのｐｎａ プローブ |
| US5705333A (en) | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
| DE4427980A1 (de) | 1994-08-08 | 1996-02-15 | Bayer Ag | Nukleinsäuren-bindende Oligomere für Therapie und Diagnostik |
| DE69632324T2 (de) | 1995-06-07 | 2005-06-16 | PerSeptive Biosystems, Inc., Framingham | Pna-dna-chimäre und pna-synthone zu deren herstellung |
| US20020016304A1 (en) * | 1996-05-16 | 2002-02-07 | Atsushi Maruyama | Carrier for stabilizing nucleic acid |
| EP0960121B1 (en) | 1996-07-24 | 2005-11-30 | BUCHARDT, Dorte | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US6512104B1 (en) * | 1996-10-01 | 2003-01-28 | Amgen Inc. | Interleukin-1β converting enzyme like cysteine protease |
| GB9621367D0 (en) * | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
| US5908845A (en) | 1996-10-30 | 1999-06-01 | Segev; David | Polyether nucleic acids |
-
1999
- 1999-01-04 US US09/225,048 patent/US6326479B1/en not_active Expired - Lifetime
- 1999-01-19 EP EP99904123A patent/EP1054893B1/en not_active Expired - Lifetime
- 1999-01-19 AU AU24591/99A patent/AU2459199A/en not_active Abandoned
- 1999-01-19 DK DK99904123T patent/DK1054893T3/da active
- 1999-01-19 WO PCT/US1999/001024 patent/WO1999037670A1/en not_active Ceased
- 1999-01-19 AT AT99904123T patent/ATE356827T1/de not_active IP Right Cessation
- 1999-01-19 DE DE69935502T patent/DE69935502T2/de not_active Expired - Lifetime
-
2001
- 2001-11-30 US US10/013,283 patent/US6770442B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69935502D1 (de) | 2007-04-26 |
| US20040102571A1 (en) | 2004-05-27 |
| ATE356827T1 (de) | 2007-04-15 |
| DE69935502T2 (de) | 2007-12-13 |
| AU2459199A (en) | 1999-08-09 |
| WO1999037670A1 (en) | 1999-07-29 |
| US6326479B1 (en) | 2001-12-04 |
| EP1054893A1 (en) | 2000-11-29 |
| EP1054893B1 (en) | 2007-03-14 |
| US6770442B2 (en) | 2004-08-03 |
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